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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CTNNB1_CHEK1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CTNNB1_CHEK1
KinaseFusionDB ID: KFG1560
FusionGDB2.0 ID: KFG1560
HgeneTgene
Gene symbol

CTNNB1

CHEK1

Gene ID

1499

1111

Gene namecatenin beta 1checkpoint kinase 1
SynonymsCTNNB|EVR7|MRD19|NEDSDV|armadilloCHK1|OZEMA21
Cytomap

3p22.1

11q24.2

Type of geneprotein-codingprotein-coding
Descriptioncatenin beta-1catenin (cadherin-associated protein), beta 1, 88kDaserine/threonine-protein kinase Chk1CHK1 checkpoint homologCheckpoint, S. pombe, homolog of, 1Chk1-Scell cycle checkpoint kinase
Modification date2024041620240411
UniProtAcc

P35222

O14757

Ensembl transtripts involved in fusion geneENST idsENST00000349496, ENST00000396183, 
ENST00000396185, ENST00000453024, 
ENST00000405570, ENST00000471014, 
ENST00000532449, ENST00000278916, 
ENST00000427383, ENST00000428830, 
ENST00000438015, ENST00000524737, 
ENST00000534070, ENST00000544373, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CTNNB1 [Title/Abstract] AND CHEK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CTNNB1(41241161)-CHEK1(125496643), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNB1

GO:0000209

protein polyubiquitination

29374064

HgeneCTNNB1

GO:0008285

negative regulation of cell population proliferation

12970740

HgeneCTNNB1

GO:0030997

regulation of centriole-centriole cohesion

18086858

HgeneCTNNB1

GO:0032355

response to estradiol

15304487

HgeneCTNNB1

GO:0033234

negative regulation of protein sumoylation

22155184

HgeneCTNNB1

GO:0043065

positive regulation of apoptotic process

12651860|12970740

HgeneCTNNB1

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

29374064

HgeneCTNNB1

GO:0043525

positive regulation of neuron apoptotic process

19591802

HgeneCTNNB1

GO:0045893

positive regulation of DNA-templated transcription

12970740|18787224

HgeneCTNNB1

GO:0045944

positive regulation of transcription by RNA polymerase II

9065402|11751639|12651860|14660579|18193033

HgeneCTNNB1

GO:0060070

canonical Wnt signaling pathway

10644691|11751639|12937339|19187541

HgeneCTNNB1

GO:0071681

cellular response to indole-3-methanol

10868478

HgeneCTNNB1

GO:0090279

regulation of calcium ion import

19996314

HgeneCTNNB1

GO:2000008

regulation of protein localization to cell surface

19996314

TgeneCHEK1

GO:0000077

DNA damage checkpoint signaling

16963448

TgeneCHEK1

GO:0006468

protein phosphorylation

33108758

TgeneCHEK1

GO:0006915

apoptotic process

23028632

TgeneCHEK1

GO:0010569

regulation of double-strand break repair via homologous recombination

15665856

TgeneCHEK1

GO:0018107

peptidyl-threonine phosphorylation

15665856

TgeneCHEK1

GO:0042770

signal transduction in response to DNA damage

16963448

TgeneCHEK1

GO:0044818

mitotic G2/M transition checkpoint

9278511

TgeneCHEK1

GO:0045787

positive regulation of cell cycle

26296656

TgeneCHEK1

GO:0045839

negative regulation of mitotic nuclear division

15311285

TgeneCHEK1

GO:0046602

regulation of mitotic centrosome separation

15311285


check buttonKinase Fusion gene breakpoints across CTNNB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across CHEK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-L5-A4OWCTNNB1chr3

41241161

CHEK1chr11

125496643



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:41241161/:125496643)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNNB1

P35222

CHEK1

O14757

FUNCTION: Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938}.FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047, PubMed:32357935). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889, PubMed:14559997). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:9278511, PubMed:19734889, PubMed:20090422). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of CTNNB1_CHEK1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CHEK1O14757humanSRCP12931S51AdGHRGPsAAFAPAA
CHEK1O14757humanCTR9Q6PD62S1081RRPRRQRsDQDsDsD
CHEK1O14757humanLAMC1P11047T258VTLNRLNtFGDEVFNLaminin_N
CHEK1O14757humanDDX19AQ9NUU7S92sPLYSVksFEELRLK
CHEK1O14757humanHNRNPA2B1P22626T159krGFGFVtFDDHDPVRRM_1
CHEK1O14757humanRPL19P84098T56LIIRkPVtVHsRARCRibosomal_L19e
CHEK1O14757humanYBX1P67809T80GFINRNDtkEDVFVHCSD
CHEK1O14757humanTICRRQ7Z2Z1T1898RPIsRTYtRKKLMGT
CHEK1O14757humanBAZ1AQ9NRL2S1320RSLRkINsAPPtETk
CHEK1O14757humanBLMP54132S539DQNkHtAsINDLEREBDHCT_assoc
CHEK1O14757humanE2F3O00716S124PALGrGGsGGGGGPP
CHEK1O14757humanCHEK1O14757S296GFskHIQsNLDFsPV
CHEK1O14757humanTRIP12Q14669S1078SGLARAAskDTISNN
CHEK1O14757humanTLK1Q9UKI8S743PHMRRsNssGNLHMA
CHEK1O14757humanCLK3P49761S157HHCKRyRsPEPDPyL
CHEK1O14757humanEPRS1P07814S910VLFDkVAsQGEVVRKWHEP-TRS
CHEK1O14757humanSETMARQ53H47S508LYDNRRRsAQWLDQETransposase_1
CHEK1O14757humanPRR5P85299S240RLLRRsRsGDVLAkN
CHEK1O14757humanE2F6O75461S52EDNVQyVsMRKALKV
CHEK1O14757humanTP53P04637S37NVLsPLPsQAMDDLMTAD2
CHEK1O14757humanTP73O15350S47EVVGGTDssMDVFHL
CHEK1O14757humanGTF3C1Q12789S667VRLVRNLsEEGLLRL
CHEK1O14757humanRBM26Q5T8P6T839TELRRkytELQLEAA
CHEK1O14757humanYBX3P16989T112GFINRNDtkEDVFVHCSD
CHEK1O14757humanINF2Q27J81S574LNWQkLPsNVAREHNFH2
CHEK1O14757humanTICRRQ7Z2Z1S1045RsVQRVHsFQQDKsD
CHEK1O14757humanCHEK1O14757T382KRMtRFFtkLDADks
CHEK1O14757humanSRCP12931Y530FTstEPQyQPGENL_
CHEK1O14757humanCDC25AP30304S76SNLQRMGssEstDsG
CHEK1O14757humanMKI67P46013T1764RsLRkADtEEEFLAFKI67R
CHEK1O14757humanTFDP1Q14186S23VFIDQNLsPGkGVVS
CHEK1O14757humanERRFI1Q9UJM3S302KPDYRRWsAEVTSST
CHEK1O14757humanFANCD2Q9BXW9S331KSKGRASsSGNQESSFancD2
CHEK1O14757humanRALYQ9UKM9T160PLVrRVktNVPVkLF
CHEK1O14757humanTP53BP1Q12888S1678ItsEEERsPAKRGRK
CHEK1O14757humanZNF638Q14966S375GsKkNYQsQADIPIr
CHEK1O14757humanSCAF11Q99590S1127QQsYkRksEQEFsFD
CHEK1O14757humanSRRM2Q9UQ35S2280PrTAVAPsAVNLADP
CHEK1O14757humanRELAQ04206T505EAITRLVtGAQRPPD
CHEK1O14757humanCHD7Q9P2D1T1227AILEKNFtFLSKGGGSNF2-rel_dom
CHEK1O14757humanGOLGA4Q13439S71KLQLRVPsVEsLFRs
CHEK1O14757humanADD3Q9UEY8S693KKKFRtPsFLKKNKK
CHEK1O14757humanKIFC1Q9BW19S26RPLIkAPsQLPLsGs
CHEK1O14757humanSEPTIN7Q16181T228kIyEFPEtDDEEENkSeptin
CHEK1O14757humanMATR3P43243S195sFDDrGPsLNPVLDy
CHEK1O14757humanCDC25AP30304S124PALkRSHsDsLDHDIM-inducer_phosp
CHEK1O14757humanSRRM2Q9UQ35T2252ArtPAIPtAVNLADS
CHEK1O14757humanMCM5P33992T633MkLQPFAtEADVEEAMCM_lid
CHEK1O14757humanSPENQ96T58T1059IKLDRLNtVAsPKDC
CHEK1O14757humanLATS2Q9NRM7S835GSHVRQDsMEPSDLWPkinase
CHEK1O14757humanRAD51Q06609T309LRKGRGEtRICKIyDRad51
CHEK1O14757humanRIF1Q5UIP0S2205VNkVRRVsFADPIyQ
CHEK1O14757humanAURKBQ96GD4S331HPWVRANsRRVLPPS
CHEK1O14757humanCWC25Q9NXE8S337PGYTRKLsAEELERK
CHEK1O14757humanRBM14Q96PK6S627sQLsFRRsPtKssLD
CHEK1O14757humanIDI1Q13907S55GLLHRAFsVFLFNTENUDIX
CHEK1O14757humanCHEK1O14757T378QRLVKRMtRFFtkLD
CHEK1O14757humanCAAP1Q9H8G2S203EGDNGMDsDMEEEAD
CHEK1O14757humanTLK1Q9UKI8S679KPFGHNQsQQDILQEPkinase
CHEK1O14757humanPRRC2CQ9Y520S661QPRPAVLsGyFkQFQ
CHEK1O14757humanTICRRQ7Z2Z1S865NALIRHksIAEVSQNTreslin_N
CHEK1O14757humanRASSF1Q9NS23-2T38ALRIARGtACNPtRQ
CHEK1O14757humanPHF2O75151S929REGtRVAsIETGLAA
CHEK1O14757humanSNCBQ16143Y127EDPPQEEyQEYEPEA
CHEK1O14757humanEXO1Q9UQ84S746PGLYkSSsADsLStT
CHEK1O14757humanPLK1P53350T210YDGERKktLCGtPNyPkinase
CHEK1O14757humanHNRNPMP52272S432HGMDrVGsEIERMGL
CHEK1O14757humanMED1Q15648T704PEKPKHQtEDDFQRE
CHEK1O14757humanCCDC6Q16204S244QPVsAPPsPRDIsMEDUF2046
CHEK1O14757humanTP53P04637T387HkkLMFktEGPDsD_
CHEK1O14757humanTICRRQ7Z2Z1S1115KsHQKsLsFskttPR
CHEK1O14757humanYBX2Q9Y2T7T115GFINRNDtkEDVFVHCSD
CHEK1O14757humanWIZO95785S1129sLEARsPsDLHIsPL
CHEK1O14757humanZC3HC1Q86WB0T84AFFSRVEtFSsLkWAzf-C3HC
CHEK1O14757humanHCKP08631Y411RVIEDNEytAREGAkPK_Tyr_Ser-Thr
CHEK1O14757humanTP53P04637T18EPPLsQEtFsDLWkLP53_TAD
CHEK1O14757humanASF1AQ9Y294S166kLEDAEssNPNLQsL
CHEK1O14757humanCDC25AP30304S178LFTQRQNsAPARMLsM-inducer_phosp
CHEK1O14757humanRASSF1Q9NS23-2T43RGtACNPtRQLVPGR
CHEK1O14757humanNUP153P49790S297QMkAkQLsAQSyGVTNup153
CHEK1O14757humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
CHEK1O14757humanLATS2Q9NRM7S408PVPSRTNsFNSHQPR
CHEK1O14757humanSLTMQ9NWH9S748WsENKkLsLDtDARF
CHEK1O14757humanOGTO15294S20EPTkRMLsFQGLAEL
CHEK1O14757humanNEK11Q8NG66S273SMLNKNPsLRPSAIEPkinase
CHEK1O14757humanRBM28Q9NW13S122RLIIRNLsFKCSEDDRRM_1
CHEK1O14757humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
CHEK1O14757humanBLMP54132T182sHFVRVStAQKSKKGBLM_N
CHEK1O14757humanSSBP1Q04837S67ATNEMWRsGDsEVyQSSB
CHEK1O14757humanMDC1Q14676T523sTtVDINtQVEKEVP
CHEK1O14757humanKPNA2P52292S54MLkRRNVssFPDDAtIBB
CHEK1O14757humanMCM3P25205S160KtIERRysDLttLVAMCM_OB
CHEK1O14757humanSRRM2Q9UQ35S1499tPRPRsRsPssPELN
CHEK1O14757humanCHEK1O14757S316EENVkYsssQPEPRT
CHEK1O14757humanPOP4O95707S10SVIyHALsQkEANDs
CHEK1O14757humanADD2P35612S713KKKFRtPsFLKKsKK
CHEK1O14757humanRAVER1Q8IY67-2S700PLGGQkRsFAHLLPs
CHEK1O14757humanADD1P35611S726KKKFRtPsFLKKsKK
CHEK1O14757humanANKRD12Q6UB98-2S76SRNEERDsDTEKEGP
CHEK1O14757humanERRFI1Q9UJM3S251RRLRRsHsGPAGsFN
CHEK1O14757humanZNF395Q9H8N7S447LSPVRSRsLsFSEPQ
CHEK1O14757humanXRCC6P12956S477RFTYrsDsFENPVLQKu_C
CHEK1O14757humanMAD2L1Q13257S185sEEVRLRsFtTTIHkHORMA
CHEK1O14757humanSTK4Q13043T340AVGDEMGtVRVASTM
CHEK1O14757humanMYCBP2O75592S3478TVFQRsYsVVASEYD
CHEK1O14757humanRPL19P84098S12rLQKrLAssVLRCGKRibosomal_L19e
CHEK1O14757humanBUD13Q9BRD0S18EYLKRYLsGADAGVD
CHEK1O14757humanTBC1D4O60343S588RMRGRLGsVDsFERs
CHEK1O14757humanMAP2K2P36507T59KRLEAFLtQkAkVGE
CHEK1O14757humanFAM122AQ96E09S37GGLRRsNsAPLIHGL
CHEK1O14757humanTP53P04637S378skkGQstsRHkkLMF
CHEK1O14757humanMAD2L1Q13257T187EVRLRsFtTTIHkVNHORMA
CHEK1O14757humanE2F6O75461S12RPARkLPsLLLDPTE
CHEK1O14757humanCCDC6Q16204S240EkLDQPVsAPPsPRDDUF2046
CHEK1O14757humanDDX24Q9GZR7S82KRKAQAVsEEEEEEE
CHEK1O14757humanMAP4P27816T521MALGKDVtPPPEtEV
CHEK1O14757humanCTTNQ14247S298EKLAkHEsQQDyskGHS1_rep
CHEK1O14757humanRBM42Q9BTD8S406RAFSRFPsFLKAKVIRRM_1
CHEK1O14757humanRBM14Q96PK6S618LsDyrRLsEsQLsFR
CHEK1O14757humanFEN1P39748T195PVLMrHLtAsEAkkLXPG_I
CHEK1O14757humanEBNA1BP2Q99848T182kYGKkVQtEVLQkRQEbp2
CHEK1O14757humanTRIM28Q13263S473sGVkRsRsGEGEVsG
CHEK1O14757humanCHEK1O14757S291sEsPsGFskHIQsNL
CHEK1O14757humanRANBP2P49792T1098QTIGPrNtFNFGsKN
CHEK1O14757humanMATR3P43243T150LQLkRRRtEEGPtLs
CHEK1O14757humanMYBBP1AQ9BQG0S1310sLVIRsPsLLQsGAk
CHEK1O14757humanSENP2Q9HC62S344GLLRRKVsIIEtKEK
CHEK1O14757humanBLMP54132S646LKHERFQsLSFPHTkBDHCT_assoc
CHEK1O14757humanCAMSAP2Q08AD1S464RGITRsIsNEGLtLN
CHEK1O14757humanCHTOPQ9Y3Y2T212ALArPVLtkEQLDNQFoP_duplication
CHEK1O14757humanCDC25BP30305S563tFRLKTRsWAGERSR
CHEK1O14757humanPRRC2BQ5JSZ5S166RGSSrLLsFsPEEFPBAT2_N
CHEK1O14757humanRBM14Q96PK6T629LsFRRsPtKssLDyR
CHEK1O14757humanLMNAP02545S307DsLsAQLsQLQkQLAFilament
CHEK1O14757humanH3C1P68431T11kQtArkstGGkAPrkHistone
CHEK1O14757humanMDM4O15151S342SkLTHSLsTSDITAI
CHEK1O14757humanZBTB11O95625S537KRKAVPKsAVQQVAQ
CHEK1O14757humanPHF8Q9UPP1S904REGtRVAsIEtGLAA
CHEK1O14757humanRACGAP1Q9H0H5S203GPVkKTRsIGsAVDQ
CHEK1O14757humanDDX19BQ9UMR2S93sPLYSVksFEELRLK
CHEK1O14757humanTLK2Q86UE8S686KPFGHNQsQQDILQEPkinase
CHEK1O14757humanARHGEF2Q92974S172LGLRRILsQstDsLN
CHEK1O14757humanPPME1Q9Y570S15MHLGRLPsrPPLPGs
CHEK1O14757humanH3-3AP84243S31AARksAPsTGGVkkPHistone
CHEK1O14757humanMATR3P43243S4____MsksFQQssLs
CHEK1O14757humanMAP4P27816T925PRLSRLAtNtsAPDL
CHEK1O14757humanING1Q9UK53-2S126LGDTAGNsGKAGADR
CHEK1O14757humanPRPF3O43395S161EERKkQLsFIsPPtP
CHEK1O14757humanTBC1D4O60343S485LVIQRHLssLtDNEQ
CHEK1O14757humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
CHEK1O14757humanHDLBPQ00341T8MSSVAVLtQEsFAEH
CHEK1O14757humanPROSER2Q86WR7S43SSSSRsRsFtLDDEs
CHEK1O14757humanCDK13Q14004S437RsRsRHssIsPstLT
CHEK1O14757humanNHSQ6T4R5T401RKLRRRKtIsGIPRR
CHEK1O14757humanRRP12Q5JTH9S1049AKRHRALsQAAVEEE
CHEK1O14757humanCLSPNQ9HAW4T916DELLDLCtGKFTsQA
CHEK1O14757humanPPP2R5DQ14738S60PsSNKRPsNstPPPt
CHEK1O14757humanDRG2P55039S72VALIGFPsVGKSTFLMMR_HSR1
CHEK1O14757humanPLRG1O43660S119TkIQRMPsEsAAQsL
CHEK1O14757humanHIVEP1P15822S1749ASSKRMLsPANsLDI
CHEK1O14757humanSRRM2Q9UQ35S2388tsPrVPLsAyErVsG
CHEK1O14757humanRASSF1Q9NS23-2S184PssKKPPsLQDARRG
CHEK1O14757humanNCBP3Q53F19S100AkRFHFRsEVNLAQR
CHEK1O14757humanZBTB11O95625S511RSRLRQRsVNEGAyI
CHEK1O14757humanCDC25AP30304T507KFRTKSRtWAGEKsK
CHEK1O14757humanFANCEQ9HB96T346LGLLRLCtWLLALSPFA_FANCE
CHEK1O14757humanSRCP12931Y419RLIEDNEytARQGAkPK_Tyr_Ser-Thr
CHEK1O14757humanFYTTD1Q96QD9T205KVQAQLNtEQLLDDVFYTT
CHEK1O14757humanCDK1P06493S208kPLFHGDsEIDQLFRPkinase
CHEK1O14757humanPLK1P53350S137LELCRRRsLLELHkRPkinase
CHEK1O14757humanPOLDIP3Q9BY77S63ARQKIGLsDArLKLG
CHEK1O14757humanBLMP54132S502HLQksFVsSNWAEtPBDHCT_assoc
CHEK1O14757humanRPL13P26373T170KEKARVItEEEkNFkRibosomal_L13e
CHEK1O14757humanLIG1P18858S76EEEDEALsPAkGQKP
CHEK1O14757humanCSNK2BP67870T213NFksPVktIR_____
CHEK1O14757humanSYKP43405S295GIISRIKsysFPKPG
CHEK1O14757humanKPNA1P52294S18LKsYKNKsLNPDEMRIBB
CHEK1O14757humanMINK1Q8N4C8T280TYLSRPPtEQLLKFPPkinase
CHEK1O14757humanCDC25CP30307S216sGLyRsPsMPENLNRM-inducer_phosp
CHEK1O14757humanSLTMQ9NWH9S815TARREDPsFERYPKN
CHEK1O14757humanMAP2K1Q02750T55KRLEAFLtQkQKVGE
CHEK1O14757humanTICRRQ7Z2Z1S1894FSRRRPIsRTYtRKK
CHEK1O14757humanRB1P06400S612MyLsPVRsPKKKGsT
CHEK1O14757humanNFKB1P19838S328INItkPAsVFVQLRRRHD_dimer
CHEK1O14757humanOSBPL11Q9BXB4S189PIsQRRPsQNAIsFF
CHEK1O14757humanFANCEQ9HB96S374LFLGRILsLTSSASRFA_FANCE
CHEK1O14757humanUIMC1Q96RL1S627HSEGRLLsFLEQsEH
CHEK1O14757humanCDC25AP30304S279VLKRPErsQEEsPPGM-inducer_phosp
CHEK1O14757humanCDC25AP30304S293GSTKrRKsMsGASPkM-inducer_phosp
CHEK1O14757humanSIN3AQ96ST3T434IRRHPtGttPPVKKK
CHEK1O14757humanSRRM2Q9UQ35S1497PQtPRPRsRsPssPE
CHEK1O14757humanCDC25BP30305S230AFAQRPssAPDLMCLM-inducer_phosp
CHEK1O14757humanNUP153P49790S330ADAkRIPsIVssPLNNup153
CHEK1O14757humanTNK1Q13470S502RMKGIsRsLEsVLsL
CHEK1O14757humanEML3Q32P44S176KLSRkAIssANLLVR
CHEK1O14757humanCEP170BQ9Y4F5S655QGLPVPGsPGGQKWV
CHEK1O14757humanLMO7Q8WWI1S1510GIMRRGEsLDNLDsP
CHEK1O14757humanMDM4O15151S367PDCRRtIsAPVVRPk


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CHEK1IDDescription0.00e+00
CHEK1GO:1901987regulation of cell cycle phase transition6.89e-10
CHEK1GO:0006913nucleocytoplasmic transport6.89e-10
CHEK1GO:0051169nuclear transport6.89e-10
CHEK1GO:0044772mitotic cell cycle phase transition7.47e-10
CHEK1GO:0000075cell cycle checkpoint signaling7.47e-10
CHEK1GO:0031570DNA integrity checkpoint signaling8.32e-10
CHEK1GO:0044774mitotic DNA integrity checkpoint signaling9.17e-10
CHEK1GO:0007093mitotic cell cycle checkpoint signaling1.25e-09
CHEK1GO:1902749regulation of cell cycle G2/M phase transition1.29e-09
CHEK1GO:0044839cell cycle G2/M phase transition3.07e-09
CHEK1GO:0000077DNA damage checkpoint signaling3.07e-09
CHEK1GO:0040029epigenetic regulation of gene expression4.31e-09
CHEK1GO:0010389regulation of G2/M transition of mitotic cell cycle4.31e-09
CHEK1GO:0034504protein localization to nucleus4.52e-09
CHEK1GO:0044773mitotic DNA damage checkpoint signaling5.63e-09
CHEK1GO:1901988negative regulation of cell cycle phase transition6.14e-09
CHEK1GO:0010948negative regulation of cell cycle process6.28e-09
CHEK1GO:0000086G2/M transition of mitotic cell cycle7.21e-09
CHEK1GO:0045814negative regulation of gene expressio1.28e-10
CHEK1GO:1901990regulation of mitotic cell cycle phase transition2.76e-08
CHEK1GO:0045786negative regulation of cell cycle3.26e-08
CHEK1GO:0006606protein import into nucleus3.27e-08
CHEK1GO:0010639negative regulation of organelle organization3.46e-08
CHEK1GO:0006260DNA replication3.92e-08
CHEK1GO:0051170import into nucleus4.24e-08
CHEK1GO:0045930negative regulation of mitotic cell cycle6.66e-08
CHEK1GO:0031507heterochromatin formation1.59e-07
CHEK1GO:1902275regulation of chromatin organization2.72e-07
CHEK1GO:0006261DNA-templated DNA replication3.10e-07
CHEK1GO:0070828heterochromatin organization3.66e-07
CHEK1GO:0007095mitotic G2 DNA damage checkpoint signaling8.33e-07
CHEK1GO:0090068positive regulation of cell cycle process1.01e-06
CHEK1GO:0050657nucleic acid transport2.47e-06
CHEK1GO:0050658RNA transport2.47e-06
CHEK1GO:0045787positive regulation of cell cycle2.75e-06
CHEK1GO:0010972negative regulation of G2/M transition of mitotic cell cycle2.75e-06
CHEK1GO:0051236establishment of RNA localization2.76e-06
CHEK1GO:0051028mRNA transport2.95e-06
CHEK1GO:1902750negative regulation of cell cycle G2/M phase transition3.61e-06
CHEK1GO:0044818mitotic G2/M transition checkpoint8.79e-06
CHEK1GO:0032200telomere organization1.15e-05
CHEK1GO:1901991negative regulation of mitotic cell cycle phase transition1.80e-05
CHEK1GO:0006403RNA localization1.86e-05
CHEK1GO:0033044regulation of chromosome organization2.33e-05
CHEK1GO:0006268DNA unwinding involved in DNA replication2.33e-05
CHEK1GO:0006275regulation of DNA replication2.36e-05
CHEK1GO:0006405RNA export from nucleus2.57e-05
CHEK1GO:0033260nuclear DNA replication2.71e-05
CHEK1GO:0006302double-strand break repair3.27e-05

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Related Drugs to CTNNB1_CHEK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CTNNB1-CHEK1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CTNNB1_CHEK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate