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Kinase Fusion Gene:CNOT1_STK38L |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CNOT1_STK38L | KinaseFusionDB ID: KFG1368 | FusionGDB2.0 ID: KFG1368 | Hgene | Tgene | Gene symbol | CNOT1 | STK38L | Gene ID | 23019 | 23012 | |
| Gene name | CCR4-NOT transcription complex subunit 1 | serine/threonine kinase 38 like | ||||||||||
| Synonyms | AD-005|CDC39|HPE12|NOT1|NOT1H|VIBOS | NDR2 | ||||||||||
| Cytomap | 16q21 | 12p11.23 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | CCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog | serine/threonine-protein kinase 38-likeNDR2 protein kinasenuclear Dbf2-related 2nuclear Dbf2-related kinase 2 | ||||||||||
| Modification date | 20240407 | 20240305 | ||||||||||
| UniProtAcc | Q9H9A5 | Q9Y2H1 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000317147, ENST00000441024, ENST00000569240, ENST00000245138, ENST00000569732, | ENST00000539577, ENST00000389032, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CNOT1 [Title/Abstract] AND STK38L [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CNOT1(58594115)-STK38L(27461271), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16778766 |
| Hgene | CNOT1 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly | 21976065 |
| Hgene | CNOT1 | GO:0017148 | negative regulation of translation | 24736845 |
| Hgene | CNOT1 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 16778766 |
| Hgene | CNOT1 | GO:0035195 | miRNA-mediated post-transcriptional gene silencing | 23172285|24768540 |
| Hgene | CNOT1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 16778766 |
| Hgene | CNOT1 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 23644599 |
| Tgene | STK38L | GO:0006468 | protein phosphorylation | 15037617 |
| Tgene | STK38L | GO:0006468 | protein phosphorylation | 15067004 |
| Tgene | STK38L | GO:0010507 | negative regulation of autophagy | 35670107 |
| Tgene | STK38L | GO:0035556 | intracellular signal transduction | 15067004 |
| Kinase Fusion gene breakpoints across CNOT1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across STK38L (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-L5-A43J | CNOT1 | chr16 | 58594115 | STK38L | chr12 | 27461271 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
| ENST00000317147 | ENST00000389032 | CNOT1 | chr16 | 58594115 | STK38L | chr12 | 27461271 | 7176 | 1119 |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000317147_ENST00000389032_CNOT1_chr16_58594115_STK38L_chr12_27461271_length(amino acids)=1119 MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:58594115/chr12:27461271) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT1 | STK38L |
| FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex. {ECO:0000269|PubMed:23221646}. | FUNCTION: Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15037617, ECO:0000269|PubMed:15067004}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| Tgene | CNOT1 | 58594115 | STK38L | 27461271 | ENST00000317147 | 2 | 14 | 384_453 | 62 | 465 | Domain | Note=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618 |
| Tgene | CNOT1 | 58594115 | STK38L | 27461271 | ENST00000317147 | 2 | 14 | 90_383 | 62 | 465 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
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Kinase Fusion Protein Structures |
| CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
| PDB file >>>114_CNOT1_STK38L | ENST00000317147 | ENST00000389032 | CNOT1 | chr16 | 58594115 | STK38L | chr12 | 27461271 | MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN | 1119 |
| 3D view using mol* of 114_CNOT1_STK38L | ||||||||||
| PDB file >>>TKFP_194_CNOT1_STK38L | ENST00000317147 | ENST00000389032 | CNOT1 | chr16 | 58594115 | STK38L | chr12 | 27461271 | MLPPQPAMNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECALLIT KPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSSDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGF QDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVG YGFCASIEECRNIIVQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSDGAQAHTWNVEVLIDVLKELNPSLN FKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDLIYRPWKHAEGQLSFIQHSLINPEIFCFADYPCHTVATDILKAPPEDDNR EIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPS IRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRR CPSILGGLAPEKDQPKSAQLPPETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQKKL RRSQHARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEADGAWVVKMFY SFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTE FYRNLTHNPPSDFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKV MNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFDDFPESDILQPVPN | 1119_CNOT1_STK38L |
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Comparison of Fusion Protein Isoforms |
| Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
| Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
| 114_CNOT1_STK38L.png |
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| 114_CNOT1_STK38L.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| 114_CNOT1_STK38L_ramachandran.png |
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Virtual Screening Results |
| Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
| 5'-kinase fusion protein case |
| 3'-kinase fusion protein case |
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| Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
| Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Netarsudil | -7.41018 | -7.42128 | -61.9029 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Netarsudil | -7.41018 | -7.42128 | -61.9029 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Sunitinib | -7.3692899999999995 | -7.373489999999999 | -53.341 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Crizotinib | -6.832160000000001 | -7.168360000000001 | -54.2523 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Crizotinib | -6.832160000000001 | -7.168360000000001 | -54.2523 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Netarsudil | -6.76922 | -6.78032 | -59.5768 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Netarsudil | -6.76922 | -6.78032 | -59.5768 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Sorafenib | -6.68748 | -6.69958 | -50.8729 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Sorafenib | -6.68748 | -6.69958 | -50.8729 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Ibrutinib | -6.62166 | -6.62166 | -55.2117 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Cobimetinib | -6.5696699999999995 | -6.57247 | -58.6706 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Lapatinib | -6.43958 | -7.60798 | -73.8131 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Lapatinib | -6.43958 | -7.60798 | -73.8131 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Osimertinib | -6.304119999999999 | -6.31182 | -47.0109 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Larotrectinib | -6.2888 | -6.2888 | -44.3325 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Avapritinib | -6.15797 | -6.95547 | -58.9915 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Avapritinib | -6.15797 | -6.95547 | -58.9915 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Avapritinib | -6.15797 | -6.95547 | -58.9915 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Avapritinib | -6.15797 | -6.95547 | -58.9915 |
| 114_CNOT1_STK38L-DOCK_HTVS_1-001 | Regorafenib | -6.05229 | -6.05229 | -55.1165 |
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Kinase-Substrate Information of CNOT1_STK38L |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| STK38L | Q9Y2H1 | human | IRF3 | Q14653 | S396 | NtVDLHIsNsHPLsL | |
| STK38L | Q9Y2H1 | human | NUAK1 | O60285 | T211 | QKDKFLQtFCGSPLY | Pkinase |
| STK38L | Q9Y2H1 | human | RAB3IP | Q96QF0 | S288 | KGHTRNKstSSAMSG | |
| STK38L | Q9Y2H1 | human | YAP1 | P46937 | S127 | PQHVRAHssPAsLQL | |
| STK38L | Q9Y2H1 | human | ULK1 | O75385 | S495 | GVLARKMsLGGGRPY | |
| STK38L | Q9Y2H1 | human | STK38L | Q9Y2H1 | S282 | NRRQLAYstVGtPDy | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| STK38L | ID | Description | 0.00e+00 |
| STK38L | GO:0031345 | negative regulation of cell projection organization | 6.69e-03 |
| STK38L | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 1.02e-02 |
| STK38L | GO:0001959 | regulation of cytokine-mediated signaling pathway | 4.20e-02 |
| STK38L | GO:0060759 | regulation of response to cytokine stimulus | 4.20e-02 |
| STK38L | GO:0031099 | regeneration | 4.20e-02 |
| STK38L | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 4.20e-02 |
| STK38L | GO:0060491 | regulation of cell projection assembly | 4.20e-02 |
| STK38L | GO:0042594 | response to starvation | 4.20e-02 |
| STK38L | GO:1902115 | regulation of organelle assembly | 4.20e-02 |
| STK38L | GO:0060560 | developmental growth involved in morphogenesis | 4.20e-02 |
| STK38L | GO:0031669 | cellular response to nutrient levels | 4.20e-02 |
| STK38L | GO:0034727 | piecemeal microautophagy of the nucleus | 4.20e-02 |
| STK38L | GO:0060245 | detection of cell density | 4.20e-02 |
| STK38L | GO:0031668 | cellular response to extracellular stimulus | 4.20e-02 |
| STK38L | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0039530 | MDA-5 signaling pathway | 4.20e-02 |
| STK38L | GO:0048671 | negative regulation of collateral sprouting | 4.20e-02 |
| STK38L | GO:0050847 | progesterone receptor signaling pathway | 4.20e-02 |
| STK38L | GO:1903059 | regulation of protein lipidation | 4.20e-02 |
| STK38L | GO:0018105 | peptidyl-serine phosphorylation | 4.20e-02 |
| STK38L | GO:0033145 | positive regulation of intracellular steroid hormone receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0072182 | regulation of nephron tubule epithelial cell differentiation | 4.20e-02 |
| STK38L | GO:0018209 | peptidyl-serine modification | 4.20e-02 |
| STK38L | GO:0016237 | lysosomal microautophagy | 4.20e-02 |
| STK38L | GO:0048638 | regulation of developmental growth | 4.20e-02 |
| STK38L | GO:0071888 | macrophage apoptotic process | 4.20e-02 |
| STK38L | GO:0072160 | nephron tubule epithelial cell differentiation | 4.20e-02 |
| STK38L | GO:0048368 | lateral mesoderm development | 4.20e-02 |
| STK38L | GO:0071496 | cellular response to external stimulus | 4.20e-02 |
| STK38L | GO:0030522 | intracellular receptor signaling pathway | 4.20e-02 |
| STK38L | GO:0010506 | regulation of autophagy | 4.20e-02 |
| STK38L | GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 4.20e-02 |
| STK38L | GO:2000696 | regulation of epithelial cell differentiation involved in kidney development | 4.20e-02 |
| STK38L | GO:0050746 | regulation of lipoprotein metabolic process | 4.20e-02 |
| STK38L | GO:0071360 | cellular response to exogenous dsRNA | 4.20e-02 |
| STK38L | GO:0060271 | cilium assembly | 4.20e-02 |
| STK38L | GO:0048339 | paraxial mesoderm development | 4.20e-02 |
| STK38L | GO:0060576 | intestinal epithelial cell development | 4.20e-02 |
| STK38L | GO:0061709 | reticulophagy | 4.20e-02 |
| STK38L | GO:0001829 | trophectodermal cell differentiation | 4.20e-02 |
| STK38L | GO:0030903 | notochord development | 4.20e-02 |
| STK38L | GO:0044804 | nucleophagy | 4.20e-02 |
| STK38L | GO:0060602 | branch elongation of an epithelium | 4.20e-02 |
| STK38L | GO:2000786 | positive regulation of autophagosome assembly | 4.20e-02 |
| STK38L | GO:0050767 | regulation of neurogenesis | 4.20e-02 |
| STK38L | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway | 4.20e-02 |
| STK38L | GO:1902018 | negative regulation of cilium assembly | 4.20e-02 |
| STK38L | GO:0044782 | cilium organization | 4.20e-02 |
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Related Drugs to CNOT1_STK38L |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CNOT1-STK38L and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CNOT1_STK38L |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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