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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CPSF6_CDK13

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: CPSF6_CDK13
	KinaseFusionDB ID: KFG1426
	FusionGDB2.0 ID: KFG1426
		Hgene	Tgene
	Gene symbol	CPSF6	CDK13
	Gene ID	11052	8621
	Gene name	cleavage and polyadenylation specific factor 6	cyclin dependent kinase 13
	Synonyms	CFIM\|CFIM68\|CFIM72\|HPBRII-4\|HPBRII-7	CDC2L\|CDC2L5\|CHDFIDD\|CHED\|hCDK13
	Cytomap	12q15	7p14.1
	Type of gene	protein-coding	protein-coding
	Description	cleavage and polyadenylation specificity factor subunit 6CPSF 68 kDa subunitcleavage and polyadenylation specific factor 6, 68kDacleavage and polyadenylation specificity factor 68 kDa subunitcleavage factor Im complex 68 kDa subunitpre-mRNA cleavage	cyclin-dependent kinase 13CDC2-related protein kinase 5cell division cycle 2-like protein kinase 5cell division protein kinase 13cholinesterase-related cell division controller
	Modification date	20240411	20240407
	UniProtAcc	Q16630	Q14004
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000266679, ENST00000435070, ENST00000456847, ENST00000551516, ENST00000550987,	ENST00000181839, ENST00000340829, ENST00000484589,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: CPSF6 [Title/Abstract] AND CDK13 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CPSF6(69656342)-CDK13(40027198), # samples:1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CPSF6	GO:0006397	mRNA processing	14690600
Hgene	CPSF6	GO:0031124	mRNA 3'-end processing	20695905
Hgene	CPSF6	GO:0051179	localization	30916345
Hgene	CPSF6	GO:0051262	protein tetramerization	20695905
Hgene	CPSF6	GO:0051290	protein heterotetramerization	23187700
Tgene	CDK13	GO:0009966	regulation of signal transduction	26748711
Tgene	CDK13	GO:0032968	positive regulation of transcription elongation by RNA polymerase II	26748711
Tgene	CDK13	GO:0045944	positive regulation of transcription by RNA polymerase II	20952539

Kinase Fusion gene breakpoints across CPSF6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across CDK13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-D7-8574-01A	CPSF6	chr12	69656342	CDK13	chr7	40027198

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000551516	ENST00000181839	CPSF6	chr12	69656342	CDK13	chr7	40027198	5654	1164

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000551516_ENST00000181839_CPSF6_chr12_69656342_CDK13_chr7_40027198_length(amino acids)=1164
MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSI
SPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSS
GGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPE
DKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDII
GIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL
MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE
ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYM
LALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQL
KSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGG
IQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPE
PDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDN
FGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFE

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69656342/chr7:40027198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CPSF6 Q16630	CDK13 Q14004
FUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). {ECO:0000269\|PubMed:14690600, ECO:0000269\|PubMed:15169763, ECO:0000269\|PubMed:19864460, ECO:0000269\|PubMed:20695905, ECO:0000269\|PubMed:21295486, ECO:0000269\|PubMed:23187700, ECO:0000269\|PubMed:29276085, ECO:0000269\|PubMed:8626397, ECO:0000269\|PubMed:9659921}.; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). {ECO:0000269\|PubMed:24130490}.	FUNCTION: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269\|PubMed:16721827, ECO:0000269\|PubMed:1731328, ECO:0000269\|PubMed:18480452, ECO:0000269\|PubMed:20952539}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

CPSF6

69656342

CDK13

40027198

ENST00000551516

705_998

403

1453

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

CPSF6

69656342

CDK13

40027198

ENST00000551516

705_998

403

1513

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>124_CPSF6_CDK13	ENST00000551516	ENST00000181839	CPSF6	chr12	69656342	CDK13	chr7	40027198	MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSI SPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSS GGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPE DKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDII GIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYM LALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQL KSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGG IQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPE PDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDN FGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFE	1164
3D view using mol* of 124_CPSF6_CDK13

PDB file >>>TKFP_205_CPSF6_CDK13	ENST00000551516	ENST00000181839	CPSF6	chr12	69656342	CDK13	chr7	40027198	MADGVDHIDIYADVGEEFNQEAEYEREAENERGTGIVTETVTESVTESANIVIVRRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSI SPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSS GGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPE DKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDII GIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYM LALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQL KSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGG IQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPE PDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDN FGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFE	1164_CPSF6_CDK13

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CPSF6_CDK13 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/124_CPSF6_CDK13.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

124_CPSF6_CDK13.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

124_CPSF6_CDK13_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
124_CPSF6_CDK13-DOCK_HTVS_1-001	Netarsudil	-7.03377	-7.0448699999999995	-46.3618
124_CPSF6_CDK13-DOCK_HTVS_1-001	Netarsudil	-7.03377	-7.0448699999999995	-46.3618
124_CPSF6_CDK13-DOCK_HTVS_1-001	Pralsetinib	-6.22895	-6.32045	-46.7204
124_CPSF6_CDK13-DOCK_HTVS_1-001	Cobimetinib	-6.17689	-6.17969	-38.8708
124_CPSF6_CDK13-DOCK_HTVS_1-001	Gilteritinib	-6.175730000000001	-6.20213	-43.7845
124_CPSF6_CDK13-DOCK_HTVS_1-001	Gilteritinib	-6.175730000000001	-6.20213	-43.7845
124_CPSF6_CDK13-DOCK_HTVS_1-001	Pralsetinib	-6.1064300000000005	-6.19793	-48.0336
124_CPSF6_CDK13-DOCK_HTVS_1-001	Lapatinib	-6.07702	-6.16582	-50.9228
124_CPSF6_CDK13-DOCK_HTVS_1-001	Dabrafenib	-6.037999999999999	-6.454	-39.2633
124_CPSF6_CDK13-DOCK_HTVS_1-001	Dabrafenib	-6.037999999999999	-6.454	-39.2633
124_CPSF6_CDK13-DOCK_HTVS_1-001	Pralsetinib	-6.0287	-6.1202	-45.9383
124_CPSF6_CDK13-DOCK_HTVS_1-001	Ruxolitinib	-5.96842	-5.96842	-33.8232
124_CPSF6_CDK13-DOCK_HTVS_1-001	Zanubrutinib	-5.9589300000000005	-5.9589300000000005	-29.77
124_CPSF6_CDK13-DOCK_HTVS_1-001	Pralsetinib	-5.86386	-5.95536	-45.1021
124_CPSF6_CDK13-DOCK_HTVS_1-001	Axitinib	-5.84141	-5.844609999999999	-35.8481
124_CPSF6_CDK13-DOCK_HTVS_1-001	Futibatinib	-5.82965	-5.82965	-37.6853
124_CPSF6_CDK13-DOCK_HTVS_1-001	Cabozantinib	-5.82511	-5.8701099999999995	-40.289
124_CPSF6_CDK13-DOCK_HTVS_1-001	Cabozantinib	-5.82511	-5.8701099999999995	-40.289
124_CPSF6_CDK13-DOCK_HTVS_1-001	Nilotinib	-5.80971	-6.73451	-46.1064
124_CPSF6_CDK13-DOCK_HTVS_1-001	Nilotinib	-5.80971	-6.73451	-46.1064

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Kinase-Substrate Information of CPSF6_CDK13

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
CDK13	Q14004	human	SERINC5	Q86VE9	S360	ARCCFCFsPGGEDTE	Serinc
CDK13	Q14004	human	EIF4EBP1	Q13541	S65	FLMECrNsPVtktPP	eIF_4EBP
CDK13	Q14004	human	EIF4B	P23588	S406	RPRERHPsWRsEEtQ
CDK13	Q14004	human	POLR2A	P24928	S1616	TPQSPSysPtsPsYS	RNA_pol_Rpb1_R
CDK13	Q14004	human	EIF4EBP1	Q13541	T70	rNsPVtktPPRDLPt	eIF_4EBP
CDK13	Q14004	human	POLR2A	P24928	S1619	SPSysPtsPsYSPTS	RNA_pol_Rpb1_R
CDK13	Q14004	human	EIF4EBP1	Q13541	T46	GGtLFsttPGGtRII	eIF_4EBP
CDK13	Q14004	human	EIF4B	P23588	S422	RERsRtGsEssQtGt

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
CDK13	ID	Description	0.00e+00
CDK13	GO:0006446	regulation of translational initiation	5.02e-03
CDK13	GO:0006413	translational initiation	5.52e-03
CDK13	GO:0032329	serine transport	3.03e-02
CDK13	GO:0006563	L-serine metabolic process	3.03e-02
CDK13	GO:0009070	serine family amino acid biosynthetic process	3.06e-02
CDK13	GO:0045947	negative regulation of translational initiation	3.06e-02
CDK13	GO:0006658	phosphatidylserine metabolic process	3.06e-02
CDK13	GO:0006353	DNA-templated transcription termination	3.49e-02
CDK13	GO:0009069	serine family amino acid metabolic process	4.13e-02
CDK13	GO:0033120	positive regulation of RNA splicing	4.28e-02
CDK13	GO:0015804	neutral amino acid transport	4.90e-02
CDK13	GO:1901607	alpha-amino acid biosynthetic process	5.33e-02
CDK13	GO:0008652	amino acid biosynthetic process	5.49e-02
CDK13	GO:0015807	L-amino acid transport	5.95e-02
CDK13	GO:0006575	cellular modified amino acid metabolic process	6.91e-02
CDK13	GO:0045931	positive regulation of mitotic cell cycle	6.91e-02
CDK13	GO:0042552	myelination	6.91e-02
CDK13	GO:0007272	ensheathment of neurons	6.91e-02
CDK13	GO:0008366	axon ensheathment	6.91e-02
CDK13	GO:0006865	amino acid transport	6.91e-02
CDK13	GO:0031929	TOR signaling	7.32e-02
CDK13	GO:0043484	regulation of RNA splicing	7.56e-02
CDK13	GO:1901605	alpha-amino acid metabolic process	8.26e-02
CDK13	GO:0000082	G1/S transition of mitotic cell cycle	8.63e-02
CDK13	GO:0008654	phospholipid biosynthetic process	8.63e-02
CDK13	GO:0044843	cell cycle G1/S phase transition	8.63e-02
CDK13	GO:0006520	amino acid metabolic process	8.63e-02
CDK13	GO:0006650	glycerophospholipid metabolic process	8.63e-02
CDK13	GO:0017148	negative regulation of translation	8.63e-02
CDK13	GO:0045787	positive regulation of cell cycle	8.63e-02
CDK13	GO:0046394	carboxylic acid biosynthetic process	8.63e-02
CDK13	GO:0051607	defense response to virus	8.63e-02
CDK13	GO:0140546	defense response to symbiont	8.63e-02
CDK13	GO:0016053	organic acid biosynthetic process	8.63e-02
CDK13	GO:0034249	negative regulation of amide metabolic process	8.63e-02
CDK13	GO:0046942	carboxylic acid transport	8.63e-02
CDK13	GO:0015849	organic acid transport	8.63e-02
CDK13	GO:0006644	phospholipid metabolic process	8.93e-02
CDK13	GO:0046486	glycerolipid metabolic process	9.04e-02
CDK13	GO:0051347	positive regulation of transferase activity	9.34e-02
CDK13	GO:0009615	response to virus	9.50e-02
CDK13	GO:0015711	organic anion transport	9.50e-02
CDK13	GO:0044772	mitotic cell cycle phase transition	9.75e-02
CDK13	GO:0008380	RNA splicing	9.75e-02

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Related Drugs to CPSF6_CDK13

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning CPSF6-CDK13 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to CPSF6_CDK13

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date