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Kinase Fusion Gene:CSK_RBPMS |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CSK_RBPMS | KinaseFusionDB ID: KFG1451 | FusionGDB2.0 ID: KFG1451 | Hgene | Tgene | Gene symbol | CSK | RBPMS | Gene ID | 1445 | 11030 | |
| Gene name | C-terminal Src kinase | RNA binding protein, mRNA processing factor | ||||||||||
| Synonyms | - | HERMES | ||||||||||
| Cytomap | 15q24.1 | 8p12 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | tyrosine-protein kinase CSKC-Src kinaseCSK, non-receptor tyrosine kinasec-src tyrosine kinaseprotein-tyrosine kinase CYL | RNA-binding protein with multiple splicingRNA binding protein with multiple splicingheart and RRM expressed sequence | ||||||||||
| Modification date | 20240411 | 20240407 | ||||||||||
| UniProtAcc | P41240 | Q93062 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000220003, ENST00000309470, ENST00000439220, ENST00000567571, | ENST00000287771, ENST00000320203, ENST00000339877, ENST00000397323, ENST00000517860, ENST00000519647, ENST00000520161, ENST00000520191, ENST00000520916, ENST00000538486, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CSK [Title/Abstract] AND RBPMS [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CSK(75095537)-RBPMS(30376233), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSK | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport | 20605918 |
| Tgene | RBPMS | GO:0060395 | SMAD protein signal transduction | 17099224 |
| Kinase Fusion gene breakpoints across CSK (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across RBPMS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | DL059086 | CSK | chr15 | 75095537 | RBPMS | chr8 | 30376233 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:75095537/:30376233) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSK | RBPMS |
| FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. | FUNCTION: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). {ECO:0000269|PubMed:17099224, ECO:0000269|PubMed:26347403}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CSK_RBPMS |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CSK | P41240 | human | EEF2 | P13639 | Y265 | kkLWGDryFDPANGk | GTP_EFTU |
| CSK | P41240 | human | YES1 | P07947 | Y537 | FtAtEPQyQPGENL_ | |
| CSK | P41240 | human | PTPRC | P08575 | Y1218 | MVSTFEQyQFLyDVI | Y_phosphatase |
| CSK | P41240 | human | LCK | P06239 | Y505 | FTAtEGQyQPQP___ | |
| CSK | P41240 | human | SRC | P12931 | Y530 | FTstEPQyQPGENL_ | |
| CSK | P41240 | human | HCK | P08631 | Y411 | RVIEDNEytAREGAk | PK_Tyr_Ser-Thr |
| CSK | P41240 | human | MAPT | P10636-8 | Y29 | DRKDQGGytMHQDQE | |
| CSK | P41240 | human | MAPT | P10636-8 | Y197 | KsGDRsGyssPGsPG | |
| CSK | P41240 | human | EEF2 | P13639 | Y373 | kYRCELLyEGPPDDE | |
| CSK | P41240 | human | SRC | P12931 | Y419 | RLIEDNEytARQGAk | PK_Tyr_Ser-Thr |
| CSK | P41240 | human | FYN | P06241 | Y531 | FtAtEPQyQPGENL_ |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CSK | ID | Description | 0.00e+00 |
| CSK | GO:0038094 | Fc-gamma receptor signaling pathway | 4.27e-13 |
| CSK | GO:0038093 | Fc receptor signaling pathway | 6.25e-12 |
| CSK | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 3.99e-11 |
| CSK | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 3.99e-11 |
| CSK | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 9.76e-11 |
| CSK | GO:0018108 | peptidyl-tyrosine phosphorylation | 3.27e-08 |
| CSK | GO:0018212 | peptidyl-tyrosine modification | 3.27e-08 |
| CSK | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus | 5.72e-08 |
| CSK | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 5.72e-08 |
| CSK | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 8.55e-08 |
| CSK | GO:0002861 | regulation of inflammatory response to antigenic stimulus | 1.85e-07 |
| CSK | GO:0031295 | T cell costimulation | 1.85e-07 |
| CSK | GO:0031294 | lymphocyte costimulation | 2.02e-07 |
| CSK | GO:0002757 | immune response-activating signaling pathway | 3.99e-07 |
| CSK | GO:0050728 | negative regulation of inflammatory response | 4.21e-07 |
| CSK | GO:0050777 | negative regulation of immune response | 4.25e-07 |
| CSK | GO:0002764 | immune response-regulating signaling pathway | 4.58e-07 |
| CSK | GO:0006909 | phagocytosis | 7.82e-07 |
| CSK | GO:0002437 | inflammatory response to antigenic stimulus | 9.38e-07 |
| CSK | GO:0050870 | positive regulation of T cell activation | 9.38e-07 |
| CSK | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 1.41e-06 |
| CSK | GO:0031348 | negative regulation of defense response | 2.83e-06 |
| CSK | GO:0022409 | positive regulation of cell-cell adhesion | 2.83e-06 |
| CSK | GO:0051251 | positive regulation of lymphocyte activation | 3.05e-06 |
| CSK | GO:0036120 | cellular response to platelet-derived growth factor stimulus | 3.05e-06 |
| CSK | GO:0036119 | response to platelet-derived growth factor | 3.81e-06 |
| CSK | GO:0002696 | positive regulation of leukocyte activation | 5.26e-06 |
| CSK | GO:0050863 | regulation of T cell activation | 5.26e-06 |
| CSK | GO:1903037 | regulation of leukocyte cell-cell adhesion | 5.26e-06 |
| CSK | GO:0050867 | positive regulation of cell activation | 5.89e-06 |
| CSK | GO:0050900 | leukocyte migration | 5.89e-06 |
| CSK | GO:0007159 | leukocyte cell-cell adhesion | 7.55e-06 |
| CSK | GO:0050727 | regulation of inflammatory response | 7.86e-06 |
| CSK | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 1.05e-05 |
| CSK | GO:0032102 | negative regulation of response to external stimulus | 1.35e-05 |
| CSK | GO:0045785 | positive regulation of cell adhesion | 1.35e-05 |
| CSK | GO:0022407 | regulation of cell-cell adhesion | 1.46e-05 |
| CSK | GO:2000116 | regulation of cysteine-type endopeptidase activity | 1.71e-05 |
| CSK | GO:0046777 | protein autophosphorylation | 1.80e-05 |
| CSK | GO:0048013 | ephrin receptor signaling pathway | 2.23e-05 |
| CSK | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 3.11e-05 |
| CSK | GO:0052548 | regulation of endopeptidase activity | 7.30e-05 |
| CSK | GO:0052547 | regulation of peptidase activity | 9.80e-05 |
| CSK | GO:0045862 | positive regulation of proteolysis | 1.51e-04 |
| CSK | GO:0071801 | regulation of podosome assembly | 2.35e-04 |
| CSK | GO:2001233 | regulation of apoptotic signaling pathway | 2.40e-04 |
| CSK | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 3.14e-04 |
| CSK | GO:0050852 | T cell receptor signaling pathway | 4.27e-04 |
| CSK | GO:0071800 | podosome assembly | 4.73e-04 |
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Related Drugs to CSK_RBPMS |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CSK-RBPMS and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CSK_RBPMS |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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