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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ROCK1-RNF38

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ROCK1-RNF38
	FusionPDB ID: 75316
	FusionGDB2.0 ID: 75316
		Hgene	Tgene
	Gene symbol	ROCK1	RNF38
	Gene ID	6093	152006
	Gene name	Rho associated coiled-coil containing protein kinase 1	ring finger protein 38
	Synonyms	P160ROCK\|ROCK-I	-
	Cytomap	18q11.1	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 1p160 ROCK-1renal carcinoma antigen NY-REN-35	E3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38
	Modification date	20200322	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000399799,	ENST00000350199, ENST00000357058, ENST00000377877, ENST00000377885, ENST00000491349, ENST00000353739, ENST00000259605,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	24 X 16 X 12=4608	4 X 4 X 5=80
	# samples	31	5
	** MAII score	log2(31/4608*10)=-3.89380059616807 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ROCK1 [Title/Abstract] AND RNF38 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ROCK1(18690779)-RNF38(36376124), # samples:2
Anticipated loss of major functional domain due to fusion event.	ROCK1-RNF38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-RNF38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-RNF38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ROCK1-RNF38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK1	GO:0006468	protein phosphorylation	23093407
Hgene	ROCK1	GO:0007159	leukocyte cell-cell adhesion	12082081
Hgene	ROCK1	GO:0018105	peptidyl-serine phosphorylation	18573880
Hgene	ROCK1	GO:0022614	membrane to membrane docking	12082081
Hgene	ROCK1	GO:0030334	regulation of cell migration	23093407
Hgene	ROCK1	GO:0032091	negative regulation of protein binding	18573880
Hgene	ROCK1	GO:0032956	regulation of actin cytoskeleton organization	25911094
Hgene	ROCK1	GO:0050900	leukocyte migration	12082081
Hgene	ROCK1	GO:0050901	leukocyte tethering or rolling	12082081
Hgene	ROCK1	GO:0070507	regulation of microtubule cytoskeleton organization	23093407
Tgene	RNF38	GO:0016567	protein ubiquitination	23973461

Fusion gene breakpoints across ROCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-56-A49D-01A	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-
ChimerDB4	LUSC	TCGA-56-A49D-01A	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-
ChimerDB4	LUSC	TCGA-56-A49D	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000259605	RNF38	chr9	36376124	-	5776	1034	899	2419	506
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000353739	RNF38	chr9	36376124	-	5776	1034	899	2419	506
ENST00000399799	ROCK1	chr18	18690779	-	ENST00000259605	RNF38	chr9	36390613	-	5926	1034	899	2569	556

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-	0.007385061	0.992615
ENST00000399799	ENST00000353739	ROCK1	chr18	18690779	-	RNF38	chr9	36376124	-	0.007385061	0.992615
ENST00000399799	ENST00000259605	ROCK1	chr18	18690779	-	RNF38	chr9	36390613	-	0.005170948	0.994829

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75316_75316_1_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000259605_length(amino acids)=506AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVR
PSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHD
QLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHL
SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTG
RSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSE

--------------------------------------------------------------

>75316_75316_2_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36376124_ENST00000353739_length(amino acids)=506AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVR
PSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHD
QLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHL
SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTG
RSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSE

--------------------------------------------------------------

>75316_75316_3_ROCK1-RNF38_ROCK1_chr18_18690779_ENST00000399799_RNF38_chr9_36390613_ENST00000259605_length(amino acids)=556AA_BP=45
MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHF
KAFFQSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSIS
QDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGC
SVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHL
PVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFE
LDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:18690779/chr9:36376124)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

239_404

54.0

516.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

239_404

4.0

466.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

239_404

4.0

516.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

239_404

466.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

115_131

54.0

516.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

57_71

54.0

516.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

115_131

4.0

466.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

57_71

4.0

466.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

115_131

4.0

516.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

57_71

4.0

516.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

115_131

466.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

57_71

466.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000259605

463_504

54.0

516.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000350199

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000353739

463_504

4.0

466.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000357058

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36376124

ENST00000377885

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000259605

463_504

4.0

516.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000350199

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000353739

463_504

466.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000357058

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr18:18690779

chr9:36390613

ENST00000377885

463_504

433.0

Zinc finger

RING-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1011_1102

31.0

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

422_692

31.0

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1011_1102

31.0

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

422_692

31.0

1355.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

636_980

31.0

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

636_980

31.0

1355.0

Compositional bias

Note=Glu-rich

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1118_1317

31.0

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

341_409

31.0

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

479_556

31.0

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

76_338

31.0

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

949_1015

31.0

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1118_1317

31.0

1355.0

Domain

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

341_409

31.0

1355.0

Domain

AGC-kinase C-terminal

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

479_556

31.0

1355.0

Domain

REM-1

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

76_338

31.0

1355.0

Domain

Protein kinase

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

949_1015

31.0

1355.0

Domain

RhoBD

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

82_90

31.0

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

82_90

31.0

1355.0

Nucleotide binding

ATP

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1115_1354

31.0

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

707_946

31.0

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

998_1010

31.0

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1115_1354

31.0

1355.0

Region

Note=Auto-inhibitory

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

707_946

31.0

1355.0

Region

SHROOM3 binding

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

998_1010

31.0

1355.0

Region

Note=RHOA binding

Hgene

ROCK1

chr18:18690779

chr9:36376124

ENST00000399799

1228_1281

31.0

1355.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

ROCK1

chr18:18690779

chr9:36390613

ENST00000399799

1228_1281

31.0

1355.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1080_ROCK1_18690779_RNF38_36376124_1080_ROCK1_18690779_RNF38_36376124_ranked_0.pdb	ROCK1	18690779	18690779	ENST00000259605	RNF38	chr9	36376124	-	MLVLVRGHCHSSSNMSTGDSFETRFEKMDNLLRDPKSEVNSDCLLSEDSPSPKRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVR PSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHD QLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHL SPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTG RSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSE	506

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ROCK1_pLDDT.png

RNF38_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ROCK1
RNF38

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ROCK1	chr18:18690779	chr9:36376124	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1
Hgene	ROCK1	chr18:18690779	chr9:36390613	ENST00000399799	-	1	33	368_727	31.0	1355.0	FHOD1

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Related Drugs to ROCK1-RNF38

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ROCK1-RNF38

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source