UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:DNAH1_PRKCD

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: DNAH1_PRKCD
KinaseFusionDB ID: KFG1709
FusionGDB2.0 ID: KFG1709
HgeneTgene
Gene symbol

DNAH1

PRKCD

Gene ID

25981

5580

Gene namedynein axonemal heavy chain 1protein kinase C delta
SynonymsCILD37|DNAHC1|HDHC7|HL-11|HL11|HSRF-1|SPGF18|XLHSRF-1ALPS3|CVID9|MAY1|PKCD|nPKC-delta
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptiondynein axonemal heavy chain 1axonemal beta dynein heavy chain 1ciliary dynein heavy chain 1dynein heavy chain 1, axonemaldynein, axonemal, heavy polypeptide 1heat shock regulated protein 1testicular tissue protein Li 60protein kinase C delta typeprotein kinase C delta VIIItyrosine-protein kinase PRKCD
Modification date2024041120240403
UniProtAcc

Q0VDD8

Q969G5

Ensembl transtripts involved in fusion geneENST idsENST00000420323, ENST00000466628, 
ENST00000477794, ENST00000330452, 
ENST00000394729, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: DNAH1 [Title/Abstract] AND PRKCD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAH1(52391751)-PRKCD(53221356), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAH1

GO:0036159

inner dynein arm assembly

24360805

TgenePRKCD

GO:0006468

protein phosphorylation

10713049|12649167|16611985|34593629

TgenePRKCD

GO:0006915

apoptotic process

10770950|12649167

TgenePRKCD

GO:0018105

peptidyl-serine phosphorylation

18285462

TgenePRKCD

GO:0018107

peptidyl-threonine phosphorylation

10770950

TgenePRKCD

GO:0032147

activation of protein kinase activity

10713049

TgenePRKCD

GO:0034644

cellular response to UV

17303575

TgenePRKCD

GO:0042119

neutrophil activation

10770950

TgenePRKCD

GO:0043687

post-translational protein modification

19059439

TgenePRKCD

GO:0070301

cellular response to hydrogen peroxide

10713049

TgenePRKCD

GO:0071447

cellular response to hydroperoxide

19059439

TgenePRKCD

GO:1904385

cellular response to angiotensin

18285462

TgenePRKCD

GO:2000303

regulation of ceramide biosynthetic process

17303575


check buttonKinase Fusion gene breakpoints across DNAH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across PRKCD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-24-1603-01ADNAH1chr3

52391751

PRKCDchr3

53221356



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000420323ENST00000394729DNAH1chr352391751PRKCDchr35322135653711577

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000420323_ENST00000394729_DNAH1_chr3_52391751_PRKCD_chr3_53221356_length(amino acids)=1577
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLY
EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52391751/chr3:53221356)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH1

Q0VDD8

PRKCD

Q969G5

FUNCTION: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.FUNCTION: Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity). {ECO:0000250|UniProtKB:Q91VJ2, ECO:0000250|UniProtKB:Q9Z1H9, ECO:0000269|PubMed:19262564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneDNAH152391751PRKCD53221356ENST000004203231218604_675450677DomainNote=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618
TgeneDNAH152391751PRKCD53221356ENST000004203231319604_675450677DomainNote=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618


Top

Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>144_DNAH1_PRKCDENST00000420323ENST00000394729DNAH1chr352391751PRKCDchr353221356
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLY
EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD
1577
3D view using mol* of 144_DNAH1_PRKCD
PDB file >>>TKFP_237_DNAH1_PRKCDENST00000420323ENST00000394729DNAH1chr352391751PRKCDchr353221356
MDSGKVAPPSGLEGSFGWGISLRSSMEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLPHLPLP
PAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMSQNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIG
STTRLLAQTDFPLQAYEPKMQVPFQVLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFPIYLPL
KVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKYKWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRP
ILNAGVTTEGRPPLQVCQYWVPRIQLLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALSTPRMR
KGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPERGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSK
VRAECNKVTAMSLFHSSLSKYSHLEEFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLMELVKY
MLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFIMDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATH
AVPQLEKLVMEDIFISGDPLLESVGLHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVREVVLT
HLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEVDSICEEFRSISRKIYEKPNSIEELAELREWMKGIP
ERLVGLEERIVKVMDDYQVMDEFLYNLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVVAGFSI
HVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEFQPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEK
NVVEAFKTMHKCVKQFKDMPACQEVALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQDHIESI
SKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDHIVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLE
EWLNCQRSWLYLEPIFSSEDINQQLPVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLETKRSAF
PRFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLY
EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRD
1577_DNAH1_PRKCD


Top

Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

Top

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

DNAH1_PRKCD does not have any known PDB structures.

Top

pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.


Top

Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

Top

Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.


Top

Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case

Top

check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy

Top

Kinase-Substrate Information of DNAH1_PRKCD


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PRKCDQ05655humanHDAC5Q9UQL6S259FPLRkTAsEPNLKVR
PRKCDQ05655humanPTPRAP18433-2S204PLLARSPsTNRKYPP
PRKCDQ05655humanBCL2P10415S70RDPVARtsPLQtPAA
PRKCDQ05655humanHNRNPKP61978S302GrGGrGGsrArNLPL
PRKCDQ05655humanSLC9A1P19634S648KTRQRLRsYNRHtLVNEXCaM_BD
PRKCDQ05655humanSHOC2Q9UQ13T71VAFSVDNtIKRPNPA
PRKCDQ05655humanBLVRAP53004S237sFHFksGsLENVPNVBiliv-reduc_cat
PRKCDQ05655humanMUC1P15941T1224RyVPPsstDRsPyEK
PRKCDQ05655humanADD1P35611S726KKKFRtPsFLKKsKK
PRKCDQ05655humanNCF1P14598S370PAVPPRPsADLILNRp47_phox_C
PRKCDQ05655humanFBXO25Q8TCJ0S178DLLQDLSsTLCILIR
PRKCDQ05655humanENOX2Q16206S504ENLKEKEsCASRLCA
PRKCDQ05655humanMARK2Q7KZI7T596rGVssRstFHAGQLR
PRKCDQ05655humanTNNI3P19429T143RGKFKRPtLRrVrIsTroponin
PRKCDQ05655humanFOSL1P15407T217LEPEALHtPTLMTtP
PRKCDQ05655humanBEST1O76090S358SAQFRRAsFMGSTFN
PRKCDQ05655humanRPS6KB2Q9UBS0S473PPSGTKKsKRGRGRP
PRKCDQ05655humanNCF4Q15080S315RQARGLPsQKRLFPWPB1
PRKCDQ05655humanNCF1P14598S303RGAPPRRssIRNAHsNECFESHC
PRKCDQ05655humanCARD9Q9H257T231CKVERKHtLKLRHAM
PRKCDQ05655humanITGB2P05107T758NPLFksAtttVMNPkIntegrin_b_cyt
PRKCDQ05655humanPRKCDQ05655T218TAANSRDtIFQkERF
PRKCDQ05655humanTRPV4Q9HBA0S162FDIVSRGsTADLDGL
PRKCDQ05655humanLCP1P13796S5___MARGsVsDEEMM
PRKCDQ05655humanSQSTM1Q13501S349sskEVDPstGELQsL
PRKCDQ05655humanKRT8P05787S74tVNQsLLsPLVLEVDKeratin_2_head
PRKCDQ05655humanGAPDHP04406T246NVsVVDLtCrLEkPAGp_dh_C
PRKCDQ05655humanGAPDHP04406S241rVPtANVsVVDLtCrGp_dh_C
PRKCDQ05655humanNRG1Q02297-6S286LHDRLRQsLRSERNNNeuregulin
PRKCDQ05655humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
PRKCDQ05655humanDAP3P51398S31MGTQARQsIAAHLDN
PRKCDQ05655humanSTAT1P42224S727TDNLLPMsPEEFDEVSTAT1_TAZ2bind
PRKCDQ05655humanNCF4Q15080T154LRRLRPRtRKVKSVs
PRKCDQ05655humanPRKCDQ05655S503kENIFGEsRAstFCGPkinase
PRKCDQ05655humanRPS6P62753S235IAKRRRLssLRAsts
PRKCDQ05655humanITGB2P05107S745FEkEKLksQWNNDNPIntegrin_b_cyt
PRKCDQ05655humanPRKCDQ05655S299NQVtQRAsRRsDsAs
PRKCDQ05655humanSLC29A1Q99808S281QPTNESHsIkAILkNNucleoside_tran
PRKCDQ05655humanTIRAPP58753Y106AAQDLVSyLEGSTASTIR_2
PRKCDQ05655humanDAP3P51398S280tLKREDksPIAPEELDAP3
PRKCDQ05655humanCTTNQ14247S405KtQtPPVsPAPQPtE
PRKCDQ05655humanDAB2P98082S24QAAPKAPsKKEKKKG
PRKCDQ05655humanPTPN22Q9Y2R2S35FLkLkRQsTKYKADK
PRKCDQ05655humanPRKD1Q15139S742GEksFRRsVVGtPAyPkinase
PRKCDQ05655humanPRKCDQ05655S302tQRAsRRsDsAssEP
PRKCDQ05655humanNCF1P14598S348PGPQsPGsPLEEERQ
PRKCDQ05655humanBLVRAP53004S230LKRNRyLsFHFksGsBiliv-reduc_cat
PRKCDQ05655humanPRKCDQ05655S645LNEkARLsysDKNLIPkinase_C
PRKCDQ05655humanDAP3P51398T237ItRVRNAtDAVGIVLDAP3
PRKCDQ05655humanPRKCDQ05655S304RAsRRsDsAssEPVG
PRKCDQ05655humanFGF1P05230S131VGLKKNGsCKRGPRTFGF
PRKCDQ05655humanPRKCDQ05655T295AEALNQVtQRAsRRs
PRKCDQ05655humanSMPD1P17405S510DGNYSGSsHVVLDHEASMase_C
PRKCDQ05655humanH3C1P68431T45PHryrPGtVALrEIRHistone
PRKCDQ05655humanCHATP28329-3S476HKAAVPAsEKLLLLKCarn_acyltransf
PRKCDQ05655humanCYBAP13498T147ERPQIGGtIkQPPsNCytochrom_B558a
PRKCDQ05655humanPTPRAP18433-2S180QAGSHSNsFRLSNGR
PRKCDQ05655humanTP53P04637S46AMDDLMLsPDDIEQWTAD2
PRKCDQ05655humanPGRP06401S400GAEAsARsPRSYLVAProg_receptor
PRKCDQ05655humanPREX1Q8TCU6S313RVtGsKKsTKRTKsI
PRKCDQ05655humanADAM17P78536T735kPFPAPQtPGRLQPA
PRKCDQ05655humanCDH1P12830T790TRNDVAPtLMsVPRy
PRKCDQ05655humanC5AR1P21730S334sVVREsKsFTRsTVD
PRKCDQ05655humanIRS1P35568S574RLPGHRHsAFVPTRs
PRKCDQ05655humanPLSCR3Q9NRY6T21PPPPYPVtPGYPEPA
PRKCDQ05655humanNADKO95544S46RGRAKsrsLsAsPAL
PRKCDQ05655humanTRPV4Q9HBA0T175GLLPFLLtHKKRLTD
PRKCDQ05655humanPPP1R14AQ96A00T38QkRHARVtVkYDRREPP1_inhibitor
PRKCDQ05655humanNCF1P14598S320QRsRKRLsQDAYRRNNECFESHC
PRKCDQ05655humanNCF1P14598S359EERQtQRsKPQPAVPp47_phox_C
PRKCDQ05655humanG6PDP11413-3S210FGRDLQSsDRLSNHIG6PD_N
PRKCDQ05655humanNADKO95544S64kEFRRtRsLHGPCPV
PRKCDQ05655humanCDK5Q00535T77LHsDkKLtLVFEFCDPkinase
PRKCDQ05655humanLIMK2P53671S283EGtLRRRsLRRsNsI
PRKCDQ05655humanDAP3P51398S185FDQPLEAstWLkNFkDAP3
PRKCDQ05655humanNR2F6P10588S83CKSFFKRsIRRNLsYzf-C4
PRKCDQ05655humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
PRKCDQ05655humanHVCN1Q96D96-4S77GMLRKLFsSHRFQVI
PRKCDQ05655humanTNNI3P19429S23PAPIRRRssNyRAyATroponin-I_N
PRKCDQ05655humanIRS1P35568S323MVGGKPGsFRVRAss
PRKCDQ05655humanIL6STP40189T890GQVERFEtVGMEAAt
PRKCDQ05655humanDAP3P51398T186DQPLEAstWLkNFkTDAP3
PRKCDQ05655humanPRKCDQ05655T141EDEAkFPtMNRRGAI
PRKCDQ05655humanRPS3P23396S6__MAVQIskkRkFVA
PRKCDQ05655humanPRKD1Q15139S738ARIIGEksFRRsVVGPkinase
PRKCDQ05655humanPLD2O14939T566FIQRWNFtKTTKAKy
PRKCDQ05655humanBAG3O95817S187sSSSSSAsLPsSGRs
PRKCDQ05655humanMCUQ8NE86S92VISVRLPsRRERCQF
PRKCDQ05655humanCHATP28329-3S440VPTYESAsIRRFQEGCarn_acyltransf
PRKCDQ05655humanFOSL1P15407T227LMTtPSLtPFtPSLV
PRKCDQ05655humanSHC1P29353-2S29EEWTRHGsFVNKPTR
PRKCDQ05655humanEGFRP00533T678RHIVRKRtLRRLLQE
PRKCDQ05655humanELAVL1Q15717S318GDkILQVsFkTNkSH
PRKCDQ05655humanRPS6P62753S236AKRRRLssLRAstsK
PRKCDQ05655humanNFE2L2Q16236S40SREVFDFsQRRkEYE
PRKCDQ05655humanHAX1O00165S210QPkSYFksIsVtkIT
PRKCDQ05655humanRPS3P23396T221kDEILPttPIsEQkG
PRKCDQ05655humanCTNNB1P35222S715GYRQDDPsyRsFHsG
PRKCDQ05655humanPRKD1Q15139S412PLMRVVQsVKHTKRK
PRKCDQ05655humanIRS1P35568S307TRRsRtEsItAtsPA
PRKCDQ05655humanGSK3AP49840S21sGrARtssFAEPGGG
PRKCDQ05655humanCXCR4P61073S324LtsVsRGssLkILsk
PRKCDQ05655humanHVCN1Q96D96-4T9SKFLRHFtVVGDDYH
PRKCDQ05655humanTNNI3P19429S24APIRRRssNyRAyAtTroponin-I_N
PRKCDQ05655humanPPP1R14BQ96C90T57VRRQGKVtVkYDRKEPP1_inhibitor
PRKCDQ05655humanTSC2P49815S939sFRARstsLNERPKs
PRKCDQ05655humanFCER1GP30273S69DGVytGLstRNQEtyITAM
PRKCDQ05655humanTBL1XR1Q9BZK7S123AAAsQQGsAKNGENT
PRKCDQ05655humanGSK3BP49841S9SGRPRttsFAEsCkP
PRKCDQ05655humanSTAT3P40763S727NtIDLPMsPrTLDSL
PRKCDQ05655humanCXCR4P61073S325tsVsRGssLkILskG
PRKCDQ05655humanDNM1LO00429S616PIPIMPAsPQKGHAV
PRKCDQ05655humanTRPV4Q9HBA0S189DEEFREPsTGKTCLP
PRKCDQ05655humanEP300Q09472S89SELLRSGsSPNLNMG
PRKCDQ05655humanTSC2P49815S932DDtPEkDsFRARsts
PRKCDQ05655humanLMNAP02545S22QAsstPLsPtRItRL
PRKCDQ05655humanFLI1Q01543T312TNGEFKMtDPDEVAREts
PRKCDQ05655humanMETP08581S985PHLDRLVsARsVsPt
PRKCDQ05655humanELAVL1Q15717S221QAQrFrFsPMGVDHM
PRKCDQ05655humanIRS1P35568S441SPCDFRSsFRsVtPD
PRKCDQ05655humanTACSTD2P09758S322GELRkEPsL______
PRKCDQ05655humanBLVRAP53004S33DLRNPHPsSAFLNLIGFO_IDH_MocA
PRKCDQ05655humanPA2G4Q9UQ80S360ELkALLQssAsRKtQ
PRKCDQ05655humanHVCN1Q96D96T29SKFLRHFtVVGDDyH
PRKCDQ05655humanCATP04040S167LFPSFIHsQKRNPQTCatalase
PRKCDQ05655humanTP73O15350-2S289GQVLGRRsFEGRICAP53
PRKCDQ05655humanSRCP12931S12KSKPKDAsQRRRsLE
PRKCDQ05655humanG6PDP11413-3T266NIACVILtFKEPFGTG6PD_C
PRKCDQ05655humanCHN2P52757S171EKVsRRLsRsKNEPR
PRKCDQ05655humanPEBP1P30086S153RGKFkVAsFRKKYELPBP
PRKCDQ05655humanSHOC2Q9UQ13S297GLRYNRLsAIPRSLALRR_8
PRKCDQ05655humanNCF1P14598S315AHsIHQRsRKRLsQDNECFESHC
PRKCDQ05655humanBLVRAP53004S21VGVGRAGsVRMRDLRGFO_IDH_MocA
PRKCDQ05655humanNCF1P14598S379DLILNRCsEstKRKLp47_phox_C
PRKCDQ05655humanRASGRP3Q8IV61T133YDWMRRVtQRKKVSK
PRKCDQ05655humanHVCN1Q96D96S97GMLRKLFsSHRFQVI


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PRKCDIDDescription0.00e+00
PRKCDGO:1901653cellular response to peptide3.02e-10
PRKCDGO:0010506regulation of autophagy8.59e-10
PRKCDGO:0010821regulation of mitochondrion organization5.80e-09
PRKCDGO:0043434response to peptide hormone6.55e-09
PRKCDGO:0034504protein localization to nucleus6.55e-09
PRKCDGO:0071375cellular response to peptide hormone stimulus6.55e-09
PRKCDGO:0006935chemotaxis1.84e-08
PRKCDGO:0042330taxis1.84e-08
PRKCDGO:0043254regulation of protein-containing complex assembly2.92e-08
PRKCDGO:0009410response to xenobiotic stimulus4.41e-08
PRKCDGO:0000302response to reactive oxygen species5.28e-08
PRKCDGO:0006606protein import into nucleus5.58e-08
PRKCDGO:0051170import into nucleus6.64e-08
PRKCDGO:0060326cell chemotaxis6.64e-08
PRKCDGO:0032868response to insulin6.92e-08
PRKCDGO:0006979response to oxidative stress8.72e-08
PRKCDGO:1903829positive regulation of protein localization1.00e-07
PRKCDGO:0051347positive regulation of transferase activity1.25e-07
PRKCDGO:0072593reactive oxygen species metabolic process1.40e-07
PRKCDGO:0006801superoxide metabolic process2.26e-07
PRKCDGO:0051222positive regulation of protein transport2.58e-07
PRKCDGO:0031334positive regulation of protein-containing complex assembly2.75e-07
PRKCDGO:0034599cellular response to oxidative stress3.07e-07
PRKCDGO:0062197cellular response to chemical stress3.20e-07
PRKCDGO:0032869cellular response to insulin stimulus3.68e-07
PRKCDGO:1904951positive regulation of establishment of protein localization3.84e-07
PRKCDGO:0006913nucleocytoplasmic transport4.45e-07
PRKCDGO:0051169nuclear transport4.45e-07
PRKCDGO:0032386regulation of intracellular transport5.33e-07
PRKCDGO:0033674positive regulation of kinase activity5.34e-07
PRKCDGO:0033157regulation of intracellular protein transport7.81e-07
PRKCDGO:0001666response to hypoxia1.27e-06
PRKCDGO:0000422autophagy of mitochondrion1.58e-06
PRKCDGO:0061726mitochondrion disassembly1.58e-06
PRKCDGO:1900180regulation of protein localization to nucleus1.87e-06
PRKCDGO:0042542response to hydrogen peroxide1.90e-06
PRKCDGO:0050921positive regulation of chemotaxis1.97e-06
PRKCDGO:0036293response to decreased oxygen levels1.97e-06
PRKCDGO:0097193intrinsic apoptotic signaling pathway2.18e-06
PRKCDGO:1903146regulation of autophagy of mitochondrion2.18e-06
PRKCDGO:0032388positive regulation of intracellular transport2.40e-06
PRKCDGO:0042554superoxide anion generation2.42e-06
PRKCDGO:2001233regulation of apoptotic signaling pathway2.62e-06
PRKCDGO:0043410positive regulation of MAPK cascade2.62e-06
PRKCDGO:0034614cellular response to reactive oxygen species2.77e-06
PRKCDGO:0031330negative regulation of cellular catabolic process2.95e-06
PRKCDGO:0090316positive regulation of intracellular protein transport3.29e-06
PRKCDGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator3.29e-06
PRKCDGO:0070482response to oxygen levels3.89e-06

Top

Related Drugs to DNAH1_PRKCD


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning DNAH1-PRKCD and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to DNAH1_PRKCD


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate