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Kinase Fusion Gene:DDX3X_PRKD1 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: DDX3X_PRKD1 | KinaseFusionDB ID: KFG1667 | FusionGDB2.0 ID: KFG1667 | Hgene | Tgene | Gene symbol | DDX3X | PRKD1 | Gene ID | 1654 | 5587 | |
Gene name | DEAD-box helicase 3 X-linked | protein kinase D1 | ||||||||||
Synonyms | CAP-Rf|DBX|DDX14|DDX3|HLP2|MRX102|MRXSSB | CHDED|PKC-MU|PKCM|PKD|PRKCM | ||||||||||
Cytomap | Xp11.4 | 14q12 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | ATP-dependent RNA helicase DDX3XDEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linkedDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedDEAD box protein 3, X-chromosomalDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3DEAD/H box-3helicase-like protein 2 | serine/threonine-protein kinase D1nPKC-D1nPKC-muprotein kinase C mu typeprotein kinase C, muprotein kinase D | ||||||||||
Modification date | 20240407 | 20240411 | ||||||||||
UniProtAcc | O00571 | Q15139 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000399959, ENST00000441189, ENST00000457138, ENST00000478993, ENST00000542215, | ENST00000331968, ENST00000415220, ENST00000551644, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DDX3X [Title/Abstract] AND PRKD1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DDX3X | GO:0009615 | response to virus | 18636090 |
Hgene | DDX3X | GO:0010501 | RNA secondary structure unwinding | 22872150 |
Hgene | DDX3X | GO:0010628 | positive regulation of gene expression | 10074132 |
Hgene | DDX3X | GO:0030308 | negative regulation of cell growth | 16818630 |
Hgene | DDX3X | GO:0031333 | negative regulation of protein-containing complex assembly | 17667941 |
Hgene | DDX3X | GO:0031954 | positive regulation of protein autophosphorylation | 30341167 |
Hgene | DDX3X | GO:0032481 | positive regulation of type I interferon production | 23478265 |
Hgene | DDX3X | GO:0032727 | positive regulation of interferon-alpha production | 30341167 |
Hgene | DDX3X | GO:0032728 | positive regulation of interferon-beta production | 27980081|31575075 |
Hgene | DDX3X | GO:0034063 | stress granule assembly | 21883093 |
Hgene | DDX3X | GO:0034157 | positive regulation of toll-like receptor 7 signaling pathway | 30341167 |
Hgene | DDX3X | GO:0034161 | positive regulation of toll-like receptor 8 signaling pathway | 30341167 |
Hgene | DDX3X | GO:0035556 | intracellular signal transduction | 18636090 |
Hgene | DDX3X | GO:0045727 | positive regulation of translation | 18596238|22872150 |
Hgene | DDX3X | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16818630|18636090|28128295 |
Hgene | DDX3X | GO:0071243 | cellular response to arsenic-containing substance | 21883093 |
Hgene | DDX3X | GO:0071470 | cellular response to osmotic stress | 21883093 |
Hgene | DDX3X | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 23413191 |
Hgene | DDX3X | GO:0098586 | cellular response to virus | 31575075 |
Hgene | DDX3X | GO:1902523 | positive regulation of protein K63-linked ubiquitination | 27980081 |
Tgene | PRKD1 | GO:0034599 | cellular response to oxidative stress | 12505989 |
Tgene | PRKD1 | GO:0046777 | protein autophosphorylation | 24623306 |
Tgene | PRKD1 | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 22095288 |
Kinase Fusion gene breakpoints across DDX3X (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across PRKD1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerKB4 | . | DDX3X | chrX | 41202468 | PRKD1 | chr14 | 41202468 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DDX3X | PRKD1 |
FUNCTION: Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity (PubMed:29222110). In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs (PubMed:17357160, PubMed:21589879). Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA (PubMed:30256975). Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation (PubMed:16818630, PubMed:18264132). Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity (PubMed:16818630, PubMed:18264132). CDKN1A up-regulation may be cell-type specific (PubMed:18264132). Binds CDH1/E-cadherin promoter and represses its transcription (PubMed:18264132). Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis (PubMed:28128295). May positively regulate TP53 transcription (PubMed:28842590). Associates with mRNPs, predominantly with spliced mRNAs carrying an exon junction complex (EJC) (PubMed:17095540, PubMed:18596238). Involved in the regulation of translation initiation (PubMed:18628297, PubMed:17667941, PubMed:22872150). Not involved in the general process of translation, but promotes efficient translation of selected complex mRNAs, containing highly structured 5'-untranslated regions (UTR) (PubMed:20837705, PubMed:22872150). This function depends on helicase activity (PubMed:20837705, PubMed:22872150). Might facilitate translation by resolving secondary structures of 5'-UTRs during ribosome scanning (PubMed:20837705). Alternatively, may act prior to 43S ribosomal scanning and promote 43S pre-initiation complex entry to mRNAs exhibiting specific RNA motifs, by performing local remodeling of transcript structures located close to the cap moiety (PubMed:22872150). Independently of its ATPase activity, promotes the assembly of functional 80S ribosomes and disassembles from ribosomes prior to the translation elongation process (PubMed:22323517). Positively regulates the translation of cyclin E1/CCNE1 mRNA and consequently promotes G1/S-phase transition during the cell cycle (PubMed:20837705). May activate TP53 translation (PubMed:28842590). Required for endoplasmic reticulum stress-induced ATF4 mRNA translation (PubMed:29062139). Independently of its ATPase/helicase activity, enhances IRES-mediated translation; this activity requires interaction with EIF4E (PubMed:17667941, PubMed:22323517). Independently of its ATPase/helicase activity, has also been shown specifically repress cap-dependent translation, possibly by acting on translation initiation factor EIF4E (PubMed:17667941). Involved in innate immunity, acting as a viral RNA sensor. Binds viral RNAs and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:31575075, PubMed:20127681, PubMed:21170385). Potentiate MAVS/RIGI-mediated induction of IFNB in early stages of infection (PubMed:20127681, PubMed:21170385). Enhances IFNB1 expression via IRF3/IRF7 pathway and participates in NFKB activation in the presence of MAVS and TBK1 (PubMed:18583960, PubMed:18636090, PubMed:21170385, PubMed:27980081, PubMed:19913487). Involved in TBK1 and IKBKE-dependent IRF3 activation leading to IFNB induction, acts as a scaffolding adapter that links IKBKE and IRF3 and coordinates their activation (PubMed:23478265). Involved in the TLR7/TLR8 signaling pathway leading to type I interferon induction, including IFNA4 production. In this context, acts as an upstream regulator of IRF7 activation by MAP3K14/NIK and CHUK/IKKA. Stimulates CHUK autophosphorylation and activation following physiological activation of the TLR7 and TLR8 pathways, leading to MAP3K14/CHUK-mediated activatory phosphorylation of IRF7 (PubMed:30341167). Also stimulates MAP3K14/CHUK-dependent NF-kappa-B signaling (PubMed:30341167). Negatively regulates TNF-induced IL6 and IL8 expression, via the NF-kappa-B pathway. May act by interacting with RELA/p65 and trapping it in the cytoplasm (PubMed:27736973). May also bind IFNB promoter; the function is independent of IRF3 (PubMed:18583960). Involved in both stress and inflammatory responses (By similarity). Independently of its ATPase/helicase activity, required for efficient stress granule assembly through its interaction with EIF4E, hence promotes survival in stressed cells (PubMed:21883093). Independently of its helicase activity, regulates NLRP3 inflammasome assembly through interaction with NLRP3 and hence promotes cell death by pyroptosis during inflammation. This function is independent of helicase activity (By similarity). Therefore DDX3X availability may be used to interpret stress signals and choose between pro-survival stress granules and pyroptotic NLRP3 inflammasomes and serve as a live-or-die checkpoint in stressed cells (By similarity). In association with GSK3A/B, negatively regulates extrinsic apoptotic signaling pathway via death domain receptors, including TNFRSF10B, slowing down the rate of CASP3 activation following death receptor stimulation (PubMed:18846110). Cleavage by caspases may inactivate DDX3X and relieve the inhibition (PubMed:18846110). Independently of its ATPase/helicase activity, allosteric activator of CSNK1E. Stimulates CSNK1E-mediated phosphorylation of DVL2, thereby involved in the positive regulation of Wnt/beta-catenin signaling pathway. Also activates CSNK1A1 and CSNK1D in vitro, but it is uncertain if these targets are physiologically relevant (PubMed:23413191, PubMed:29222110). ATPase and casein kinase-activating functions are mutually exclusive (PubMed:29222110). May be involved in mitotic chromosome segregation (PubMed:21730191). {ECO:0000250|UniProtKB:Q62167, ECO:0000269|PubMed:16818630, ECO:0000269|PubMed:17095540, ECO:0000269|PubMed:17357160, ECO:0000269|PubMed:17667941, ECO:0000269|PubMed:18264132, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:18596238, ECO:0000269|PubMed:18628297, ECO:0000269|PubMed:18636090, ECO:0000269|PubMed:18846110, ECO:0000269|PubMed:19913487, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20837705, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:21730191, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22323517, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:23413191, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27736973, ECO:0000269|PubMed:27980081, ECO:0000269|PubMed:28128295, ECO:0000269|PubMed:28842590, ECO:0000269|PubMed:29062139, ECO:0000269|PubMed:29222110, ECO:0000269|PubMed:30256975, ECO:0000269|PubMed:30341167, ECO:0000269|PubMed:31575075, ECO:0000305}.; FUNCTION: (Microbial infection) Facilitates hepatitis C virus (HCV) replication (PubMed:29899501). During infection, HCV core protein inhibits the interaction between MAVS and DDX3X and therefore impairs MAVS-dependent INFB induction and might recruit DDX3X to HCV replication complex (PubMed:21170385). {ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates HIV-1 replication (PubMed:15507209, PubMed:18583960, PubMed:21589879, PubMed:22872150, PubMed:29899501). Acts as a cofactor for XPO1-mediated nuclear export of HIV-1 Rev RNAs (PubMed:15507209, PubMed:18583960, PubMed:29899501). This function is strongly stimulated in the presence of TBK1 and requires DDX3X ATPase activity (PubMed:18583960). {ECO:0000269|PubMed:15507209, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21589879, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Zika virus (ZIKV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Dengue virus (DENV) replication. {ECO:0000269|PubMed:29899501}.; FUNCTION: (Microbial infection) Facilitates Venezuelan equine encephalitis virus (VEEV) replication. {ECO:0000269|PubMed:27105836}. | FUNCTION: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response (PubMed:10764790, PubMed:12505989, PubMed:12637538, PubMed:17442957, PubMed:18509061, PubMed:19135240, PubMed:19211839). Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation (PubMed:10523301). Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1 (PubMed:12505989). Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2 (PubMed:18509061). In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling (PubMed:18332134). Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation (PubMed:19211839). In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents (PubMed:10764790). In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines (PubMed:17442957). Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor (PubMed:15471852). Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (PubMed:24623306). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity). {ECO:0000250|UniProtKB:Q62101, ECO:0000269|PubMed:10523301, ECO:0000269|PubMed:10764790, ECO:0000269|PubMed:12505989, ECO:0000269|PubMed:12637538, ECO:0000269|PubMed:15471852, ECO:0000269|PubMed:17442957, ECO:0000269|PubMed:18332134, ECO:0000269|PubMed:18509061, ECO:0000269|PubMed:19135240, ECO:0000269|PubMed:19211839, ECO:0000269|PubMed:24623306}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of DDX3X_PRKD1 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S486 | RPLsRAQssPAAPAs | |
PRKD1 | Q15139 | human | ATP7B | P35670 | S1453 | DDDGDKWsLLLNGRD | |
PRKD1 | Q15139 | human | CERT1 | Q9Y5P4 | S132 | ssLRRHGsMVsLVsG | |
PRKD1 | Q15139 | human | CTNNB1 | P35222 | T120 | QFdAAHPtNVQRLAE | |
PRKD1 | Q15139 | human | DLC1 | Q96QB1 | S1244 | NtLKRENsSPRVMQR | |
PRKD1 | Q15139 | human | DNM1L | O00429 | S637 | VPVARKLsAREQRDC | |
PRKD1 | Q15139 | human | CTNNB1 | P35222 | T112 | EGMQIPstQFdAAHP | |
PRKD1 | Q15139 | human | TLR5 | O60602 | S805 | yQLMKHQsIRGFVQK | TIR |
PRKD1 | Q15139 | human | REM1 | O75628 | S18 | TPLHRRAstPLPLsP | |
PRKD1 | Q15139 | human | SPHK2 | Q9NRA0 | S421 | sPLHRsVsDLPLPLP | |
PRKD1 | Q15139 | human | MAP3K5 | Q99683 | T838 | GINPCTEtFTGtLQY | Pkinase |
PRKD1 | Q15139 | human | ATP7B | P35670 | S1121 | AHSERPLsAPASHLN | Hydrolase |
PRKD1 | Q15139 | human | PAK4 | O96013 | S99 | MsVTRsNsLRRDsPP | |
PRKD1 | Q15139 | human | PIK3R1 | P27986 | S154 | stLYRtQsSSNLAEL | RhoGAP |
PRKD1 | Q15139 | human | AKT1 | P31749 | S473 | RPHFPQFsysAsGtA | Pkinase_C |
PRKD1 | Q15139 | human | PPP1R14A | Q96A00 | T38 | QkRHARVtVkYDRRE | PP1_inhibitor |
PRKD1 | Q15139 | human | KAT7 | O95251 | T97 | kKYPLRQtRssGsEt | |
PRKD1 | Q15139 | human | MYBPC3 | Q14896 | S304 | SLLKKRDsFRtPRDs | |
PRKD1 | Q15139 | human | PIP5K1C | O60331 | S448 | NTVFRKNsSLKSsPS | |
PRKD1 | Q15139 | human | PI4KB | Q9UBF8-2 | S294 | SNLKRtAsNPKVENE | |
PRKD1 | Q15139 | human | PTRH2 | Q9Y3E5 | S5 | ___MPSKsLVMEYLA | |
PRKD1 | Q15139 | human | RTKN | Q9BST9-2 | S435 | QALAKQGsLYHEMAI | |
PRKD1 | Q15139 | human | CTTN | Q14247 | S298 | EKLAkHEsQQDyskG | HS1_rep |
PRKD1 | Q15139 | human | ATP7B | P35670 | S481 | ILAKsPQsTRAVAPQ | |
PRKD1 | Q15139 | human | TFAP2A | P05549 | S258 | GVLRRAKsKNGGRSL | TF_AP-2 |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S910 | KALGERVsIL_____ | |
PRKD1 | Q15139 | human | RIN1 | Q13671 | S351 | RPLLRsMsAAFCSLL | |
PRKD1 | Q15139 | human | ITGB4 | P16144-2 | T1736 | EFVSRTLttSGTLST | |
PRKD1 | Q15139 | human | PI4KB | Q9UBF8 | S294 | SNLkRTAsNPKVENE | |
PRKD1 | Q15139 | human | AP2B1 | P63010 | Y277 | LPkDsDyyNMLLkKL | Adaptin_N |
PRKD1 | Q15139 | human | OXTR | P30559 | S261 | RVALARVsSVKLISK | 7tm_1 |
PRKD1 | Q15139 | human | AP2B1 | P63010 | S258 | ANSAVVLsAVKVLMk | Adaptin_N |
PRKD1 | Q15139 | human | BAD | Q92934 | S99 | PFrGrsRsAPPNLWA | Bcl-2_BAD |
PRKD1 | Q15139 | human | ATP7B | P35670 | S478 | APDILAKsPQsTRAV | |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S172 | GQLVRNDsLWHRsDs | Miff |
PRKD1 | Q15139 | human | TFAP2A | P05549 | S326 | EFLNRQHsDPNEQVT | TF_AP-2 |
PRKD1 | Q15139 | human | MAP4K1 | Q92918 | S171 | AtLARRLsFIGtPyW | Pkinase |
PRKD1 | Q15139 | human | TLR4 | O00206 | S790 | VELYRLLsRNTYLEW | TIR |
PRKD1 | Q15139 | human | HSPB1 | P04792 | S82 | RALsRQLssGVsEIr | |
PRKD1 | Q15139 | human | TCAP | O15273 | S157 | GALRRsLsRSMsQEA | Telethonin |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S155 | FPLRKtVsEPNLkLR | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S978 | sPLKRSHsLAKLGSL | |
PRKD1 | Q15139 | human | BAD | Q92934 | S75 | EIRsRHssyPAGtED | Bcl-2_BAD |
PRKD1 | Q15139 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
PRKD1 | Q15139 | human | PAK5 | Q9P286 | S99 | ISVTRSNsLRKESPP | |
PRKD1 | Q15139 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S275 | DNVRYGIsNIDTTIE | Miff |
PRKD1 | Q15139 | human | PAK4 | O96013 | S474 | kEVPRRksLVGtPyW | Pkinase |
PRKD1 | Q15139 | human | MARK2 | Q7KZI7 | S400 | HkVQRsVsANPKQRR | |
PRKD1 | Q15139 | human | RABEP1 | Q15276 | S407 | DGLRRAQstDsLGts | Rabaptin |
PRKD1 | Q15139 | human | CREB1 | P16220-1 | S98 | KDLKRLFsGtQISTI | |
PRKD1 | Q15139 | human | KAT7 | O95251 | T331 | LRLQGQItEGsNMIk | |
PRKD1 | Q15139 | human | BAD | Q92934 | S118 | GRELRRMsDEFVDsF | Bcl-2_BAD |
PRKD1 | Q15139 | human | SPHK2 | Q9NRA0 | S419 | AHsPLHRsVsDLPLP | |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S738 | ARIIGEksFRRsVVG | Pkinase |
PRKD1 | Q15139 | human | HDAC7 | Q8WUI4 | S358 | WPLsRtRsEPLPPsA | |
PRKD1 | Q15139 | human | CACNA1C | Q13936 | S1981 | ASLGRRAsFHLECLK | |
PRKD1 | Q15139 | human | CTTN | Q14247 | S348 | EAVTskTsNIRANFE | |
PRKD1 | Q15139 | human | JUN | P05412 | S63 | kNsDLLtsPDVGLLk | Jun |
PRKD1 | Q15139 | human | PIP4K2A | P48426 | T376 | KAAHAAktVKHGAGA | PIP5K |
PRKD1 | Q15139 | human | KCNH2 | Q12809 | S284 | ASVRRAssADDIEAM | |
PRKD1 | Q15139 | human | SPRY2 | O43597 | S112 | APLSRSIsTVssGsR | |
PRKD1 | Q15139 | human | ARFIP1 | P53367 | S132 | LELVRKWsLNtyKCT | Arfaptin |
PRKD1 | Q15139 | human | PTRH2 | Q9Y3E5 | S87 | GkVAAQCsHAAVSAy | PTH2 |
PRKD1 | Q15139 | human | FAM83G | A6ND36 | S356 | YALVKAKsVDEIAKI | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S402 | MGVSRsAstVIAyAM | DSPc |
PRKD1 | Q15139 | human | PAK4 | O96013 | S181 | SRDKRPLsGPDVGtP | |
PRKD1 | Q15139 | human | MBP | P02686-5 | S162 | FKLGGRDsRSGSPMA | Myelin_MBP |
PRKD1 | Q15139 | human | CFL1 | P23528 | S3 | _____MAsGVAVsDG | |
PRKD1 | Q15139 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
PRKD1 | Q15139 | human | RIN1 | Q13671 | S292 | QLLRREssVGyRVPA | |
PRKD1 | Q15139 | human | SSH1 | Q8WYL5 | S937 | SNLtRssssDsIHsV | |
PRKD1 | Q15139 | human | MFF | Q9GZY8 | S155 | GRLkRERsMsENAVR | Miff |
PRKD1 | Q15139 | human | PRKD1 | Q15139 | S742 | GEksFRRsVVGtPAy | Pkinase |
PRKD1 | Q15139 | human | SNAI1 | O95863 | S11 | SFLVRKPsDPNRKPN | |
PRKD1 | Q15139 | human | OSBP | P22059 | S240 | tALQRsLsELESLkL | |
PRKD1 | Q15139 | human | VASP | P50552 | S157 | EHIERRVsNAGGPPA | |
PRKD1 | Q15139 | human | HSPB6 | O14558 | S16 | PSWLRRAsAPLPGLS | Crystallin |
PRKD1 | Q15139 | human | VASP | P50552 | S322 | TtLPRMkssssVttS | |
PRKD1 | Q15139 | human | AKT1 | P31749 | T308 | kDGAtMKtFCGtPEy | Pkinase |
PRKD1 | Q15139 | human | TCAP | O15273 | S161 | RsLsRSMsQEAQRG_ | Telethonin |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
PRKD1 | ID | Description | 0.00e+00 |
PRKD1 | GO:0097306 | cellular response to alcohol | 4.24e-04 |
PRKD1 | GO:0006936 | muscle contraction | 4.24e-04 |
PRKD1 | GO:1903829 | positive regulation of protein localization | 4.24e-04 |
PRKD1 | GO:0032970 | regulation of actin filament-based process | 4.55e-04 |
PRKD1 | GO:1903532 | positive regulation of secretion by cell | 4.55e-04 |
PRKD1 | GO:2001233 | regulation of apoptotic signaling pathway | 4.55e-04 |
PRKD1 | GO:0051047 | positive regulation of secretion | 5.28e-04 |
PRKD1 | GO:1904627 | response to phorbol 13-acetate 12-myristate | 5.28e-04 |
PRKD1 | GO:1904628 | cellular response to phorbol 13-acetate 12-myristate | 5.28e-04 |
PRKD1 | GO:0097193 | intrinsic apoptotic signaling pathway | 5.28e-04 |
PRKD1 | GO:0003012 | muscle system process | 7.04e-04 |
PRKD1 | GO:0090199 | regulation of release of cytochrome c from mitochondria | 1.19e-03 |
PRKD1 | GO:0006937 | regulation of muscle contraction | 1.19e-03 |
PRKD1 | GO:1901655 | cellular response to ketone | 1.46e-03 |
PRKD1 | GO:0006941 | striated muscle contraction | 1.73e-03 |
PRKD1 | GO:2001242 | regulation of intrinsic apoptotic signaling pathway | 1.83e-03 |
PRKD1 | GO:0001836 | release of cytochrome c from mitochondria | 2.18e-03 |
PRKD1 | GO:0051222 | positive regulation of protein transport | 2.50e-03 |
PRKD1 | GO:1901654 | response to ketone | 2.57e-03 |
PRKD1 | GO:0070584 | mitochondrion morphogenesis | 2.71e-03 |
PRKD1 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 2.71e-03 |
PRKD1 | GO:0034329 | cell junction assembly | 2.71e-03 |
PRKD1 | GO:1904951 | positive regulation of establishment of protein localization | 2.71e-03 |
PRKD1 | GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 2.97e-03 |
PRKD1 | GO:0032956 | regulation of actin cytoskeleton organization | 3.04e-03 |
PRKD1 | GO:0007015 | actin filament organization | 3.04e-03 |
PRKD1 | GO:0097191 | extrinsic apoptotic signaling pathway | 3.04e-03 |
PRKD1 | GO:0045670 | regulation of osteoclast differentiation | 3.04e-03 |
PRKD1 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 3.29e-03 |
PRKD1 | GO:0010506 | regulation of autophagy | 3.69e-03 |
PRKD1 | GO:2001234 | negative regulation of apoptotic signaling pathway | 3.69e-03 |
PRKD1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 3.69e-03 |
PRKD1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 3.75e-03 |
PRKD1 | GO:0090257 | regulation of muscle system process | 3.75e-03 |
PRKD1 | GO:0010821 | regulation of mitochondrion organization | 3.81e-03 |
PRKD1 | GO:0043535 | regulation of blood vessel endothelial cell migration | 3.82e-03 |
PRKD1 | GO:0008654 | phospholipid biosynthetic process | 3.92e-03 |
PRKD1 | GO:0097305 | response to alcohol | 3.92e-03 |
PRKD1 | GO:0003007 | heart morphogenesis | 4.72e-03 |
PRKD1 | GO:1902903 | regulation of supramolecular fiber organization | 4.94e-03 |
PRKD1 | GO:0110053 | regulation of actin filament organization | 5.17e-03 |
PRKD1 | GO:0035115 | embryonic forelimb morphogenesis | 5.17e-03 |
PRKD1 | GO:0045671 | negative regulation of osteoclast differentiation | 5.17e-03 |
PRKD1 | GO:0010959 | regulation of metal ion transport | 5.17e-03 |
PRKD1 | GO:0048660 | regulation of smooth muscle cell proliferation | 5.17e-03 |
PRKD1 | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 5.30e-03 |
PRKD1 | GO:0048659 | smooth muscle cell proliferation | 5.52e-03 |
PRKD1 | GO:1900182 | positive regulation of protein localization to nucleus | 5.70e-03 |
PRKD1 | GO:0051347 | positive regulation of transferase activity | 5.94e-03 |
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Related Drugs to DDX3X_PRKD1 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning DDX3X-PRKD1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DDX3X_PRKD1 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |