About FusionPDB

3D structures of fusion proteins are critical in developing fusion protein-specific targeted therapeutics. Previously, we provided over 3.5K 3D structures of human fusion proteins in FusionPDB 1.0. In FusionPDB 2.0, we provide ~ 71K 3D structures of human fusion proteins across three open reading frame fusion genes (In-frame, 5UTR-3CDS (N-truncated protein), and 5CSD-3UTR (C-truncated protein)). We also provide the kinase domain and DNA-binding domain mutated fusion proteins' 3D structures of TCGA and CCLE, which can be a resource of the personalized therapy development. Our continued effort through FusionPDB will serve as the foundation for developing fusion protein-targeted therapeutic approaches.