Description | dual specificity protein kinase CLK4protein serine threonine kinase Clk4 | calcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1Ca(2+)/Mn(2+)-ATPase 2C1HUSSY-28secretory pathway Ca(2+)-transporting ATPase type 1secretory |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000316308, ENST00000520957, ENST00000522749, | ENST00000328560, ENST00000359644, ENST00000393221, ENST00000422190, ENST00000428331, ENST00000504381, ENST00000504948, ENST00000505330, ENST00000507488, ENST00000508532, ENST00000509150, ENST00000510168, ENST00000513801, ENST00000533801, |
Hgene | Tgene |
CLK4
Q9HAZ1 | ATP2C1
P98194 |
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11170754, ECO:0000269|PubMed:19168442}. | FUNCTION: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:16192278, PubMed:30923126, PubMed:21187401, PubMed:12707275, PubMed:20439740). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:20439740, PubMed:14632183). Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:14632183, PubMed:10615129, PubMed:20439740). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401). {ECO:0000250|UniProtKB:Q80XR2, ECO:0000269|PubMed:10615129, ECO:0000269|PubMed:12707275, ECO:0000269|PubMed:14632183, ECO:0000269|PubMed:16192278, ECO:0000269|PubMed:16332677, ECO:0000269|PubMed:20439740, ECO:0000269|PubMed:21187401, ECO:0000269|PubMed:30923126}. |
Kinase | GOID | GO term | P.adjust |
CLK4 | ID | Description | 0.00e+00 |
CLK4 | GO:0051651 | maintenance of location in cell | 4.18e-02 |
CLK4 | GO:1902105 | regulation of leukocyte differentiation | 4.18e-02 |
CLK4 | GO:0051235 | maintenance of location | 4.18e-02 |
CLK4 | GO:1903706 | regulation of hemopoiesis | 4.18e-02 |
CLK4 | GO:0048732 | gland development | 4.18e-02 |
CLK4 | GO:0016055 | Wnt signaling pathway | 4.18e-02 |
CLK4 | GO:0033327 | Leydig cell differentiation | 4.18e-02 |
CLK4 | GO:0060020 | Bergmann glial cell differentiation | 4.18e-02 |
CLK4 | GO:0198738 | cell-cell signaling by wnt | 4.18e-02 |
CLK4 | GO:0001553 | luteinization | 4.18e-02 |
CLK4 | GO:0002327 | immature B cell differentiation | 4.18e-02 |
CLK4 | GO:0033690 | positive regulation of osteoblast proliferation | 4.18e-02 |
CLK4 | GO:1900272 | negative regulation of long-term synaptic potentiation | 4.18e-02 |
CLK4 | GO:1905244 | regulation of modification of synaptic structure | 4.18e-02 |
CLK4 | GO:1905939 | regulation of gonad development | 4.18e-02 |
CLK4 | GO:0030238 | male sex determination | 4.18e-02 |
CLK4 | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | 4.18e-02 |
CLK4 | GO:0071871 | response to epinephrine | 4.18e-02 |
CLK4 | GO:0001768 | establishment of T cell polarity | 4.18e-02 |
CLK4 | GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 4.18e-02 |
CLK4 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway | 4.18e-02 |
CLK4 | GO:0001767 | establishment of lymphocyte polarity | 4.18e-02 |
CLK4 | GO:1900006 | positive regulation of dendrite development | 4.18e-02 |
CLK4 | GO:2000095 | regulation of Wnt signaling pathwa | 2.54e-03 |
CLK4 | GO:0060192 | negative regulation of lipase activity | 4.18e-02 |
CLK4 | GO:1902036 | regulation of hematopoietic stem cell differentiation | 4.18e-02 |
CLK4 | GO:0038083 | peptidyl-tyrosine autophosphorylation | 4.18e-02 |
CLK4 | GO:0035372 | protein localization to microtubule | 4.18e-02 |
CLK4 | GO:0007530 | sex determination | 4.18e-02 |
CLK4 | GO:0060008 | Sertoli cell differentiation | 4.18e-02 |
CLK4 | GO:0051457 | maintenance of protein location in nucleus | 4.18e-02 |
CLK4 | GO:0051882 | mitochondrial depolarization | 4.18e-02 |
CLK4 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination | 4.18e-02 |
CLK4 | GO:2000114 | regulation of establishment of cell polarity | 4.18e-02 |
CLK4 | GO:0030318 | melanocyte differentiation | 4.18e-02 |
CLK4 | GO:2000773 | negative regulation of cellular senescence | 4.18e-02 |
CLK4 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 4.18e-02 |
CLK4 | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 4.18e-02 |
CLK4 | GO:0051894 | positive regulation of focal adhesion assembly | 4.18e-02 |
CLK4 | GO:2000050 | regulation of non-canonical Wnt signaling pathway | 4.18e-02 |
CLK4 | GO:0032878 | regulation of establishment or maintenance of cell polarity | 4.18e-02 |
CLK4 | GO:0030325 | adrenal gland development | 4.18e-02 |
CLK4 | GO:0099563 | modification of synaptic structure | 4.18e-02 |
CLK4 | GO:1903055 | positive regulation of extracellular matrix organization | 4.18e-02 |
CLK4 | GO:0033688 | regulation of osteoblast proliferation | 4.18e-02 |
CLK4 | GO:0150117 | positive regulation of cell-substrate junction organization | 4.18e-02 |
CLK4 | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 4.18e-02 |
CLK4 | GO:0045907 | positive regulation of vasoconstriction | 4.18e-02 |
CLK4 | GO:0038094 | Fc-gamma receptor signaling pathway | 4.18e-02 |