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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CDC7_ZNF529

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CDC7_ZNF529
KinaseFusionDB ID: KFG1036
FusionGDB2.0 ID: KFG1036
HgeneTgene
Gene symbol

CDC7

ZNF529

Gene ID

8317

57711

Gene namecell division cycle 7zinc finger protein 529
SynonymsCDC7L1|HsCDC7|Hsk1|huCDC7-
Cytomap

1p22.1

19q13.12

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle 7-related protein kinaseCDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1CDC7-related kinasecell division cycle 7 homologcell division cycle 7-like protein 1epididymis secretory sperm binding proteinzinc finger protein 529
Modification date2024040320240411
UniProtAcc

Q6P1J9

Q6P280

Ensembl transtripts involved in fusion geneENST idsENST00000234626, ENST00000428239, 
ENST00000430031, ENST00000497611, 
ENST00000334116, ENST00000586458, 
ENST00000591340, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CDC7 [Title/Abstract] AND ZNF529 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDC7(91991316)-ZNF529(37092971), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonKinase Fusion gene breakpoints across CDC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ZNF529 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0CF124104CDC7chr1

91991316

ZNF529chr19

37092971



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:91991316/:37092971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC7

Q6P1J9

ZNF529

Q6P280

FUNCTION: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622, ECO:0000269|PubMed:16630820, ECO:0000269|PubMed:16989776, ECO:0000269|PubMed:19136632, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477, ECO:0000269|PubMed:21329879}.FUNCTION: May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of CDC7_ZNF529


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CDC7O00311humanNCLP19338T121PGkALVAtPGkkGAA
CDC7O00311humanCLSPNQ9HAW4S1129LADGDLHsDGPGRMR
CDC7O00311humanDTD1Q8TEA8S194tPRKEDRsAssGAEG
CDC7O00311humanTOP2AP11388S1525PIKyLEEsDEDDLF_
CDC7O00311humanDBF4Q9UBU7S312DLETHLLsEQHRNFAzf-DBF
CDC7O00311humanCDC7O00311S216ELLkFVQsEAQQERCPkinase
CDC7O00311humanMCM2P49736S41RtDALtssPGRDLPP
CDC7O00311humanCLSPNQ9HAW4S260SLESGVHsFEEGsEL
CDC7O00311humanDBF4Q9UBU7T281DGDKyGGtsIQLQLK
CDC7O00311humanCLSPNQ9HAW4S110IYkTVADsDESYMEK
CDC7O00311humanDTD1Q8TEA8S196RKEDRsAssGAEGDV
CDC7O00311humanCLSPNQ9HAW4S1147WKNIDDAsQMDLFHR
CDC7O00311humanDTD1Q8TEA8T187EssKERNtPRKEDRs
CDC7O00311humanCDC7O00311S277GKDGkEGsVGLSVQR
CDC7O00311humanCDC7O00311S296ERNFNIHssISHEsP
CDC7O00311humanMCM2P49736S40RRtDALtssPGRDLP
CDC7O00311humanDTD1Q8TEA8S181RAKGPsEssKERNtP
CDC7O00311humanDTD1Q8TEA8S197KEDRsAssGAEGDVs
CDC7O00311humanNPM1P06748T199VkKsIrDtPAkNAQK
CDC7O00311humanMCM2P49736S220NVFkERIsDMCkENRMCM_N
CDC7O00311humanCLSPNQ9HAW4S721sVPKsLssDstLLLF
CDC7O00311humanDTD1Q8TEA8S179KTRAKGPsEssKERN
CDC7O00311humanMCM2P49736S31LtssPGRssRRtDAL
CDC7O00311humanMCM2P49736S7_MAEssEsFtMAssP
CDC7O00311humanMFAP1P55081S116EPEVVGEsDsEVEGD
CDC7O00311humanMCM2P49736S5___MAEssEsFtMAs
CDC7O00311humanCDC7O00311S318SkTVDVLsRKLATKK
CDC7O00311humanCLSPNQ9HAW4S67kVLQDsDsETEDTNA
CDC7O00311humanDTD1Q8TEA8S204sGAEGDVssErEP__
CDC7O00311humanAURKBQ96GD4T236RRktMCGtLDyLPPEPkinase
CDC7O00311humanCDC7O00311S239TGNkIPLsGPVPkEL
CDC7O00311humanNCLP19338T76tkkVAVAtPAkkAAV
CDC7O00311humanCDC7O00311S285VGLSVQRsVFGERNF
CDC7O00311humanCDC7O00311S297RNFNIHssISHEsPA
CDC7O00311humanMCM2P49736S4____MAEssEsFtMA
CDC7O00311humanCLSPNQ9HAW4S704KENNDGssEIGkAVG
CDC7O00311humanMCM2P49736S108DVEELtAsQREAAERMCM2_N
CDC7O00311humanNPM1P06748S137EEDVkLLsIsGkRsA
CDC7O00311humanDTD1Q8TEA8S205GAEGDVssErEP___
CDC7O00311humanPSIP1O75475S206MVkQPCPsEsDIItE
CDC7O00311humanDBF4Q9UBU7T273QVKLRIQtDGDKyGG
CDC7O00311humanRAD18Q9NS91S434IQEVLSSsESDSCNS
CDC7O00311humanMCM2P49736S53LPPFEDEsEGLLGtEMCM2_N
CDC7O00311humanMCM2P49736S139RRGLLyDsDEEDEERMCM2_N
CDC7O00311humanCLSPNQ9HAW4S265VHsFEEGsELSKGTT
CDC7O00311humanMCM2P49736S27GNDPLtssPGRssRR
CDC7O00311humanTOP2AP11388S1213QMAEVLPsPRGQRVI
CDC7O00311humanCLSPNQ9HAW4S744YFPTEEKsETDENsG
CDC7O00311humanDTD1Q8TEA8S182AKGPsEssKERNtPR


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CDC7IDDescription0.00e+00
CDC7GO:0090068positive regulation of cell cycle process1.21e-04
CDC7GO:1902749regulation of cell cycle G2/M phase transition1.21e-04
CDC7GO:0045787positive regulation of cell cycle1.51e-04
CDC7GO:0033260nuclear DNA replication1.55e-04
CDC7GO:0044839cell cycle G2/M phase transition1.55e-04
CDC7GO:0044786cell cycle DNA replication1.61e-04
CDC7GO:0090329regulation of DNA-templated DNA replication1.68e-04
CDC7GO:1901987regulation of cell cycle phase transition2.61e-04
CDC7GO:0032508DNA duplex unwinding6.32e-04
CDC7GO:0032392DNA geometric change7.05e-04
CDC7GO:0006260DNA replication7.05e-04
CDC7GO:0071103DNA conformation change7.05e-04
CDC7GO:0000727double-strand break repair via break-induced replication7.05e-04
CDC7GO:0033262regulation of nuclear cell cycle DNA replication7.22e-04
CDC7GO:2000105positive regulation of DNA-templated DNA replication7.22e-04
CDC7GO:0010389regulation of G2/M transition of mitotic cell cycle8.11e-04
CDC7GO:0000377RNA splicin4.17e-05
CDC7GO:0000086G2/M transition of mitotic cell cycle1.50e-03
CDC7GO:0006261DNA-templated DNA replication2.11e-03
CDC7GO:0051984positive regulation of chromosome segregation2.11e-03
CDC7GO:0044772mitotic cell cycle phase transition2.51e-03
CDC7GO:0008380RNA splicing2.58e-03
CDC7GO:1902751positive regulation of cell cycle G2/M phase transition2.63e-03
CDC7GO:0045740positive regulation of DNA replication3.58e-03
CDC7GO:0051054positive regulation of DNA metabolic process1.04e-02
CDC7GO:0010972negative regulation of G2/M transition of mitotic cell cycle1.04e-02
CDC7GO:1902750negative regulation of cell cycle G2/M phase transition1.10e-02
CDC7GO:0010948negative regulation of cell cycle process1.15e-02
CDC7GO:0006310DNA recombination1.33e-02
CDC7GO:1901990regulation of mitotic cell cycle phase transition1.46e-02
CDC7GO:0010639negative regulation of organelle organization1.51e-02
CDC7GO:0034644cellular response to UV1.55e-02
CDC7GO:2001251negative regulation of chromosome organization1.64e-02
CDC7GO:0045786negative regulation of cell cycle1.93e-02
CDC7GO:0048024regulation of mRNA splicin2.03e-03
CDC7GO:0007059chromosome segregation2.00e-02
CDC7GO:0006334nucleosome assembly2.24e-02
CDC7GO:1901989positive regulation of cell cycle phase transition2.24e-02
CDC7GO:0071482cellular response to light stimulus2.33e-02
CDC7GO:0050684regulation of mRNA processing2.50e-02
CDC7GO:0051983regulation of chromosome segregation2.52e-02
CDC7GO:0034728nucleosome organization2.73e-02
CDC7GO:0007093mitotic cell cycle checkpoint signaling2.83e-02
CDC7GO:0009411response to UV3.16e-02
CDC7GO:0000724double-strand break repair via homologous recombination3.98e-02
CDC7GO:0072331signal transduction by p53 class mediator3.98e-02
CDC7GO:0000725recombinational repair3.98e-02
CDC7GO:0043484regulation of RNA splicing3.98e-02
CDC7GO:0071478cellular response to radiation3.98e-02

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Related Drugs to CDC7_ZNF529


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CDC7-ZNF529 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CDC7_ZNF529


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate