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Kinase Fusion Gene:CDK11A_CDK11B |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CDK11A_CDK11B | KinaseFusionDB ID: KFG1045 | FusionGDB2.0 ID: KFG1045 | Hgene | Tgene | Gene symbol | CDK11A | CDK11B | Gene ID | 728642 | 984 | |
| Gene name | cyclin dependent kinase 11A | cyclin dependent kinase 11B | ||||||||||
| Synonyms | CDC2L2|CDC2L3|CDK11-p110|CDK11-p46|CDK11-p58|PITSLRE|p58GTA | CDC2L1|CDK11|CDK11-p110|CDK11-p46|CDK11-p58|CLK-1|PITSLREA|PK58|p58|p58CDC2L1|p58CLK-1 | ||||||||||
| Cytomap | 1p36.33 | 1p36.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | cyclin-dependent kinase 11APITSLRE BPITSLRE serine/threonine-protein kinase CDC2L2cell division cycle 2-like 2 (PITSLRE proteins)cell division cycle 2-like protein kinase 2cell division protein kinase 11Agalactosyltransferase-associated protein kina | cyclin-dependent kinase 11BCDC-related protein kinase p58PITSLRE serine/threonine-protein kinase CDC2L1cell division cycle 2-like 1 (PITSLRE proteins)cell division protein kinase 11Bgalactosyltransferase-associated protein kinase p58/GTAp58 CLK-1 | ||||||||||
| Modification date | 20240407 | 20240407 | ||||||||||
| UniProtAcc | Q9UQ88 | P21127 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000357760, ENST00000358779, ENST00000378633, ENST00000378638, ENST00000404249, ENST00000356200, ENST00000378635, ENST00000495016, | ENST00000317673, ENST00000340677, ENST00000341832, ENST00000407249, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CDK11A [Title/Abstract] AND CDK11B [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CDK11A(1647785)-CDK11B(1580623), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK11A | GO:0006468 | protein phosphorylation | 12501247 |
| Hgene | CDK11A | GO:0050684 | regulation of mRNA processing | 12501247 |
| Tgene | CDK11B | GO:0006468 | protein phosphorylation | 12501247 |
| Tgene | CDK11B | GO:0050684 | regulation of mRNA processing | 12501247 |
| Kinase Fusion gene breakpoints across CDK11A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across CDK11B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BI905981 | CDK11A | chr1 | 1647785 | CDK11B | chr1 | 1580623 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:1647785/chr1:1580623) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK11A | CDK11B |
| FUNCTION: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090}. | FUNCTION: Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:12624090, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:2217177}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CDK11A_CDK11B |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CDK11A | Q9UQ88 | human | SPDEF | O95238 | S238 | SEESWTDsEVDssCS | |
| CDK11A | Q9UQ88 | human | SPDEF | O95238 | S243 | TDsEVDssCSGQPIH | |
| CDK11A | Q9UQ88 | human | SPDEF | O95238 | S242 | WTDsEVDssCSGQPI | |
| CDK11A | Q9UQ88-10 | human | CDK11B | P21127-12 | T370 | KHEYFREtPLPIDPS | |
| CDK11B | P21127 | human | AR | P10275 | S310 | TEDTAEysPFKGGYT | Androgen_recep |
| CDK11B | P21127 | human | EIF3F | O00303 | S46 | PAAAPASsSDPAAAA |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CDK11A | ID | Description | 0.00e+00 |
| CDK11A | GO:0010454 | negative regulation of cell fate commitment | 8.26e-03 |
| CDK11A | GO:0060433 | bronchus development | 8.26e-03 |
| CDK11A | GO:0061140 | lung secretory cell differentiation | 8.26e-03 |
| CDK11A | GO:0010455 | positive regulation of cell fate commitment | 8.26e-03 |
| CDK11A | GO:0072148 | epithelial cell fate commitment | 8.26e-03 |
| CDK11A | GO:0060576 | intestinal epithelial cell development | 8.26e-03 |
| CDK11A | GO:0060479 | lung cell differentiation | 8.57e-03 |
| CDK11A | GO:0060487 | lung epithelial cell differentiation | 8.57e-03 |
| CDK11A | GO:0060575 | intestinal epithelial cell differentiation | 8.57e-03 |
| CDK11A | GO:0002068 | glandular epithelial cell development | 9.91e-03 |
| CDK11A | GO:0010453 | regulation of cell fate commitment | 1.01e-02 |
| CDK11A | GO:0060428 | lung epithelium development | 1.01e-02 |
| CDK11A | GO:0002066 | columnar/cuboidal epithelial cell development | 1.10e-02 |
| CDK11A | GO:0002067 | glandular epithelial cell differentiation | 1.43e-02 |
| CDK11A | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 2.16e-02 |
| CDK11A | GO:0050684 | regulation of mRNA processing | 2.16e-02 |
| CDK11A | GO:0048565 | digestive tract development | 2.16e-02 |
| CDK11A | GO:0055123 | digestive system development | 2.23e-02 |
| CDK11A | GO:0030324 | lung development | 2.63e-02 |
| CDK11A | GO:0030323 | respiratory tube development | 2.63e-02 |
| CDK11A | GO:0002064 | epithelial cell development | 2.67e-02 |
| CDK11A | GO:0060541 | respiratory system development | 2.67e-02 |
| CDK11A | GO:0045165 | cell fate commitment | 3.40e-02 |
| CDK11A | GO:1903311 | regulation of mRNA metabolic process | 4.12e-02 |
| CDK11A | GO:0001558 | regulation of cell growth | 4.55e-02 |
| CDK11A | GO:0016049 | cell growth | 5.20e-02 |
| CDK11B | ID | Description | 0.00e+00 |
| CDK11B | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0033327 | Leydig cell differentiation | 1.28e-02 |
| CDK11B | GO:0060601 | lateral sprouting from an epithelium | 1.28e-02 |
| CDK11B | GO:0060736 | prostate gland growth | 1.28e-02 |
| CDK11B | GO:0060742 | epithelial cell differentiation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 1.28e-02 |
| CDK11B | GO:0075522 | IRES-dependent viral translational initiation | 1.28e-02 |
| CDK11B | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0035112 | genitalia morphogenesis | 1.28e-02 |
| CDK11B | GO:0071394 | cellular response to testosterone stimulus | 1.28e-02 |
| CDK11B | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway | 1.28e-02 |
| CDK11B | GO:0030238 | male sex determination | 1.28e-02 |
| CDK11B | GO:0060572 | morphogenesis of an epithelial bud | 1.28e-02 |
| CDK11B | GO:0001732 | formation of cytoplasmic translation initiation complex | 1.28e-02 |
| CDK11B | GO:0072520 | seminiferous tubule development | 1.28e-02 |
| CDK11B | GO:0045945 | positive regulation of transcription by RNA polymerase III | 1.28e-02 |
| CDK11B | GO:0071391 | cellular response to estrogen stimulus | 1.28e-02 |
| CDK11B | GO:0060749 | mammary gland alveolus development | 1.28e-02 |
| CDK11B | GO:0061377 | mammary gland lobule development | 1.28e-02 |
| CDK11B | GO:0019081 | viral translation | 1.28e-02 |
| CDK11B | GO:0060444 | branching involved in mammary gland duct morphogenesis | 1.28e-02 |
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Related Drugs to CDK11A_CDK11B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CDK11A-CDK11B and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CDK11A_CDK11B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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