| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:CDK16_CBFA2T3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CDK16_CBFA2T3 | KinaseFusionDB ID: KFG1111 | FusionGDB2.0 ID: KFG1111 | Hgene | Tgene | Gene symbol | CDK16 | CBFA2T3 | Gene ID | 5127 | 863 | |
| Gene name | cyclin dependent kinase 16 | CBFA2/RUNX1 partner transcriptional co-repressor 3 | ||||||||||
| Synonyms | PCTAIRE|PCTAIRE1|PCTGAIRE|PCTK1 | ETO2|MTG16|MTGR2|RUNX1T3|ZMYND4 | ||||||||||
| Cytomap | Xp11.3 | 16q24.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | cyclin-dependent kinase 16PCTAIRE-motif protein kinase 1cell division protein kinase 16serine/threonine-protein kinase PCTAIRE-1testis secretory sperm-binding protein Li 224n | protein CBFA2T3CBFA2/RUNX1 translocation partner 3MTG8-related gene 2MTG8-related protein 2core-binding factor, runt domain, alpha subunit 2; translocated to, 3myeloid translocation gene 8 and 16bmyeloid translocation gene on chromosome 16 proteinz | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q00536 | O75081 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000357227, ENST00000276052, ENST00000457458, ENST00000517997, ENST00000518022, | ENST00000268679, ENST00000327483, ENST00000360302, ENST00000436887, ENST00000448839, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CDK16 [Title/Abstract] AND CBFA2T3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CDK16(47078321)-CBFA2T3(88954307), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CDK16 | GO:0010508 | positive regulation of autophagy | 32098961 |
| Tgene | CBFA2T3 | GO:0001666 | response to hypoxia | 23840896 |
| Tgene | CBFA2T3 | GO:0008285 | negative regulation of cell population proliferation | 23840896 |
| Tgene | CBFA2T3 | GO:0030851 | granulocyte differentiation | 15231665 |
| Tgene | CBFA2T3 | GO:0045820 | negative regulation of glycolytic process | 23840896 |
| Tgene | CBFA2T3 | GO:0045892 | negative regulation of DNA-templated transcription | 23840896|25974097 |
| Tgene | CBFA2T3 | GO:1903715 | regulation of aerobic respiration | 23840896 |
| Kinase Fusion gene breakpoints across CDK16 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CBFA2T3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BM193217 | CDK16 | chrX | 47078321 | CBFA2T3 | chr16 | 88954307 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47078321/:88954307) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CDK16 | CBFA2T3 |
| FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}. | FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O54972, ECO:0000269|PubMed:12183414, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16966434, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23840896, ECO:0000269|PubMed:25974097, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.; FUNCTION: Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486). {ECO:0000269|PubMed:11823486}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of CDK16_CBFA2T3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CDK16 | Q00536 | human | PRKAR1A | P10644 | S83 | DsREDEIsPPPPNPV | |
| CDK16 | Q00536 | human | PRC1 | O43663 | T481 | RrGLAPNtPGkARkL | |
| CDK16 | Q00536 | human | CDKN1B | P46527 | S10 | NVRVSNGsPsLErMD | |
| CDK16 | Q00536 | human | CCNY | Q8ND76 | S336 | NLtLPRWsPAIIS__ |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CDK16 | ID | Description | 0.00e+00 |
| CDK16 | GO:0071900 | regulation of protein serine/threonine kinase activity | 3.40e-03 |
| CDK16 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 1.00e-02 |
| CDK16 | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 1.00e-02 |
| CDK16 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 1.04e-02 |
| CDK16 | GO:0006469 | negative regulation of protein kinase activity | 2.59e-02 |
| CDK16 | GO:0033673 | negative regulation of kinase activity | 2.59e-02 |
| CDK16 | GO:0051348 | negative regulation of transferase activity | 2.67e-02 |
| CDK16 | GO:0033002 | muscle cell proliferation | 2.67e-02 |
| CDK16 | GO:0140014 | mitotic nuclear division | 2.67e-02 |
| CDK16 | GO:0001933 | negative regulation of protein phosphorylation | 2.67e-02 |
| CDK16 | GO:0042326 | negative regulation of phosphorylation | 2.67e-02 |
| CDK16 | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 2.67e-02 |
| CDK16 | GO:0045936 | negative regulation of phosphate metabolic process | 2.67e-02 |
| CDK16 | GO:0010563 | negative regulation of phosphorus metabolic process | 2.67e-02 |
| CDK16 | GO:0051256 | mitotic spindle midzone assembly | 2.67e-02 |
| CDK16 | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 2.67e-02 |
| CDK16 | GO:0000022 | mitotic spindle elongation | 2.67e-02 |
| CDK16 | GO:0071236 | cellular response to antibiotic | 2.67e-02 |
| CDK16 | GO:0071377 | cellular response to glucagon stimulus | 2.67e-02 |
| CDK16 | GO:0140694 | non-membrane-bounded organelle assembly | 2.67e-02 |
| CDK16 | GO:0071285 | cellular response to lithium ion | 2.67e-02 |
| CDK16 | GO:0051231 | spindle elongation | 2.67e-02 |
| CDK16 | GO:0051255 | spindle midzone assembly | 2.67e-02 |
| CDK16 | GO:0043434 | response to peptide hormone | 2.67e-02 |
| CDK16 | GO:0031400 | negative regulation of protein modification process | 2.67e-02 |
| CDK16 | GO:0000280 | nuclear division | 2.67e-02 |
| CDK16 | GO:0010226 | response to lithium ion | 2.67e-02 |
| CDK16 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 2.67e-02 |
| CDK16 | GO:0046007 | negative regulation of activated T cell proliferation | 2.67e-02 |
| CDK16 | GO:2000479 | regulation of cAMP-dependent protein kinase activity | 2.67e-02 |
| CDK16 | GO:0044772 | mitotic cell cycle phase transition | 2.71e-02 |
| CDK16 | GO:0043086 | negative regulation of catalytic activity | 2.71e-02 |
| CDK16 | GO:0006977 | DNA damage respons | 3.81e-03 |
| CDK16 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity | 2.71e-02 |
| CDK16 | GO:0048285 | organelle fission | 2.71e-02 |
| CDK16 | GO:0033762 | response to glucagon | 3.17e-02 |
| CDK16 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 3.28e-02 |
| CDK16 | GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | 3.28e-02 |
| CDK16 | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | 3.77e-02 |
| CDK16 | GO:0044819 | mitotic G1/S transition checkpoint signaling | 3.77e-02 |
| CDK16 | GO:0010458 | exit from mitosis | 3.97e-02 |
| CDK16 | GO:0031116 | positive regulation of microtubule polymerization | 3.97e-02 |
| CDK16 | GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 4.28e-02 |
| CDK16 | GO:0046677 | response to antibiotic | 4.28e-02 |
| CDK16 | GO:0070306 | lens fiber cell differentiation | 4.28e-02 |
| CDK16 | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation | 4.76e-02 |
| CDK16 | GO:0046006 | regulation of activated T cell proliferation | 4.88e-02 |
| CDK16 | GO:0045214 | sarcomere organization | 4.89e-02 |
| CDK16 | GO:0050798 | activated T cell proliferation | 5.00e-02 |
Top |
Related Drugs to CDK16_CBFA2T3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CDK16-CBFA2T3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to CDK16_CBFA2T3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |