| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:DAPK1_ARL6IP5 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: DAPK1_ARL6IP5 | KinaseFusionDB ID: KFG1592 | FusionGDB2.0 ID: KFG1592 | Hgene | Tgene | Gene symbol | DAPK1 | ARL6IP5 | Gene ID | 1612 | 10550 | |
| Gene name | death associated protein kinase 1 | ADP ribosylation factor like GTPase 6 interacting protein 5 | ||||||||||
| Synonyms | DAPK|ROCO3 | DERP11|GTRAP3-18|HSPC127|JWA|PRAF3|Yip6b|addicsin|hp22|jmx | ||||||||||
| Cytomap | 9q21.33 | 3p14.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | death-associated protein kinase 1DAP kinase 1 | PRA1 family protein 3ADP-ribosylation factor GTPase 6 interacting protein 5ADP-ribosylation factor-like 6 interacting protein 5ADP-ribosylation factor-like protein 6-interacting protein 5ADP-ribosylation-like factor 6 interacting protein 5ARL-6-inter | ||||||||||
| Modification date | 20240407 | 20240407 | ||||||||||
| UniProtAcc | P53355 | O75915 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000358077, ENST00000408954, ENST00000466188, ENST00000469640, ENST00000472284, ENST00000491893, | ENST00000273258, ENST00000478935, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DAPK1 [Title/Abstract] AND ARL6IP5 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DAPK1(90149183)-ARL6IP5(69155217), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DAPK1 | GO:0002834 | regulation of response to tumor cell | 11573098 |
| Hgene | DAPK1 | GO:0006468 | protein phosphorylation | 10629061 |
| Hgene | DAPK1 | GO:0017148 | negative regulation of translation | 18995835 |
| Hgene | DAPK1 | GO:0035556 | intracellular signal transduction | 10629061 |
| Hgene | DAPK1 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 16132846 |
| Hgene | DAPK1 | GO:0046777 | protein autophosphorylation | 10629061|12730201 |
| Hgene | DAPK1 | GO:0071346 | cellular response to type II interferon | 18995835 |
| Tgene | ARL6IP5 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 18387645 |
| Tgene | ARL6IP5 | GO:0015031 | protein transport | 18167356 |
| Tgene | ARL6IP5 | GO:0071407 | cellular response to organic cyclic compound | 12562531 |
| Kinase Fusion gene breakpoints across DAPK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across ARL6IP5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AI051167 | DAPK1 | chr9 | 90149183 | ARL6IP5 | chr3 | 69155217 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:90149183/:69155217) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DAPK1 | ARL6IP5 |
| FUNCTION: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.; FUNCTION: Isoform 2 cannot induce apoptosis but can induce membrane blebbing. | FUNCTION: Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8R5J9, ECO:0000250|UniProtKB:Q9ES40}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of DAPK1_ARL6IP5 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| DAPK1 | P53355 | human | RIGI | O95786 | S654 | IEGNPkLsFLkPGIL | Helicase_C |
| DAPK1 | P53355 | human | CAMKK2 | Q96RR4 | S511 | RREERsLsAPGNLLT | |
| DAPK1 | P53355 | human | HSF1 | Q00613 | S230 | PkYSRQFsLEHVHGS | |
| DAPK1 | P53355 | human | TP53 | P04637 | T18 | EPPLsQEtFsDLWkL | P53_TAD |
| DAPK1 | P53355 | human | PIN1 | Q13526 | S71 | HsQSRRPssWRQEKI | Rotamase |
| DAPK1 | P53355 | human | DAPK1 | P53355 | S289 | QALSRKAsAVNMEkF | |
| DAPK1 | P53355 | human | RIGI | O95786 | T671 | RGktNQNtGMtLPAQ | Helicase_C |
| DAPK1 | P53355 | human | TP53 | P04637 | S269 | GNLLGRNsFEVRVCA | P53 |
| DAPK1 | P53355 | human | TPM1 | P09493 | S283 | HALNDMtsI______ | Tropomyosin |
| DAPK1 | P53355 | human | GRIN2B | Q13224 | S1303 | NKLRRQHsyDtFVDL | NMDAR2_C |
| DAPK1 | P53355 | human | RIGI | O95786 | S764 | kEkMMNDsILRLQtW | |
| DAPK1 | P53355 | human | DAPK1 | P53355 | S308 | ARKKWkQsVRLISLC | |
| DAPK1 | P53355 | human | RIGI | O95786 | T770 | DsILRLQtWDEAVFR | |
| DAPK1 | P53355 | human | RPL13A | P40429 | S77 | PYHFrAPsRIFWRTV | Ribosomal_L13 |
| DAPK1 | P53355 | human | MYL12B | O14950 | S20 | KRPQRAtsNVFAMFD | |
| DAPK1 | P53355 | human | RIGI | O95786 | S8 | MTTEQRRsLQAFQDY | CARD_2 |
| DAPK1 | P53355 | human | BECN1 | Q14457 | T119 | LSRRLkVtGDLFDIM | BH3 |
| DAPK1 | P53355 | human | TP53 | P04637 | S20 | PLsQEtFsDLWkLLP | P53_TAD |
| DAPK1 | P53355 | human | RIGI | O95786 | T674 | tNQNtGMtLPAQkCI | Helicase_C |
| DAPK1 | P53355 | human | MYL9 | P24844 | S20 | KRPQRAtsNVFAMFD | |
| DAPK1 | P53355 | human | MCM3 | P25205 | S160 | KtIERRysDLttLVA | MCM_OB |
| DAPK1 | P53355 | human | PELI1 | Q96FA3 | S39 | GDRGRRKsRFALFKR | Pellino |
| DAPK1 | P53355 | human | RIGI | O95786 | T667 | ILTGRGktNQNtGMt | Helicase_C |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| DAPK1 | ID | Description | 0.00e+00 |
| DAPK1 | GO:0034599 | cellular response to oxidative stress | 1.47e-05 |
| DAPK1 | GO:0062197 | cellular response to chemical stress | 2.68e-05 |
| DAPK1 | GO:0006979 | response to oxidative stress | 7.07e-05 |
| DAPK1 | GO:0034614 | cellular response to reactive oxygen species | 9.35e-04 |
| DAPK1 | GO:0000302 | response to reactive oxygen species | 2.32e-03 |
| DAPK1 | GO:0000422 | autophagy of mitochondrion | 6.28e-03 |
| DAPK1 | GO:0061726 | mitochondrion disassembly | 6.28e-03 |
| DAPK1 | GO:0001666 | response to hypoxia | 6.28e-03 |
| DAPK1 | GO:0036293 | response to decreased oxygen levels | 6.93e-03 |
| DAPK1 | GO:0071346 | cellular response to type II interferon | 7.89e-03 |
| DAPK1 | GO:0070482 | response to oxygen levels | 7.89e-03 |
| DAPK1 | GO:0010506 | regulation of autophagy | 8.26e-03 |
| DAPK1 | GO:0034341 | response to type II interferon | 9.20e-03 |
| DAPK1 | GO:1903008 | organelle disassembly | 9.20e-03 |
| DAPK1 | GO:0031331 | positive regulation of cellular catabolic process | 9.20e-03 |
| DAPK1 | GO:0071280 | cellular response to copper ion | 9.20e-03 |
| DAPK1 | GO:0010508 | positive regulation of autophagy | 9.20e-03 |
| DAPK1 | GO:0071480 | cellular response to gamma radiation | 9.20e-03 |
| DAPK1 | GO:0016242 | negative regulation of macroautophagy | 1.23e-02 |
| DAPK1 | GO:0046688 | response to copper ion | 1.53e-02 |
| DAPK1 | GO:0000423 | mitophagy | 1.53e-02 |
| DAPK1 | GO:0022411 | cellular component disassembly | 1.53e-02 |
| DAPK1 | GO:0062098 | regulation of programmed necrotic cell death | 1.53e-02 |
| DAPK1 | GO:1903146 | regulation of autophagy of mitochondrion | 1.53e-02 |
| DAPK1 | GO:0070266 | necroptotic process | 2.04e-02 |
| DAPK1 | GO:2000378 | negative regulation of reactive oxygen species metabolic process | 2.04e-02 |
| DAPK1 | GO:0010665 | regulation of cardiac muscle cell apoptotic process | 2.04e-02 |
| DAPK1 | GO:0042149 | cellular response to glucose starvation | 2.04e-02 |
| DAPK1 | GO:0010332 | response to gamma radiation | 2.05e-02 |
| DAPK1 | GO:0010662 | regulation of striated muscle cell apoptotic process | 2.06e-02 |
| DAPK1 | GO:0010659 | cardiac muscle cell apoptotic process | 2.11e-02 |
| DAPK1 | GO:0090257 | regulation of muscle system process | 2.11e-02 |
| DAPK1 | GO:0010658 | striated muscle cell apoptotic process | 2.18e-02 |
| DAPK1 | GO:0043331 | response to dsRNA | 2.19e-02 |
| DAPK1 | GO:0097300 | programmed necrotic cell death | 2.35e-02 |
| DAPK1 | GO:0043462 | regulation of ATP-dependent activity | 2.53e-02 |
| DAPK1 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 2.53e-02 |
| DAPK1 | GO:0050435 | amyloid-beta metabolic process | 2.54e-02 |
| DAPK1 | GO:0070301 | cellular response to hydrogen peroxide | 2.63e-02 |
| DAPK1 | GO:0071479 | cellular response to ionizing radiation | 2.80e-02 |
| DAPK1 | GO:0030239 | myofibril assembly | 2.81e-02 |
| DAPK1 | GO:0055002 | striated muscle cell development | 2.90e-02 |
| DAPK1 | GO:0006302 | double-strand break repair | 2.92e-02 |
| DAPK1 | GO:0010822 | positive regulation of mitochondrion organization | 2.92e-02 |
| DAPK1 | GO:0010660 | regulation of muscle cell apoptotic process | 3.54e-02 |
| DAPK1 | GO:0034249 | negative regulation of amide metabolic process | 3.54e-02 |
| DAPK1 | GO:0097194 | execution phase of apoptosis | 3.54e-02 |
| DAPK1 | GO:0032496 | response to lipopolysaccharide | 3.54e-02 |
| DAPK1 | GO:0009895 | negative regulation of catabolic process | 3.54e-02 |
Top |
Related Drugs to DAPK1_ARL6IP5 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning DAPK1-ARL6IP5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to DAPK1_ARL6IP5 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |