Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionAI protocol FusionNW FGviewer FusionScan Fusion gene & MMEJ Predict fusion protein 3D structure Publication Contact
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About FusionPDB

Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, there are still many fusion proteins awaiting being targeted for therapeutics with multiple different mechanisms. Due to the lack of the whole fusion protein sequences, whole 3D structures of the fusion proteins, it was hard to develop novel therapeutic approaches of fusion gene patients. To fill these critical gaps, we developed a new computational pipeline and a resource of human fusion proteins, named FusionPDB available at https://compbio.uth.edu/FusionPDB. FusionPDB provides ~ 42K fusion protein sequences (of 16K in-frame fusion genes, Level 1), 2300 + 1267 fusion protein 3D structures (of 2300 recurrent + 266 manually curated in-frame fusion genes, Level 2), pLDDT score distribution check around the best active sites of 1267 fusion proteins (of 266 manually curated in-frame fusion genes, Level 3), and virtual screening results of 68 chosen fusion proteins (out of 266 manually curated in-frame fusion genes, Level 4). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until covering all human fusion proteins in the future. Fusionscreen pipeline

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Examples: Gene symbol: BCR or ABL1
bullet pointBrowse by important cellular gene groups of Level3 fusion proteins

Kinases

Transcription factors

Cancer Gene Census

Tumor suppressors

IUPHAR drug targets

Cell metabolism genes

Human essential genes

Epigenetic factors


bullet pointBrowse by important cellular gene groups of Level2 fusion proteins

Kinases

Transcription factors

Cancer Gene Census

Tumor suppressors

IUPHAR drug targets

Cell metabolism genes

Human essential genes

Epigenetic factors


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