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Fusion Protein:WWOX-WWOX

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: WWOX-WWOX
	FusionPDB ID: 99501
	FusionGDB2.0 ID: 99501
		Hgene	Tgene
	Gene symbol	WWOX	WWOX
	Gene ID	51741	51741
	Gene name	WW domain containing oxidoreductase	WW domain containing oxidoreductase
	Synonyms	D16S432E\|EIEE28\|FOR\|FRA16D\|HHCMA56\|PRO0128\|SCAR12\|SDR41C1\|WOX1	D16S432E\|EIEE28\|FOR\|FRA16D\|HHCMA56\|PRO0128\|SCAR12\|SDR41C1\|WOX1
	Cytomap	16q23.1-q23.2	16q23.1-q23.2
	Type of gene	protein-coding	protein-coding
	Description	WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1	WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000408984, ENST00000566780, ENST00000355860, ENST00000402655, ENST00000406884, ENST00000539474, ENST00000565791, ENST00000569818,	ENST00000355860, ENST00000408984, ENST00000565791, ENST00000569818, ENST00000402655, ENST00000406884, ENST00000566780, ENST00000539474,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	26 X 26 X 8=5408	30 X 23 X 10=6900
	# samples	31	36
	** MAII score	log2(31/5408*10)=-4.12475503100795 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(36/6900*10)=-4.26052755022322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: WWOX [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: WWOX [Title/Abstract] AND WWOX [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	WWOX(78466649)-WWOX(79245500), # samples:2 WWOX(78707278)-WWOX(78707156), # samples:2
Anticipated loss of major functional domain due to fusion event.	WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. WWOX-WWOX seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. WWOX-WWOX seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. WWOX-WWOX seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	WWOX	GO:0030178	negative regulation of Wnt signaling pathway	19465938
Hgene	WWOX	GO:0071560	cellular response to transforming growth factor beta stimulus	19366691
Tgene	WWOX	GO:0030178	negative regulation of Wnt signaling pathway	19465938
Tgene	WWOX	GO:0071560	cellular response to transforming growth factor beta stimulus	19366691

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:78466649/chr16:79245500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across WWOX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000566780

WWOX

chr16

78466649

ENST00000539474

WWOX

chr16

79245500

2482

1422

366

1610

414

ENST00000408984

WWOX

chr16

78466649

ENST00000539474

WWOX

chr16

79245500

2201

1141

1329

414

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000566780	ENST00000539474	WWOX	chr16	78466649	+	WWOX	chr16	79245500	+	0.007019572	0.9929804
ENST00000408984	ENST00000539474	WWOX	chr16	78466649	+	WWOX	chr16	79245500	+	0.004926908	0.995073

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for WWOX-WWOX

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
WWOX	chr16	78466649	WWOX	chr16	79245500	1141	352	LLFTLARPFTKSMQQGAATTVYCAAV
WWOX	chr16	78466649	WWOX	chr16	79245500	1422	352	LLFTLARPFTKSMQQGAATTVYCAAV

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Potential FusionNeoAntigen Information of WWOX-WWOX in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

WWOX-WWOX_78466649_79245500.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B48:01	MQQGAATTV	0.9619	0.8872	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-A02:21	MQQGAATTV	0.8667	0.8722	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B13:02	MQQGAATTV	0.8114	0.9717	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:01	MQQGAATTV	0.7831	0.9743	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:13	MQQGAATTV	0.7745	0.9914	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B13:01	MQQGAATTV	0.598	0.9983	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:10	MQQGAATTV	0.4742	0.9127	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B52:01	MQQGAATTV	0.061	0.9945	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:01	MQQGAATTVY	0.9999	0.7323	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:25	MQQGAATTVY	0.9936	0.955	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:02	MQQGAATTVY	0.984	0.9611	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:03	MQQGAATTVY	0.9042	0.7819	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:18	MQQGAATTVY	0.8371	0.7565	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B13:02	SMQQGAATTV	0.3554	0.9526	11	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:01	SMQQGAATTVY	0.9999	0.8194	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:25	SMQQGAATTVY	0.9949	0.8633	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:02	SMQQGAATTVY	0.9919	0.8796	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B56:01	RPFTKSMQQGA	0.825	0.5177	6	17
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B13:02	KSMQQGAATTV	0.7443	0.9502	10	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-A02:05	MQQGAATTV	0.9648	0.8518	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:04	MQQGAATTV	0.8192	0.9809	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B48:03	MQQGAATTV	0.7786	0.9014	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:08	MQQGAATTV	0.7101	0.9323	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:05	MQQGAATTV	0.6914	0.9754	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B51:07	MQQGAATTV	0.0631	0.9959	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:07	MQQGAATTVY	0.9989	0.6062	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:04	MQQGAATTVY	0.9909	0.7583	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:21	MQQGAATTVY	0.9851	0.942	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:05	MQQGAATTVY	0.9392	0.9378	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:31	MQQGAATTVY	0.879	0.942	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:07	SMQQGAATTVY	0.9997	0.6795	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:21	SMQQGAATTVY	0.9899	0.8745	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:05	SMQQGAATTVY	0.9461	0.845	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:31	SMQQGAATTVY	0.9164	0.8472	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:73	MQQGAATTV	0.8901	0.9886	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-A02:14	MQQGAATTV	0.8712	0.8827	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-A02:06	MQQGAATTV	0.8667	0.8722	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:02	MQQGAATTV	0.8303	0.9912	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:30	MQQGAATTV	0.8026	0.9845	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B40:12	MQQGAATTV	0.7786	0.9014	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B39:11	MQQGAATTV	0.6359	0.8822	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B40:21	MQQGAATTV	0.5367	0.913	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:09	MQQGAATTV	0.2555	0.9627	12	21
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:135	MQQGAATTVY	0.9999	0.7402	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:33	MQQGAATTVY	0.9999	0.7323	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:125	MQQGAATTVY	0.9999	0.7323	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:27	MQQGAATTVY	0.9999	0.7172	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:34	MQQGAATTVY	0.9999	0.7323	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:50	MQQGAATTVY	0.9998	0.7563	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:24	MQQGAATTVY	0.9997	0.7882	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:53	MQQGAATTVY	0.9991	0.6991	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:12	MQQGAATTVY	0.9987	0.7474	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:35	MQQGAATTVY	0.9985	0.705	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:54	MQQGAATTVY	0.9938	0.6935	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:39	MQQGAATTVY	0.9936	0.8141	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:68	MQQGAATTVY	0.964	0.5695	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:20	MQQGAATTVY	0.9404	0.9645	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B35:28	MQQGAATTVY	0.93	0.9719	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B35:20	MQQGAATTVY	0.8674	0.9747	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B48:02	MQQGAATTVY	0.6887	0.9659	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B18:04	MQQGAATTVY	0.634	0.9128	12	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:33	SMQQGAATTVY	0.9999	0.8194	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:125	SMQQGAATTVY	0.9999	0.8194	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:27	SMQQGAATTVY	0.9999	0.8197	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:135	SMQQGAATTVY	0.9999	0.8378	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:34	SMQQGAATTVY	0.9999	0.8194	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:50	SMQQGAATTVY	0.9999	0.7659	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:12	SMQQGAATTVY	0.9995	0.8669	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:53	SMQQGAATTVY	0.9995	0.7769	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:35	SMQQGAATTVY	0.9995	0.735	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:39	SMQQGAATTVY	0.9952	0.8348	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B15:20	SMQQGAATTVY	0.946	0.8698	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B35:28	SMQQGAATTVY	0.9266	0.9089	11	22
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	HLA-B55:02	RPFTKSMQQGA	0.9236	0.6808	6	17

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Potential FusionNeoAntigen Information of WWOX-WWOX in HLA II

WWOX-WWOX_78466649_79245500.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	DRB1-0902	ARPFTKSMQQGAATT	5	20
WWOX-WWOX	chr16	78466649	chr16	79245500	1141	DRB1-0902	LARPFTKSMQQGAAT	4	19

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Fusion breakpoint peptide structures of WWOX-WWOX

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8080	RPFTKSMQQGAATT	WWOX	WWOX	chr16	78466649	chr16	79245500	1141

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of WWOX-WWOX

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	8080	RPFTKSMQQGAATT	-8.62545	-8.73885
HLA-B14:02	3BVN	8080	RPFTKSMQQGAATT	-3.26321	-4.29851
HLA-B52:01	3W39	8080	RPFTKSMQQGAATT	-6.23413	-6.34753
HLA-B52:01	3W39	8080	RPFTKSMQQGAATT	-4.55402	-5.58932
HLA-A24:02	5HGA	8080	RPFTKSMQQGAATT	-8.62578	-8.73918
HLA-A24:02	5HGA	8080	RPFTKSMQQGAATT	-6.438	-7.4733
HLA-B44:05	3DX8	8080	RPFTKSMQQGAATT	-5.68484	-5.79824
HLA-B44:05	3DX8	8080	RPFTKSMQQGAATT	-3.64855	-4.68385
HLA-A02:01	6TDR	8080	RPFTKSMQQGAATT	-5.14764	-6.18294

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Vaccine Design for the FusionNeoAntigens of WWOX-WWOX

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
WWOX-WWOX	chr16	78466649	chr16	79245500	10	21	KSMQQGAATTV	AAGTCCATGCAACAGGGAGCTGCCACCACCGTG
WWOX-WWOX	chr16	78466649	chr16	79245500	11	21	SMQQGAATTV	TCCATGCAACAGGGAGCTGCCACCACCGTG
WWOX-WWOX	chr16	78466649	chr16	79245500	11	22	SMQQGAATTVY	TCCATGCAACAGGGAGCTGCCACCACCGTGTAC
WWOX-WWOX	chr16	78466649	chr16	79245500	12	21	MQQGAATTV	ATGCAACAGGGAGCTGCCACCACCGTG
WWOX-WWOX	chr16	78466649	chr16	79245500	12	22	MQQGAATTVY	ATGCAACAGGGAGCTGCCACCACCGTGTAC
WWOX-WWOX	chr16	78466649	chr16	79245500	6	17	RPFTKSMQQGA	AGGCCTTTCACCAAGTCCATGCAACAGGGAGCT

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
WWOX-WWOX	chr16	78466649	chr16	79245500	4	19	LARPFTKSMQQGAAT	TTGGCGAGGCCTTTCACCAAGTCCATGCAACAGGGAGCTGCCACC
WWOX-WWOX	chr16	78466649	chr16	79245500	5	20	ARPFTKSMQQGAATT	GCGAGGCCTTTCACCAAGTCCATGCAACAGGGAGCTGCCACCACC

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Information of the samples that have these potential fusion neoantigens of WWOX-WWOX

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
N/A	WWOX-WWOX	chr16	78466649	ENST00000408984	chr16	79245500	ENST00000539474	AY405915

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Potential target of CAR-T therapy development for WWOX-WWOX

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to WWOX-WWOX

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to WWOX-WWOX

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)