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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CSNK1A1_C3orf72

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CSNK1A1_C3orf72
KinaseFusionDB ID: KFG1454
FusionGDB2.0 ID: KFG1454
HgeneTgene
Gene symbol

CSNK1A1

C3orf72

Gene ID

1452

401089

Gene namecasein kinase 1 alpha 1FOXL2 neighbor
SynonymsCK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975C3orf72
Cytomap

5q32

3q22.3

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77pFOXL2 neighbor proteinFLJ43329 protein
Modification date2024040720240305
UniProtAcc

P48729

Q6ZUU3

Ensembl transtripts involved in fusion geneENST idsENST00000261798, ENST00000377843, 
ENST00000515748, ENST00000515768, 
ENST00000504676, ENST00000515435, 
ENST00000606299, ENST00000606719, 
ENST00000383165, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CSNK1A1 [Title/Abstract] AND C3orf72 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CSNK1A1(148929638)-C3orf72(138668354), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

HgeneCSNK1A1

GO:0031670

cellular response to nutrient

22017875|22017877

HgeneCSNK1A1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19364825

HgeneCSNK1A1

GO:0035025

positive regulation of Rho protein signal transduction

25500533

HgeneCSNK1A1

GO:1904263

positive regulation of TORC1 signaling

22017875|22017877


check buttonKinase Fusion gene breakpoints across CSNK1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across C3orf72 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-Z6-A8JECSNK1A1chr5

148929638

C3orf72chr3

138668354



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148929638/:138668354)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1A1

P48729

C3orf72

Q6ZUU3

FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of CSNK1A1_C3orf72


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CSNK1A1P48729humanSLC4A1P02730S303IDAYMAQsRGELLHSBand_3_cyto
CSNK1A1P48729humanFOXG1P55316S19MIPKSSFsINSLVPE
CSNK1A1P48729humanYWHAQP27348S232LTLWtsDsAGEECDA
CSNK1A1P48729humanTARDBPQ13148S379NSYsGsNsGAAIGWG
CSNK1A1P48729humanFOXO4P98177S268ssNAsSVsTRLsPLR
CSNK1A1P48729humanTARDBPQ13148S393GsAsNAGsGsGFNGG
CSNK1A1P48729humanCARD11Q9BXL7S615RYSFGPSsIHSSSSS
CSNK1A1P48729humanATF1P18846S47EsQDSSDsIGssQKApKID
CSNK1A1P48729humanSNCAP37840T64EktkEQVtNVGGAVVSynuclein
CSNK1A1P48729humanHSPA1BP0DMV8T636GGsGsGPtIEEVD__
CSNK1A1P48729humanTP53P04637S37NVLsPLPsQAMDDLMTAD2
CSNK1A1P48729humanTARDBPQ13148S387GAAIGWGsAsNAGsG
CSNK1A1P48729humanJADE1Q6IE81S18EDsDDNGsLsTTWSQEPL1
CSNK1A1P48729humanBACE1P56817S498DDFADDIsLLk____
CSNK1A1P48729humanCTPS2Q9NRF8S568LsSsDrysDAsDDsF
CSNK1A1P48729humanLGALS3P17931S12FsLHDALsGSGNPNP
CSNK1A1P48729humanTARDBPQ13148T116LGLPWkTtEQDLkEYRRM_1
CSNK1A1P48729humanMALT1Q9UDY8S573GTEYsAEsLVRNLQWPeptidase_C14
CSNK1A1P48729humanBIDP55957S64LQtDGNRsSHsRLGR
CSNK1A1P48729humanERGP11308S38TEMTASsssDyGQTs
CSNK1A1P48729humanAPCP25054S1507FsCsssLsALsLDEPAPC_r
CSNK1A1P48729humanAGO2Q9UKV8S831sAEGsHtsGQsNGRD
CSNK1A1P48729humanCREB1P16220S142PRIEEEKsEEETSAP
CSNK1A1P48729humanHSP90AB1P08238S718LEGDEDAsRMEEVD_
CSNK1A1P48729humanVHLP40337S72SVNsREPsQVIFCNrVHL
CSNK1A1P48729humanSQSTM1Q13501S349sskEVDPstGELQsL
CSNK1A1P48729humanATF1P18846S36AQQVSSLsESEEsQD
CSNK1A1P48729humanATMQ13315S1270SHFDEVksIANQIQE
CSNK1A1P48729humanPHLPP1O60346S1379GSKGLWDsLsVEEAVPP2C
CSNK1A1P48729humanIFNAR1P17181S535SSQTsQDsGNysNED
CSNK1A1P48729humanTP53P04637T18EPPLsQEtFsDLWkLP53_TAD
CSNK1A1P48729humanNLRP3Q96P20S806KLVELDLsDNALGDFLRR_6
CSNK1A1P48729humanCREB1P16220S100EsEDsQEsVDsVtDspKID
CSNK1A1P48729humanMYCP01106S267PPTtssDsEEEQEDEMyc_N
CSNK1A1P48729humanCTNNB1P35222S45GATtTAPsLsGkGNP
CSNK1A1P48729humanSLC4A1P02730T42AAHDtEAtAtDyHtt
CSNK1A1P48729humanRHOBP62745S185ALQkRYGsQNGCINC
CSNK1A1P48729humanTUT1Q9H6E5S6__MAAVDsDVEsLPr
CSNK1A1P48729humanERGP11308S39EMTASsssDyGQTsK
CSNK1A1P48729humanTARDBPQ13148T25IPSEDDGtVLLSTVTTDP43_N
CSNK1A1P48729humanLRP6O75581S1490AILNPPPsPAtERsH
CSNK1A1P48729humanYWHAZP63104T232LTLWtsDtQGDEAEA
CSNK1A1P48729humanGJA1P17302S325NRMGQAGstIsNsHAConnexin43
CSNK1A1P48729humanDEPTORQ8TB45T149kLMsPENtLLQPREEDEP
CSNK1A1P48729humanTARDBPQ13148S2______MsEyIRVtE
CSNK1A1P48729humanZRANB1Q9UGI0S209RWRGsCssGNsQRRS
CSNK1A1P48729humanTARDBPQ13148S409GssMDskssGWGM__
CSNK1A1P48729humanEIF6P56537S175EDQDELssLLQVPLVeIF-6
CSNK1A1P48729humanTARDBPQ13148S242ADDQIAQsLCGEDLIRRM_1
CSNK1A1P48729humanPHLPP1O60346T1363HVQsVLLtPQDEFFIPP2C
CSNK1A1P48729humanERGP11308S37KTEMTASsssDyGQT
CSNK1A1P48729humanGJA1P17302S328GQAGstIsNsHAQPFConnexin43
CSNK1A1P48729humanCDC25AP30304S82GssEstDsGFCLDsP
CSNK1A1P48729humanECE1P42892S36EDLVDsLsEGDAyPN
CSNK1A1P48729humanTARDBPQ13148S407GFGssMDskssGWGM
CSNK1A1P48729humanAPCP25054S1510sssLsALsLDEPFIQ
CSNK1A1P48729humanCTNND1O60716-3S268PQVRVGGssVDLHRF
CSNK1A1P48729humanTARDBPQ13148S254DLIIKGIsVHISNAE
CSNK1A1P48729humanOSBP2Q969R2S762ECSKVMHssPssPsSOxysterol_BP
CSNK1A1P48729humanFOXO1Q12778S322PRtssNAstIsGRLs
CSNK1A1P48729humanSRPK2P78362S497SRtVsAsstGDLPkA
CSNK1A1P48729humanNFATC3Q12968T204NEAAARFtLGsPLts
CSNK1A1P48729humanNFAT5O94916S158LLDNsRMsCQDEGCG
CSNK1A1P48729humanAPCP25054S1504PDGFsCsssLsALsLAPC_r
CSNK1A1P48729humanHNRNPCP07910S260sEGGADDsAEEGDLL
CSNK1A1P48729humanOSBP2Q969R2S766VMHssPssPsSDGKQOxysterol_BP
CSNK1A1P48729humanECE1P42892S34DEEDLVDsLsEGDAy
CSNK1A1P48729humanTARDBPQ13148S305GLGNNQGsNMGGGMN
CSNK1A1P48729humanMYCP01106S82PLsPsRRsGLCsPSyMyc_N
CSNK1A1P48729humanBIDP55957S67DGNRsSHsRLGRIEABID
CSNK1A1P48729humanFOXO4P98177S265PRSssNAsSVsTRLs
CSNK1A1P48729humanRORAP35398S100CKGFFRRsQQSNATYzf-C4
CSNK1A1P48729humanSNCAP37840S87ktVEGAGsIAAATGFSynuclein
CSNK1A1P48729humanATF1P18846S51SSDsIGssQKAHGILpKID
CSNK1A1P48729humanSNCAP37840S129NEAyEMPsEEGyQDySynuclein
CSNK1A1P48729humanTARDBPQ13148T88NKRkMDEtDAssAVk
CSNK1A1P48729humanGJA1P17302S330AGstIsNsHAQPFDFConnexin43
CSNK1A1P48729humanMDM4O15151S289DDLEDSKsLSDDTDV
CSNK1A1P48729humanKCNIP3Q9Y2W7S63APQGSDSsDSELELS
CSNK1A1P48729humanNR3C2P08235T800LPLEDQItLIQYSWMHormone_recep
CSNK1A1P48729humanTARDBPQ13148S410ssMDskssGWGM___
CSNK1A1P48729humanRAPGEF2Q9Y4G8S1248AADsGRGsWTSCSsG
CSNK1A1P48729humanLGALS3P17931S6__MADNFsLHDALsG
CSNK1A1P48729humanTIAM1Q13009S329DVNAGEGsEFADsGI
CSNK1A1P48729humanNFATC3Q12968S211tLGsPLtsPGGsPGG
CSNK1A1P48729humanCTNND1O60716-3S269QVRVGGssVDLHRFH
CSNK1A1P48729humanTARDBPQ13148S347LAsQQNQsGPsGNNQ
CSNK1A1P48729humanCDH1P12830S844GsGsEAAsLSsLNsSCADH_Y-type_LIR
CSNK1A1P48729humanCREB1P16220S97TIAEsEDsQEsVDsV
CSNK1A1P48729humanZRANB1Q9UGI0T35RAQRPSGtIItEDPF
CSNK1A1P48729humanAGO2Q9UKV8S834GsHtsGQsNGRDHQA
CSNK1A1P48729humanTARDBPQ13148S395AsNAGsGsGFNGGFG
CSNK1A1P48729humanTARDBPQ13148S273SNRQLERsGrFGGNP
CSNK1A1P48729humanPRKNO60260S378AyHEGECsAVFEASG
CSNK1A1P48729humanLRP6O75581T1493NPPPsPAtERsHytM
CSNK1A1P48729humanCBX4O00257T437ARsIsTPtCLGGsPA
CSNK1A1P48729humanFOXO1Q12778S325ssNAstIsGRLsPIM
CSNK1A1P48729humanRAPGEF2Q9Y4G8S1244ASLDAADsGRGsWTS
CSNK1A1P48729humanTARDBPQ13148S403GFNGGFGssMDskss
CSNK1A1P48729humanFADDQ13158S194QNRsGAMsPMsWNsD
CSNK1A1P48729humanNR3C2P08235S936DSMHDLVsDLLEFCFHormone_recep
CSNK1A1P48729humanHNRNPCP07910S253EtNVkMEsEGGADDs
CSNK1A1P48729humanDEPTORQ8TB45S287sMssCGssGyFsssP
CSNK1A1P48729humanRELAQ04206S316FksIMkksPFsGPtD
CSNK1A1P48729humanCDK5Q00535S159GIPVRCYsAEVVTLWPkinase
CSNK1A1P48729humanHSP90AA1P07900S726LEGDDDtsRMEEVD_
CSNK1A1P48729humanTARDBPQ13148S375GsGNNSYsGsNsGAA
CSNK1A1P48729humanTARDBPQ13148S404FNGGFGssMDskssG
CSNK1A1P48729humanATF1P18846S41SLsESEEsQDSSDsI
CSNK1A1P48729humanHSP90AA1P07900T725PLEGDDDtsRMEEVD
CSNK1A1P48729humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
CSNK1A1P48729humanJADE1Q6IE81S20sDDNGsLsTTWSQNSEPL1
CSNK1A1P48729humanDEPTORQ8TB45S286ssMssCGssGyFsss
CSNK1A1P48729humanTARDBPQ13148S91kMDEtDAssAVkVKR
CSNK1A1P48729humanNFATC3Q12968S215PLtsPGGsPGGCPGE
CSNK1A1P48729humanTARDBPQ13148S389AIGWGsAsNAGsGsG
CSNK1A1P48729humanOSBP2Q969R2S768HssPssPsSDGKQKTOxysterol_BP
CSNK1A1P48729humanATF1P18846S50DSSDsIGssQKAHGIpKID
CSNK1A1P48729humanLRP6O75581S1607HLYPPPPsPCTDss_
CSNK1A1P48729humanTARDBPQ13148S292NQGGFGNsrGGGAGL
CSNK1A1P48729humanUVRAGQ9P2Y5S522QyktPPPsyNSALAQ
CSNK1A1P48729humanAGO2Q9UKV8S828EHDsAEGsHtsGQsN
CSNK1A1P48729humanYBX1P67809S176EkNEGsEsAPEGQAQ
CSNK1A1P48729humanPHLPP1O60346S1359VPRPHVQsVLLtPQDPP2C
CSNK1A1P48729humanAGO2Q9UKV8S824LVDKEHDsAEGsHts
CSNK1A1P48729humanHNRNPCP07910S299EGEDDRDsANGEDDs
CSNK1A1P48729humanTARDBPQ13148S92MDEtDAssAVkVKRA
CSNK1A1P48729humanAPCP25054S1505DGFsCsssLsALsLDAPC_r
CSNK1A1P48729humanNFATC3Q12968S207AARFtLGsPLtsPGG
CSNK1A1P48729humanLRP6O75581T1572EPVPPPPtPRsQyLs
CSNK1A1P48729humanOSBP2Q969R2S763CSKVMHssPssPsSDOxysterol_BP
CSNK1A1P48729humanTARDBPQ13148S342GMMGMLAsQQNQsGP
CSNK1A1P48729humanEIF6P56537S174IEDQDELssLLQVPLeIF-6
CSNK1A1P48729humanDEPTORQ8TB45S263RKstsFMsVsPsKEI
CSNK1A1P48729humanTARDBPQ13148S183kLPNskQsQDEPLRS
CSNK1A1P48729humanKDM1AO60341S687HVGsTTAsRGELFLFAmino_oxidase
CSNK1A1P48729humanPHLPP1O60346S1381KGLWDsLsVEEAVEAPP2C
CSNK1A1P48729humanPRKNO60260S101GCEREPQsLTRVDLs
CSNK1A1P48729humanTARDBPQ13148Y4____MsEyIRVtEDETDP43_N
CSNK1A1P48729humanNFATC3Q12968T210FtLGsPLtsPGGsPG
CSNK1A1P48729humanTARDBPQ13148S369EPNQAFGsGNNSYsG
CSNK1A1P48729humanCDC25AP30304S79QRMGssEstDsGFCL
CSNK1A1P48729humanTARDBPQ13148S377GNNSYsGsNsGAAIG
CSNK1A1P48729humanBHLHE40O14503S243GSDTDTDsGYGGESE
CSNK1A1P48729humanDEPTORQ8TB45S291CGssGyFsssPtLss
CSNK1A1P48729humanCREB1P16220S94QISTIAEsEDsQEsV
CSNK1A1P48729humanAGO2Q9UKV8T830DsAEGsHtsGQsNGR
CSNK1A1P48729humanTARDBPQ13148S350QQNQsGPsGNNQNQG


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CSNK1A1IDDescription0.00e+00
CSNK1A1GO:2000278regulation of DNA biosynthetic process4.81e-06
CSNK1A1GO:2001233regulation of apoptotic signaling pathway4.81e-06
CSNK1A1GO:0062197cellular response to chemical stress4.81e-06
CSNK1A1GO:1903320regulation of protein modification by small protein conjugation or removal4.81e-06
CSNK1A1GO:0031647regulation of protein stability4.86e-06
CSNK1A1GO:0031400negative regulation of protein modification process7.63e-06
CSNK1A1GO:0031396regulation of protein ubiquitination7.63e-06
CSNK1A1GO:0051402neuron apoptotic process8.45e-06
CSNK1A1GO:0043525positive regulation of neuron apoptotic process8.45e-06
CSNK1A1GO:1901873regulation of post-translational protein modification8.45e-06
CSNK1A1GO:0050821protein stabilization9.82e-06
CSNK1A1GO:0034599cellular response to oxidative stress3.58e-05
CSNK1A1GO:0009895negative regulation of catabolic process4.21e-05
CSNK1A1GO:0043122regulation of canonical NF-kappaB signal transduction4.21e-05
CSNK1A1GO:0071897DNA biosynthetic process4.21e-05
CSNK1A1GO:0010506regulation of autophagy4.21e-05
CSNK1A1GO:1990000amyloid fibril formation4.21e-05
CSNK1A1GO:0042176regulation of protein catabolic process4.74e-05
CSNK1A1GO:0051972regulation of telomerase activity6.01e-05
CSNK1A1GO:0050767regulation of neurogenesis8.00e-05
CSNK1A1GO:0007249canonical NF-kappaB signal transduction8.00e-05
CSNK1A1GO:0016049cell growth8.00e-05
CSNK1A1GO:0031331positive regulation of cellular catabolic process8.00e-05
CSNK1A1GO:0006979response to oxidative stress8.40e-05
CSNK1A1GO:0043523regulation of neuron apoptotic process1.05e-04
CSNK1A1GO:0071214cellular response to abiotic stimulus1.52e-04
CSNK1A1GO:0104004cellular response to environmental stimulus1.52e-04
CSNK1A1GO:0000082G1/S transition of mitotic cell cycle1.74e-04
CSNK1A1GO:1990138neuron projection extension1.97e-04
CSNK1A1GO:1990778protein localization to cell periphery2.15e-04
CSNK1A1GO:0006109regulation of carbohydrate metabolic process2.49e-04
CSNK1A1GO:0051960regulation of nervous system development2.49e-04
CSNK1A1GO:0007004telomere maintenance via telomerase2.60e-04
CSNK1A1GO:2000573positive regulation of DNA biosynthetic process2.60e-04
CSNK1A1GO:1903829positive regulation of protein localization2.75e-04
CSNK1A1GO:0044843cell cycle G1/S phase transition2.81e-04
CSNK1A1GO:0043123positive regulation of canonical NF-kappaB signal transduction2.81e-04
CSNK1A1GO:0031334positive regulation of protein-containing complex assembly2.93e-04
CSNK1A1GO:2001056positive regulation of cysteine-type endopeptidase activity3.02e-04
CSNK1A1GO:0051973positive regulation of telomerase activity3.18e-04
CSNK1A1GO:0006278RNA-templated DNA biosynthetic process3.26e-04
CSNK1A1GO:0072659protein localization to plasma membrane3.29e-04
CSNK1A1GO:1902253regulation of intrinsic apoptotic signaling pathway by p53 class mediator3.33e-04
CSNK1A1GO:0042098T cell proliferation4.08e-04
CSNK1A1GO:0090090negative regulation of canonical Wnt signaling pathway4.19e-04
CSNK1A1GO:0010833telomere maintenance via telomere lengthening4.24e-04
CSNK1A1GO:0051090regulation of DNA-binding transcription factor activity4.28e-04
CSNK1A1GO:0046651lymphocyte proliferation4.36e-04
CSNK1A1GO:0032943mononuclear cell proliferation4.79e-04

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Related Drugs to CSNK1A1_C3orf72


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CSNK1A1-C3orf72 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CSNK1A1_C3orf72


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate