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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CDK19_FAM96B

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CDK19_FAM96B
KinaseFusionDB ID: KFG1138
FusionGDB2.0 ID: KFG1138
HgeneTgene
Gene symbol

CDK19

FAM96B

Gene ID

23097

51647

Gene namecyclin dependent kinase 19cytosolic iron-sulfur assembly component 2B
SynonymsCDC2L6|CDK11|DEE87|EIEE87|bA346C16.3CGI-128|CIA2B|FAM96B|MIP18
Cytomap

6q21

16q22.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 19CDC2-related protein kinase 6CDK8-like cyclin-dependent kinasecell division cycle 2-like 6 (CDK8-like)cell division cycle 2-like protein kinase 6cell division protein kinase 19cyclin-dependent kinase (CDC2-like) 11cyclin-dcytosolic iron-sulfur assembly component 2BMSS19-interacting protein of 18 kDafamily with sequence similarity 96 member Bmitotic spindle-associated MMXD complex subunit MIP18
Modification date2024041120240411
UniProtAcc

Q9BWU1

Q9Y3D0

Ensembl transtripts involved in fusion geneENST idsENST00000323817, ENST00000368911, 
ENST00000413605, ENST00000497709, 
ENST00000422424, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CDK19 [Title/Abstract] AND FAM96B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDK19(111067329)-FAM96B(66967642), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonKinase Fusion gene breakpoints across CDK19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across FAM96B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-60-2712-01ACDK19chr6

111067329

FAM96Bchr16

66967642



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:111067329/chr16:66967642)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK19

Q9BWU1

FAM96B

Q9Y3D0

FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:29848660}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of CDK19_FAM96B


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CDK19Q9BWU1humanPAK1Q13153S174TPAVPPVsEDEDDDD
CDK19Q9BWU1humanEIF3FO00303T119GAARVIGtLLGTVDKJAB
CDK19Q9BWU1humanNOTCH1P46531S2513EHPFLtPsPEsPDQW
CDK19Q9BWU1humanNOTCH1P46531T2511VPEHPFLtPsPEsPD
CDK19Q9BWU1humanEIF3FO00303S46PAAAPASsSDPAAAA
CDK19Q9BWU1humanNOTCH1P46531S2516FLtPsPEsPDQWsss


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CDK19IDDescription0.00e+00
CDK19GO:0048754branching morphogenesis of an epithelial tube2.21e-02
CDK19GO:0061138morphogenesis of a branching epithelium2.21e-02
CDK19GO:0001763morphogenesis of a branching structure2.21e-02
CDK19GO:0060562epithelial tube morphogenesis2.21e-02
CDK19GO:0006887exocytosis2.21e-02
CDK19GO:0016032viral process2.21e-02
CDK19GO:0007440foregut morphogenesis2.21e-02
CDK19GO:0060245detection of cell density2.21e-02
CDK19GO:0060525prostate glandular acinus development2.21e-02
CDK19GO:0060768regulation of epithelial cell proliferation involved in prostate gland development2.21e-02
CDK19GO:0060947cardiac vascular smooth muscle cell differentiation2.21e-02
CDK19GO:0062042regulation of cardiac epithelial to mesenchymal transition2.21e-02
CDK19GO:0071372cellular response to follicle-stimulating hormone stimulus2.21e-02
CDK19GO:2000048negative regulation of cell-cell adhesion mediated by cadherin2.21e-02
CDK19GO:0007409axonogenesis2.21e-02
CDK19GO:0003263cardioblast proliferation2.21e-02
CDK19GO:0003264regulation of cardioblast proliferation2.21e-02
CDK19GO:0032966negative regulation of collagen biosynthetic process2.21e-02
CDK19GO:0033148positive regulation of intracellular estrogen receptor signaling pathway2.21e-02
CDK19GO:0048103somatic stem cell division2.21e-02
CDK19GO:0048505regulation of timing of cell differentiation2.21e-02
CDK19GO:0060742epithelial cell differentiation involved in prostate gland development2.21e-02
CDK19GO:0060767epithelial cell proliferation involved in prostate gland development2.21e-02
CDK19GO:0061314Notch signaling involved in heart development2.21e-02
CDK19GO:0075522IRES-dependent viral translational initiation2.21e-02
CDK19GO:0097400interleukin-17-mediated signaling pathway2.21e-02
CDK19GO:1904238pericyte cell differentiation2.21e-02
CDK19GO:1905651regulation of artery morphogenesis2.21e-02
CDK19GO:0043410positive regulation of MAPK cascade2.21e-02
CDK19GO:0002328pro-B cell differentiation2.21e-02
CDK19GO:0003157endocardium development2.21e-02
CDK19GO:0003183mitral valve morphogenesis2.21e-02
CDK19GO:0003207cardiac chamber formation2.21e-02
CDK19GO:0010713negative regulation of collagen metabolic process2.21e-02
CDK19GO:0033145positive regulation of intracellular steroid hormone receptor signaling pathway2.21e-02
CDK19GO:0040034regulation of developmen1.91e-03
CDK19GO:0060379cardiac muscle cell myoblast differentiation2.21e-02
CDK19GO:0072017distal tubule development2.21e-02
CDK19GO:0097084vascular associated smooth muscle cell development2.21e-02
CDK19GO:1902337regulation of apoptotic process involved in morphogenesis2.21e-02
CDK19GO:1905456regulation of lymphoid progenitor cell differentiation2.21e-02
CDK19GO:0003174mitral valve development2.21e-02
CDK19GO:0042670retinal cone cell differentiation2.21e-02
CDK19GO:0048711positive regulation of astrocyte differentiation2.21e-02
CDK19GO:0070278extracellular matrix constituent secretion2.21e-02
CDK19GO:1904748regulation of apoptotic process involved in development2.21e-02
CDK19GO:0003222ventricular trabecula myocardium morphogenesis2.21e-02
CDK19GO:0045605negative regulation of epidermal cell differentiation2.21e-02
CDK19GO:0045683negative regulation of epidermis development2.21e-02

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Related Drugs to CDK19_FAM96B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CDK19-FAM96B and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CDK19_FAM96B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate