Ensembl transtripts involved in fusion gene | ENST ids | ENST00000460734, ENST00000539173, ENST00000437626, ENST00000389863, ENST00000348831, ENST00000360697,
| ENST00000270162, |
Hgene | Tgene |
ADARB1
P78563 | SIK1
P57059 |
FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:19908260, ECO:0000269|PubMed:21289159}.; FUNCTION: [Isoform 1]: Has a lower catalytic activity than isoform 2. {ECO:0000269|PubMed:9149227}.; FUNCTION: [Isoform 2]: Has a higher catalytic activity than isoform 1. {ECO:0000269|PubMed:9149227}. | FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity). {ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280, ECO:0000269|PubMed:19622832, ECO:0000269|PubMed:29211348}. |
Kinase | GOID | GO term | P.adjust |
SIK1 | ID | Description | 0.00e+00 |
SIK1 | GO:0044849 | estrous cycle | 3.20e-02 |
SIK1 | GO:0060766 | negative regulation of androgen receptor signaling pathway | 3.20e-02 |
SIK1 | GO:0010832 | negative regulation of myotube differentiation | 3.20e-02 |
SIK1 | GO:1902894 | negative regulation of miRNA transcription | 3.20e-02 |
SIK1 | GO:2000629 | negative regulation of miRNA metabolic process | 3.20e-02 |
SIK1 | GO:0060765 | regulation of androgen receptor signaling pathway | 3.20e-02 |
SIK1 | GO:0033144 | negative regulation of intracellular steroid hormone receptor signaling pathway | 3.20e-02 |
SIK1 | GO:0051154 | negative regulation of striated muscle cell differentiation | 3.20e-02 |
SIK1 | GO:0007595 | lactation | 3.20e-02 |
SIK1 | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 3.20e-02 |
SIK1 | GO:0010830 | regulation of myotube differentiation | 3.20e-02 |
SIK1 | GO:0042220 | response to cocaine | 3.20e-02 |
SIK1 | GO:0030521 | androgen receptor signaling pathway | 3.20e-02 |
SIK1 | GO:0051148 | negative regulation of muscle cell differentiation | 3.20e-02 |
SIK1 | GO:1902893 | regulation of miRNA transcription | 3.20e-02 |
SIK1 | GO:0042698 | ovulation cycle | 3.20e-02 |
SIK1 | GO:0061614 | miRNA transcription | 3.20e-02 |
SIK1 | GO:0014823 | response to activity | 3.20e-02 |
SIK1 | GO:0033143 | regulation of intracellular steroid hormone receptor signaling pathway | 3.20e-02 |
SIK1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 3.20e-02 |
SIK1 | GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | 3.20e-02 |
SIK1 | GO:2000628 | regulation of miRNA metabolic process | 3.20e-02 |
SIK1 | GO:0007589 | body fluid secretion | 3.20e-02 |
SIK1 | GO:0140747 | regulation of ncRNA transcription | 3.20e-02 |
SIK1 | GO:0043279 | response to alkaloid | 3.20e-02 |
SIK1 | GO:0002042 | cell migration involved in sprouting angiogenesis | 3.20e-02 |
SIK1 | GO:0051153 | regulation of striated muscle cell differentiation | 3.20e-02 |
SIK1 | GO:0010596 | negative regulation of endothelial cell migration | 3.20e-02 |
SIK1 | GO:0021549 | cerebellum development | 3.20e-02 |
SIK1 | GO:0010586 | miRNA metabolic process | 3.20e-02 |
SIK1 | GO:0032355 | response to estradiol | 3.20e-02 |
SIK1 | GO:0022037 | metencephalon development | 3.20e-02 |
SIK1 | GO:0010633 | negative regulation of epithelial cell migration | 3.20e-02 |
SIK1 | GO:0045814 | negative regulation of gene expressio | 1.27e-02 |
SIK1 | GO:0014902 | myotube differentiation | 3.23e-02 |
SIK1 | GO:0030879 | mammary gland development | 3.23e-02 |
SIK1 | GO:0098781 | ncRNA transcription | 3.23e-02 |
SIK1 | GO:0043401 | steroid hormone mediated signaling pathway | 3.23e-02 |
SIK1 | GO:0043393 | regulation of protein binding | 3.23e-02 |
SIK1 | GO:0010565 | regulation of cellular ketone metabolic process | 3.23e-02 |
SIK1 | GO:0030183 | B cell differentiation | 3.27e-02 |
SIK1 | GO:0043535 | regulation of blood vessel endothelial cell migration | 3.27e-02 |
SIK1 | GO:0030902 | hindbrain development | 3.28e-02 |
SIK1 | GO:0051147 | regulation of muscle cell differentiation | 3.31e-02 |
SIK1 | GO:0043534 | blood vessel endothelial cell migration | 3.61e-02 |
SIK1 | GO:0002040 | sprouting angiogenesis | 3.69e-02 |
SIK1 | GO:0009755 | hormone-mediated signaling pathway | 3.69e-02 |
SIK1 | GO:0032869 | cellular response to insulin stimulus | 3.81e-02 |
SIK1 | GO:0071383 | cellular response to steroid hormone stimulus | 3.81e-02 |