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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CNGA1_TXK

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: CNGA1_TXK
	KinaseFusionDB ID: KFG1366
	FusionGDB2.0 ID: KFG1366
		Hgene	Tgene
	Gene symbol	CNGA1	TXK
	Gene ID	1259	7294
	Gene name	cyclic nucleotide gated channel subunit alpha 1	TXK tyrosine kinase
	Synonyms	CNCG\|CNCG1\|CNG-1\|CNG1\|RCNC1\|RCNCa\|RCNCalpha\|RP49	BTKL\|PSCTK5\|PTK4\|RLK\|TKL
	Cytomap	4p12	4p12
	Type of gene	protein-coding	protein-coding
	Description	cGMP-gated cation channel alpha-1CNG channel alpha-1cyclic nucleotide gated channel alpha 1cyclic nucleotide-gated cation channel 1cyclic nucleotide-gated channel, photoreceptorinterleukin-1 homologuerod photoreceptor cGMP-gated channel subunit alph	tyrosine-protein kinase TXKPTK4 protein tyrosine kinase 4protein-tyrosine kinase 4resting lymphocyte kinase
	Modification date	20240413	20240411
	UniProtAcc	P29973	P42681
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000402813, ENST00000514170, ENST00000358519, ENST00000544810, ENST00000420489,	ENST00000264316, ENST00000510457, ENST00000507351,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: CNGA1 [Title/Abstract] AND TXK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TXK	GO:0006468	protein phosphorylation	17177976
Tgene	TXK	GO:0010468	regulation of gene expression	11859127
Tgene	TXK	GO:0032729	positive regulation of type II interferon production	10523612\|11859127
Tgene	TXK	GO:0045944	positive regulation of transcription by RNA polymerase II	11859127
Tgene	TXK	GO:0046777	protein autophosphorylation	12081135\|17177976
Tgene	TXK	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	11859127

Kinase Fusion gene breakpoints across CNGA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across TXK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CCLE	HARA	CNGA1	chr4	48018500	TXK	chr4	48106972
CCLE	GB2	CNGA1	chr4	47944058	TXK	chr4	48112620
CCLE	GB2	CNGA1	chr4	47945198	TXK	chr4	48112620
CCLE	GB2	CNGA1	chr4	47944058	TXK	chr4	48106972

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000358519	ENST00000264316	CNGA1	chr4	47944058	TXK	chr4	48112620	3117	586
ENST00000358519	ENST00000264316	CNGA1	chr4	47945198	TXK	chr4	48112620	3009	550
ENST00000358519	ENST00000264316	CNGA1	chr4	47944058	TXK	chr4	48106972	3051	564

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000358519_ENST00000264316_CNGA1_chr4_47944058_TXK_chr4_48112620_length(amino acids)=586
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF
NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW
TMVIARNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSG
QWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAI
NEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDL
AARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISE

--------------------------------------------------------------

>ENST00000358519_ENST00000264316_CNGA1_chr4_47945198_TXK_chr4_48112620_length(amino acids)=550
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF
NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEENEGLIPSNYVTENKITNLEIYEWYHRNITR
NQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVG
LMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRK
PLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK
FPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELL

--------------------------------------------------------------

>ENST00000358519_ENST00000264316_CNGA1_chr4_47944058_TXK_chr4_48106972_length(amino acids)=564
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF
NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW
TMVIARWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQH
NAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH
SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR
YVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCW

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:/chr4:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CNGA1 P29973	TXK P42681
FUNCTION: Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential. {ECO:0000250\|UniProtKB:Q00194}.	FUNCTION: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976). Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976). Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor. {ECO:0000269\|PubMed:10523612, ECO:0000269\|PubMed:11564877, ECO:0000269\|PubMed:11859127, ECO:0000269\|PubMed:17177976, ECO:0000269\|PubMed:9813138}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

CNGA1

47944058

TXK

48106972

ENST00000358519

271_527

148

528

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

CNGA1

47944058

TXK

48112620

ENST00000358519

271_527

126

528

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

CNGA1

47945198

TXK

48112620

ENST00000358519

271_527

126

528

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

CNGA1

47944058

TXK

48106972

ENST00000358519

150_246

148

528

Domain

Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191

Tgene

CNGA1

47944058

TXK

48112620

ENST00000358519

150_246

126

528

Domain

Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191

Tgene

CNGA1

47945198

TXK

48112620

ENST00000358519

150_246

126

528

Domain

Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>113_CNGA1_TXK	ENST00000358519	ENST00000264316	CNGA1	chr4	47944058	TXK	chr4	48106972	MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW TMVIARWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQH NAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR YVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCW	564
3D view using mol* of 113_CNGA1_TXK

PDB file >>>TKFP_191_CNGA1_TXK	ENST00000358519	ENST00000264316	CNGA1	chr4	47944058	TXK	chr4	48112620	MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW TMVIARNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSG QWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAI NEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDL AARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISE	586_CNGA1_TXK
PDB file >>>TKFP_192_CNGA1_TXK	ENST00000358519	ENST00000264316	CNGA1	chr4	47945198	TXK	chr4	48112620	MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEENEGLIPSNYVTENKITNLEIYEWYHRNITR NQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVG LMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRK PLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK FPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELL	550_CNGA1_TXK
3D view using mol* of TKFP_192_CNGA1_TXK

PDB file >>>TKFP_193_CNGA1_TXK	ENST00000358519	ENST00000264316	CNGA1	chr4	47944058	TXK	chr4	48106972	MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYKSLRKGGPSQREQYLPGAIALF NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW TMVIARWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQH NAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR YVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCW	564_CNGA1_TXK
3D view using mol* of TKFP_193_CNGA1_TXK

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/TKFP_191_CNGA1_TXK_vs_TKFP_192_CNGA1_TXK_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_191_CNGA1_TXK_vs_TKFP_193_CNGA1_TXK_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_192_CNGA1_TXK_vs_TKFP_193_CNGA1_TXK_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_191_CNGA1_TXK_vs_TKFP_192_CNGA1_TXK.png

./secondary_str/TKFP_193_CNGA1_TXK_vs_TKFP_191_CNGA1_TXK.png

./secondary_str/TKFP_193_CNGA1_TXK_vs_TKFP_192_CNGA1_TXK.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CNGA1_TXK does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/113_CNGA1_TXK.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

113_CNGA1_TXK.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

113_CNGA1_TXK_ramachandran.png

TKFP_192_CNGA1_TXK_ramachandran.png

TKFP_193_CNGA1_TXK_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
113_CNGA1_TXK-DOCK_HTVS_1-001	Avapritinib	-7.46323	-7.79453	-47.1223
113_CNGA1_TXK-DOCK_HTVS_1-001	Avapritinib	-7.46323	-7.79453	-47.1223
113_CNGA1_TXK-DOCK_HTVS_1-001	Avapritinib	-7.46323	-7.79453	-47.1223
113_CNGA1_TXK-DOCK_HTVS_1-001	Avapritinib	-7.46323	-7.79453	-47.1223
113_CNGA1_TXK-DOCK_HTVS_1-001	Selpercatinib	-6.82989	-6.86039	-54.0956
113_CNGA1_TXK-DOCK_HTVS_1-001	Lapatinib	-6.70061	-6.78941	-59.0095
113_CNGA1_TXK-DOCK_HTVS_1-001	Ponatinib	-6.3156	-6.5222	-36.8796
113_CNGA1_TXK-DOCK_HTVS_1-001	Ponatinib	-6.3156	-6.5222	-36.8796
113_CNGA1_TXK-DOCK_HTVS_1-001	Ponatinib	-6.3156	-6.5222	-36.8796
113_CNGA1_TXK-DOCK_HTVS_1-001	Lapatinib	-6.20104	-6.28984	-52.7944
113_CNGA1_TXK-DOCK_HTVS_1-001	Lapatinib	-6.13644	-7.3048399999999996	-62.5096
113_CNGA1_TXK-DOCK_HTVS_1-001	Lapatinib	-6.13644	-7.3048399999999996	-62.5096
113_CNGA1_TXK-DOCK_HTVS_1-001	Midostaurin	-6.09185	-6.09185	-25.9118
113_CNGA1_TXK-DOCK_HTVS_1-001	Larotrectinib	-6.037669999999999	-6.037669999999999	-49.6817
113_CNGA1_TXK-DOCK_HTVS_1-001	Selpercatinib	-6.014390000000001	-6.0448900000000005	-50.7249
113_CNGA1_TXK-DOCK_HTVS_1-001	Selpercatinib	-6.014390000000001	-6.0448900000000005	-50.7249
113_CNGA1_TXK-DOCK_HTVS_1-001	Palbociclib	-6.00157	-6.4084699999999994	-37.6435
113_CNGA1_TXK-DOCK_HTVS_1-001	Futibatinib	-5.99408	-5.99408	-42.736999999999995
113_CNGA1_TXK-DOCK_HTVS_1-001	Nilotinib	-5.93133	-6.85613	-42.9542
113_CNGA1_TXK-DOCK_HTVS_1-001	Nilotinib	-5.93133	-6.85613	-42.9542

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Kinase-Substrate Information of CNGA1_TXK

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
TXK	P42681	human	TXK	P42681	Y420	RYVLDDEyVSSFGAK	PK_Tyr_Ser-Thr
TXK	P42681	human	TXK	P42681	Y91	KIQVKALyDFLPREP	SH3_1

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
TXK	ID	Description	0.00e+00
TXK	GO:0060330	regulation of response to type II interferon	1.16e-02
TXK	GO:0060334	regulation of type II interferon-mediated signaling pathway	1.16e-02
TXK	GO:0060333	type II interferon-mediated signaling pathway	1.16e-02
TXK	GO:0007202	activation of phospholipase C activity	1.16e-02
TXK	GO:0010863	positive regulation of phospholipase C activity	1.16e-02
TXK	GO:1900274	regulation of phospholipase C activity	1.16e-02
TXK	GO:0010518	positive regulation of phospholipase activity	1.16e-02
TXK	GO:0010543	regulation of platelet activation	1.16e-02
TXK	GO:0010517	regulation of phospholipase activity	1.16e-02
TXK	GO:0001961	positive regulation of cytokine-mediated signaling pathway	1.16e-02
TXK	GO:0060193	positive regulation of lipase activity	1.16e-02
TXK	GO:0060760	positive regulation of response to cytokine stimulus	1.16e-02
TXK	GO:0042246	tissue regeneration	1.16e-02
TXK	GO:0032729	positive regulation of type II interferon production	1.16e-02
TXK	GO:0060191	regulation of lipase activity	1.16e-02
TXK	GO:0140888	interferon-mediated signaling pathway	1.34e-02
TXK	GO:0007229	integrin-mediated signaling pathway	1.34e-02
TXK	GO:0032609	type II interferon production	1.34e-02
TXK	GO:0032649	regulation of type II interferon production	1.34e-02
TXK	GO:0071346	cellular response to type II interferon	1.34e-02
TXK	GO:0030168	platelet activation	1.39e-02
TXK	GO:0034341	response to type II interferon	1.39e-02
TXK	GO:0050852	T cell receptor signaling pathway	1.39e-02
TXK	GO:0001959	regulation of cytokine-mediated signaling pathway	1.59e-02
TXK	GO:0060759	regulation of response to cytokine stimulus	1.63e-02
TXK	GO:0031099	regeneration	1.63e-02
TXK	GO:0046777	protein autophosphorylation	1.63e-02
TXK	GO:0050851	antigen receptor-mediated signaling pathway	1.63e-02
TXK	GO:0007596	blood coagulation	1.66e-02
TXK	GO:0050817	coagulation	1.66e-02
TXK	GO:0007599	hemostasis	1.66e-02
TXK	GO:0002429	immune response-activating cell surface receptor signaling pathway	2.21e-02
TXK	GO:0045089	positive regulation of innate immune response	2.27e-02
TXK	GO:0002768	immune response-regulating cell surface receptor signaling pathway	2.27e-02
TXK	GO:0050878	regulation of body fluid levels	2.28e-02
TXK	GO:0002833	positive regulation of response to biotic stimulus	2.28e-02
TXK	GO:0042060	wound healing	2.49e-02
TXK	GO:0045088	regulation of innate immune response	2.49e-02
TXK	GO:0002757	immune response-activating signaling pathway	2.65e-02
TXK	GO:0031349	positive regulation of defense response	2.65e-02
TXK	GO:0001819	positive regulation of cytokine production	2.65e-02
TXK	GO:0002764	immune response-regulating signaling pathway	2.65e-02

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Related Drugs to CNGA1_TXK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning CNGA1-TXK and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to CNGA1_TXK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date