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Kinase Fusion Gene:DMTN_PKN2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: DMTN_PKN2 | KinaseFusionDB ID: KFG1707 | FusionGDB2.0 ID: KFG1707 | Hgene | Tgene | Gene symbol | DMTN | PKN2 | Gene ID | 2039 | 5586 | |
| Gene name | dematin actin binding protein | protein kinase N2 | ||||||||||
| Synonyms | DMT|EPB49 | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | ||||||||||
| Cytomap | 8p21.3 | 1p22.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | dematinerythrocyte membrane protein band 4.9 (dematin) | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | ||||||||||
| Modification date | 20240411 | 20240323 | ||||||||||
| UniProtAcc | Q08495 | Q16513 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265800, ENST00000358242, ENST00000381470, ENST00000415253, ENST00000432128, ENST00000443491, ENST00000517600, ENST00000519907, ENST00000523266, ENST00000523782, | ENST00000370521, ENST00000316005, ENST00000370505, ENST00000370513, ENST00000495119, ENST00000544045, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DMTN [Title/Abstract] AND PKN2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DMTN(21927698)-PKN2(89299434), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DMTN | GO:0032956 | regulation of actin cytoskeleton organization | 22927433 |
| Hgene | DMTN | GO:0065003 | protein-containing complex assembly | 18347014 |
| Hgene | DMTN | GO:0071320 | cellular response to cAMP | 22927433 |
| Tgene | PKN2 | GO:0006468 | protein phosphorylation | 17332740 |
| Tgene | PKN2 | GO:0010631 | epithelial cell migration | 21754995 |
| Kinase Fusion gene breakpoints across DMTN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PKN2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BP417512 | DMTN | chr8 | 21927698 | PKN2 | chr1 | 89299434 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21927698/:89299434) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DMTN | PKN2 |
| FUNCTION: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation. {ECO:0000269|PubMed:10565303, ECO:0000269|PubMed:11856323, ECO:0000269|PubMed:18347014, ECO:0000269|PubMed:19241372, ECO:0000269|PubMed:22927433, ECO:0000269|PubMed:23355471}. | FUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis (PubMed:27104747). {ECO:0000269|PubMed:10226025, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11777936, ECO:0000269|PubMed:11781095, ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:15364941, ECO:0000269|PubMed:17332740, ECO:0000269|PubMed:20188095, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:21754995, ECO:0000269|PubMed:27104747, ECO:0000269|PubMed:9121475}.; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. {ECO:0000269|PubMed:15364941}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of DMTN_PKN2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| PKN2 | Q16513 | human | NOS3 | P29474 | S1179 | RIRtQsFsLQERQLR | |
| PKN2 | Q16513 | human | MEFV | O15553 | S208 | VRLRRNAssAGRLQG | |
| PKN2 | Q16513 | human | MEFV | O15553 | S242 | SGKMRPRsLEVTIST |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| PKN2 | ID | Description | 0.00e+00 |
| PKN2 | GO:0032102 | negative regulation of response to external stimulus | 2.18e-02 |
| PKN2 | GO:0014745 | negative regulation of muscle adaptation | 2.18e-02 |
| PKN2 | GO:0006527 | arginine catabolic process | 2.18e-02 |
| PKN2 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly | 2.18e-02 |
| PKN2 | GO:0030728 | ovulation | 2.18e-02 |
| PKN2 | GO:0141086 | negative regulation of inflammasome-mediated signaling pathway | 2.18e-02 |
| PKN2 | GO:0030810 | positive regulation of nucleotide biosynthetic process | 2.18e-02 |
| PKN2 | GO:1900373 | positive regulation of purine nucleotide biosynthetic process | 2.18e-02 |
| PKN2 | GO:0010544 | negative regulation of platelet activation | 2.18e-02 |
| PKN2 | GO:0003184 | pulmonary valve morphogenesis | 2.18e-02 |
| PKN2 | GO:0032695 | negative regulation of interleukin-12 production | 2.18e-02 |
| PKN2 | GO:0006525 | arginine metabolic process | 2.18e-02 |
| PKN2 | GO:0045981 | positive regulation of nucleotide metabolic process | 2.18e-02 |
| PKN2 | GO:1900544 | positive regulation of purine nucleotide metabolic process | 2.18e-02 |
| PKN2 | GO:0003177 | pulmonary valve development | 2.18e-02 |
| PKN2 | GO:0019430 | removal of superoxide radicals | 2.18e-02 |
| PKN2 | GO:0071450 | cellular response to oxygen radical | 2.18e-02 |
| PKN2 | GO:0071451 | cellular response to superoxide | 2.18e-02 |
| PKN2 | GO:0002026 | regulation of the force of heart contraction | 2.18e-02 |
| PKN2 | GO:0009065 | glutamine family amino acid catabolic process | 2.18e-02 |
| PKN2 | GO:0000303 | response to superoxide | 2.18e-02 |
| PKN2 | GO:0000305 | response to oxygen radical | 2.18e-02 |
| PKN2 | GO:0007263 | nitric oxide mediated signal transduction | 2.18e-02 |
| PKN2 | GO:0070168 | negative regulation of biomineral tissue development | 2.18e-02 |
| PKN2 | GO:0032682 | negative regulation of chemokine production | 2.18e-02 |
| PKN2 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 2.18e-02 |
| PKN2 | GO:0030808 | regulation of nucleotide biosynthetic process | 2.18e-02 |
| PKN2 | GO:1900371 | regulation of purine nucleotide biosynthetic process | 2.18e-02 |
| PKN2 | GO:0034405 | response to fluid shear stress | 2.18e-02 |
| PKN2 | GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 2.18e-02 |
| PKN2 | GO:0048873 | homeostasis of number of cells within a tissue | 2.18e-02 |
| PKN2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 2.18e-02 |
| PKN2 | GO:0043267 | negative regulation of potassium ion transport | 2.18e-02 |
| PKN2 | GO:0044546 | NLRP3 inflammasome complex assembly | 2.18e-02 |
| PKN2 | GO:0070269 | pyroptosis | 2.18e-02 |
| PKN2 | GO:0141085 | regulation of inflammasome-mediated signaling pathway | 2.18e-02 |
| PKN2 | GO:0001990 | regulation of systemic arterial blood pressure by hormone | 2.18e-02 |
| PKN2 | GO:0003180 | aortic valve morphogenesis | 2.18e-02 |
| PKN2 | GO:0031281 | positive regulation of cyclase activity | 2.18e-02 |
| PKN2 | GO:0140632 | canonical inflammasome complex assembly | 2.18e-02 |
| PKN2 | GO:0051349 | positive regulation of lyase activity | 2.18e-02 |
| PKN2 | GO:0003203 | endocardial cushion morphogenesis | 2.18e-02 |
| PKN2 | GO:0045454 | cell redox homeostasis | 2.18e-02 |
| PKN2 | GO:1900016 | negative regulation of cytokine production involved in inflammatory response | 2.18e-02 |
| PKN2 | GO:0141084 | inflammasome-mediated signaling pathway | 2.18e-02 |
| PKN2 | GO:0003176 | aortic valve development | 2.18e-02 |
| PKN2 | GO:0060412 | ventricular septum morphogenesis | 2.18e-02 |
| PKN2 | GO:0032691 | negative regulation of interleukin-1 beta production | 2.18e-02 |
| PKN2 | GO:0003044 | regulation of systemic arterial blood pressure mediated by a chemical signal | 2.18e-02 |
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Related Drugs to DMTN_PKN2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning DMTN-PKN2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DMTN_PKN2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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