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Fusion Protein:XRCC5-TRIM22

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: XRCC5-TRIM22
	FusionPDB ID: 99772
	FusionGDB2.0 ID: 99772
		Hgene	Tgene
	Gene symbol	XRCC5	TRIM22
	Gene ID	7520	10346
	Gene name	X-ray repair cross complementing 5	tripartite motif containing 22
	Synonyms	KARP-1\|KARP1\|KU80\|KUB2\|Ku86\|NFIV	GPSTAF50\|RNF94\|STAF50
	Cytomap	2q35	11p15.4
	Type of gene	protein-coding	protein-coding
	Description	X-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKu	E3 ubiquitin-protein ligase TRIM2250 kDa-stimulated trans-acting factorRING finger protein 94RING-type E3 ubiquitin transferase TRIM22staf-50stimulated trans-acting factor (50 kDa)tripartite binding motif 22tripartite motif protein TRIM22tripartit
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000392132, ENST00000392133, ENST00000471649,	ENST00000379965,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 7=910	7 X 5 X 4=140
	# samples	12	6
	** MAII score	log2(12/910*10)=-2.92283213947754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/140*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: XRCC5 [Title/Abstract] AND TRIM22 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: XRCC5 [Title/Abstract] AND TRIM22 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	XRCC5(216974180)-TRIM22(5719545), # samples:1
Anticipated loss of major functional domain due to fusion event.	XRCC5-TRIM22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. XRCC5-TRIM22 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. XRCC5-TRIM22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. XRCC5-TRIM22 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	XRCC5	GO:0002218	activation of innate immune response	28712728
Hgene	XRCC5	GO:0006303	double-strand break repair via nonhomologous end joining	26359349
Hgene	XRCC5	GO:0045860	positive regulation of protein kinase activity	22504299
Hgene	XRCC5	GO:0071480	cellular response to gamma radiation	26359349
Tgene	TRIM22	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	23077300
Tgene	TRIM22	GO:0051091	positive regulation of DNA-binding transcription factor activity	23077300
Tgene	TRIM22	GO:0051092	positive regulation of NF-kappaB transcription factor activity	23077300

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216974180/chr11:5719545)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000392133

XRCC5

chr2

216974180

ENST00000379965

TRIM22

chr11

5719545

2675

482

1459

462

ENST00000392132

XRCC5

chr2

216974180

ENST00000379965

TRIM22

chr11

5719545

2354

161

1138

360

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392133	ENST00000379965	XRCC5	chr2	216974180	+	TRIM22	chr11	5719545	+	0.000647694	0.9993523
ENST00000392132	ENST00000379965	XRCC5	chr2	216974180	+	TRIM22	chr11	5719545	+	0.000688842	0.9993112

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for XRCC5-TRIM22

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
XRCC5	chr2	216974180	TRIM22	chr11	5719545	161	34	KRLRTGNMVRSGNKNYIQIERQKILK
XRCC5	chr2	216974180	TRIM22	chr11	5719545	482	136	KRLRTGNMVRSGNKNYIQIERQKILK

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Potential FusionNeoAntigen Information of XRCC5-TRIM22 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

XRCC5-TRIM22_216974180_5719545.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:01	MVRSGNKNY	0.9959	0.9042	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:25	MVRSGNKNY	0.9779	0.9339	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:02	MVRSGNKNY	0.9383	0.941	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:07	MVRSGNKNY	0.9922	0.653	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:95	VRSGNKNYI	0.8841	0.731	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:27	VRSGNKNYI	0.8593	0.9495	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:05	VRSGNKNYI	0.8476	0.9522	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:04	MVRSGNKNY	0.6599	0.9048	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C12:16	VRSGNKNYI	0.0008	0.9487	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:27	MVRSGNKNY	0.9959	0.9061	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:125	MVRSGNKNY	0.9959	0.9042	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:34	MVRSGNKNY	0.9959	0.9042	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:33	MVRSGNKNY	0.9959	0.9042	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:135	MVRSGNKNY	0.9953	0.9092	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:50	MVRSGNKNY	0.9928	0.9409	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:11	MVRSGNKNY	0.9924	0.8663	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:35	MVRSGNKNY	0.9913	0.8896	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:08	MVRSGNKNY	0.9905	0.8743	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B35:43	MVRSGNKNY	0.9869	0.8751	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:39	MVRSGNKNY	0.9773	0.8588	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B15:12	MVRSGNKNY	0.971	0.8952	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-B35:11	MVRSGNKNY	0.9235	0.9395	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:01	VRSGNKNYI	0.8888	0.7059	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-A25:01	MVRSGNKNY	0.7497	0.8936	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-A30:01	MVRSGNKNY	0.6274	0.8616	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C06:08	VRSGNKNYI	0.5687	0.9899	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:22	VRSGNKNYI	0.5223	0.7105	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C12:02	MVRSGNKNY	0.3868	0.9672	7	16
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C07:04	VRSGNKNYI	0.3094	0.8986	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C06:06	VRSGNKNYI	0.11	0.9848	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C06:02	VRSGNKNYI	0.0025	0.9889	8	17
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	HLA-C06:17	VRSGNKNYI	0.0025	0.9889	8	17

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Potential FusionNeoAntigen Information of XRCC5-TRIM22 in HLA II

XRCC5-TRIM22_216974180_5719545.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0802	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0803	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0805	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0807	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0807	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0808	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0808	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0809	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0811	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0811	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0813	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0814	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0815	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0818	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0819	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0821	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0823	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0824	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0825	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0825	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0827	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0829	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0829	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0830	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0832	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0833	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0834	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0834	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0835	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0836	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0837	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0837	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0838	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-0840	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1101	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1105	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1108	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1109	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1110	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1111	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1112	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1114	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1115	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1119	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1120	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1124	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1127	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1128	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1129	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1131	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1132	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1133	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1137	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1139	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1145	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1149	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1151	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1153	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1153	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1161	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1162	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1164	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1166	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1168	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1169	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1172	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1172	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1173	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1174	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1175	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1179	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1180	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1181	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1182	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1186	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1187	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1190	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1191	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1193	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1194	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1195	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1196	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1216	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1222	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1302	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1303	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1305	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1307	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-13100	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-13100	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-13100	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-13101	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-13101	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1310	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1310	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1312	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1313	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1314	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1316	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1321	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1323	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1326	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1326	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1329	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1330	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1331	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1331	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1333	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1334	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1336	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1337	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1338	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1338	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1339	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1341	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1346	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1346	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1346	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1347	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1349	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1350	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1355	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1356	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1360	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1362	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1363	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1365	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1365	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1366	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1367	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1373	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1374	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1382	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1385	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1385	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1386	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1386	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1388	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1390	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1395	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1396	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1397	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1399	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1401	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1402	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1402	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1403	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1404	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1407	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1407	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1407	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1409	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1413	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1413	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1414	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1414	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1414	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1418	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1419	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1422	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1422	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1424	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1425	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1425	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1426	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1427	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1428	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1430	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1430	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1431	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1432	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1436	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1436	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1436	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1438	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1439	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1440	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1441	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1441	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1442	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1442	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1442	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1444	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1444	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1444	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1446	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1447	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1448	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1448	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1449	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1449	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1450	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1451	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1451	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1453	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1453	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1454	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1455	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1458	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1460	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1461	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1462	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1463	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1463	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1467	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1467	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1468	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1468	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1468	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1469	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1469	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1470	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1471	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1473	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1477	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1482	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1485	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1485	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1486	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1487	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1488	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1489	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1490	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1493	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1493	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1493	RSGNKNYIQIERQKI	9	24
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1494	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1494	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1497	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1498	GNKNYIQIERQKILK	11	26
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1498	SGNKNYIQIERQKIL	10	25
XRCC5-TRIM22	chr2	216974180	chr11	5719545	161	DRB1-1499	GNKNYIQIERQKILK	11	26

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Fusion breakpoint peptide structures of XRCC5-TRIM22

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
6277	NMVRSGNKNYIQIE	XRCC5	TRIM22	chr2	216974180	chr11	5719545	161

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of XRCC5-TRIM22

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B52:01	3W39	6277	NMVRSGNKNYIQIE	-6.65674	-6.65674
HLA-B44:05	3DX8	6277	NMVRSGNKNYIQIE	-6.36866	-6.36866

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Vaccine Design for the FusionNeoAntigens of XRCC5-TRIM22

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
XRCC5-TRIM22	chr2	216974180	chr11	5719545	7	16	MVRSGNKNY	GTGCGGTCGGGGAATAAGAATTATATC
XRCC5-TRIM22	chr2	216974180	chr11	5719545	8	17	VRSGNKNYI	CGGTCGGGGAATAAGAATTATATCCAG

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
XRCC5-TRIM22	chr2	216974180	chr11	5719545	10	25	SGNKNYIQIERQKIL	GGGAATAAGAATTATATCCAGATCGAGAGACAGAAGATTCTGAAA
XRCC5-TRIM22	chr2	216974180	chr11	5719545	11	26	GNKNYIQIERQKILK	AATAAGAATTATATCCAGATCGAGAGACAGAAGATTCTGAAAGGG
XRCC5-TRIM22	chr2	216974180	chr11	5719545	9	24	RSGNKNYIQIERQKI	TCGGGGAATAAGAATTATATCCAGATCGAGAGACAGAAGATTCTG

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Information of the samples that have these potential fusion neoantigens of XRCC5-TRIM22

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
STAD	XRCC5-TRIM22	chr2	216974180	ENST00000392132	chr11	5719545	ENST00000379965	TCGA-BR-A4PE-01A

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Potential target of CAR-T therapy development for XRCC5-TRIM22

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to XRCC5-TRIM22

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to XRCC5-TRIM22

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)