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Kinase Fusion Gene:DPYD_CSNK1G1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: DPYD_CSNK1G1 | KinaseFusionDB ID: KFG1745 | FusionGDB2.0 ID: KFG1745 | Hgene | Tgene | Gene symbol | DPYD | CSNK1G1 | Gene ID | 1806 | 53944 | |
| Gene name | dihydropyrimidine dehydrogenase | casein kinase 1 gamma 1 | ||||||||||
| Synonyms | DHP|DHPDHASE|DPD|DYPD | CK1gamma1 | ||||||||||
| Cytomap | 1p21.3 | 15q22.31 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | dihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenase | casein kinase I isoform gamma-1 | ||||||||||
| Modification date | 20240407 | 20240305 | ||||||||||
| UniProtAcc | Q12882 | Q9HCP0 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000306031, ENST00000370192, ENST00000423006, ENST00000474241, | ENST00000303032, ENST00000303052, ENST00000607537, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DPYD [Title/Abstract] AND CSNK1G1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DPYD(98386440)-CSNK1G1(64551440), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DPYD | GO:0006210 | thymine catabolic process | 10410956 |
| Hgene | DPYD | GO:0006212 | uracil catabolic process | 1512248|18075467 |
| Hgene | DPYD | GO:0006214 | thymidine catabolic process | 1512248 |
| Kinase Fusion gene breakpoints across DPYD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CSNK1G1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-13-1510-01A | DPYD | chr1 | 98386440 | CSNK1G1 | chr15 | 64551440 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:98386440/:64551440) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DPYD | CSNK1G1 |
| FUNCTION: Involved in pyrimidine base degradation (PubMed:1512248). Catalyzes the reduction of uracil and thymine (PubMed:1512248). Also involved the degradation of the chemotherapeutic drug 5-fluorouracil (PubMed:1512248). {ECO:0000269|PubMed:1512248}. | FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of DPYD_CSNK1G1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CSNK1G1 | Q9HCP0 | human | SNCA | P37840 | T64 | EktkEQVtNVGGAVV | Synuclein |
| CSNK1G1 | Q9HCP0 | human | APC | P25054 | S1507 | FsCsssLsALsLDEP | APC_r |
| CSNK1G1 | Q9HCP0 | human | LRP6 | O75581 | T1479 | SSsstKGtyFPAILN | |
| CSNK1G1 | Q9HCP0 | human | APC | P25054 | S1505 | DGFsCsssLsALsLD | APC_r |
| CSNK1G1 | Q9HCP0 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
| CSNK1G1 | Q9HCP0 | human | LYN | P07948 | S13 | SKGkDsLsDDGVDLk | |
| CSNK1G1 | Q9HCP0 | human | APC | P25054 | S1510 | sssLsALsLDEPFIQ | |
| CSNK1G1 | Q9HCP0 | human | APC | P25054 | S1504 | PDGFsCsssLsALsL | APC_r |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CSNK1G1 | ID | Description | 0.00e+00 |
| CSNK1G1 | GO:0031400 | negative regulation of protein modification process | 5.63e-06 |
| CSNK1G1 | GO:0006469 | negative regulation of protein kinase activity | 1.52e-05 |
| CSNK1G1 | GO:0033673 | negative regulation of kinase activity | 1.52e-05 |
| CSNK1G1 | GO:0051348 | negative regulation of transferase activity | 2.11e-05 |
| CSNK1G1 | GO:0071900 | regulation of protein serine/threonine kinase activity | 4.35e-05 |
| CSNK1G1 | GO:0001933 | negative regulation of protein phosphorylation | 4.70e-05 |
| CSNK1G1 | GO:0042326 | negative regulation of phosphorylation | 5.39e-05 |
| CSNK1G1 | GO:0045936 | negative regulation of phosphate metabolic process | 7.41e-05 |
| CSNK1G1 | GO:0010563 | negative regulation of phosphorus metabolic process | 7.41e-05 |
| CSNK1G1 | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 1.24e-04 |
| CSNK1G1 | GO:0043086 | negative regulation of catalytic activity | 1.59e-04 |
| CSNK1G1 | GO:1902993 | positive regulation of amyloid precursor protein catabolic process | 1.21e-03 |
| CSNK1G1 | GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 2.61e-03 |
| CSNK1G1 | GO:0032496 | response to lipopolysaccharide | 3.73e-03 |
| CSNK1G1 | GO:0042176 | regulation of protein catabolic process | 3.89e-03 |
| CSNK1G1 | GO:0002237 | response to molecule of bacterial origin | 3.89e-03 |
| CSNK1G1 | GO:0034142 | toll-like receptor 4 signaling pathway | 3.98e-03 |
| CSNK1G1 | GO:1902991 | regulation of amyloid precursor protein catabolic process | 3.98e-03 |
| CSNK1G1 | GO:0140895 | cell surface toll-like receptor signaling pathway | 4.50e-03 |
| CSNK1G1 | GO:0050727 | regulation of inflammatory response | 4.50e-03 |
| CSNK1G1 | GO:0043434 | response to peptide hormone | 4.50e-03 |
| CSNK1G1 | GO:0009410 | response to xenobiotic stimulus | 4.50e-03 |
| CSNK1G1 | GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 4.50e-03 |
| CSNK1G1 | GO:0042987 | amyloid precursor protein catabolic process | 4.57e-03 |
| CSNK1G1 | GO:0002752 | cell surface pattern recognition receptor signaling pathway | 4.65e-03 |
| CSNK1G1 | GO:0014015 | positive regulation of gliogenesis | 4.70e-03 |
| CSNK1G1 | GO:0051656 | establishment of organelle localization | 4.70e-03 |
| CSNK1G1 | GO:0031349 | positive regulation of defense response | 4.86e-03 |
| CSNK1G1 | GO:0140029 | exocytic process | 5.46e-03 |
| CSNK1G1 | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 5.46e-03 |
| CSNK1G1 | GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 6.35e-03 |
| CSNK1G1 | GO:0031110 | regulation of microtubule polymerization or depolymerization | 6.64e-03 |
| CSNK1G1 | GO:0042982 | amyloid precursor protein metabolic process | 6.64e-03 |
| CSNK1G1 | GO:0014013 | regulation of gliogenesis | 8.46e-03 |
| CSNK1G1 | GO:0042177 | negative regulation of protein catabolic process | 8.67e-03 |
| CSNK1G1 | GO:0043200 | response to amino acid | 1.05e-02 |
| CSNK1G1 | GO:0031109 | microtubule polymerization or depolymerization | 1.12e-02 |
| CSNK1G1 | GO:0051209 | release of sequestered calcium ion into cytosol | 1.12e-02 |
| CSNK1G1 | GO:0051283 | negative regulation of sequestering of calcium ion | 1.12e-02 |
| CSNK1G1 | GO:0051282 | regulation of sequestering of calcium ion | 1.12e-02 |
| CSNK1G1 | GO:0070555 | response to interleukin-1 | 1.12e-02 |
| CSNK1G1 | GO:0001101 | response to acid chemical | 1.12e-02 |
| CSNK1G1 | GO:0051208 | sequestering of calcium ion | 1.13e-02 |
| CSNK1G1 | GO:0010950 | positive regulation of endopeptidase activity | 1.31e-02 |
| CSNK1G1 | GO:0070507 | regulation of microtubule cytoskeleton organization | 1.37e-02 |
| CSNK1G1 | GO:0051494 | negative regulation of cytoskeleton organization | 1.37e-02 |
| CSNK1G1 | GO:1902904 | negative regulation of supramolecular fiber organization | 1.41e-02 |
| CSNK1G1 | GO:0010952 | positive regulation of peptidase activity | 1.43e-02 |
| CSNK1G1 | GO:1903169 | regulation of calcium ion transmembrane transport | 1.46e-02 |
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Related Drugs to DPYD_CSNK1G1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning DPYD-CSNK1G1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DPYD_CSNK1G1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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