UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CNTN1_LRRK2

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CNTN1_LRRK2
KinaseFusionDB ID: KFG1372
FusionGDB2.0 ID: KFG1372
HgeneTgene
Gene symbol

CNTN1

LRRK2

Gene ID

1272

120892

Gene namecontactin 1leucine rich repeat kinase 2
SynonymsCMYP12|F3|GP135|MYPCNAURA17|DARDARIN|PARK8|RIPK7|ROCO2
Cytomap

12q12

12q12

Type of geneprotein-codingprotein-coding
Descriptioncontactin-1glycoprotein gP135neural cell surface protein F3leucine-rich repeat serine/threonine-protein kinase 2augmented in rheumatoid arthritis 17
Modification date2024030520240416
UniProtAcc

Q12860

Q5S007

Ensembl transtripts involved in fusion geneENST idsENST00000547702, ENST00000551295, 
ENST00000547849, ENST00000347616, 
ENST00000348761, ENST00000550305, 
ENST00000360099, 		ENST00000343742, 
ENST00000298910, ENST00000481256, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CNTN1 [Title/Abstract] AND LRRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLRRK2

GO:0000165

MAPK cascade

17200152

TgeneLRRK2

GO:0001934

positive regulation of protein phosphorylation

22012985

TgeneLRRK2

GO:0007254

JNK cascade

19302196

TgeneLRRK2

GO:0007266

Rho protein signal transduction

25500533

TgeneLRRK2

GO:0010955

negative regulation of protein processing

21370995

TgeneLRRK2

GO:0018105

peptidyl-serine phosphorylation

19576176

TgeneLRRK2

GO:0018107

peptidyl-threonine phosphorylation

21048939

TgeneLRRK2

GO:0031398

positive regulation of protein ubiquitination

16352719|20173330

TgeneLRRK2

GO:0032092

positive regulation of protein binding

21370995

TgeneLRRK2

GO:0034260

negative regulation of GTPase activity

22423108

TgeneLRRK2

GO:0043068

positive regulation of programmed cell death

17200152

TgeneLRRK2

GO:0045860

positive regulation of protein kinase activity

19302196

TgeneLRRK2

GO:0046039

GTP metabolic process

21048939

TgeneLRRK2

GO:0046777

protein autophosphorylation

16269541|16321986|17200152|17442267

TgeneLRRK2

GO:1902499

positive regulation of protein autoubiquitination

16352719

TgeneLRRK2

GO:1903125

negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation

21850687

TgeneLRRK2

GO:1903215

negative regulation of protein targeting to mitochondrion

21370995


check buttonKinase Fusion gene breakpoints across CNTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across LRRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40728769

CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40722162

CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40631771

CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40637352

CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40681153

CCLESBC-5CNTN1chr12

41086394

LRRK2chr12

40740555

CCLESBC-5CNTN1chr12

41222103

LRRK2chr12

40745341



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNTN1

Q12860

LRRK2

Q5S007

FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). {ECO:0000250}.FUNCTION: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:27830463, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of CNTN1_LRRK2


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
LRRK2Q5S007humanMAPTP10636-8T231KKVAVVRtPPKsPss
LRRK2Q5S007humanLRRK2Q5S007T2031CCRMGIKtsEGtPGFPkinase
LRRK2Q5S007humanRAB10P61026T73AGQERFHtITtsYYRRas
LRRK2Q5S007humanLRRK2Q5S007T424ASANALStLLEQNVN
LRRK2Q5S007humanRDXP35241T564AGRDKyKtLRQIRQGERM_C
LRRK2Q5S007humanLRRK2Q5S007T1967QQDKASLtRtLQHRIPkinase
LRRK2Q5S007humanDNAJC6O75061S570sATstSAsPtLRVGE
LRRK2Q5S007humanLRRK2Q5S007Y1485GFPAIRDyHFVNAtE
LRRK2Q5S007humanLRRK2Q5S007Y1402FAGREEFystHPHFMRoc
LRRK2Q5S007humanEZRP15311T567QGRDkyKtLRQIRQGERM_C
LRRK2Q5S007humanLRRK2Q5S007S1853PRLtIPIsQIAPDLI
LRRK2Q5S007humanLRRK2Q5S007T1503ALAKLRKtIINEsLN
LRRK2Q5S007humanRAB5BP61020T6__MTSRStARPNGQP
LRRK2Q5S007humanLRRK2Q5S007S955RKRKILssDDsLRSs
LRRK2Q5S007humanLRRK2Q5S007S1292PNEMGKLsKIWDLPLLRR_4
LRRK2Q5S007humanLRRK2Q5S007T1404GREEFystHPHFMtQRoc
LRRK2Q5S007humanMAP3K5Q99683T838GINPCTEtFTGtLQYPkinase
LRRK2Q5S007humanLRRK2Q5S007S973SHMRHsDsIssLAsE
LRRK2Q5S007humanLRRK2Q5S007T838KQtNIAstLARMVIR
LRRK2Q5S007humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
LRRK2Q5S007humanLRRK2Q5S007S1457VGtHLDVsDEKQRKA
LRRK2Q5S007humanLRRK2Q5S007T1491DyHFVNAtEESDALA
LRRK2Q5S007humanLRRK2Q5S007S1443FNIKARAsssPVILVRoc
LRRK2Q5S007humanMAPTP10636-8T263VKskIGstENLkHQPTubulin-binding
LRRK2Q5S007humanNSFP46459T645RKLLIIGtTSRKDVLAAA
LRRK2Q5S007humanLRRK2Q5S007T1470KACMsKItKELLNKR
LRRK2Q5S007humanDNM1LO00429T595NWRGMLktSkAEELL
LRRK2Q5S007humanLRRK2Q5S007T1343KLMIVGNtGsGKttLRoc
LRRK2Q5S007humanLRRK2Q5S007T1969DKASLtRtLQHRIALPkinase
LRRK2Q5S007humanLRRK2Q5S007S1253RVEKLHLsHNKLKEILRR_4
LRRK2Q5S007humanHDAC3O15379S424DHDNDKEsDVEI___
LRRK2Q5S007humanLRRK2Q5S007S1345MIVGNtGsGKttLLQRoc
LRRK2Q5S007humanLRRK2Q5S007S935NLQRHsNsLGPIFDH
LRRK2Q5S007humanMAPTP10636-8T153DGKtKIAtPRGAAPP
LRRK2Q5S007humanAPPP05067T743VEVDAAVtPEERHLSAPP_amyloid
LRRK2Q5S007humanMAPTP10636-8T149AKGADGKtKIAtPRG
LRRK2Q5S007humanLRRK2Q5S007S2032CRMGIKtsEGtPGFRPkinase
LRRK2Q5S007humanAP2M1Q96CW1T156SQItsQVtGQIGWRR
LRRK2Q5S007humanMAP3K5Q99683T825LKIsDFGtSkRLAGIPkinase
LRRK2Q5S007humanSQSTM1Q13501T138CNGPVVGtRYkCsVCZZ
LRRK2Q5S007humanLRRK2Q5S007S1913KIFNKHtsLRLLRQEPkinase
LRRK2Q5S007humanLRRK2Q5S007S1444NIKARAsssPVILVGRoc
LRRK2Q5S007humanRPS11P62280T28kRVLLGEtGkEkLPRRibosomal_S17_N
LRRK2Q5S007humanRAB8AP61006T72AGQERFRtITTAyyRRas
LRRK2Q5S007humanLRRK2Q5S007T2524LAEKMRRtSVE____
LRRK2Q5S007humanLRRK2Q5S007T776QDVRKALtISIGKGD
LRRK2Q5S007humanLRRK2Q5S007T1452sPVILVGtHLDVsDERoc
LRRK2Q5S007humanLRRK2Q5S007S1283SYNLELRsFPNEMGKLRR_4
LRRK2Q5S007humanLRRK2Q5S007T1368DLGMQSAtVGIDVKDRoc
LRRK2Q5S007humanLRRK2Q5S007T1410stHPHFMtQRALYLARoc
LRRK2Q5S007humanLRRK2Q5S007T1612KIMAQILtVKVEGCPCOR
LRRK2Q5S007humanLRRK2Q5S007S1403AGREEFystHPHFMtRoc
LRRK2Q5S007humanLRRK2Q5S007S910LVKKKsNsIsVGEFY
LRRK2Q5S007humanLRRK2Q5S007S1467KQRKACMsKItKELL
LRRK2Q5S007humanLRRK2Q5S007T1849NPDQPRLtIPIsQIA
LRRK2Q5S007humanTP53P04637T377kskkGQstsRHkkLM
LRRK2Q5S007humanLRRK2Q5S007T1357LLQQLMKtKKSDLGMRoc
LRRK2Q5S007humanLARS1Q9P2J5T293NIFLVAAtLRPETMFtRNA-synt_1
LRRK2Q5S007humanRPS11P62280T46NIGLGFktPkEAIEGRibosomal_S17_N
LRRK2Q5S007humanLRRK2Q5S007S2257CNSFSKQsKQKNFLL
LRRK2Q5S007humanLRRK2Q5S007T524PEESREDtEFHHKLN
LRRK2Q5S007humanLRRK2Q5S007T2483NRKNTEGtQKQKEIQ
LRRK2Q5S007humanTP53P04637T304HELPPGStkRALPNN
LRRK2Q5S007humanLRRK2Q5S007T1912VKIFNKHtsLRLLRQPkinase
LRRK2Q5S007humanMAPTP10636-8T169QkGQANAtRIPAktP
LRRK2Q5S007humanFZD3Q9NPG1T598RSRDGRYtPCSYRGM
LRRK2Q5S007humanLRRK2Q5S007T1348GNtGsGKttLLQQLMRoc
LRRK2Q5S007humanLRRK2Q5S007S1124NkISGICsPLRLkEL
LRRK2Q5S007humanMAPTP10636-8T181ktPPAPktPPssGEP
LRRK2Q5S007humanRPS15P62841T136GRPGIGAtHssRFIP
LRRK2Q5S007humanLRRK2Q5S007T833tSNLRKQtNIAstLA
LRRK2Q5S007humanLRRK2Q5S007S5___MAsGsCQGCEED
LRRK2Q5S007humanLRRK2Q5S007Y1332RLKKAVPyNRMKLMI
LRRK2Q5S007humanLRRK2Q5S007T2035GIKtsEGtPGFRAPEPkinase
LRRK2Q5S007humanMSNP26038T558LGRDKyKtLRQIRQGERM_C
LRRK2Q5S007humanLRRK2Q5S007S1445IKARAsssPVILVGtRoc
LRRK2Q5S007humanMAPTP10636-8T212tPGsRsRtPsLPtPP
LRRK2Q5S007humanLRRK2Q5S007S1647KFPKNYMsQYFKLLECOR
LRRK2Q5S007humanLRRK2Q5S007S1508RKtIINEsLNFKIRD
LRRK2Q5S007humanLRRK2Q5S007T826GPLFPDKtSNLRKQt
LRRK2Q5S007humanSNAPINO95295T117NHsVAKEtARRRAML
LRRK2Q5S007humanMAPTP10636-8T205ssPGsPGtPGsRsRt
LRRK2Q5S007humanLRRK2Q5S007S1536ELEKIILsERKNVPICOR
LRRK2Q5S007humanRPS11P62280T54PkEAIEGtyIDkkCPRibosomal_S17_N
LRRK2Q5S007humanLRRK2Q5S007S3_____MAsGsCQGCE


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
LRRK2IDDescription0.00e+00
LRRK2GO:0072659protein localization to plasma membrane1.78e-06
LRRK2GO:1990778protein localization to cell periphery4.16e-06
LRRK2GO:0010821regulation of mitochondrion organization1.16e-05
LRRK2GO:1903829positive regulation of protein localization1.85e-05
LRRK2GO:1903649regulation of cytoplasmic transport1.85e-05
LRRK2GO:0010506regulation of autophagy3.41e-05
LRRK2GO:0045732positive regulation of protein catabolic process3.41e-05
LRRK2GO:0032535regulation of cellular component size3.86e-05
LRRK2GO:0006979response to oxidative stress4.92e-05
LRRK2GO:1902946protein localization to early endosome4.92e-05
LRRK2GO:1905668positive regulation of protein localization to endosome4.92e-05
LRRK2GO:1905666regulation of protein localization to endosome5.76e-05
LRRK2GO:0034599cellular response to oxidative stress5.76e-05
LRRK2GO:1903651positive regulation of cytoplasmic transport7.97e-05
LRRK2GO:0072594establishment of protein localization to organelle8.74e-05
LRRK2GO:0061951establishment of protein localization to plasma membrane8.74e-05
LRRK2GO:0051656establishment of organelle localization8.77e-05
LRRK2GO:0034614cellular response to reactive oxygen species8.77e-05
LRRK2GO:0048311mitochondrion distribution8.77e-05
LRRK2GO:0006606protein import into nucleus9.89e-05
LRRK2GO:0022411cellular component disassembly1.03e-04
LRRK2GO:0051170import into nucleus1.03e-04
LRRK2GO:2000641regulation of early endosome to late endosome transport1.03e-04
LRRK2GO:0062197cellular response to chemical stress1.11e-04
LRRK2GO:0006913nucleocytoplasmic transport1.29e-04
LRRK2GO:0051169nuclear transport1.29e-04
LRRK2GO:0032386regulation of intracellular transport1.38e-04
LRRK2GO:0007405neuroblast proliferation1.46e-04
LRRK2GO:0031503protein-containing complex localization1.46e-04
LRRK2GO:0032388positive regulation of intracellular transport1.91e-04
LRRK2GO:0042176regulation of protein catabolic process1.91e-04
LRRK2GO:0000302response to reactive oxygen species2.02e-04
LRRK2GO:0036010protein localization to endosome2.15e-04
LRRK2GO:1902115regulation of organelle assembly2.57e-04
LRRK2GO:0099003vesicle-mediated transport in synapse2.61e-04
LRRK2GO:0090140regulation of mitochondrial fission2.73e-04
LRRK2GO:0051403stress-activated MAPK cascade3.07e-04
LRRK2GO:0016242negative regulation of macroautophagy3.16e-04
LRRK2GO:1903076regulation of protein localization to plasma membrane3.32e-04
LRRK2GO:0031098stress-activated protein kinase signaling cascade3.35e-04
LRRK2GO:0010737protein kinase A signaling4.96e-04
LRRK2GO:0000266mitochondrial fission5.66e-04
LRRK2GO:0070585protein localization to mitochondrion6.46e-04
LRRK2GO:0050808synapse organization6.76e-04
LRRK2GO:0045022early endosome to late endosome transport6.87e-04
LRRK2GO:0050804modulation of chemical synaptic transmission6.87e-04
LRRK2GO:0099177regulation of trans-synaptic signaling6.87e-04
LRRK2GO:1904375regulation of protein localization to cell periphery6.90e-04
LRRK2GO:0090199regulation of release of cytochrome c from mitochondria6.94e-04

Top

Related Drugs to CNTN1_LRRK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CNTN1-LRRK2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to CNTN1_LRRK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate