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Kinase Fusion Gene:ACTB_MAP3K14 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ACTB_MAP3K14 | KinaseFusionDB ID: KFG125 | FusionGDB2.0 ID: KFG125 | Hgene | Tgene | Gene symbol | ACTB | MAP3K14 | Gene ID | 728378 | 9020 | |
| Gene name | mitogen-activated protein kinase kinase kinase 14 | |||||||||||
| Synonyms | FTDCR1B|HS|HSNIK|IMD112|NIK | |||||||||||
| Cytomap | 17q21.31 | |||||||||||
| Type of gene | protein-coding | |||||||||||
| Description | mitogen-activated protein kinase kinase kinase 14NF-kappa-beta-inducing kinaseserine/threonine-protein kinase NIK | |||||||||||
| Modification date | 20240305 | |||||||||||
| UniProtAcc | P60709 | Q99558 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000331789, ENST00000464611, | ENST00000344686, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ACTB [Title/Abstract] AND MAP3K14 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ACTB(5566782)-MAP3K14(43362859), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP3K14 | GO:0051607 | defense response to virus | 21478870 |
| Kinase Fusion gene breakpoints across ACTB (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MAP3K14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | CF145032 | ACTB | chr7 | 5566782 | MAP3K14 | chr17 | 43362859 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:5566782/:43362859) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACTB | MAP3K14 |
| FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:Q6QAQ1, ECO:0000269|PubMed:29581253, ECO:0000269|PubMed:29925947}. | FUNCTION: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. {ECO:0000269|PubMed:15084608}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ACTB_MAP3K14 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K14 | Q99558 | human | CHUK | O15111 | S176 | AKDVDQGsLCtsFVG | Pkinase |
| MAP3K14 | Q99558 | human | G6PD | P11413 | S486 | PIPYIYGsRGPtEAD | G6PD_C |
| MAP3K14 | Q99558 | human | G6PD | P11413 | S278 | VAMEKPAsTNSDDVR | G6PD_C |
| MAP3K14 | Q99558 | human | NFKB2 | Q00653 | S870 | kEDsAyGsQsVEQEA | |
| MAP3K14 | Q99558 | human | NFKBIA | P25963 | S32 | LLDDRHDsGLDsMkD | |
| MAP3K14 | Q99558 | human | ACTR2 | P61160 | T238 | QKLALEttVLVESYT | Actin |
| MAP3K14 | Q99558 | human | NFKBIA | P25963 | S36 | RHDsGLDsMkDEEyE | |
| MAP3K14 | Q99558 | human | ACTR2 | P61160 | Y202 | kLLLLRGyAFNHsAD | Actin |
| MAP3K14 | Q99558 | human | G6PD | P11413 | S40 | IFIIMGAsGDLAKKK | G6PD_N |
| MAP3K14 | Q99558 | human | ACTR2 | P61160 | T237 | EQKLALEttVLVESY | Actin |
| MAP3K14 | Q99558 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
| MAP3K14 | Q99558 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
| MAP3K14 | Q99558 | human | CHUK | O15111 | S180 | DQGsLCtsFVGTLQY | Pkinase |
| MAP3K14 | Q99558 | human | G6PD | P11413 | S8 | MAEQVALsrtQVCGI | |
| MAP3K14 | Q99558 | human | NFKB2 | Q00653 | S866 | tAEVkEDsAyGsQsV |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K14 | ID | Description | 0.00e+00 |
| MAP3K14 | GO:0007249 | canonical NF-kappaB signal transduction | 3.39e-04 |
| MAP3K14 | GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 3.97e-04 |
| MAP3K14 | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 4.82e-04 |
| MAP3K14 | GO:0038061 | non-canonical NF-kappaB signal transduction | 8.60e-04 |
| MAP3K14 | GO:0002221 | pattern recognition receptor signaling pathway | 2.04e-03 |
| MAP3K14 | GO:0071356 | cellular response to tumor necrosis factor | 2.04e-03 |
| MAP3K14 | GO:0070498 | interleukin-1-mediated signaling pathway | 2.04e-03 |
| MAP3K14 | GO:0002758 | innate immune response-activating signaling pathway | 2.04e-03 |
| MAP3K14 | GO:0034612 | response to tumor necrosis factor | 2.04e-03 |
| MAP3K14 | GO:0002218 | activation of innate immune response | 2.22e-03 |
| MAP3K14 | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 3.06e-03 |
| MAP3K14 | GO:0045089 | positive regulation of innate immune response | 3.06e-03 |
| MAP3K14 | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 3.06e-03 |
| MAP3K14 | GO:0032496 | response to lipopolysaccharide | 3.06e-03 |
| MAP3K14 | GO:0034142 | toll-like receptor 4 signaling pathway | 3.06e-03 |
| MAP3K14 | GO:0002237 | response to molecule of bacterial origin | 3.09e-03 |
| MAP3K14 | GO:0002833 | positive regulation of response to biotic stimulus | 3.09e-03 |
| MAP3K14 | GO:0140895 | cell surface toll-like receptor signaling pathway | 3.35e-03 |
| MAP3K14 | GO:0051090 | regulation of DNA-binding transcription factor activity | 3.67e-03 |
| MAP3K14 | GO:0002752 | cell surface pattern recognition receptor signaling pathway | 3.73e-03 |
| MAP3K14 | GO:0045088 | regulation of innate immune response | 3.80e-03 |
| MAP3K14 | GO:0002757 | immune response-activating signaling pathway | 4.80e-03 |
| MAP3K14 | GO:0031349 | positive regulation of defense response | 4.80e-03 |
| MAP3K14 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 4.80e-03 |
| MAP3K14 | GO:0002764 | immune response-regulating signaling pathway | 5.16e-03 |
| MAP3K14 | GO:0071347 | cellular response to interleukin-1 | 7.21e-03 |
| MAP3K14 | GO:0070555 | response to interleukin-1 | 1.10e-02 |
| MAP3K14 | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 1.15e-02 |
| MAP3K14 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 1.18e-02 |
| MAP3K14 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 1.41e-02 |
| MAP3K14 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 1.87e-02 |
| MAP3K14 | GO:0050851 | antigen receptor-mediated signaling pathway | 1.98e-02 |
| MAP3K14 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 2.71e-02 |
| MAP3K14 | GO:0034599 | cellular response to oxidative stress | 2.86e-02 |
| MAP3K14 | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 3.00e-02 |
| MAP3K14 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 3.51e-02 |
| MAP3K14 | GO:0018105 | peptidyl-serine phosphorylation | 3.51e-02 |
| MAP3K14 | GO:0051146 | striated muscle cell differentiation | 3.53e-02 |
| MAP3K14 | GO:0019321 | pentose metabolic process | 3.53e-02 |
| MAP3K14 | GO:0018209 | peptidyl-serine modification | 3.53e-02 |
| MAP3K14 | GO:0062197 | cellular response to chemical stress | 3.55e-02 |
| MAP3K14 | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development | 3.55e-02 |
| MAP3K14 | GO:0070417 | cellular response to cold | 3.55e-02 |
| MAP3K14 | GO:0002467 | germinal center formation | 3.56e-02 |
| MAP3K14 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 3.56e-02 |
| MAP3K14 | GO:0042994 | cytoplasmic sequestering of transcription factor | 3.56e-02 |
| MAP3K14 | GO:0030522 | intracellular receptor signaling pathway | 3.56e-02 |
| MAP3K14 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 3.56e-02 |
| MAP3K14 | GO:0010038 | response to metal ion | 3.56e-02 |
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Related Drugs to ACTB_MAP3K14 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ACTB-MAP3K14 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ACTB_MAP3K14 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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