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Kinase Fusion Gene:CDCA4_PTK2B |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CDCA4_PTK2B | KinaseFusionDB ID: KFG1037 | FusionGDB2.0 ID: KFG1037 | Hgene | Tgene | Gene symbol | CDCA4 | PTK2B | Gene ID | 55038 | 2185 | |
| Gene name | cell division cycle associated 4 | protein tyrosine kinase 2 beta | ||||||||||
| Synonyms | HEPP|SEI-3/HEPP | CADTK|CAKB|FADK2|FAK2|PKB|PTK|PYK2|RAFTK | ||||||||||
| Cytomap | 14q32.33 | 8p21.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | cell division cycle-associated protein 4hematopoietic progenitor protein | protein-tyrosine kinase 2-betaCAK-betaFADK 2PTK2B protein tyrosine kinase 2 betacalcium-dependent tyrosine kinasecalcium-regulated non-receptor proline-rich tyrosine kinasecell adhesion kinase betafocal adhesion kinase 2proline-rich tyrosine kinas | ||||||||||
| Modification date | 20240408 | 20240416 | ||||||||||
| UniProtAcc | Q9BXL8 | Q14289 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000336219, ENST00000392590, | ENST00000338238, ENST00000346049, ENST00000397497, ENST00000397501, ENST00000420218, ENST00000517339, ENST00000519650, ENST00000544172, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CDCA4 [Title/Abstract] AND PTK2B [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CDCA4(105482575)-PTK2B(27202136), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTK2B | GO:0010595 | positive regulation of endothelial cell migration | 21245381 |
| Tgene | PTK2B | GO:0018108 | peptidyl-tyrosine phosphorylation | 7544443 |
| Tgene | PTK2B | GO:0038083 | peptidyl-tyrosine autophosphorylation | 9545257 |
| Tgene | PTK2B | GO:0043267 | negative regulation of potassium ion transport | 7544443 |
| Tgene | PTK2B | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 19880522 |
| Kinase Fusion gene breakpoints across CDCA4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PTK2B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AW859660 | CDCA4 | chr14 | 105482575 | PTK2B | chr8 | 27202136 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:105482575/:27202136) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDCA4 | PTK2B |
| FUNCTION: May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:16984923}. | FUNCTION: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:12771146, ECO:0000269|PubMed:12893833, ECO:0000269|PubMed:14585963, ECO:0000269|PubMed:15050747, ECO:0000269|PubMed:15166227, ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:18086875, ECO:0000269|PubMed:18339875, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:18765415, ECO:0000269|PubMed:19086031, ECO:0000269|PubMed:19207108, ECO:0000269|PubMed:19244237, ECO:0000269|PubMed:19428251, ECO:0000269|PubMed:19648005, ECO:0000269|PubMed:19880522, ECO:0000269|PubMed:20001213, ECO:0000269|PubMed:20381867, ECO:0000269|PubMed:20521079, ECO:0000269|PubMed:21357692, ECO:0000269|PubMed:21533080, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:8670418, ECO:0000269|PubMed:8849729}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CDCA4_PTK2B |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PTK2B | Q14289 | human | TGFB1I1 | O43294 | Y60 | SGDKDHLystVCKPR | Paxillin |
| PTK2B | Q14289 | human | ID3 | Q02535 | Y48 | LDDMNHCySRLRELV | HLH |
| PTK2B | Q14289 | human | CTTN | Q14247 | Y470 | AyATEAVyESAEAPG | |
| PTK2B | Q14289 | human | ID3 | Q02535 | S18 | yEAVCCLsERsLAIA | |
| PTK2B | Q14289 | human | ID3 | Q02535 | S5 | ___MkALsPVRGCyE | |
| PTK2B | Q14289 | human | NPHP1 | O15259 | Y46 | PNKRQHIyQRCIQLK | |
| PTK2B | Q14289 | human | LAT | O43561-2 | Y171 | SMESIDDyVNVPESG | LAT |
| PTK2B | Q14289 | human | SNCA | P37840 | Y125 | VDPDNEAyEMPsEEG | Synuclein |
| PTK2B | Q14289 | human | PTK2 | Q05397 | Y407 | IIDEEDtytMPSTRD | |
| PTK2B | Q14289 | human | NOS3 | P29474 | Y657 | FGLGSRAyPHFCAFA | Flavodoxin_1 |
| PTK2B | Q14289 | human | NPHP1 | O15259 | Y349 | GNQFRANyFLQPELM | |
| PTK2B | Q14289 | human | CTTN | Q14247 | Y486 | yPAEDStyDEYENDL | |
| PTK2B | Q14289 | human | ID3 | Q02535 | Y11 | LsPVRGCyEAVCCLs | |
| PTK2B | Q14289 | human | CTTN | Q14247 | Y421 | rLPssPVyEDAAsFK | |
| PTK2B | Q14289 | human | PTK2B | Q14289 | Y402 | CsIEsDIyAEIPDEt | |
| PTK2B | Q14289 | human | STIM1 | Q13586 | Y361 | THEVEVQyYNIKKQN | SOAR |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PTK2B | ID | Description | 0.00e+00 |
| PTK2B | GO:0034329 | cell junction assembly | 1.42e-03 |
| PTK2B | GO:1901888 | regulation of cell junction assembly | 1.42e-03 |
| PTK2B | GO:0051924 | regulation of calcium ion transport | 1.81e-03 |
| PTK2B | GO:0045860 | positive regulation of protein kinase activity | 1.86e-03 |
| PTK2B | GO:0048041 | focal adhesion assembly | 1.86e-03 |
| PTK2B | GO:0007044 | cell-substrate junction assembly | 1.99e-03 |
| PTK2B | GO:0150115 | cell-substrate junction organization | 1.99e-03 |
| PTK2B | GO:0033674 | positive regulation of kinase activity | 1.99e-03 |
| PTK2B | GO:0045862 | positive regulation of proteolysis | 1.99e-03 |
| PTK2B | GO:0007229 | integrin-mediated signaling pathway | 1.99e-03 |
| PTK2B | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 1.99e-03 |
| PTK2B | GO:0010919 | regulation of inositol phosphate biosynthetic process | 2.57e-03 |
| PTK2B | GO:0010959 | regulation of metal ion transport | 2.57e-03 |
| PTK2B | GO:0051347 | positive regulation of transferase activity | 2.71e-03 |
| PTK2B | GO:1903052 | positive regulation of proteolysis involved in protein catabolic process | 2.71e-03 |
| PTK2B | GO:0006816 | calcium ion transport | 3.22e-03 |
| PTK2B | GO:1903169 | regulation of calcium ion transmembrane transport | 3.93e-03 |
| PTK2B | GO:0031214 | biomineral tissue development | 3.93e-03 |
| PTK2B | GO:0010634 | positive regulation of epithelial cell migration | 3.93e-03 |
| PTK2B | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 3.93e-03 |
| PTK2B | GO:0010758 | regulation of macrophage chemotaxis | 3.93e-03 |
| PTK2B | GO:0032958 | inositol phosphate biosynthetic process | 3.93e-03 |
| PTK2B | GO:0045766 | positive regulation of angiogenesis | 3.93e-03 |
| PTK2B | GO:1904018 | positive regulation of vasculature development | 3.93e-03 |
| PTK2B | GO:0070168 | negative regulation of biomineral tissue development | 3.93e-03 |
| PTK2B | GO:0030808 | regulation of nucleotide biosynthetic process | 4.15e-03 |
| PTK2B | GO:1900371 | regulation of purine nucleotide biosynthetic process | 4.15e-03 |
| PTK2B | GO:0031334 | positive regulation of protein-containing complex assembly | 4.16e-03 |
| PTK2B | GO:0034405 | response to fluid shear stress | 4.24e-03 |
| PTK2B | GO:0032271 | regulation of protein polymerization | 4.24e-03 |
| PTK2B | GO:0043267 | negative regulation of potassium ion transport | 4.84e-03 |
| PTK2B | GO:0031281 | positive regulation of cyclase activity | 5.21e-03 |
| PTK2B | GO:0051349 | positive regulation of lyase activity | 5.21e-03 |
| PTK2B | GO:0010594 | regulation of endothelial cell migration | 5.21e-03 |
| PTK2B | GO:0048246 | macrophage chemotaxis | 5.21e-03 |
| PTK2B | GO:0072593 | reactive oxygen species metabolic process | 5.21e-03 |
| PTK2B | GO:1903050 | regulation of proteolysis involved in protein catabolic process | 5.21e-03 |
| PTK2B | GO:0007160 | cell-matrix adhesion | 5.21e-03 |
| PTK2B | GO:0022898 | regulation of transmembrane transporter activity | 5.21e-03 |
| PTK2B | GO:0043647 | inositol phosphate metabolic process | 5.43e-03 |
| PTK2B | GO:1905521 | regulation of macrophage migration | 5.43e-03 |
| PTK2B | GO:1900542 | regulation of purine nucleotide metabolic process | 6.04e-03 |
| PTK2B | GO:0006140 | regulation of nucleotide metabolic process | 6.15e-03 |
| PTK2B | GO:0032409 | regulation of transporter activity | 6.62e-03 |
| PTK2B | GO:0030838 | positive regulation of actin filament polymerization | 6.62e-03 |
| PTK2B | GO:0031279 | regulation of cyclase activity | 6.98e-03 |
| PTK2B | GO:1902930 | regulation of alcohol biosynthetic process | 7.03e-03 |
| PTK2B | GO:0043542 | endothelial cell migration | 7.03e-03 |
| PTK2B | GO:0051258 | protein polymerization | 7.03e-03 |
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Related Drugs to CDCA4_PTK2B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CDCA4-PTK2B and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CDCA4_PTK2B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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