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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PAX5-JAK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PAX5-JAK2
	FusionPDB ID: 62951
	FusionGDB2.0 ID: 62951
		Hgene	Tgene
	Gene symbol	PAX5	JAK2
	Gene ID	5079	3717
	Gene name	paired box 5	Janus kinase 2
	Synonyms	ALL3\|BSAP	JTK10\|THCYT3
	Cytomap	9p13.2	9p24.1
	Type of gene	protein-coding	protein-coding
	Description	paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5	tyrosine-protein kinase JAK2JAK-2Janus kinase 2 (a protein tyrosine kinase)
	Modification date	20200313	20200329
	UniProtAcc	Q02548	O60674
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358127, ENST00000377847, ENST00000377852, ENST00000377853, ENST00000446742, ENST00000520154, ENST00000522003, ENST00000523145, ENST00000523241, ENST00000414447, ENST00000520281,	ENST00000487310, ENST00000381652, ENST00000539801, ENST00000544510,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 7=1575	22 X 26 X 9=5148
	# samples	10	15
	** MAII score	log2(10/1575*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/5148*10)=-5.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PAX5 [Title/Abstract] AND JAK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PAX5-JAK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	JAK2	GO:0010811	positive regulation of cell-substrate adhesion	10925297
Tgene	JAK2	GO:0019221	cytokine-mediated signaling pathway	8609418
Tgene	JAK2	GO:0033209	tumor necrosis factor-mediated signaling pathway	8609418
Tgene	JAK2	GO:0034612	response to tumor necrosis factor	8609418
Tgene	JAK2	GO:0035409	histone H3-Y41 phosphorylation	19783980
Tgene	JAK2	GO:0035722	interleukin-12-mediated signaling pathway	7528775
Tgene	JAK2	GO:0046677	response to antibiotic	16280321
Tgene	JAK2	GO:0050727	regulation of inflammatory response	10925297
Tgene	JAK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Tgene	JAK2	GO:0070671	response to interleukin-12	7528775

Fusion gene breakpoints across PAX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across JAK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	PAX5	chr9	37002644	-	JAK2	chr9	5081724	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358127	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1667	679	75	1643	522
ENST00000358127	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	3036	679	75	1643	522
ENST00000358127	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1702	679	75	1643	522
ENST00000523241	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1602	614	10	1578	522
ENST00000523241	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2971	614	10	1578	522
ENST00000523241	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1637	614	10	1578	522
ENST00000520154	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1602	614	10	1578	522
ENST00000520154	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2971	614	10	1578	522
ENST00000520154	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1637	614	10	1578	522
ENST00000377852	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1602	614	10	1578	522
ENST00000377852	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2971	614	10	1578	522
ENST00000377852	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1637	614	10	1578	522
ENST00000377853	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1602	614	10	1578	522
ENST00000377853	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2971	614	10	1578	522
ENST00000377853	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1637	614	10	1578	522
ENST00000446742	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1394	406	0	1370	456
ENST00000446742	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2763	406	0	1370	456
ENST00000446742	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1429	406	0	1370	456
ENST00000377847	PAX5	chr9	37002644	-	ENST00000539801	JAK2	chr9	5081724	+	1592	604	0	1568	522
ENST00000377847	PAX5	chr9	37002644	-	ENST00000381652	JAK2	chr9	5081724	+	2961	604	0	1568	522
ENST00000377847	PAX5	chr9	37002644	-	ENST00000544510	JAK2	chr9	5081724	+	1627	604	0	1568	522

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62951_62951_1_PAX5-JAK2_PAX5_chr9_37002644_ENST00000358127_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_2_PAX5-JAK2_PAX5_chr9_37002644_ENST00000358127_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_3_PAX5-JAK2_PAX5_chr9_37002644_ENST00000358127_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_4_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377847_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_5_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377847_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_6_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377847_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_7_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377852_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_8_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377852_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_9_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377852_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_10_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377853_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_11_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377853_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_12_PAX5-JAK2_PAX5_chr9_37002644_ENST00000377853_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_13_PAX5-JAK2_PAX5_chr9_37002644_ENST00000446742_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=456AA_BP=135
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE
RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASD
VWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI

--------------------------------------------------------------

>62951_62951_14_PAX5-JAK2_PAX5_chr9_37002644_ENST00000446742_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=456AA_BP=135
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE
RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASD
VWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI

--------------------------------------------------------------

>62951_62951_15_PAX5-JAK2_PAX5_chr9_37002644_ENST00000446742_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=456AA_BP=135
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLG
KGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKE
RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASD
VWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI

--------------------------------------------------------------

>62951_62951_16_PAX5-JAK2_PAX5_chr9_37002644_ENST00000520154_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_17_PAX5-JAK2_PAX5_chr9_37002644_ENST00000520154_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_18_PAX5-JAK2_PAX5_chr9_37002644_ENST00000520154_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_19_PAX5-JAK2_PAX5_chr9_37002644_ENST00000523241_JAK2_chr9_5081724_ENST00000381652_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_20_PAX5-JAK2_PAX5_chr9_37002644_ENST00000523241_JAK2_chr9_5081724_ENST00000539801_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

>62951_62951_21_PAX5-JAK2_PAX5_chr9_37002644_ENST00000523241_JAK2_chr9_5081724_ENST00000544510_length(amino acids)=522AA_BP=201
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYS
ISGILGITSPSADTNKRKRDEDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA
VKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK
RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PAX5 Q02548	JAK2 O60674
FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269\|PubMed:10811620, ECO:0000269\|PubMed:27181361, ECO:0000269\|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269\|PubMed:23678172, ECO:0000269\|PubMed:31941781}.	FUNCTION: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). {ECO:0000269\|PubMed:12023369, ECO:0000269\|PubMed:19783980, ECO:0000269\|PubMed:20098430, ECO:0000269\|PubMed:21368206, ECO:0000269\|PubMed:21423214, ECO:0000269\|PubMed:7615558, ECO:0000269\|PubMed:9618263}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (227) >>>227.pdbFusion protein BP residue: 135 CIF file (227) >>>227.cif	PAX5	chr9	37002644	-	JAK2	chr9	5081724	+	MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVR PCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSHSIVSTGSVTQ VSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEDYELLTENDMLPNMR IGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTG EVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLK LIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRD LATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESL TESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVF HLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI	456
3D view using mol* of 227 (AA BP:135)


PDB file (341) >>>341.pdbFusion protein BP residue: 201 CIF file (341) >>>341.cif	PAX5	chr9	37002644	-	JAK2	chr9	5081724	+	MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVR PCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIA EYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQP VPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRD EDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNF GSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE FMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNV	522
3D view using mol* of 341 (AA BP:201)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PAX5_pLDDT.png

JAK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PAX5_JAK2_227_PAE.png (AA BP:135)

PAX5_JAK2_227_pLDDT.png (AA BP:135)

PAX5_JAK2_227_pLDDT_and_active_sites.png (AA BP:135)

PAX5_JAK2_227_violinplot.png (AA BP:135)

PAX5_JAK2_341_pLDDT.png (AA BP:201)

PAX5_JAK2_341_pLDDT_and_active_sites.png (AA BP:201)

PAX5_JAK2_341_violinplot.png (AA BP:201)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

PAX5_JAK2_227.png

PAX5_JAK2_341.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
227	1.026	365	1.039	920.612	0.494	0.736	0.967	0.773	1.052	0.735	0.771	Chain A: 101,102,103,104,105,106,107,109,110,111,1 12,113,177,178,179,180,181,182,183,187,204,206,222 ,226,235,251,253,254,255,256,257,258,259,260,262,2 63,264,266,267,268,300,302,303,304,305,307,317,318 ,319,341,344,370,375,377,380,381,382,383,386
341	1.043	523	1.034	1642.284	0.49	0.763	0.99	0.683	1.116	0.612	0.756	Chain A: 173,174,175,176,177,179,180,181,182,183,1 87,188,189,190,245,246,247,248,249,250,251,252,253 ,270,272,273,274,278,280,281,283,284,285,287,288,2 91,292,301,317,319,320,321,322,324,325,326,328,329 ,332,333,364,365,366,368,369,370,371,373,383,384,3 85,386,387,388,389,392,395,397,398,399,400,401,402 ,403,404,405,406,407,408,410,411,415,416,419,421,4 36,441,442,443,446,447,448,449,452

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
JAK2	PRMT5, SOCS1, PPIA, IL12RB2, EPOR, FYN, STAT5A, STAT5B, SH2B2, CXCR4, DNAJA3, HSPA8, TEC, PTPN12, PTK2, CSF2RB, GHR, VAV1, SIRPA, IRS1, BRCA1, GRB2, EGFR, PTK2B, PTPN11, TNFRSF1A, SOCS3, PTPN6, LYN, HTR2A, ERBB2, ELP2, KIT, RAF1, SH2B1, IL5RA, PPP2R1B, IFNGR1, IFNGR2, CCR5, PRLR, IL6ST, SHC1, GRB10, TUB, TSHR, STAT3, INSR, STAM, PTPN1, STAM2, IL2RB, CTLA4, ALK, IKBKG, FGFR1, STAT1, HSP90AA1, HSP90AB1, ASB2, SKP2, GTF2I, HIST3H3, HIST2H3C, CDKN1B, VHL, PIK3R1, MAP3K5, AGTR1, PTAFR, JAK2, IL4R, IL2RG, PPP1CC, ERBB3, CALM1, SRC, JAK3, PLCG1, HES1, HES5, Ifngr1, ASS1, RBMX, TRAF6, EZH2, DTX3L, EMD, KPNB1, NAP1L1, RCN1, SLC2A1, UBP1, ARL11, HSFY1, HDAC6, HNRNPL, CBL, RNF123, Lmo4, GOLPH3, IGF1R, PARP9, LNX1, LDOC1, CSK, MPL, CUL4A, CUL4B, M, JAK1, AMY1C, BPIFA2, ARHGAP18, BACH1, IGHA2, HMMR, MUC7, CST2, IGJ, PBK, MUC5B, SPRR3, ZG16B, VCP,
PAX5	TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1, KAT2B, CDKN1B, UBE3A, RAD52, HMGB3, HOXC8, MAPK9, NFYC, FBLN1, GRHL2, DTX2, CSNK2A1, UBE2I, CCNC, BCAS2, C1orf109, GNG13, ZMYM5, SEC14L4, RNF144B, OSGIN1, CIB3, SAE1, STAC, TLK2, HMBOX1, NGLY1, NEIL2, LONRF1, LDLRAP1, LARP4, UBXN7, ACOT12, CKS1B, KLHL38, HGS, CXorf38, KRTAP10-8, PNMA5, KRTAP9-3, UBXN2B, CDK3, BKRF1, HIST1H3A, PAX8, KLHL14,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PAX5
JAK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PAX5-JAK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PAX5-JAK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
PAX5	JAK2	Gastric Adenocarcinoma	MyCancerGenome
PAX5	JAK2	Glioblastoma	MyCancerGenome
PAX5	JAK2	Invasive Breast Carcinoma	MyCancerGenome
PAX5	JAK2	Acute Myeloid Leukemia	MyCancerGenome
PAX5	JAK2	Adenocarcinoma Of Unknown Primary	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PAX5	C0006413	Burkitt Lymphoma	4	ORPHANET
Hgene	PAX5	C1292769	Precursor B-cell lymphoblastic leukemia	4	ORPHANET
Hgene	PAX5	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2	CTD_human
Hgene	PAX5	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human;UNIPROT
Hgene	PAX5	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	PAX5	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	PAX5	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	JAK2	C0032463	Polycythemia Vera	12	CTD_human;ORPHANET;UNIPROT
Tgene	JAK2	C0040028	Thrombocythemia, Essential	10	CTD_human;ORPHANET
Tgene	JAK2	C0001815	Primary Myelofibrosis	9	CGI;CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	JAK2	C3489628	Thrombocytosis, Autosomal Dominant	8	CTD_human
Tgene	JAK2	C0019154	Hepatic Vein Thrombosis	3	CTD_human;ORPHANET
Tgene	JAK2	C0856761	Budd-Chiari Syndrome	3	CTD_human;ORPHANET
Tgene	JAK2	C0009324	Ulcerative Colitis	2	CTD_human
Tgene	JAK2	C0027022	Myeloproliferative disease	2	CTD_human
Tgene	JAK2	C0151744	Myocardial Ischemia	2	CTD_human
Tgene	JAK2	C0836924	Thrombocytosis	2	CTD_human
Tgene	JAK2	C3281125	THROMBOCYTHEMIA 3	2	UNIPROT
Tgene	JAK2	C0000786	Spontaneous abortion	1	CTD_human
Tgene	JAK2	C0000822	Abortion, Tubal	1	CTD_human
Tgene	JAK2	C0006663	Calcinosis	1	CTD_human
Tgene	JAK2	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Tgene	JAK2	C0018824	Heart valve disease	1	CTD_human
Tgene	JAK2	C0019207	Hepatoma, Morris	1	CTD_human
Tgene	JAK2	C0019208	Hepatoma, Novikoff	1	CTD_human
Tgene	JAK2	C0021368	Inflammation	1	CTD_human
Tgene	JAK2	C0023418	leukemia	1	CTD_human
Tgene	JAK2	C0023467	Leukemia, Myelocytic, Acute	1	CGI;CTD_human;UNIPROT
Tgene	JAK2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	JAK2	C0023904	Liver Neoplasms, Experimental	1	CTD_human
Tgene	JAK2	C0025472	Mesenteric Vascular Occlusion	1	CTD_human
Tgene	JAK2	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Tgene	JAK2	C0032461	Polycythemia	1	CTD_human
Tgene	JAK2	C0032962	Pregnancy Complications	1	CTD_human
Tgene	JAK2	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	JAK2	C0040038	Thromboembolism	1	CTD_human
Tgene	JAK2	C0042487	Venous Thrombosis	1	CTD_human
Tgene	JAK2	C0086404	Experimental Hepatoma	1	CTD_human
Tgene	JAK2	C0149871	Deep Vein Thrombosis	1	CTD_human
Tgene	JAK2	C0263628	Tumoral calcinosis	1	CTD_human
Tgene	JAK2	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	JAK2	C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
Tgene	JAK2	C0521174	Microcalcification	1	CTD_human
Tgene	JAK2	C1527405	Erythrocytosis	1	CTD_human
Tgene	JAK2	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Tgene	JAK2	C3241937	Nonalcoholic Steatohepatitis	1	CTD_human
Tgene	JAK2	C3495676	Anorectal Malformations	1	GENOMICS_ENGLAND
Tgene	JAK2	C3830362	Early Pregnancy Loss	1	CTD_human
Tgene	JAK2	C4048328	cervical cancer	1	CTD_human
Tgene	JAK2	C4303761	Familial thrombocytosis	1	ORPHANET
Tgene	JAK2	C4552766	Miscarriage	1	CTD_human