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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CDK4_MAPK13

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CDK4_MAPK13
KinaseFusionDB ID: KFG1168
FusionGDB2.0 ID: KFG1168
HgeneTgene
Gene symbol

CDK4

MAPK13

Gene ID

1019

5603

Gene namecyclin dependent kinase 4mitogen-activated protein kinase 13
SynonymsCMM3|PSK-J3MAPK 13|MAPK-13|PRKM13|SAPK4|p38delta
Cytomap

12q14.1

6p21.31

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 4cell division protein kinase 4mitogen-activated protein kinase 13MAP kinase 13MAP kinase p38 deltamitogen-activated protein kinase p38 deltastress-activated protein kinase 4
Modification date2024041620240305
UniProtAcc

P11802

O15264

Ensembl transtripts involved in fusion geneENST idsENST00000257904, ENST00000312990, 
ENST00000549606, ENST00000540325, 
ENST00000551888, 		ENST00000211287, 
ENST00000373761, ENST00000373766, 
ENST00000373759, ENST00000490334, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CDK4 [Title/Abstract] AND MAPK13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK4

GO:0000082

G1/S transition of mitotic cell cycle

19237565

HgeneCDK4

GO:0006468

protein phosphorylation

8114739

HgeneCDK4

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

19124461

HgeneCDK4

GO:0051726

regulation of cell cycle

19124461

TgeneMAPK13

GO:0006970

response to osmotic stress

9731215

TgeneMAPK13

GO:0018105

peptidyl-serine phosphorylation

15850461

TgeneMAPK13

GO:0034644

cellular response to UV

9218798

TgeneMAPK13

GO:0051403

stress-activated MAPK cascade

9218798

TgeneMAPK13

GO:0070301

cellular response to hydrogen peroxide

9218798

TgeneMAPK13

GO:0071347

cellular response to interleukin-1

9218798

TgeneMAPK13

GO:0072709

cellular response to sorbitol

9218798

TgeneMAPK13

GO:0072740

cellular response to anisomycin

9218798

TgeneMAPK13

GO:1903936

cellular response to sodium arsenite

9218798


check buttonKinase Fusion gene breakpoints across CDK4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across MAPK13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLELPS141CDK4chr12

58144703

MAPK13chr6

36104487

CCLELPS853CDK4chr12

58144703

MAPK13chr6

36104487

CCLE95T1000CDK4chr12

58144703

MAPK13chr6

36104487



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000257904ENST00000211287CDK4chr1258144703MAPK13chr6361044872128176

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000257904_ENST00000211287_CDK4_chr12_58144703_MAPK13_chr6_36104487_length(amino acids)=176
MRMATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIK

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr6:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK4

P11802

MAPK13

O15264

FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:9003781}.FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneCDK458144703MAPK1336104487ENST0000025790401225_3080366DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>94_CDK4_MAPK13ENST00000257904ENST00000211287CDK4chr1258144703MAPK13chr636104487
MRMATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIK
176
3D view using mol* of 94_CDK4_MAPK13
PDB file >>>TKFP_163_CDK4_MAPK13ENST00000257904ENST00000211287CDK4chr1258144703MAPK13chr636104487
MRMATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIK
176_CDK4_MAPK13


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CDK4_MAPK13 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/94_CDK4_MAPK13.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
94_CDK4_MAPK13.png
all structure sitemap plddt3 94_CDK4_MAPK13.png
94_CDK4_MAPK13.png
all structure sitemap plddt4 94_CDK4_MAPK13.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

94_CDK4_MAPK13_ramachandran.png
all structure CDK4-MAPK13

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case
all structure CDK4-MAPK13

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
94_CDK4_MAPK13-DOCK_HTVS_1-001Sunitinib-9.13786-9.14206-50.6077
94_CDK4_MAPK13-DOCK_HTVS_1-001Nilotinib-8.57349-8.71309-57.644
94_CDK4_MAPK13-DOCK_HTVS_1-001Nilotinib-8.57349-8.71309-57.644
94_CDK4_MAPK13-DOCK_HTVS_1-001Midostaurin-8.10971-8.10971-50.7424
94_CDK4_MAPK13-DOCK_HTVS_1-001Midostaurin-8.06565-8.06565-46.0579
94_CDK4_MAPK13-DOCK_HTVS_1-001Larotrectinib-7.85301-7.85301-46.1854
94_CDK4_MAPK13-DOCK_HTVS_1-001Midostaurin-7.557189999999999-7.557189999999999-48.5279
94_CDK4_MAPK13-DOCK_HTVS_1-001Nilotinib-7.53518-8.45998-58.8759
94_CDK4_MAPK13-DOCK_HTVS_1-001Nilotinib-7.53518-8.45998-58.8759
94_CDK4_MAPK13-DOCK_HTVS_1-001Larotrectinib-7.53516-7.53516-41.448
94_CDK4_MAPK13-DOCK_HTVS_1-001Larotrectinib-7.4169-7.4169-47.4932
94_CDK4_MAPK13-DOCK_HTVS_1-001Baricitinib-7.40936-7.40936-45.6581
94_CDK4_MAPK13-DOCK_HTVS_1-001Sorafenib-7.37666-7.38876-52.0913
94_CDK4_MAPK13-DOCK_HTVS_1-001Sorafenib-7.37666-7.38876-52.0913
94_CDK4_MAPK13-DOCK_HTVS_1-001Midostaurin-7.36963-7.36963-43.6549
94_CDK4_MAPK13-DOCK_HTVS_1-001Trilaciclib-7.059080000000001-8.64788-49.6632
94_CDK4_MAPK13-DOCK_HTVS_1-001Trilaciclib-7.059080000000001-8.64788-49.6632
94_CDK4_MAPK13-DOCK_HTVS_1-001Trilaciclib-7.059080000000001-8.64788-49.6632
94_CDK4_MAPK13-DOCK_HTVS_1-001Trilaciclib-7.059080000000001-8.64788-49.6632
94_CDK4_MAPK13-DOCK_HTVS_1-001Lapatinib-6.9627-7.0515-66.7234

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Kinase-Substrate Information of CDK4_MAPK13


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CDK4P11802humanRB1P06400S780strPPtLsPIPHIPrRb_C
CDK4P11802humanTFEBP19484S467KASsRRssFsMEEGDDUF3371
CDK4P11802humanRBL2Q08999T401SKALRIStPLtGVRY
CDK4P11802humanTFEBP19484T331RVHGLPttsPsGMNMDUF3371
CDK4P11802humanFOXM1Q08050T510EDSSQsPtPRPKKSy
CDK4P11802humanCDC25AP30304S40ASAAGGLsPVTNLTV
CDK4P11802humanFOXO1Q12778S249EGGkSGksPrRrAAs
CDK4P11802humanTP73O15350T86AASASPYtPEHAASV
CDK4P11802humanDNMT1P26358S127VGMADANsPPKPLsk
CDK4P11802humanMEF2DQ14814S98KGFNGCDsPEPDGEDHJURP_C
CDK4P11802humanFOXM1Q08050T611ETLPISstPSkSVLP
CDK4P11802humanTSC2P49815S1452LPSssPRsPsGLrPr
CDK4P11802humanFOXM1Q08050S508sWEDSSQsPtPRPKK
CDK4P11802humanEGLN2Q96KS0S130EDGGDAPsPsKRPWA
CDK4P11802humanTCF3P15923S245PMLGGGSsPLPLPPG
CDK4P11802humanWDR77Q9BQA1S264CVTGLVFsPHSVPFL
CDK4P11802humanVCPP55072S664LkANLRksPVAkDVD
CDK4P11802humanDNMT1P26358S954TFNIKLSsPVkRPRkBAH
CDK4P11802humanTFEBP19484S211LVGVTSSsCPADLTQ
CDK4P11802humanRB1P06400T356DsFEtQRtPRksNLD
CDK4P11802humanFOXM1Q08050S522KSySGLRsPtRCVSE
CDK4P11802humanRB1P06400T826LPtPtkMtPRsRILVRb_C
CDK4P11802humanTCF3P15923S139LNsPGPLsPsGMKGT
CDK4P11802humanRBL2Q08999S672tLyDRySsPPAsTtR
CDK4P11802humanFLCNQ8NFG4S571HLMSTVRsPTASESR
CDK4P11802humanRB1P06400S795sPykFPssPLrIPGGRb_C
CDK4P11802humanRUNX3Q13761S356SSSGGDRsPTRMLASRunxI
CDK4P11802humanCELF1Q92879S302TSSGSsPsSSSSNSV
CDK4P11802humanRB1P06400T252PINGsPRtPRRGQNR
CDK4P11802humanRBL1P28749S975HIKQQPGsPRRIsQQRb_C
CDK4P11802humanRBL1P28749T369KRSFAPstPLtGRRY
CDK4P11802humanKAT2AQ92830T272LNYWKLEtPAQFRQRPCAF_N
CDK4P11802humanGATA4P43694S105AYTPPPVsPRFsFPGGATA-N
CDK4P11802humanRB1P06400S788PIPHIPrsPykFPssRb_C
CDK4P11802humanFOXM1Q08050T627tPEsWRLtPPAKVGG
CDK4P11802humanCDKN1AP38936S98GGRRPGTsPALLQGT
CDK4P11802humanRB1P06400S249AVIPINGsPRtPRRG
CDK4P11802humanSMAD3P84022T179PQSNIPEtPPPGYLS
CDK4P11802humanRBL2Q08999S1035NMDAPPLsPyPFVRt
CDK4P11802humanSMAD3P84022S213NLsPNPMsPAHNNLD
CDK4P11802humanRB1P06400S612MyLsPVRsPKKKGsT
CDK4P11802humanFLCNQ8NFG4S73GAsVEsssPGPKKSD
CDK4P11802humanFOXM1Q08050S704IDVPKPGsPEPQVSG
CDK4P11802humanTFEBP19484S142AGNsAPNsPMAMLHIMITF_TFEB_C_3_N
CDK4P11802humanRUNX2Q13950S465MVPGGDRsPSRMLPPRunxI
CDK4P11802humanRBL1P28749S640RRDMQPLsPIsVHER
CDK4P11802humanPELP1Q8IZL8S477ADALKLRsPRGsPDGNUC202
CDK4P11802humanCDKN1AP38936S130sGEQAEGsPGGPGDs
CDK4P11802humanFOXM1Q08050S489PPLEEWPsPAPSFkE
CDK4P11802humanSMAD3P84022S208DAGsPNLsPNPMsPA
CDK4P11802humanBRCA1P38398S632LVVSRNLsPPNCTEL
CDK4P11802humanTFEBP19484S114HIsPAQGsPkPPPAAMITF_TFEB_C_3_N
CDK4P11802humanSMAD3P84022S204NHSMDAGsPNLsPNP
CDK4P11802humanFOXM1Q08050S4____MKTsPRRPLIL
CDK4P11802humanKAT2AQ92830S372EEIYGANsPIWESGF
CDK4P11802humanTFE3P19532S246PTGSAPNsPMALLTIMITF_TFEB_C_3_N
CDK4P11802humanFLNAP21333S2152tRRRRAPsVANVGsHFilamin
CDK4P11802humanRB1P06400T373VNVIPPHtPVRTVMNRB_A
CDK4P11802humanSOD2P04179S106SIFWTNLsPNGGGEPSod_Fe_N
CDK4P11802humanRPRMQ9NS64S98LVKDRRPsKEVEAVV
CDK4P11802humanMDM4O15151S314TECKKFNsPSKRYCFzf-RanBP
CDK4P11802humanFOXM1Q08050T600EVGGPFKtPIkETLP
CDK4P11802humanTP53P04637R249CMGGMNRrPILTIITP53
CDK4P11802humanRBL1P28749S964MMDAPPLsPFPHIKQRb_C
CDK4P11802humanVCPP55072T509kFLkFGMtPskGVLF
CDK4P11802humanTOB2Q14106S254PAPQSQLsPNAKEFVPAM2
CDK4P11802humanRB1P06400S608tAADMyLsPVRsPKK
CDK4P11802humanRB1P06400S807PGGNIyIsPLksPykRb_C
CDK4P11802humanFLNAP21333S1459kCsGPGLsPGMVRANFilamin
CDK4P11802humanSMAD3P84022T8MSSILPFtPPIVkRL
CDK4P11802humanFOXM1Q08050T620SkSVLPRtPEsWRLt
CDK4P11802humanWDR77Q9BQA1S306FVRDATWsPLNHSLL
CDK4P11802humanSPOPO43791S6__MSRVPsPPPPAEM
CDK4P11802humanRASSF1Q9NS23-2S203TsVRRRtsFYLPKDARA
CDK4P11802humanTSC2P49815S1217MSLENPLsPFSSDIN
CDK4P11802humanRB1P06400S811IyIsPLksPykIsEGRb_C
CDK4P11802humanWDR77Q9BQA1T5___MRkEtPPPLVPP
CDK4P11802humanFOXM1Q08050S451LLFGEGFsPLLPVQT
CDK4P11802humanMEF2DQ14814S110GEDsLEQsPLLEDKyHJURP_C
CDK4P11802humanFLCNQ8NFG4S62NSRMRAHsPAEGAsV
CDK4P11802humanFOXM1Q08050S35SEEEPKRsPAQQEsN
MAPK13O15264humanMEF2DQ14814S180LTDPRLLsPQQPALQ
MAPK13O15264humanEEF2KO00418S396TFDsLPssPssAtPH
MAPK13O15264humanMAPTP10636-8S396GAEIVyKsPVVsGDt
MAPK13O15264humanMAPTP10636-8S404PVVsGDtsPRHLsNV
MAPK13O15264humanMEF2DQ14814S121EDKyRRAsEELDGLFHJURP_C
MAPK13O15264humanMEF2DQ14814S251NkVIPAksPPPPtHS
MAPK13O15264humanSTMN1P16949S25QAFELILsPrskEsVStathmin
MAPK13O15264humanISL1P61371S269GTPMVAAsPERHDGG
MAPK13O15264humanMEF2DQ14814S275PDLRVITsQAGKGLM
MAPK13O15264humanSTMN1P16949S38sVPEFPLsPPkKkDLStathmin
MAPK13O15264humanSQSTM1Q13501T269GGkRsRLtPVsPEss
MAPK13O15264humanCCND3P30281T283QGPsQtstPtDVtAI
MAPK13O15264humanMEF2DQ14814S472EPGDGLssPAGGSYE
MAPK13O15264humanGYS1P13807S723sssLStPsEPLsPts
MAPK13O15264humanEEF2KO00418S359GtEEKCGsPQVRtLs
MAPK13O15264humanMAPTP10636-8T217sRtPsLPtPPtREPK
MAPK13O15264humanHSF1Q00613S307EPPsPPQsPRVEEAsVert_HS_TF
MAPK13O15264humanNLRP1Q9C000S107PSEPHLGsPSQPTST
MAPK13O15264humanMEF2DQ14814S444SIkSEPVsPsRERsP
MAPK13O15264humanHSF1Q00613S303RVkEEPPsPPQsPRVVert_HS_TF
MAPK13O15264humanKAT5Q92993-2T106VEVVsPAtPVPSETA
MAPK13O15264humanMAPTP10636-8T212tPGsRsRtPsLPtPP
MAPK13O15264humanGYS1P13807S727StPsEPLsPtssLGE
MAPK13O15264humanMEF2DQ14814S231GYVsARAsPGLLPVA
MAPK13O15264humanHSF1Q00613S326ssVDtLLsPTALIDsVert_HS_TF
MAPK13O15264humanGYS1P13807T278kRkPDIVtPNGLNVkGlycogen_syn
MAPK13O15264humanSQSTM1Q13501S272RsRLtPVsPEssstE
MAPK13O15264humanKAT5Q92993T158VEVVsPAtPVPSETA


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CDK4IDDescription0.00e+00
CDK4GO:0031667response to nutrient levels1.70e-05
CDK4GO:2000377regulation of reactive oxygen species metabolic process1.84e-04
CDK4GO:2000134negative regulation of G1/S transition of mitotic cell cycle1.95e-04
CDK4GO:0045786negative regulation of cell cycle1.95e-04
CDK4GO:1902807negative regulation of cell cycle G1/S phase transition1.95e-04
CDK4GO:0009267cellular response to starvation1.95e-04
CDK4GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage2.11e-04
CDK4GO:1901991negative regulation of mitotic cell cycle phase transition2.11e-04
CDK4GO:0097193intrinsic apoptotic signaling pathway2.11e-04
CDK4GO:0010948negative regulation of cell cycle process2.11e-04
CDK4GO:0044772mitotic cell cycle phase transition2.11e-04
CDK4GO:0051216cartilage development2.28e-04
CDK4GO:0002062chondrocyte differentiation2.42e-04
CDK4GO:0070482response to oxygen levels2.46e-04
CDK4GO:0042594response to starvation2.46e-04
CDK4GO:0009895negative regulation of catabolic process2.47e-04
CDK4GO:1901990regulation of mitotic cell cycle phase transition2.60e-04
CDK4GO:0072593reactive oxygen species metabolic process3.09e-04
CDK4GO:0045599negative regulation of fat cell differentiation3.40e-04
CDK4GO:0006978DNA damage respons4.28e-06
CDK4GO:0045930negative regulation of mitotic cell cycle3.40e-04
CDK4GO:0042772DNA damage respons5.08e-06
CDK4GO:0000082G1/S transition of mitotic cell cycle3.40e-04
CDK4GO:0055093response to hyperoxia3.61e-04
CDK4GO:0045598regulation of fat cell differentiation3.61e-04
CDK4GO:0044839cell cycle G2/M phase transition4.66e-04
CDK4GO:0030330DNA damage respons8.75e-06
CDK4GO:0044843cell cycle G1/S phase transition4.79e-04
CDK4GO:0006606protein import into nucleus4.79e-04
CDK4GO:0031668cellular response to extracellular stimulus4.79e-04
CDK4GO:0060537muscle tissue development4.79e-04
CDK4GO:0061448connective tissue development4.91e-04
CDK4GO:0051170import into nucleus5.05e-04
CDK4GO:1901987regulation of cell cycle phase transition6.15e-04
CDK4GO:0072331signal transduction by p53 class mediator6.18e-04
CDK4GO:0036296response to increased oxygen levels6.20e-04
CDK4GO:0010660regulation of muscle cell apoptotic process6.20e-04
CDK4GO:0034504protein localization to nucleus6.75e-04
CDK4GO:2000045regulation of G1/S transition of mitotic cell cycle6.94e-04
CDK4GO:0050673epithelial cell proliferation7.37e-04
CDK4GO:0010657muscle cell apoptotic process7.40e-04
CDK4GO:0030308negative regulation of cell growth7.40e-04
CDK4GO:0042770signal transduction in response to DNA damage7.40e-04
CDK4GO:0007264small GTPase mediated signal transduction7.73e-04
CDK4GO:1904705regulation of vascular associated smooth muscle cell proliferation7.73e-04
CDK4GO:0016049cell growth8.07e-04
CDK4GO:1990874vascular associated smooth muscle cell proliferation8.07e-04
CDK4GO:0062012regulation of small molecule metabolic process8.69e-04
CDK4GO:0007265Ras protein signal transduction9.11e-04

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Related Drugs to CDK4_MAPK13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CDK4-MAPK13 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CDK4_MAPK13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate