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Kinase Fusion Gene:CSNK1A1_RDX |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: CSNK1A1_RDX | KinaseFusionDB ID: KFG1464 | FusionGDB2.0 ID: KFG1464 | Hgene | Tgene | Gene symbol | CSNK1A1 | RDX | Gene ID | 1452 | 5962 | |
Gene name | casein kinase 1 alpha 1 | radixin | ||||||||||
Synonyms | CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975 | DFNB24 | ||||||||||
Cytomap | 5q32 | 11q22.3 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | casein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p | radixin | ||||||||||
Modification date | 20240407 | 20240411 | ||||||||||
UniProtAcc | P48729 | P35241 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261798, ENST00000377843, ENST00000504676, ENST00000515435, ENST00000515748, ENST00000515768, ENST00000606299, ENST00000606719, | ENST00000343115, ENST00000405097, ENST00000528498, ENST00000528900, ENST00000530301, ENST00000544551, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CSNK1A1 [Title/Abstract] AND RDX [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CSNK1A1(148877432)-RDX(110160312), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CSNK1A1 | GO:0006468 | protein phosphorylation | 18305108 |
Hgene | CSNK1A1 | GO:0031670 | cellular response to nutrient | 22017875|22017877 |
Hgene | CSNK1A1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19364825 |
Hgene | CSNK1A1 | GO:0035025 | positive regulation of Rho protein signal transduction | 25500533 |
Hgene | CSNK1A1 | GO:1904263 | positive regulation of TORC1 signaling | 22017875|22017877 |
Kinase Fusion gene breakpoints across CSNK1A1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across RDX (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | L26953 | CSNK1A1 | chr5 | 148877432 | RDX | chr11 | 110160312 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:148877432/:110160312) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CSNK1A1 | RDX |
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:23902688}. | FUNCTION: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CSNK1A1_RDX |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
CSNK1A1 | P48729 | human | SLC4A1 | P02730 | S303 | IDAYMAQsRGELLHS | Band_3_cyto |
CSNK1A1 | P48729 | human | FOXG1 | P55316 | S19 | MIPKSSFsINSLVPE | |
CSNK1A1 | P48729 | human | YWHAQ | P27348 | S232 | LTLWtsDsAGEECDA | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S379 | NSYsGsNsGAAIGWG | |
CSNK1A1 | P48729 | human | FOXO4 | P98177 | S268 | ssNAsSVsTRLsPLR | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S393 | GsAsNAGsGsGFNGG | |
CSNK1A1 | P48729 | human | CARD11 | Q9BXL7 | S615 | RYSFGPSsIHSSSSS | |
CSNK1A1 | P48729 | human | ATF1 | P18846 | S47 | EsQDSSDsIGssQKA | pKID |
CSNK1A1 | P48729 | human | SNCA | P37840 | T64 | EktkEQVtNVGGAVV | Synuclein |
CSNK1A1 | P48729 | human | HSPA1B | P0DMV8 | T636 | GGsGsGPtIEEVD__ | |
CSNK1A1 | P48729 | human | TP53 | P04637 | S37 | NVLsPLPsQAMDDLM | TAD2 |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S387 | GAAIGWGsAsNAGsG | |
CSNK1A1 | P48729 | human | JADE1 | Q6IE81 | S18 | EDsDDNGsLsTTWSQ | EPL1 |
CSNK1A1 | P48729 | human | BACE1 | P56817 | S498 | DDFADDIsLLk____ | |
CSNK1A1 | P48729 | human | CTPS2 | Q9NRF8 | S568 | LsSsDrysDAsDDsF | |
CSNK1A1 | P48729 | human | LGALS3 | P17931 | S12 | FsLHDALsGSGNPNP | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | T116 | LGLPWkTtEQDLkEY | RRM_1 |
CSNK1A1 | P48729 | human | MALT1 | Q9UDY8 | S573 | GTEYsAEsLVRNLQW | Peptidase_C14 |
CSNK1A1 | P48729 | human | BID | P55957 | S64 | LQtDGNRsSHsRLGR | |
CSNK1A1 | P48729 | human | ERG | P11308 | S38 | TEMTASsssDyGQTs | |
CSNK1A1 | P48729 | human | APC | P25054 | S1507 | FsCsssLsALsLDEP | APC_r |
CSNK1A1 | P48729 | human | AGO2 | Q9UKV8 | S831 | sAEGsHtsGQsNGRD | |
CSNK1A1 | P48729 | human | CREB1 | P16220 | S142 | PRIEEEKsEEETSAP | |
CSNK1A1 | P48729 | human | HSP90AB1 | P08238 | S718 | LEGDEDAsRMEEVD_ | |
CSNK1A1 | P48729 | human | VHL | P40337 | S72 | SVNsREPsQVIFCNr | VHL |
CSNK1A1 | P48729 | human | SQSTM1 | Q13501 | S349 | sskEVDPstGELQsL | |
CSNK1A1 | P48729 | human | ATF1 | P18846 | S36 | AQQVSSLsESEEsQD | |
CSNK1A1 | P48729 | human | ATM | Q13315 | S1270 | SHFDEVksIANQIQE | |
CSNK1A1 | P48729 | human | PHLPP1 | O60346 | S1379 | GSKGLWDsLsVEEAV | PP2C |
CSNK1A1 | P48729 | human | IFNAR1 | P17181 | S535 | SSQTsQDsGNysNED | |
CSNK1A1 | P48729 | human | TP53 | P04637 | T18 | EPPLsQEtFsDLWkL | P53_TAD |
CSNK1A1 | P48729 | human | NLRP3 | Q96P20 | S806 | KLVELDLsDNALGDF | LRR_6 |
CSNK1A1 | P48729 | human | CREB1 | P16220 | S100 | EsEDsQEsVDsVtDs | pKID |
CSNK1A1 | P48729 | human | MYC | P01106 | S267 | PPTtssDsEEEQEDE | Myc_N |
CSNK1A1 | P48729 | human | CTNNB1 | P35222 | S45 | GATtTAPsLsGkGNP | |
CSNK1A1 | P48729 | human | SLC4A1 | P02730 | T42 | AAHDtEAtAtDyHtt | |
CSNK1A1 | P48729 | human | RHOB | P62745 | S185 | ALQkRYGsQNGCINC | |
CSNK1A1 | P48729 | human | TUT1 | Q9H6E5 | S6 | __MAAVDsDVEsLPr | |
CSNK1A1 | P48729 | human | ERG | P11308 | S39 | EMTASsssDyGQTsK | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | T25 | IPSEDDGtVLLSTVT | TDP43_N |
CSNK1A1 | P48729 | human | LRP6 | O75581 | S1490 | AILNPPPsPAtERsH | |
CSNK1A1 | P48729 | human | YWHAZ | P63104 | T232 | LTLWtsDtQGDEAEA | |
CSNK1A1 | P48729 | human | GJA1 | P17302 | S325 | NRMGQAGstIsNsHA | Connexin43 |
CSNK1A1 | P48729 | human | DEPTOR | Q8TB45 | T149 | kLMsPENtLLQPREE | DEP |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S2 | ______MsEyIRVtE | |
CSNK1A1 | P48729 | human | ZRANB1 | Q9UGI0 | S209 | RWRGsCssGNsQRRS | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S409 | GssMDskssGWGM__ | |
CSNK1A1 | P48729 | human | EIF6 | P56537 | S175 | EDQDELssLLQVPLV | eIF-6 |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S242 | ADDQIAQsLCGEDLI | RRM_1 |
CSNK1A1 | P48729 | human | PHLPP1 | O60346 | T1363 | HVQsVLLtPQDEFFI | PP2C |
CSNK1A1 | P48729 | human | ERG | P11308 | S37 | KTEMTASsssDyGQT | |
CSNK1A1 | P48729 | human | GJA1 | P17302 | S328 | GQAGstIsNsHAQPF | Connexin43 |
CSNK1A1 | P48729 | human | CDC25A | P30304 | S82 | GssEstDsGFCLDsP | |
CSNK1A1 | P48729 | human | ECE1 | P42892 | S36 | EDLVDsLsEGDAyPN | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S407 | GFGssMDskssGWGM | |
CSNK1A1 | P48729 | human | APC | P25054 | S1510 | sssLsALsLDEPFIQ | |
CSNK1A1 | P48729 | human | CTNND1 | O60716-3 | S268 | PQVRVGGssVDLHRF | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S254 | DLIIKGIsVHISNAE | |
CSNK1A1 | P48729 | human | OSBP2 | Q969R2 | S762 | ECSKVMHssPssPsS | Oxysterol_BP |
CSNK1A1 | P48729 | human | FOXO1 | Q12778 | S322 | PRtssNAstIsGRLs | |
CSNK1A1 | P48729 | human | SRPK2 | P78362 | S497 | SRtVsAsstGDLPkA | |
CSNK1A1 | P48729 | human | NFATC3 | Q12968 | T204 | NEAAARFtLGsPLts | |
CSNK1A1 | P48729 | human | NFAT5 | O94916 | S158 | LLDNsRMsCQDEGCG | |
CSNK1A1 | P48729 | human | APC | P25054 | S1504 | PDGFsCsssLsALsL | APC_r |
CSNK1A1 | P48729 | human | HNRNPC | P07910 | S260 | sEGGADDsAEEGDLL | |
CSNK1A1 | P48729 | human | OSBP2 | Q969R2 | S766 | VMHssPssPsSDGKQ | Oxysterol_BP |
CSNK1A1 | P48729 | human | ECE1 | P42892 | S34 | DEEDLVDsLsEGDAy | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S305 | GLGNNQGsNMGGGMN | |
CSNK1A1 | P48729 | human | MYC | P01106 | S82 | PLsPsRRsGLCsPSy | Myc_N |
CSNK1A1 | P48729 | human | BID | P55957 | S67 | DGNRsSHsRLGRIEA | BID |
CSNK1A1 | P48729 | human | FOXO4 | P98177 | S265 | PRSssNAsSVsTRLs | |
CSNK1A1 | P48729 | human | RORA | P35398 | S100 | CKGFFRRsQQSNATY | zf-C4 |
CSNK1A1 | P48729 | human | SNCA | P37840 | S87 | ktVEGAGsIAAATGF | Synuclein |
CSNK1A1 | P48729 | human | ATF1 | P18846 | S51 | SSDsIGssQKAHGIL | pKID |
CSNK1A1 | P48729 | human | SNCA | P37840 | S129 | NEAyEMPsEEGyQDy | Synuclein |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | T88 | NKRkMDEtDAssAVk | |
CSNK1A1 | P48729 | human | GJA1 | P17302 | S330 | AGstIsNsHAQPFDF | Connexin43 |
CSNK1A1 | P48729 | human | MDM4 | O15151 | S289 | DDLEDSKsLSDDTDV | |
CSNK1A1 | P48729 | human | KCNIP3 | Q9Y2W7 | S63 | APQGSDSsDSELELS | |
CSNK1A1 | P48729 | human | NR3C2 | P08235 | T800 | LPLEDQItLIQYSWM | Hormone_recep |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S410 | ssMDskssGWGM___ | |
CSNK1A1 | P48729 | human | RAPGEF2 | Q9Y4G8 | S1248 | AADsGRGsWTSCSsG | |
CSNK1A1 | P48729 | human | LGALS3 | P17931 | S6 | __MADNFsLHDALsG | |
CSNK1A1 | P48729 | human | TIAM1 | Q13009 | S329 | DVNAGEGsEFADsGI | |
CSNK1A1 | P48729 | human | NFATC3 | Q12968 | S211 | tLGsPLtsPGGsPGG | |
CSNK1A1 | P48729 | human | CTNND1 | O60716-3 | S269 | QVRVGGssVDLHRFH | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S347 | LAsQQNQsGPsGNNQ | |
CSNK1A1 | P48729 | human | CDH1 | P12830 | S844 | GsGsEAAsLSsLNsS | CADH_Y-type_LIR |
CSNK1A1 | P48729 | human | CREB1 | P16220 | S97 | TIAEsEDsQEsVDsV | |
CSNK1A1 | P48729 | human | ZRANB1 | Q9UGI0 | T35 | RAQRPSGtIItEDPF | |
CSNK1A1 | P48729 | human | AGO2 | Q9UKV8 | S834 | GsHtsGQsNGRDHQA | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S395 | AsNAGsGsGFNGGFG | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S273 | SNRQLERsGrFGGNP | |
CSNK1A1 | P48729 | human | PRKN | O60260 | S378 | AyHEGECsAVFEASG | |
CSNK1A1 | P48729 | human | LRP6 | O75581 | T1493 | NPPPsPAtERsHytM | |
CSNK1A1 | P48729 | human | CBX4 | O00257 | T437 | ARsIsTPtCLGGsPA | |
CSNK1A1 | P48729 | human | FOXO1 | Q12778 | S325 | ssNAstIsGRLsPIM | |
CSNK1A1 | P48729 | human | RAPGEF2 | Q9Y4G8 | S1244 | ASLDAADsGRGsWTS | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S403 | GFNGGFGssMDskss | |
CSNK1A1 | P48729 | human | FADD | Q13158 | S194 | QNRsGAMsPMsWNsD | |
CSNK1A1 | P48729 | human | NR3C2 | P08235 | S936 | DSMHDLVsDLLEFCF | Hormone_recep |
CSNK1A1 | P48729 | human | HNRNPC | P07910 | S253 | EtNVkMEsEGGADDs | |
CSNK1A1 | P48729 | human | DEPTOR | Q8TB45 | S287 | sMssCGssGyFsssP | |
CSNK1A1 | P48729 | human | RELA | Q04206 | S316 | FksIMkksPFsGPtD | |
CSNK1A1 | P48729 | human | CDK5 | Q00535 | S159 | GIPVRCYsAEVVTLW | Pkinase |
CSNK1A1 | P48729 | human | HSP90AA1 | P07900 | S726 | LEGDDDtsRMEEVD_ | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S375 | GsGNNSYsGsNsGAA | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S404 | FNGGFGssMDskssG | |
CSNK1A1 | P48729 | human | ATF1 | P18846 | S41 | SLsESEEsQDSSDsI | |
CSNK1A1 | P48729 | human | HSP90AA1 | P07900 | T725 | PLEGDDDtsRMEEVD | |
CSNK1A1 | P48729 | human | TP53 | P04637 | S20 | PLsQEtFsDLWkLLP | P53_TAD |
CSNK1A1 | P48729 | human | JADE1 | Q6IE81 | S20 | sDDNGsLsTTWSQNS | EPL1 |
CSNK1A1 | P48729 | human | DEPTOR | Q8TB45 | S286 | ssMssCGssGyFsss | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S91 | kMDEtDAssAVkVKR | |
CSNK1A1 | P48729 | human | NFATC3 | Q12968 | S215 | PLtsPGGsPGGCPGE | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S389 | AIGWGsAsNAGsGsG | |
CSNK1A1 | P48729 | human | OSBP2 | Q969R2 | S768 | HssPssPsSDGKQKT | Oxysterol_BP |
CSNK1A1 | P48729 | human | ATF1 | P18846 | S50 | DSSDsIGssQKAHGI | pKID |
CSNK1A1 | P48729 | human | LRP6 | O75581 | S1607 | HLYPPPPsPCTDss_ | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S292 | NQGGFGNsrGGGAGL | |
CSNK1A1 | P48729 | human | UVRAG | Q9P2Y5 | S522 | QyktPPPsyNSALAQ | |
CSNK1A1 | P48729 | human | AGO2 | Q9UKV8 | S828 | EHDsAEGsHtsGQsN | |
CSNK1A1 | P48729 | human | YBX1 | P67809 | S176 | EkNEGsEsAPEGQAQ | |
CSNK1A1 | P48729 | human | PHLPP1 | O60346 | S1359 | VPRPHVQsVLLtPQD | PP2C |
CSNK1A1 | P48729 | human | AGO2 | Q9UKV8 | S824 | LVDKEHDsAEGsHts | |
CSNK1A1 | P48729 | human | HNRNPC | P07910 | S299 | EGEDDRDsANGEDDs | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S92 | MDEtDAssAVkVKRA | |
CSNK1A1 | P48729 | human | APC | P25054 | S1505 | DGFsCsssLsALsLD | APC_r |
CSNK1A1 | P48729 | human | NFATC3 | Q12968 | S207 | AARFtLGsPLtsPGG | |
CSNK1A1 | P48729 | human | LRP6 | O75581 | T1572 | EPVPPPPtPRsQyLs | |
CSNK1A1 | P48729 | human | OSBP2 | Q969R2 | S763 | CSKVMHssPssPsSD | Oxysterol_BP |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S342 | GMMGMLAsQQNQsGP | |
CSNK1A1 | P48729 | human | EIF6 | P56537 | S174 | IEDQDELssLLQVPL | eIF-6 |
CSNK1A1 | P48729 | human | DEPTOR | Q8TB45 | S263 | RKstsFMsVsPsKEI | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S183 | kLPNskQsQDEPLRS | |
CSNK1A1 | P48729 | human | KDM1A | O60341 | S687 | HVGsTTAsRGELFLF | Amino_oxidase |
CSNK1A1 | P48729 | human | PHLPP1 | O60346 | S1381 | KGLWDsLsVEEAVEA | PP2C |
CSNK1A1 | P48729 | human | PRKN | O60260 | S101 | GCEREPQsLTRVDLs | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | Y4 | ____MsEyIRVtEDE | TDP43_N |
CSNK1A1 | P48729 | human | NFATC3 | Q12968 | T210 | FtLGsPLtsPGGsPG | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S369 | EPNQAFGsGNNSYsG | |
CSNK1A1 | P48729 | human | CDC25A | P30304 | S79 | QRMGssEstDsGFCL | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S377 | GNNSYsGsNsGAAIG | |
CSNK1A1 | P48729 | human | BHLHE40 | O14503 | S243 | GSDTDTDsGYGGESE | |
CSNK1A1 | P48729 | human | DEPTOR | Q8TB45 | S291 | CGssGyFsssPtLss | |
CSNK1A1 | P48729 | human | CREB1 | P16220 | S94 | QISTIAEsEDsQEsV | |
CSNK1A1 | P48729 | human | AGO2 | Q9UKV8 | T830 | DsAEGsHtsGQsNGR | |
CSNK1A1 | P48729 | human | TARDBP | Q13148 | S350 | QQNQsGPsGNNQNQG |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
CSNK1A1 | ID | Description | 0.00e+00 |
CSNK1A1 | GO:2000278 | regulation of DNA biosynthetic process | 4.81e-06 |
CSNK1A1 | GO:2001233 | regulation of apoptotic signaling pathway | 4.81e-06 |
CSNK1A1 | GO:0062197 | cellular response to chemical stress | 4.81e-06 |
CSNK1A1 | GO:1903320 | regulation of protein modification by small protein conjugation or removal | 4.81e-06 |
CSNK1A1 | GO:0031647 | regulation of protein stability | 4.86e-06 |
CSNK1A1 | GO:0031400 | negative regulation of protein modification process | 7.63e-06 |
CSNK1A1 | GO:0031396 | regulation of protein ubiquitination | 7.63e-06 |
CSNK1A1 | GO:0051402 | neuron apoptotic process | 8.45e-06 |
CSNK1A1 | GO:0043525 | positive regulation of neuron apoptotic process | 8.45e-06 |
CSNK1A1 | GO:1901873 | regulation of post-translational protein modification | 8.45e-06 |
CSNK1A1 | GO:0050821 | protein stabilization | 9.82e-06 |
CSNK1A1 | GO:0034599 | cellular response to oxidative stress | 3.58e-05 |
CSNK1A1 | GO:0009895 | negative regulation of catabolic process | 4.21e-05 |
CSNK1A1 | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 4.21e-05 |
CSNK1A1 | GO:0071897 | DNA biosynthetic process | 4.21e-05 |
CSNK1A1 | GO:0010506 | regulation of autophagy | 4.21e-05 |
CSNK1A1 | GO:1990000 | amyloid fibril formation | 4.21e-05 |
CSNK1A1 | GO:0042176 | regulation of protein catabolic process | 4.74e-05 |
CSNK1A1 | GO:0051972 | regulation of telomerase activity | 6.01e-05 |
CSNK1A1 | GO:0050767 | regulation of neurogenesis | 8.00e-05 |
CSNK1A1 | GO:0007249 | canonical NF-kappaB signal transduction | 8.00e-05 |
CSNK1A1 | GO:0016049 | cell growth | 8.00e-05 |
CSNK1A1 | GO:0031331 | positive regulation of cellular catabolic process | 8.00e-05 |
CSNK1A1 | GO:0006979 | response to oxidative stress | 8.40e-05 |
CSNK1A1 | GO:0043523 | regulation of neuron apoptotic process | 1.05e-04 |
CSNK1A1 | GO:0071214 | cellular response to abiotic stimulus | 1.52e-04 |
CSNK1A1 | GO:0104004 | cellular response to environmental stimulus | 1.52e-04 |
CSNK1A1 | GO:0000082 | G1/S transition of mitotic cell cycle | 1.74e-04 |
CSNK1A1 | GO:1990138 | neuron projection extension | 1.97e-04 |
CSNK1A1 | GO:1990778 | protein localization to cell periphery | 2.15e-04 |
CSNK1A1 | GO:0006109 | regulation of carbohydrate metabolic process | 2.49e-04 |
CSNK1A1 | GO:0051960 | regulation of nervous system development | 2.49e-04 |
CSNK1A1 | GO:0007004 | telomere maintenance via telomerase | 2.60e-04 |
CSNK1A1 | GO:2000573 | positive regulation of DNA biosynthetic process | 2.60e-04 |
CSNK1A1 | GO:1903829 | positive regulation of protein localization | 2.75e-04 |
CSNK1A1 | GO:0044843 | cell cycle G1/S phase transition | 2.81e-04 |
CSNK1A1 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 2.81e-04 |
CSNK1A1 | GO:0031334 | positive regulation of protein-containing complex assembly | 2.93e-04 |
CSNK1A1 | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 3.02e-04 |
CSNK1A1 | GO:0051973 | positive regulation of telomerase activity | 3.18e-04 |
CSNK1A1 | GO:0006278 | RNA-templated DNA biosynthetic process | 3.26e-04 |
CSNK1A1 | GO:0072659 | protein localization to plasma membrane | 3.29e-04 |
CSNK1A1 | GO:1902253 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 3.33e-04 |
CSNK1A1 | GO:0042098 | T cell proliferation | 4.08e-04 |
CSNK1A1 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 4.19e-04 |
CSNK1A1 | GO:0010833 | telomere maintenance via telomere lengthening | 4.24e-04 |
CSNK1A1 | GO:0051090 | regulation of DNA-binding transcription factor activity | 4.28e-04 |
CSNK1A1 | GO:0046651 | lymphocyte proliferation | 4.36e-04 |
CSNK1A1 | GO:0032943 | mononuclear cell proliferation | 4.79e-04 |
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Related Drugs to CSNK1A1_RDX |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning CSNK1A1-RDX and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CSNK1A1_RDX |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |