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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:UVRAG-RPS3

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UVRAG-RPS3
FusionPDB ID: 97811
FusionGDB2.0 ID: 97811
HgeneTgene
Gene symbol

UVRAG

RPS3

Gene ID

7405

6188

Gene nameUV radiation resistance associatedribosomal protein S3
SynonymsDHTX|VPS38|p63S3
Cytomap

11q13.5

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy40S ribosomal protein S3IMR-90 ribosomal protein S3small ribosomal subunit protein uS3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000356136, ENST00000528420, 
ENST00000525872, ENST00000531818, 
ENST00000532130, ENST00000533454, 
ENST00000538870, ENST00000539288, 
ENST00000529285, ENST00000278572, 
ENST00000524851, ENST00000526608, 
ENST00000527446, ENST00000530164, 
ENST00000531188, ENST00000534440, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 18 X 15=1107017 X 19 X 5=1615
# samples 4922
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(22/1615*10)=-2.87595873605663
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: UVRAG [Title/Abstract] AND RPS3 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: UVRAG [Title/Abstract] AND RPS3 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPS3(75112777)-UVRAG(75599872), # samples:1
UVRAG(75572825)-RPS3(75111737), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RPS3-UVRAG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-RPS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-RPS3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-RPS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-RPS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840

TgeneRPS3

GO:0006979

response to oxidative stress

23911537

TgeneRPS3

GO:0017148

negative regulation of translation

20217897

TgeneRPS3

GO:0031397

negative regulation of protein ubiquitination

19656744

TgeneRPS3

GO:0032079

positive regulation of endodeoxyribonuclease activity

18973764

TgeneRPS3

GO:0042769

DNA damage response, detection of DNA damage

23911537

TgeneRPS3

GO:0045739

positive regulation of DNA repair

23911537

TgeneRPS3

GO:0061481

response to TNF agonist

20041225

TgeneRPS3

GO:0070301

cellular response to hydrogen peroxide

23911537

TgeneRPS3

GO:1901224

positive regulation of NIK/NF-kappaB signaling

20041225

TgeneRPS3

GO:1902546

positive regulation of DNA N-glycosylase activity

15518571

TgeneRPS3

GO:1905053

positive regulation of base-excision repair

18973764

TgeneRPS3

GO:2001235

positive regulation of apoptotic signaling pathway

14988002



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75112777/chr11:75599872)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000356136UVRAGchr1175572825+ENST00000531188RPS3chr1175111737+25165111631212349
ENST00000356136UVRAGchr1175572825+ENST00000530164RPS3chr1175111737+2330511163834223
ENST00000356136UVRAGchr1175572825+ENST00000278572RPS3chr1175111737+13705111631260365
ENST00000356136UVRAGchr1175572825+ENST00000534440RPS3chr1175111737+1028511163957264
ENST00000356136UVRAGchr1175572825+ENST00000527446RPS3chr1175111737+17705111631212349
ENST00000356136UVRAGchr1175572825+ENST00000526608RPS3chr1175111737+11805111631176337
ENST00000356136UVRAGchr1175572825+ENST00000524851RPS3chr1175111737+13425111631212349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000531188UVRAGchr1175572825+RPS3chr1175111737+0.0006055940.9993944
ENST00000356136ENST00000530164UVRAGchr1175572825+RPS3chr1175111737+0.0021296620.9978703
ENST00000356136ENST00000278572UVRAGchr1175572825+RPS3chr1175111737+0.0013502190.9986498
ENST00000356136ENST00000534440UVRAGchr1175572825+RPS3chr1175111737+0.0033821690.99661785
ENST00000356136ENST00000527446UVRAGchr1175572825+RPS3chr1175111737+0.0009805980.9990194
ENST00000356136ENST00000526608UVRAGchr1175572825+RPS3chr1175111737+0.001681430.99831855
ENST00000356136ENST00000524851UVRAGchr1175572825+RPS3chr1175111737+0.001169560.9988305

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for UVRAG-RPS3

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
UVRAGchr1175572825RPS3chr1175111737511116KEFYRSEVIKNSLFVADGIFKAELNE

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Potential FusionNeoAntigen Information of UVRAG-RPS3 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
UVRAG-RPS3_75572825_75111737.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
UVRAG-RPS3chr1175572825chr1175111737511HLA-B44:03SEVIKNSLF0.99850.9487514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:01SEVIKNSLF0.96030.9333514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B47:01SEVIKNSLF0.94340.5847514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B15:25SLFVADGIF0.90940.94361120
UVRAG-RPS3chr1175572825chr1175111737511HLA-B57:03RSEVIKNSLF0.96570.9778414
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:04YRSEVIKNSLF0.99990.851314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:02YRSEVIKNSLF0.99990.7122314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:05YRSEVIKNSLF0.99990.9272314
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:13SLFVADGIFKA0.99240.84731122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:27SLFVADGIFKA0.99210.77641122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:22SLFVADGIFKA0.98860.72331122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:67SLFVADGIFKA0.98290.63081122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:24SLFVADGIFKA0.98290.63081122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:30SLFVADGIFKA0.98290.63081122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:60SLFVADGIFKA0.98270.6781122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:11SLFVADGIFKA0.98260.64591122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:16SLFVADGIFKA0.98230.63651122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:21SLFVADGIFKA0.98230.73741122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:35SLFVADGIFKA0.97750.66881122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:38SLFVADGIFKA0.97720.82621122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:04SLFVADGIFKA0.97380.78371122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:17SLFVADGIFKA0.9630.72581122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:19SLFVADGIFKA0.95890.75821122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:20SLFVADGIFKA0.89860.63911122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:29SLFVADGIFKA0.89790.63471122
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:19YRSEVIKNSLF0.99990.7587314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:05YRSEVIKNSLF0.99990.9644314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:95YRSEVIKNSLF0.99990.7368314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:27YRSEVIKNSLF0.99990.9512314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:80YRSEVIKNSLF0.99980.9378314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:67YRSEVIKNSLF0.99980.9378314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:46YRSEVIKNSLF0.99980.8759314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:10YRSEVIKNSLF0.99970.9656314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:03YRSEVIKNSLF0.9980.9425314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B40:06SEVIKNSLFVA0.99620.6732516
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:02SLFVADGIFKA0.98850.59851122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:05SLFVADGIFKA0.98730.70581122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:01SLFVADGIFKA0.98290.63081122
UVRAG-RPS3chr1175572825chr1175111737511HLA-C12:16YRSEVIKNSLF0.97170.9561314
UVRAG-RPS3chr1175572825chr1175111737511HLA-A25:01EVIKNSLF0.99880.9155614
UVRAG-RPS3chr1175572825chr1175111737511HLA-A68:02EVIKNSLFV0.99940.6453615
UVRAG-RPS3chr1175572825chr1175111737511HLA-A69:01EVIKNSLFV0.99890.777615
UVRAG-RPS3chr1175572825chr1175111737511HLA-B44:26SEVIKNSLF0.99850.9487514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B44:13SEVIKNSLF0.99850.9487514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B44:07SEVIKNSLF0.99850.9487514
UVRAG-RPS3chr1175572825chr1175111737511HLA-A25:01EVIKNSLFV0.99410.8969615
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:11SEVIKNSLF0.98580.9039514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B40:04SEVIKNSLF0.98090.6853514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:08SEVIKNSLF0.96730.8957514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:04SEVIKNSLF0.96580.9385514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:06SEVIKNSLF0.96520.9364514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:05SEVIKNSLF0.96030.9333514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B18:03SEVIKNSLF0.9520.9298514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B15:39SLFVADGIF0.91180.88861120
UVRAG-RPS3chr1175572825chr1175111737511HLA-B15:53SEVIKNSLF0.45680.8925514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B48:02SEVIKNSLF0.3310.8909514
UVRAG-RPS3chr1175572825chr1175111737511HLA-B57:04RSEVIKNSLF0.99760.7072414
UVRAG-RPS3chr1175572825chr1175111737511HLA-B57:02RSEVIKNSLF0.99010.84414
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:09YRSEVIKNSLF0.99990.9157314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:01YRSEVIKNSLF0.99990.7024314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:06YRSEVIKNSLF0.99990.8621314
UVRAG-RPS3chr1175572825chr1175111737511HLA-B27:08YRSEVIKNSLF0.99990.8606314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:02YRSEVIKNSLF0.99980.9378314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C07:22YRSEVIKNSLF0.99930.7588314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C06:08YRSEVIKNSLF0.99920.9866314
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:03SLFVADGIFKA0.99480.83771122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:14SLFVADGIFKA0.98330.67781122
UVRAG-RPS3chr1175572825chr1175111737511HLA-A02:06SLFVADGIFKA0.98230.73741122
UVRAG-RPS3chr1175572825chr1175111737511HLA-C06:17YRSEVIKNSLF0.97860.991314
UVRAG-RPS3chr1175572825chr1175111737511HLA-C06:02YRSEVIKNSLF0.97860.991314

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Potential FusionNeoAntigen Information of UVRAG-RPS3 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
UVRAG-RPS3_75572825_75111737.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0305NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0340NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0401NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0433NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0434NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0435NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0438NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0463NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0466NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0472NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0472KNSLFVADGIFKAEL924
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0474NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB1-0476NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0101NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0104NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0105NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0108NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0111NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0112NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0113NSLFVADGIFKAELN1025
UVRAG-RPS3chr1175572825chr1175111737511DRB3-0114NSLFVADGIFKAELN1025

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Fusion breakpoint peptide structures of UVRAG-RPS3

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2215EVIKNSLFVADGIFUVRAGRPS3chr1175572825chr1175111737511

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of UVRAG-RPS3

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B52:013W392215EVIKNSLFVADGIF-4.72614-4.72614
HLA-B44:053DX82215EVIKNSLFVADGIF-6.07373-6.07373

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Vaccine Design for the FusionNeoAntigens of UVRAG-RPS3

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
UVRAG-RPS3chr1175572825chr11751117371120SLFVADGIFTCCTTGTTTGTCGCTGATGGCATCTTC
UVRAG-RPS3chr1175572825chr11751117371122SLFVADGIFKATCCTTGTTTGTCGCTGATGGCATCTTCAAAGCT
UVRAG-RPS3chr1175572825chr1175111737314YRSEVIKNSLFTATAGAAGTGAAGTGATTAAGAATTCCTTGTTT
UVRAG-RPS3chr1175572825chr1175111737414RSEVIKNSLFAGAAGTGAAGTGATTAAGAATTCCTTGTTT
UVRAG-RPS3chr1175572825chr1175111737514SEVIKNSLFAGTGAAGTGATTAAGAATTCCTTGTTT
UVRAG-RPS3chr1175572825chr1175111737516SEVIKNSLFVAAGTGAAGTGATTAAGAATTCCTTGTTTGTCGCT
UVRAG-RPS3chr1175572825chr1175111737614EVIKNSLFGAAGTGATTAAGAATTCCTTGTTT
UVRAG-RPS3chr1175572825chr1175111737615EVIKNSLFVGAAGTGATTAAGAATTCCTTGTTTGTC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
UVRAG-RPS3chr1175572825chr11751117371025NSLFVADGIFKAELNAATTCCTTGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTGAAT
UVRAG-RPS3chr1175572825chr1175111737924KNSLFVADGIFKAELAAGAATTCCTTGTTTGTCGCTGATGGCATCTTCAAAGCTGAACTG

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Information of the samples that have these potential fusion neoantigens of UVRAG-RPS3

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
ESCAUVRAG-RPS3chr1175572825ENST00000356136chr1175111737ENST00000278572TCGA-R6-A6Y0

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Potential target of CAR-T therapy development for UVRAG-RPS3

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to UVRAG-RPS3

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UVRAG-RPS3

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource