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Kinase Fusion Gene:CIRBP_STK11 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: CIRBP_STK11 | KinaseFusionDB ID: KFG1293 | FusionGDB2.0 ID: KFG1293 | Hgene | Tgene | Gene symbol | CIRBP | STK11 | Gene ID | 1153 | 6794 | |
Gene name | cold inducible RNA binding protein | serine/threonine kinase 11 | ||||||||||
Synonyms | CIRP | LKB1|PJS|hLKB1 | ||||||||||
Cytomap | 19p13.3 | 19p13.3 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | cold-inducible RNA-binding proteinA18 hnRNPglycine-rich RNA binding proteintesticular tissue protein Li 39 | serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1 | ||||||||||
Modification date | 20240407 | 20240416 | ||||||||||
UniProtAcc | Q14011 | Q15831 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000588030, ENST00000589660, ENST00000588090, ENST00000591935, ENST00000589710, ENST00000588230, ENST00000413636, ENST00000586472, ENST00000589686, ENST00000444172, ENST00000587323, ENST00000320936, ENST00000587896, ENST00000589235, ENST00000585630, ENST00000586773, ENST00000590188, | ENST00000585748, ENST00000326873, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CIRBP [Title/Abstract] AND STK11 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CIRBP | GO:0009411 | response to UV | 11574538 |
Hgene | CIRBP | GO:0045727 | positive regulation of translation | 11574538 |
Hgene | CIRBP | GO:0048255 | mRNA stabilization | 11574538 |
Tgene | STK11 | GO:0006468 | protein phosphorylation | 12805220|25329316 |
Tgene | STK11 | GO:0018107 | peptidyl-threonine phosphorylation | 12805220 |
Tgene | STK11 | GO:0046777 | protein autophosphorylation | 11430832 |
Tgene | STK11 | GO:0070314 | G1 to G0 transition | 17216128 |
Tgene | STK11 | GO:0071493 | cellular response to UV-B | 25329316 |
Tgene | STK11 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11430832 |
Kinase Fusion gene breakpoints across CIRBP (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across STK11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
CCLE | SNU-478 | CIRBP | chr19 | 1272050 | STK11 | chr19 | 1218416 |
CCLE | SNU-478 | CIRBP | chr19 | 1272050 | STK11 | chr19 | 1216267 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CIRBP | STK11 |
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}. | FUNCTION: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). {ECO:0000269|PubMed:11430832, ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15016379, ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:25329316}.; FUNCTION: [Isoform 2]: Has a role in spermiogenesis. {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CIRBP_STK11 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
STK11 | Q15831 | human | PTEN | P60484 | S380 | EPDHyRYsDttDsDP | |
STK11 | Q15831 | human | SMAD4 | Q13485 | T77 | kCVTIQRtLDGRLQV | MH1 |
STK11 | Q15831 | human | NUAK2 | Q9H093 | T208 | HQGKFLQtFCGSPLY | Pkinase |
STK11 | Q15831 | human | SIRT1 | Q96EB6 | S615 | GEkNERtsVAGtVRk | |
STK11 | Q15831 | human | CRTC1 | Q6UUV9 | S151 | TSWRRtNsDsALHQs | TORC_M |
STK11 | Q15831 | human | NUAK1 | O60285 | T211 | QKDKFLQtFCGSPLY | Pkinase |
STK11 | Q15831 | human | MELK | Q14680 | T167 | NkDyHLQtCCGsLAY | Pkinase |
STK11 | Q15831 | human | PRKAA1 | Q13131 | T183 | sDGEFLRtsCGsPNy | Pkinase |
STK11 | Q15831 | human | MARK4 | Q96L34 | T214 | TLGSKLDtFCGsPPY | Pkinase |
STK11 | Q15831 | human | BRSK2 | Q8IWQ3 | T174 | VGDSLLEtSCGSPHY | Pkinase |
STK11 | Q15831 | human | SIRT1 | Q96EB6 | S732 | EAINEAIsVkQEVTD | |
STK11 | Q15831 | human | TP53 | P04637 | S392 | FktEGPDsD______ | |
STK11 | Q15831 | human | YAP1 | P46937-2 | S127 | PQHVRAHssPASLQL | |
STK11 | Q15831 | human | SIK2 | Q9H0K1 | T175 | kSGELLAtWCGSPPY | Pkinase |
STK11 | Q15831 | human | MARK2 | Q7KZI7 | T208 | tFGNKLDtFCGsPPY | Pkinase |
STK11 | Q15831 | human | STK11 | Q15831 | T363 | IEDDIIYtQDFTVPG | |
STK11 | Q15831 | human | STK11 | Q15831 | T185 | kPGNLLLtTGGtLKI | Pkinase |
STK11 | Q15831 | human | PRMT5 | O14744 | T132 | PLNQEDNtNLARVLt | PRMT5_TIM |
STK11 | Q15831 | human | STK11 | Q15831 | T189 | LLLtTGGtLKISDLG | Pkinase |
STK11 | Q15831 | human | MARK3 | P27448 | T211 | TVGGKLDtFCGsPPY | Pkinase |
STK11 | Q15831 | human | STRADA | Q7RTN6 | T329 | GLSDSLTtSTPRPSN | Pkinase |
STK11 | Q15831 | human | MARK3 | P27448 | S215 | KLDtFCGsPPYAAPE | Pkinase |
STK11 | Q15831 | human | BRSK1 | Q8TDC3-2 | T205 | VGDSLLEtSCGsPHY | Pkinase |
STK11 | Q15831 | human | STK11 | Q15831 | S428 | SSkIRRLsACkQQ__ | |
STK11 | Q15831 | human | SIK1 | P57059 | T182 | kSGEPLStWCGSPPY | Pkinase |
STK11 | Q15831 | human | PRMT5 | O14744 | T144 | VLtNHIHtGHHSSMF | PRMT5_TIM |
STK11 | Q15831 | human | PAK1 | Q13153 | T109 | QWARLLQtsNITKsE | PBD |
STK11 | Q15831 | human | STK11 | Q15831 | T402 | TEAAQLstKsRAEGR | |
STK11 | Q15831 | human | PTBP1 | P26599-1 | T138 | sNHkELktDssPNQA | RRM_5 |
STK11 | Q15831 | human | BRSK1 | Q8TDC3 | T189 | VGDSLLEtSCGSPHY | Pkinase |
STK11 | Q15831 | human | CDKN1A | P38936 | T80 | LPkLYLPtGPRRGRD | |
STK11 | Q15831 | human | SIK3 | Q9Y2K2 | T221 | TPGQLLKtWCGSPPY | Pkinase |
STK11 | Q15831 | human | STK11 | Q15831 | T336 | KDRWRsMtVVPYLED | |
STK11 | Q15831 | human | SIRT1 | Q96EB6 | S669 | EDDVLSSsSCGSNSD | |
STK11 | Q15831 | human | PRMT5 | O14744 | T139 | tNLARVLtNHIHtGH | PRMT5_TIM |
STK11 | Q15831 | human | MARK1 | Q9P0L2 | T215 | TVGNKLDtFCGsPPY | Pkinase |
STK11 | Q15831 | human | PRKAA2 | P54646 | T172 | sDGEFLRtsCGsPNy | Pkinase |
STK11 | Q15831 | human | STRADA | Q7RTN6 | T419 | SGIFGLVtNLEELEV | |
STK11 | Q15831 | human | TP53 | P04637 | S15 | PsVEPPLsQEtFsDL | P53_TAD |
STK11 | Q15831 | human | PTEN | P60484 | T383 | HyRYsDttDsDPENE | |
STK11 | Q15831 | human | SNRK | Q9NRH2 | T173 | QPGKKLttsCGSLAY | Pkinase |
STK11 | Q15831 | human | PTEN | P60484 | T382 | DHyRYsDttDsDPEN |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
STK11 | ID | Description | 0.00e+00 |
STK11 | GO:0042149 | cellular response to glucose starvation | 1.14e-07 |
STK11 | GO:0007623 | circadian rhythm | 2.40e-07 |
STK11 | GO:0032007 | negative regulation of TOR signaling | 4.34e-07 |
STK11 | GO:0032006 | regulation of TOR signaling | 4.66e-07 |
STK11 | GO:0031929 | TOR signaling | 9.10e-07 |
STK11 | GO:0009267 | cellular response to starvation | 1.08e-06 |
STK11 | GO:0009314 | response to radiation | 1.08e-06 |
STK11 | GO:0048511 | rhythmic process | 1.13e-06 |
STK11 | GO:0046777 | protein autophosphorylation | 1.59e-06 |
STK11 | GO:0009416 | response to light stimulus | 1.59e-06 |
STK11 | GO:0042594 | response to starvation | 2.63e-06 |
STK11 | GO:0010212 | response to ionizing radiation | 4.73e-06 |
STK11 | GO:0031669 | cellular response to nutrient levels | 5.85e-06 |
STK11 | GO:0032886 | regulation of microtubule-based process | 6.56e-06 |
STK11 | GO:0009411 | response to UV | 6.74e-06 |
STK11 | GO:0050770 | regulation of axonogenesis | 7.66e-06 |
STK11 | GO:0031668 | cellular response to extracellular stimulus | 9.68e-06 |
STK11 | GO:0018105 | peptidyl-serine phosphorylation | 1.23e-05 |
STK11 | GO:0072331 | signal transduction by p53 class mediator | 1.23e-05 |
STK11 | GO:0018209 | peptidyl-serine modification | 1.54e-05 |
STK11 | GO:0006109 | regulation of carbohydrate metabolic process | 1.70e-05 |
STK11 | GO:1901796 | regulation of signal transduction by p53 class mediator | 2.81e-05 |
STK11 | GO:0071496 | cellular response to external stimulus | 2.93e-05 |
STK11 | GO:0090398 | cellular senescence | 2.96e-05 |
STK11 | GO:0042752 | regulation of circadian rhythm | 3.40e-05 |
STK11 | GO:0010332 | response to gamma radiation | 4.84e-05 |
STK11 | GO:2000772 | regulation of cellular senescence | 5.88e-05 |
STK11 | GO:0042593 | glucose homeostasis | 6.84e-05 |
STK11 | GO:0033500 | carbohydrate homeostasis | 6.84e-05 |
STK11 | GO:0051347 | positive regulation of transferase activity | 7.40e-05 |
STK11 | GO:0097091 | synaptic vesicle clustering | 7.40e-05 |
STK11 | GO:0055089 | fatty acid homeostasis | 8.69e-05 |
STK11 | GO:0007409 | axonogenesis | 1.09e-04 |
STK11 | GO:0045860 | positive regulation of protein kinase activity | 1.09e-04 |
STK11 | GO:0044839 | cell cycle G2/M phase transition | 1.09e-04 |
STK11 | GO:0070314 | G1 to G0 transition | 1.09e-04 |
STK11 | GO:0010975 | regulation of neuron projection development | 1.09e-04 |
STK11 | GO:0001678 | intracellular glucose homeostasis | 1.09e-04 |
STK11 | GO:0016055 | Wnt signaling pathway | 1.12e-04 |
STK11 | GO:0071479 | cellular response to ionizing radiation | 1.12e-04 |
STK11 | GO:0198738 | cell-cell signaling by wnt | 1.12e-04 |
STK11 | GO:0034504 | protein localization to nucleus | 1.57e-04 |
STK11 | GO:0097009 | energy homeostasis | 1.63e-04 |
STK11 | GO:0031667 | response to nutrient levels | 1.66e-04 |
STK11 | GO:0097193 | intrinsic apoptotic signaling pathway | 1.72e-04 |
STK11 | GO:0045913 | positive regulation of carbohydrate metabolic process | 1.76e-04 |
STK11 | GO:0071478 | cellular response to radiation | 1.76e-04 |
STK11 | GO:0043153 | entrainment of circadian clock by photoperiod | 1.92e-04 |
STK11 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 1.92e-04 |
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Related Drugs to CIRBP_STK11 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning CIRBP-STK11 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CIRBP_STK11 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |