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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRRC2A-COL1A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRRC2A-COL1A1
FusionPDB ID: 69203
FusionGDB2.0 ID: 69203
HgeneTgene
Gene symbol

PRRC2A

COL1A1

Gene ID

7916

1277

Gene nameproline rich coiled-coil 2Acollagen type I alpha 1 chain
SynonymsBAT2|D6S51|D6S51E|G2CAFYD|EDSARTH1|EDSC|OI1|OI2|OI3|OI4
Cytomap

6p21.33

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionprotein PRRC2AHLA-B-associated transcript 2large proline-rich protein BAT2proline-rich and coiled-coil-containing protein 2Aprotein G2collagen alpha-1(I) chainalpha-1 type I collagenalpha1(I) procollagencollagen alpha 1 chain type Icollagen alpha-1(I) chain preproproteincollagen of skin, tendon and bone, alpha-1 chaincollagen, type I, alpha 1pro-alpha-1 collagen type 1type I pro
Modification date2020031320200322
UniProtAcc.

P02452

Ensembl transtripts involved in fusion geneENST idsENST00000376007, ENST00000376033, 
ENST00000383455, ENST00000383464, 
ENST00000414956, ENST00000416335, 
ENST00000422962, ENST00000428775, 
ENST00000430737, ENST00000432252, 
ENST00000435971, ENST00000439762, 
ENST00000454306, ENST00000458561, 
ENST00000466607, ENST00000468994, 
ENST00000469577, ENST00000470109, 
ENST00000473169, ENST00000484613, 
ENST00000485195, ENST00000547056, 
ENST00000547457, ENST00000547669, 
ENST00000548373, ENST00000549037, 
ENST00000549383, ENST00000549768, 
ENST00000550109, ENST00000550609, 
ENST00000550674, ENST00000551341, 
ENST00000551794, 		ENST00000225964, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 11 X 7=84744 X 105 X 13=60060
# samples 1280
** MAII scorelog2(12/847*10)=-2.81932756372368
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(80/60060*10)=-6.23026066466979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRRC2A [Title/Abstract] AND COL1A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRRC2A(31602951)-COL1A1(48267269), # samples:2
Anticipated loss of major functional domain due to fusion event.PRRC2A-COL1A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRRC2A-COL1A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRRC2A-COL1A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRRC2A-COL1A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOL1A1

GO:0010718

positive regulation of epithelial to mesenchymal transition

20018240

TgeneCOL1A1

GO:0030335

positive regulation of cell migration

20018240

TgeneCOL1A1

GO:0034504

protein localization to nucleus

20018240

TgeneCOL1A1

GO:0045893

positive regulation of transcription, DNA-templated

20018240

TgeneCOL1A1

GO:0090263

positive regulation of canonical Wnt signaling pathway

20018240


check buttonFusion gene breakpoints across PRRC2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5928-01APRRC2Achr6

31602951

+COL1A1chr17

48267269

-
ChimerDB4LUSCTCGA-34-5928PRRC2Achr6

31602951

+COL1A1chr17

48267269

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376007PRRC2Achr631602951+ENST00000225964COL1A1chr1748267269-9509546020262222006
ENST00000376033PRRC2Achr631602951+ENST00000225964COL1A1chr1748267269-9541549223462542006

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376007ENST00000225964PRRC2Achr631602951+COL1A1chr1748267269-0.001399520.99860054
ENST00000376033ENST00000225964PRRC2Achr631602951+COL1A1chr1748267269-0.0014138620.9985862

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>69203_69203_1_PRRC2A-COL1A1_PRRC2A_chr6_31602951_ENST00000376007_COL1A1_chr17_48267269_ENST00000225964_length(amino acids)=2006AA_BP=1768
MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQ
EQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD
KAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGP
YRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRD
SQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWR
QRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP
TPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPP
SQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFD
PRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPL
RQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGR
KPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGK
LGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPR
GRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRR
GRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRL
KQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKA
VGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRS
RPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSD
PHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSR
KSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRP
PPAPHDGDRKQNDHSVQTEAQSLAPFGHPIDLVPQSSLALVTRVMLVLLEPKVLAAALVPLVLLVSLVLLAESVLLAPLEMLDPLALLVL
LAKKAAKVPVVRLALLDVLVKLVPLVPLALLARKDPLVLMVLLVLLVLPGLKVLLDSVVWSACLVREEREASLVFLAPLVNLANKVPLEQ
VVNVVPLVPWAPLDWLDPLVNLDVRGLLVPKVPLDETVLLAPRVTVVRPAPLDPLVLLVLLVPLAPLALLARVVIVVRLVLLVPPVLSAL

--------------------------------------------------------------

>69203_69203_2_PRRC2A-COL1A1_PRRC2A_chr6_31602951_ENST00000376033_COL1A1_chr17_48267269_ENST00000225964_length(amino acids)=2006AA_BP=1768
MSDRSGPTAKGKDGKKYSSLNLFDTYKGKSLEIQKPAVAPRHGLQSLGKVAIARRMPPPANLPSLKAENKGNDPNVSLVPKDGTGWASKQ
EQSDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAHGDGGRASSLLSRFSREEFPTLQAAGDQD
KAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRGGLQPSGPPQFPPYRGMMPPFMYPPYLPFPPPYGPQGP
YRYPTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPSILKEDNLKEFDQLDQENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRD
SQSASGEERPPEADGKKGNSPNSEPPTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDYPDRGGPPCKPPAPEDEDEAWR
QRRKQSSSEISLAVERARRRREEEERRMQEERRAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAP
TPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPP
SQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPAPQAPPPPPKALYPGALGRPPPMPPMNFD
PRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSGLVPRERSDSGGSSSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPL
RQAADEDDKGMRSETPPVPPPPPYLASYPGFPENGAPGPPISRFPLEEPGPRPLPWPPGSDEVAKIQTPPPKKEPPKEETAQLTGPEAGR
KPARGVGSGGQGPPPPRRESRTETRWGPRPGSSRRGIPPEEPGAPPRRAGPIKKPPPPTKVEELPPKPLEQGDETPKPPKPDPLKITKGK
LGGPKETPPNGNLSPAPRLRRDYSYERVGPTSCRGRGRGEYFARGRGFRGTYGGRGRGARSREFRSYREFRGDDGRGGGTGGPNHPPAPR
GRTASETRSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSPAPARFTARGGRVFTPRGVPSRR
GRGGGRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKEKLIPGPLSPVARGGSNGGSNVGMEDGERPRRRRHGRAQQQDKPPRFRRL
KQERENAARGSEGKPSLTLPASAPGPEEALTTVTVAPAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERRGDKEAPPPVLLTPKA
VGTPGGGGGGAVPGISAMSRGDLSQRAKDLSKRSFSSQRPGMERQNRRPGPGGKAGSSGSSSGGGGGGPGGRTGPGRGDKRSWPSPKNRS
RPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGSVTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNSGLSSD
PHFEEPGPMVRGVGGTPRDSAGVSPFPPKRRERPPRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTGTEALTPHIWNRLHTATSR
KSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSGDSQVSSGPCSQRSSPDGGLKGAAEGPPKRPGGSSPLNAVPCEGPPGSEPPRRP
PPAPHDGDRKQNDHSVQTEAQSLAPFGHPIDLVPQSSLALVTRVMLVLLEPKVLAAALVPLVLLVSLVLLAESVLLAPLEMLDPLALLVL
LAKKAAKVPVVRLALLDVLVKLVPLVPLALLARKDPLVLMVLLVLLVLPGLKVLLDSVVWSACLVREEREASLVFLAPLVNLANKVPLEQ
VVNVVPLVPWAPLDWLDPLVNLDVRGLLVPKVPLDETVLLAPRVTVVRPAPLDPLVLLVLLVPLAPLALLARVVIVVRLVLLVPPVLSAL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31602951/chr17:48267269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL1A1

P02452

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOL1A1chr6:31602951chr17:48267269ENST0000022596435511229_1464853.01465.0DomainFibrillar collagen NC1
TgeneCOL1A1chr6:31602951chr17:48267269ENST0000022596435511093_1095853.01465.0MotifCell attachment site
TgeneCOL1A1chr6:31602951chr17:48267269ENST0000022596435511193_1218853.01465.0RegionNote=Nonhelical region (C-terminal)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311139_114202158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311239_124402158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311355_136002158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311413_142102158.0Compositional biasNote=Poly-Gly
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311451_145702158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131466_47102158.0Compositional biasNote=Poly-Arg
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131472_47502158.0Compositional biasNote=Poly-Glu
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131658_66902158.0Compositional biasNote=Poly-Gln
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131696_70002158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131826_83302158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131913_91602158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131955_95802158.0Compositional biasNote=Poly-Pro
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311916_210602158.0RegionNote=3 X 50 AA type C repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131337_56102158.0RegionNote=2 X type B repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+13141_181202158.0RegionNote=4 X 57 AA type A repeats
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376007+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000376033+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383455+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000383464+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000414956+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000416335+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000422962+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000428775+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000430737+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000432252+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000435971+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000439762+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000454306+13198_15402158.0RepeatNote=1-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311757_181202158.0RepeatNote=1-4
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311916_196502158.0RepeatNote=3-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1311982_203102158.0RepeatNote=3-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+1312057_210602158.0RepeatNote=3-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131281_33602158.0RepeatNote=1-3
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131337_43002158.0RepeatNote=2-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+13141_9502158.0RepeatNote=1-1
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+131488_56102158.0RepeatNote=2-2
HgenePRRC2Achr6:31602951chr17:48267269ENST00000458561+13198_15402158.0RepeatNote=1-2
TgeneCOL1A1chr6:31602951chr17:48267269ENST00000225964355138_96853.01465.0DomainVWFC
TgeneCOL1A1chr6:31602951chr17:48267269ENST000002259643551745_747853.01465.0MotifCell attachment site
TgeneCOL1A1chr6:31602951chr17:48267269ENST000002259643551162_178853.01465.0RegionNote=Nonhelical region (N-terminal)
TgeneCOL1A1chr6:31602951chr17:48267269ENST000002259643551179_1192853.01465.0RegionNote=Triple-helical region


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PRRC2A_pLDDT.png
all structure
all structure
COL1A1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
COL1A1IGFBP3, TXN, ITGA2, ITGB1, NID1, Nid1, NID2, SPARC, PRELP, PKD1, VWF, THBS1, MMP2, COL7A1, MATN2, MAG, ELAVL1, ATP13A2, C12orf57, RNH1, BARD1, BRCA1, UBC, CAPN1, COL1A1, COL1A2, PDGFA, PDGFB, GIPC2, UBXN11, DNM3, CD200R1, TMTC4, ERAL1, CAMKMT, TMEM180, OTUB1, EGFR, COLGALT2, P4HA2, PLOD1, LIN9, TIMM44, RASGEF1B, TLE3, YAF2, LPAR1, CYLD, MCPH1, HEXIM1, PPP1CC, KEAP1, PINK1, CDC42, NMRAL1, PAX3, NTPCR, FOXO1, IGLC1, DDX58, YIPF1, LAIR2, LAT, KIAA1191, SLC25A40, CTNND1, FOXD3, CHMP3, ZNF645, CD247, RANBP6, TRIM41, TNFRSF10D, KIR3DS1, SMDT1, PPIA, PEG10, TMEM44, RNF144A, VCP, TESPA1, ABHD14A, TADA1, ST3GAL3, KLF15, BGN, TGM2, COL18A1, NLRP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRRC2A
COL1A1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PRRC2A-COL1A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRRC2A-COL1A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCOL1A1C0268358Osteogenesis imperfecta, dominant perinatal lethal38CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCOL1A1C0268362Osteogenesis imperfecta type III (disorder)17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCOL1A1C0023931Lobstein Disease15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCOL1A1C0268363Osteogenesis imperfecta type IV (disorder)12GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCOL1A1C0023890Liver Cirrhosis4CTD_human
TgeneCOL1A1C0239946Fibrosis, Liver4CTD_human
TgeneCOL1A1C4551623EHLERS-DANLOS SYNDROME, ARTHROCHALASIA TYPE, 14CTD_human;GENOMICS_ENGLAND
TgeneCOL1A1C4552122EHLERS-DANLOS SYNDROME, CLASSIC TYPE, 14GENOMICS_ENGLAND;UNIPROT
TgeneCOL1A1C0020497Cortical Congenital Hyperostosis3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCOL1A1C0023893Liver Cirrhosis, Experimental3CTD_human
TgeneCOL1A1C0268345EHLERS-DANLOS SYNDROME, ARTHROCHALASIA TYPE2ORPHANET
TgeneCOL1A1C0000786Spontaneous abortion1CTD_human
TgeneCOL1A1C0000822Abortion, Tubal1CTD_human
TgeneCOL1A1C0002949Aneurysm, Dissecting1CTD_human
TgeneCOL1A1C0003504Aortic Valve Insufficiency1CTD_human
TgeneCOL1A1C0004364Autoimmune Diseases1CTD_human
TgeneCOL1A1C0005398Cholestasis, Extrahepatic1CTD_human
TgeneCOL1A1C0005779Blood Coagulation Disorders1GENOMICS_ENGLAND
TgeneCOL1A1C0006663Calcinosis1CTD_human
TgeneCOL1A1C0008311Cholangitis1CTD_human
TgeneCOL1A1C0013720Ehlers-Danlos Syndrome1GENOMICS_ENGLAND
TgeneCOL1A1C0016059Fibrosis1CTD_human
TgeneCOL1A1C0018824Heart valve disease1CTD_human
TgeneCOL1A1C0020538Hypertensive disease1CTD_human
TgeneCOL1A1C0022548Keloid1CTD_human
TgeneCOL1A1C0027719Nephrosclerosis1CTD_human
TgeneCOL1A1C0027726Nephrotic Syndrome1CTD_human
TgeneCOL1A1C0029172Oral Submucous Fibrosis1CTD_human
TgeneCOL1A1C0029434Osteogenesis Imperfecta1CTD_human;GENOMICS_ENGLAND
TgeneCOL1A1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneCOL1A1C0220679Ehlers-Danlos Syndrome, Autosomal Dominant, Type Unspecified1ORPHANET
TgeneCOL1A1C0263628Tumoral calcinosis1CTD_human
TgeneCOL1A1C0340643Dissection of aorta1CTD_human
TgeneCOL1A1C0521174Microcalcification1CTD_human
TgeneCOL1A1C1458140Bleeding tendency1GENOMICS_ENGLAND
TgeneCOL1A1C1619692Nephrogenic Fibrosing Dermopathy1CTD_human
TgeneCOL1A1C1623038Cirrhosis1CTD_human
TgeneCOL1A1C1846545Autoimmune Lymphoproliferative Syndrome Type 2B1GENOMICS_ENGLAND
TgeneCOL1A1C3830362Early Pregnancy Loss1CTD_human
TgeneCOL1A1C4277533Dissection, Blood Vessel1CTD_human
TgeneCOL1A1C4552766Miscarriage1CTD_human