| Kinase Fusion partner gene information | Kinase Fusion gene name: DDX6_ALK |
KinaseFusionDB ID: KFG1672 | FusionGDB2.0 ID: KFG1672 | | Hgene | Tgene | Gene symbol | DDX6 | ALK | Gene ID | 1656 | 238 | | Gene name | DEAD-box helicase 6 | ALK receptor tyrosine kinase |
| Synonyms | HLR2|IDDILF|P54|RCK|Rck/p54 | ALK1|CD246|NBLST3 |
| Cytomap | 11q23.3 | 2p23.2-p23.1 |
| Type of gene | protein-coding | protein-coding |
| Description | probable ATP-dependent RNA helicase DDX6ATP-dependent RNA helicase p54DEAD (Asp-Glu-Ala-Asp) box helicase 6DEAD (Asp-Glu-Ala-Asp) box polypeptide 6DEAD box protein 6DEAD box-6DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)oncoge | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase |
| Modification date | 20240407 | 20240411 |
| UniProtAcc | P26196 | Q3KRA9 |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000264018, ENST00000526070,
ENST00000534980, | ENST00000431873,
ENST00000498037, ENST00000389048,
|
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DDX6 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] |
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DDX6(118656761)-ALK(29606725), # samples:1
|
 Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Kinase Fusion gene breakpoints across DDX6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-N9-A4Q4-01A | DDX6 | chr11 | 118656761 | ALK | chr2 | 29606725 |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length
(transcript) | Seq length
(amino acids) |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq
|
Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:118656761/:29606725)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
DDX6
P26196 | ALK
Q3KRA9 |
| FUNCTION: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26098573, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:31422817}. | FUNCTION: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Phosphorylation target of the kinase
(phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| ALK | Q9UM73 | human | ALK | Q9UM73 | Y1604 | tAPGAGHyEDTILkS | |
| ALK | Q9UM73 | human | ELP3 | Q9H9T3 | Y202 | GHtSNNIyEAVkySE | Radical_SAM |
| ALK | Q9UM73 | human | ALK | Q9UM73 | Y1278 | FGMARDIyRAsyyRK | PK_Tyr_Ser-Thr |
| ALK | Q9UM73 | human | CDK9 | P50750 | Y19 | FCDEVSkyEkLAkIG | |
| ALK | Q9UM73 | human | SFPQ | P23246 | Y293 | RRPGEktyTQRCRLF | |
| ALK | Q9UM73 | human | ATIC | P31939 | Y104 | RVVACNLyPFVkTVA | MGS |
| ALK | Q9UM73 | human | SRCIN1 | Q9C0H9 | Y396 | LVKGEGLyADPyGLL | |
| ALK | Q9UM73 | human | STAT3 | P40763 | Y705 | DPGsAAPyLktKFIC | |
| ALK | Q9UM73 | human | PTPN11 | Q06124 | Y580 | REDsARVyENVGLMQ | |
| ALK | Q9UM73 | human | PBK | Q96KB5 | Y74 | NPICNDHyRsVyQkR | Pkinase |
| ALK | Q9UM73 | human | VASP | P50552 | Y39 | AFSRVQIyHNPtANs | WH1 |
| ALK | Q9UM73 | human | PTPN11 | Q06124 | Y542 | sKRkGHEytNIKysL | |
| ALK | Q9UM73 | human | GRB2 | P62993 | Y160 | QVPQQPtyVQALFDF | |
Biological Network Integration of This Kinase and Substrates
(GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Distribution of the number of studies mentioning DDX6-ALK and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024) |
Diseases associated with fusion partners.
(DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ALK | C0007131 | Non-Small Cell Lung Carcinoma | 28 | CGI;CTD_human |
| Tgene | ALK | C0027819 | Neuroblastoma | 13 | CGI;CTD_human;ORPHANET |
| Tgene | ALK | C0152013 | Adenocarcinoma of lung (disorder) | 8 | CGI;CTD_human |
| Tgene | ALK | C2751681 | NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 | 8 | CLINGEN;UNIPROT |
| Tgene | ALK | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | CGI;CTD_human |
| Tgene | ALK | C0334121 | Inflammatory Myofibroblastic Tumor | 4 | CGI;CTD_human;ORPHANET |
| Tgene | ALK | C0018199 | Granuloma, Plasma Cell | 3 | CTD_human |
| Tgene | ALK | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
| Tgene | ALK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | ALK | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston