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Kinase Fusion Gene:DHX8_TRPM7 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: DHX8_TRPM7 | KinaseFusionDB ID: KFG1690 | FusionGDB2.0 ID: KFG1690 | Hgene | Tgene | Gene symbol | DHX8 | TRPM7 | Gene ID | 1659 | 54822 | |
Gene name | DEAH-box helicase 8 | transient receptor potential cation channel subfamily M member 7 | ||||||||||
Synonyms | DDX8|Dhr2|HRH1|PRP22|PRPF22 | ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK | ||||||||||
Cytomap | 17q21.31 | 15q21.2 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | ATP-dependent RNA helicase DHX8DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)DEAH (Asp-Glu-Ala-His) box polypeptide 8DEAH box protein 8RNA helicase HRH1 | transient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase | ||||||||||
Modification date | 20240323 | 20240411 | ||||||||||
UniProtAcc | Q14562 | Q96QT4 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262415, ENST00000540306, | ENST00000561443, ENST00000313478, ENST00000560955, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DHX8 [Title/Abstract] AND TRPM7 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DHX8(41585888)-TRPM7(50906460), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DHX8 | GO:0000398 | mRNA splicing, via spliceosome | 28076346 |
Kinase Fusion gene breakpoints across DHX8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across TRPM7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-L5-A8NI | DHX8 | chr17 | 41585888 | TRPM7 | chr15 | 50906460 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
ENST00000540306 | ENST00000560955 | DHX8 | chr17 | 41585888 | TRPM7 | chr15 | 50906460 | 8063 | 2215 |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000540306_ENST00000560955_DHX8_chr17_41585888_TRPM7_chr15_50906460_length(amino acids)=2215 MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQ CTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVE ECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKH -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:41585888/chr15:50906460) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DHX8 | TRPM7 |
FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346). Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:8608946}. | FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741). Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Tgene | DHX8 | 41585888 | TRPM7 | 50906460 | ENST00000540306 | 12 | 39 | 1594_1824 | 498 | 1866 | Domain | Note=Alpha-type protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00501 |
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Kinase Fusion Protein Structures |
CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
PDB file >>>141_DHX8_TRPM7 | ENST00000540306 | ENST00000560955 | DHX8 | chr17 | 41585888 | TRPM7 | chr15 | 50906460 | MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQ CTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVE ECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKH | 2215 |
3D view using mol* of 141_DHX8_TRPM7 | ||||||||||
PDB file >>>TKFP_230_DHX8_TRPM7 | ENST00000540306 | ENST00000560955 | DHX8 | chr17 | 41585888 | TRPM7 | chr15 | 50906460 | MSAGCEEGGSGQAIAMAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTTFDTFKASLVKNGA EFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFPVLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDA EHRDRTKKKKRSRSRDRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDKYGERNLDRWRDKHVD RPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGED LNPNRRRNLVGETNEETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDE DLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANM RGIGMMPNDIPEWKKHAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGC TQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTV QKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYE RMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGR NTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMAR FLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSR LRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVR ILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEA GKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVAN MFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMV NLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVE MYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELS ISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSA VSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDL QRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNG LTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQ CTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVE ECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKH | 2215_DHX8_TRPM7 |
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Comparison of Fusion Protein Isoforms |
Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
141_DHX8_TRPM7.png |
141_DHX8_TRPM7.png |
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Potential Active Site Information |
The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
141_DHX8_TRPM7_ramachandran.png |
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Virtual Screening Results |
Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
5'-kinase fusion protein case |
3'-kinase fusion protein case |
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Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
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Kinase-Substrate Information of DHX8_TRPM7 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | S1808 | VKskykAsItALEAk | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1482 | VssLAGFtDCHRTsI | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1258 | AQkAsEAsKVHNEIt | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1287 | DDGPVRPsVWKKHGV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1537 | EMPsEEGtLNGLtsP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1404 | PPTKFFVstPsQPsC | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1387 | KNQKLGssSTsIPHL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1405 | PTKFFVstPsQPsCK | |
TRPM7 | Q96QT4 | human | PLCG2 | P16885 | T1045 | LQPESMRtEkyDPMP | |
TRPM7 | Q96QT4 | human | ANXA1 | P04083 | S5 | ___MAMVsEFLKQAW | |
TRPM7 | Q96QT4 | human | PLCG2 | P16885 | S1164 | AVKSGFRsVPLKNGY | C2 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1390 | KLGssSTsIPHLssP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1435 | KATEGDNtEFGAFVG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1265 | sKVHNEItRELsIsK | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1542 | EGtLNGLtsPFKPAM | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1463 | sNKIKILsNNNTsEN | |
TRPM7 | Q96QT4 | human | EEF2K | O00418 | S78 | ssGsPANsFHFkEAW | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1685 | QRAAQKLtFAFNQMK | Alpha_kinase |
TRPM7 | Q96QT4 | human | TMOD1 | P28289 | S2 | ______MsyRRELEK | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1851 | LNLQPGNsTKESEST | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1358 | SSGALFPsAVsPPEL | |
TRPM7 | Q96QT4 | human | TMOD1 | P28289 | T54 | GLRQKDQtTKAPTGP | Tropomodulin |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1695 | FNQMKPKsIPYSPRF | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1468 | ILsNNNTsENtLkRV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1543 | GtLNGLtsPFKPAMD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1660 | EVVNTWSsIYKEDTV | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1193 | DDKFHsGsEERIRVT | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1477 | NtLkRVssLAGFtDC | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1860 | KESESTNsVRLML__ | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1471 | NNNTsENtLkRVssL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1569 | NLMRLsQsIPFTPVP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1583 | PPRGEPVtVYRLEES | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1830 | DLKRNDYtPDkIIFP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1615 | CAKIEFLsKEEMGGG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1446 | AFVGHRDsMDLQRFK | |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | S1803 | EMEGtVKskykAsIt | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1456 | LQRFKEtsNKIKILs | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1255 | TLTAQkAsEAsKVHN | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1455 | DLQRFKEtsNKIKIL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1779 | GENLTDPsVIKAEEK | Alpha_kinase |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1163 | DGPkLFLtEEDQkKL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1476 | ENtLkRVssLAGFtD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1598 | SPNILNNsMSSWSQL | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1567 | RNNLMRLsQsIPFTP | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1191 | EKDDKFHsGsEERIR | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1551 | PFKPAMDtNYYYSAV | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1493 | RTsIPVHsKQAEKIs | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1533 | PsNREMPsEEGtLNG | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1505 | KIsRRPstEDtHEVD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1271 | ItRELsIsKHLAQNL | |
TRPM7 | Q96QT4 | human | MYH9 | P35579 | T1800 | kLQEMEGtVKskykA | Myosin_tail_1 |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | T1508 | RRPstEDtHEVDsKA | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1407 | KFFVstPsQPsCKsH | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1513 | EDtHEVDsKAALIPD | |
TRPM7 | Q96QT4 | human | TRPM7 | Q96QT4 | S1527 | DWLQDRPsNREMPsE |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
TRPM7 | ID | Description | 0.00e+00 |
TRPM7 | GO:0031032 | actomyosin structure organization | 7.27e-03 |
TRPM7 | GO:0006909 | phagocytosis | 7.27e-03 |
TRPM7 | GO:0022604 | regulation of cell morphogenesis | 7.27e-03 |
TRPM7 | GO:0032743 | positive regulation of interleukin-2 production | 7.27e-03 |
TRPM7 | GO:0006911 | phagocytosi | 9.84e-05 |
TRPM7 | GO:0010631 | epithelial cell migration | 8.26e-03 |
TRPM7 | GO:0090132 | epithelium migration | 8.26e-03 |
TRPM7 | GO:0090130 | tissue migration | 8.26e-03 |
TRPM7 | GO:0032623 | interleukin-2 production | 8.26e-03 |
TRPM7 | GO:0032663 | regulation of interleukin-2 production | 8.26e-03 |
TRPM7 | GO:0010324 | membrane invagination | 8.26e-03 |
TRPM7 | GO:1902808 | positive regulation of cell cycle G1/S phase transition | 8.26e-03 |
TRPM7 | GO:0042060 | wound healing | 9.39e-03 |
TRPM7 | GO:1903131 | mononuclear cell differentiation | 1.20e-02 |
TRPM7 | GO:0071277 | cellular response to calcium ion | 1.20e-02 |
TRPM7 | GO:0001667 | ameboidal-type cell migration | 1.24e-02 |
TRPM7 | GO:1901989 | positive regulation of cell cycle phase transition | 2.00e-02 |
TRPM7 | GO:0030168 | platelet activation | 2.36e-02 |
TRPM7 | GO:0008360 | regulation of cell shape | 2.48e-02 |
TRPM7 | GO:0051592 | response to calcium ion | 2.50e-02 |
TRPM7 | GO:0045807 | positive regulation of endocytosis | 2.76e-02 |
TRPM7 | GO:0010634 | positive regulation of epithelial cell migration | 3.40e-02 |
TRPM7 | GO:0043534 | blood vessel endothelial cell migration | 3.45e-02 |
TRPM7 | GO:1902075 | cellular response to salt | 3.88e-02 |
TRPM7 | GO:0071248 | cellular response to metal ion | 3.88e-02 |
TRPM7 | GO:1902806 | regulation of cell cycle G1/S phase transition | 4.07e-02 |
TRPM7 | GO:0002285 | lymphocyte activation involved in immune response | 4.08e-02 |
TRPM7 | GO:0007596 | blood coagulation | 4.18e-02 |
TRPM7 | GO:0050817 | coagulation | 4.18e-02 |
TRPM7 | GO:0071241 | cellular response to inorganic substance | 4.18e-02 |
TRPM7 | GO:0007599 | hemostasis | 4.18e-02 |
TRPM7 | GO:0002274 | myeloid leukocyte activation | 4.33e-02 |
TRPM7 | GO:0032984 | protein-containing complex disassembly | 4.33e-02 |
TRPM7 | GO:0090068 | positive regulation of cell cycle process | 4.33e-02 |
TRPM7 | GO:0002699 | positive regulation of immune effector process | 4.33e-02 |
TRPM7 | GO:0044843 | cell cycle G1/S phase transition | 4.33e-02 |
TRPM7 | GO:0032429 | regulation of phospholipase A2 activity | 4.33e-02 |
TRPM7 | GO:0033034 | positive regulation of myeloid cell apoptotic process | 4.33e-02 |
TRPM7 | GO:0043542 | endothelial cell migration | 4.33e-02 |
TRPM7 | GO:0030100 | regulation of endocytosis | 4.33e-02 |
TRPM7 | GO:0007343 | egg activation | 4.33e-02 |
TRPM7 | GO:0031340 | positive regulation of vesicle fusion | 4.33e-02 |
TRPM7 | GO:0045625 | regulation of T-helper 1 cell differentiation | 4.33e-02 |
TRPM7 | GO:0010632 | regulation of epithelial cell migration | 4.33e-02 |
TRPM7 | GO:0002366 | leukocyte activation involved in immune response | 4.33e-02 |
TRPM7 | GO:0002263 | cell activation involved in immune response | 4.33e-02 |
TRPM7 | GO:0051146 | striated muscle cell differentiation | 4.33e-02 |
TRPM7 | GO:0002732 | positive regulation of dendritic cell cytokine production | 4.33e-02 |
TRPM7 | GO:0032957 | inositol trisphosphate metabolic process | 4.33e-02 |
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Related Drugs to DHX8_TRPM7 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning DHX8-TRPM7 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DHX8_TRPM7 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |