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Kinase Fusion Gene:ACVRL1_SLC43A2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ACVRL1_SLC43A2 | KinaseFusionDB ID: KFG163 | FusionGDB2.0 ID: KFG163 | Hgene | Tgene | Gene symbol | ACVRL1 | SLC43A2 | Gene ID | 94 | 124935 | |
| Gene name | activin A receptor like type 1 | solute carrier family 43 member 2 | ||||||||||
| Synonyms | ACVRLK1|ALK-1|ALK1|HHT|HHT2|ORW2|SKR3|TSR-I | LAT4 | ||||||||||
| Cytomap | 12q13.13 | 17p13.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | serine/threonine-protein kinase receptor R3TGF-B superfamily receptor type Iactivin A receptor type II-like 1activin A receptor type ILactivin A receptor, type II-like kinase 1 | large neutral amino acids transporter small subunit 4L-type amino acid transporter 4solute carrier family 43 (amino acid system L transporter), member 2 | ||||||||||
| Modification date | 20240403 | 20240411 | ||||||||||
| UniProtAcc | P37023 | Q8N370 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000388922, ENST00000419526, ENST00000550683, ENST00000550084, | ENST00000574274, ENST00000301335, ENST00000382147, ENST00000412517, ENST00000571650, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ACVRL1 [Title/Abstract] AND SLC43A2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ACVRL1(52312899)-SLC43A2(1481617), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACVRL1 | GO:0007165 | signal transduction | 15702480 |
| Hgene | ACVRL1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 15702480 |
| Hgene | ACVRL1 | GO:0010596 | negative regulation of endothelial cell migration | 17068149 |
| Hgene | ACVRL1 | GO:0030308 | negative regulation of cell growth | 17068149 |
| Hgene | ACVRL1 | GO:0030509 | BMP signaling pathway | 12065756|22718755 |
| Hgene | ACVRL1 | GO:0030513 | positive regulation of BMP signaling pathway | 17068149 |
| Hgene | ACVRL1 | GO:0045893 | positive regulation of DNA-templated transcription | 12393874 |
| Hgene | ACVRL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19366699 |
| Hgene | ACVRL1 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 19494318 |
| Tgene | SLC43A2 | GO:0015818 | isoleucine transport | 15659399 |
| Tgene | SLC43A2 | GO:0015820 | L-leucine transport | 15659399 |
| Tgene | SLC43A2 | GO:0015821 | methionine transport | 15659399 |
| Tgene | SLC43A2 | GO:0015823 | phenylalanine transport | 30379325 |
| Tgene | SLC43A2 | GO:0051956 | negative regulation of amino acid transport | 26305885 |
| Tgene | SLC43A2 | GO:1905533 | negative regulation of L-leucine import across plasma membrane | 26305885 |
| Kinase Fusion gene breakpoints across ACVRL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across SLC43A2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-D7-A4Z0-01A | ACVRL1 | chr12 | 52312899 | SLC43A2 | chr17 | 1481617 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
| ENST00000388922 | ENST00000301335 | ACVRL1 | chr12 | 52312899 | SLC43A2 | chr17 | 1481617 | 8357 | 649 |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000388922_ENST00000301335_ACVRL1_chr12_52312899_SLC43A2_chr17_1481617_length(amino acids)=649 MLQPPSQSREAAAPAAPSEPLPGSSPVRGRARTPARRPALAVQLRPRGGGEVAPVRRRLAPRHPQSGPRGTMTLGSPRKGLLMLLMALVT QGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPP SEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVA RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPILSFILHTIV RGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQ -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:52312899/chr17:1481617) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACVRL1 | SLC43A2 |
| FUNCTION: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:26176610}. | FUNCTION: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:30379325, PubMed:15659399). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| Hgene | ACVRL1 | 52312899 | SLC43A2 | 1481617 | ENST00000388922 | 9 | 10 | 172_201 | 4591 | 504 | Domain | Note=GS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00585 |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase Fusion Protein Structures |
| CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
| PDB file >>>19_ACVRL1_SLC43A2 | ENST00000388922 | ENST00000301335 | ACVRL1 | chr12 | 52312899 | SLC43A2 | chr17 | 1481617 | MLQPPSQSREAAAPAAPSEPLPGSSPVRGRARTPARRPALAVQLRPRGGGEVAPVRRRLAPRHPQSGPRGTMTLGSPRKGLLMLLMALVT QGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPP SEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVA RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPILSFILHTIV RGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQ | 649 |
| 3D view using mol* of 19_ACVRL1_SLC43A2 | ||||||||||
| PDB file >>>HKFP_22_ACVRL1_SLC43A2 | ENST00000388922 | ENST00000301335 | ACVRL1 | chr12 | 52312899 | SLC43A2 | chr17 | 1481617 | MLQPPSQSREAAAPAAPSEPLPGSSPVRGRARTPARRPALAVQLRPRGGGEVAPVRRRLAPRHPQSGPRGTMTLGSPRKGLLMLLMALVT QGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPP SEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVA RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFL QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPILSFILHTIV RGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMGPLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQ | 649_ACVRL1_SLC43A2 |
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Comparison of Fusion Protein Isoforms |
| Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
| Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
| 19_ACVRL1_SLC43A2.png |
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| 19_ACVRL1_SLC43A2.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| 19_ACVRL1_SLC43A2_ramachandran.png |
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Virtual Screening Results |
| Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
| 5'-kinase fusion protein case |
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| 3'-kinase fusion protein case |
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| Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
| Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Larotrectinib | -9.28668 | -9.28668 | -51.2265 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Larotrectinib | -8.71345 | -8.71345 | -52.7833 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Midostaurin | -8.11995 | -8.11995 | -45.8813 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Gilteritinib | -8.07576 | -8.102160000000001 | -50.6383 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Gilteritinib | -8.07576 | -8.102160000000001 | -50.6383 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Netarsudil | -7.9867300000000006 | -7.99783 | -50.9982 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Netarsudil | -7.9867300000000006 | -7.99783 | -50.9982 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Ruxolitinib | -7.66763 | -7.66763 | -36.4649 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Lapatinib | -7.6249 | -7.7137 | -67.7551 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Pacritinib | -7.584789999999999 | -7.58989 | -49.0037 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Lapatinib | -7.504160000000001 | -7.592960000000001 | -67.3815 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Acalabrutinib | -7.392519999999999 | -7.406619999999999 | -49.9276 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Acalabrutinib | -7.392519999999999 | -7.406619999999999 | -49.9276 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Afatinib | -7.09738 | -7.27968 | -46.0557 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Afatinib | -7.09738 | -7.27968 | -46.0557 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Upadacitinib | -7.09657 | -7.097569999999999 | -36.842 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Afatinib | -7.09598 | -7.27968 | -46.0557 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Pexidartinib | -6.97536 | -7.67616 | -45.3733 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Pexidartinib | -6.97536 | -7.67616 | -45.3733 |
| 19_ACVRL1_SLC43A2-DOCK_HTVS_1-001 | Neratinib | -6.97352 | -7.15942 | -62.8231 |
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Kinase-Substrate Information of ACVRL1_SLC43A2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| ACVRL1 | P37023 | human | ENG | P17813 | S646 | StNHSIGsTQstPCS | |
| ACVRL1 | P37023 | human | ENG | P17813 | T640 | AssESSStNHSIGsT | |
| ACVRL1 | P37023 | human | ENG | P17813 | T654 | TQstPCStSSMA___ | |
| ACVRL1 | P37023 | human | ENG | P17813 | S649 | HSIGsTQstPCStSS |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| ACVRL1 | ID | Description | 0.00e+00 |
| ACVRL1 | GO:0035907 | dorsal aorta development | 8.94e-03 |
| ACVRL1 | GO:0062042 | regulation of cardiac epithelial to mesenchymal transition | 8.94e-03 |
| ACVRL1 | GO:0031953 | negative regulation of protein autophosphorylation | 8.94e-03 |
| ACVRL1 | GO:0097084 | vascular associated smooth muscle cell development | 8.94e-03 |
| ACVRL1 | GO:0036302 | atrioventricular canal development | 8.94e-03 |
| ACVRL1 | GO:0070278 | extracellular matrix constituent secretion | 8.94e-03 |
| ACVRL1 | GO:1905065 | positive regulation of vascular associated smooth muscle cell differentiation | 8.94e-03 |
| ACVRL1 | GO:0003222 | ventricular trabecula myocardium morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | 8.94e-03 |
| ACVRL1 | GO:0060841 | venous blood vessel development | 8.94e-03 |
| ACVRL1 | GO:0051152 | positive regulation of smooth muscle cell differentiation | 8.94e-03 |
| ACVRL1 | GO:0060973 | cell migration involved in heart development | 8.94e-03 |
| ACVRL1 | GO:0003228 | atrial cardiac muscle tissue development | 8.94e-03 |
| ACVRL1 | GO:0003148 | outflow tract septum morphogenesis | 8.94e-03 |
| ACVRL1 | GO:1905063 | regulation of vascular associated smooth muscle cell differentiation | 8.94e-03 |
| ACVRL1 | GO:0032967 | positive regulation of collagen biosynthetic process | 8.94e-03 |
| ACVRL1 | GO:0010714 | positive regulation of collagen metabolic process | 8.94e-03 |
| ACVRL1 | GO:0048745 | smooth muscle tissue development | 8.94e-03 |
| ACVRL1 | GO:0003272 | endocardial cushion formation | 8.94e-03 |
| ACVRL1 | GO:0003209 | cardiac atrium morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0061384 | heart trabecula morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0060317 | cardiac epithelial to mesenchymal transition | 8.94e-03 |
| ACVRL1 | GO:0001569 | branching involved in blood vessel morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0003230 | cardiac atrium development | 8.94e-03 |
| ACVRL1 | GO:0032965 | regulation of collagen biosynthetic process | 8.94e-03 |
| ACVRL1 | GO:0035909 | aorta morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0035886 | vascular associated smooth muscle cell differentiation | 8.94e-03 |
| ACVRL1 | GO:0003203 | endocardial cushion morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0031952 | regulation of protein autophosphorylation | 8.94e-03 |
| ACVRL1 | GO:0030513 | positive regulation of BMP signaling pathway | 8.94e-03 |
| ACVRL1 | GO:0010712 | regulation of collagen metabolic process | 8.94e-03 |
| ACVRL1 | GO:0051150 | regulation of smooth muscle cell differentiation | 8.94e-03 |
| ACVRL1 | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0061383 | trabecula morphogenesis | 8.94e-03 |
| ACVRL1 | GO:0032964 | collagen biosynthetic process | 8.94e-03 |
| ACVRL1 | GO:0003197 | endocardial cushion development | 9.42e-03 |
| ACVRL1 | GO:0072132 | mesenchyme morphogenesis | 9.86e-03 |
| ACVRL1 | GO:0003229 | ventricular cardiac muscle tissue development | 9.86e-03 |
| ACVRL1 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 9.86e-03 |
| ACVRL1 | GO:0055008 | cardiac muscle tissue morphogenesis | 9.94e-03 |
| ACVRL1 | GO:0001947 | heart looping | 9.99e-03 |
| ACVRL1 | GO:0035904 | aorta development | 9.99e-03 |
| ACVRL1 | GO:0061371 | determination of heart left/right asymmetry | 9.99e-03 |
| ACVRL1 | GO:0003143 | embryonic heart tube morphogenesis | 9.99e-03 |
| ACVRL1 | GO:0003208 | cardiac ventricle morphogenesis | 9.99e-03 |
| ACVRL1 | GO:0060411 | cardiac septum morphogenesis | 9.99e-03 |
| ACVRL1 | GO:0071260 | cellular response to mechanical stimulus | 9.99e-03 |
| ACVRL1 | GO:0060415 | muscle tissue morphogenesis | 1.00e-02 |
| ACVRL1 | GO:0051145 | smooth muscle cell differentiation | 1.00e-02 |
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Related Drugs to ACVRL1_SLC43A2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ACVRL1-SLC43A2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ACVRL1_SLC43A2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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