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Kinase Fusion Gene:DVL2_MAP3K10 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: DVL2_MAP3K10 | KinaseFusionDB ID: KFG1762 | FusionGDB2.0 ID: KFG1762 | Hgene | Tgene | Gene symbol | DVL2 | MAP3K10 | Gene ID | 1856 | 4294 | |
| Gene name | dishevelled segment polarity protein 2 | mitogen-activated protein kinase kinase kinase 10 | ||||||||||
| Synonyms | - | MEKK10|MLK2|MST | ||||||||||
| Cytomap | 17p13.1 | 19q13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | segment polarity protein dishevelled homolog DVL-2dishevelled 2 (homologous to Drosophila dsh)dishevelled, dsh homolog 2 | mitogen-activated protein kinase kinase kinase 10MKN28 derived nonreceptor_type serine/threonine kinaseMKN28 kinasemixed lineage kinase 2protein kinase MST | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | O14641 | Q02779 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000005340, ENST00000574642, ENST00000575458, | ENST00000253055, ENST00000593906, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DVL2 [Title/Abstract] AND MAP3K10 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DVL2(7130524)-MAP3K10(40698200), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DVL2 | GO:0006355 | regulation of DNA-templated transcription | 11742073 |
| Hgene | DVL2 | GO:0042127 | regulation of cell population proliferation | 18787224 |
| Hgene | DVL2 | GO:0043507 | positive regulation of JUN kinase activity | 17593335 |
| Hgene | DVL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12805222|17593335 |
| Hgene | DVL2 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 17593335 |
| Hgene | DVL2 | GO:0060070 | canonical Wnt signaling pathway | 17593335|18787224 |
| Hgene | DVL2 | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 12805222 |
| Tgene | MAP3K10 | GO:0018105 | peptidyl-serine phosphorylation | 19801649 |
| Tgene | MAP3K10 | GO:0018107 | peptidyl-threonine phosphorylation | 19801649 |
| Kinase Fusion gene breakpoints across DVL2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MAP3K10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | BF527861 | DVL2 | chr17 | 7130524 | MAP3K10 | chr19 | 40698200 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:7130524/:40698200) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DVL2 | MAP3K10 |
| FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499}. | FUNCTION: Activates the JUN N-terminal pathway. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of DVL2_MAP3K10 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K10 | Q02779 | human | DYRK2 | Q92630 | T381 | YEHQRVytyIQsRFY | Pkinase |
| MAP3K10 | Q02779 | human | TCF3 | P15923 | S379 | AGAPGALsPsyDGGL | |
| MAP3K10 | Q02779 | human | TCF3 | P15923 | T355 | NFsssPstPVGsPQG | |
| MAP3K10 | Q02779 | human | TCF3 | P15923 | S359 | sPstPVGsPQGLAGt | |
| MAP3K10 | Q02779 | human | TCF3 | P15923 | S341 | KALASIYsPDHssNN | |
| MAP3K10 | Q02779 | human | TCF3 | P15923 | S352 | ssNNFsssPstPVGs | |
| MAP3K10 | Q02779 | human | DYRK2 | Q92630 | S449 | sQKLLDAsKRAKNFV | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K10 | ID | Description | 0.00e+00 |
| MAP3K10 | GO:0045725 | positive regulation of glycogen biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K10 | GO:0106057 | negative regulation of calcineurin-mediated signaling | 1.79e-02 |
| MAP3K10 | GO:0033151 | V(D)J recombination | 1.79e-02 |
| MAP3K10 | GO:0070875 | positive regulation of glycogen metabolic process | 1.79e-02 |
| MAP3K10 | GO:0050849 | negative regulation of calcium-mediated signaling | 1.79e-02 |
| MAP3K10 | GO:0005979 | regulation of glycogen biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0010962 | regulation of glucan biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0070873 | regulation of glycogen metabolic process | 1.79e-02 |
| MAP3K10 | GO:0032885 | regulation of polysaccharide biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K10 | GO:0106056 | regulation of calcineurin-mediated signaling | 1.79e-02 |
| MAP3K10 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 1.79e-02 |
| MAP3K10 | GO:0010907 | positive regulation of glucose metabolic process | 1.79e-02 |
| MAP3K10 | GO:0033173 | calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K10 | GO:0005978 | glycogen biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0009250 | glucan biosynthetic process | 1.79e-02 |
| MAP3K10 | GO:0032881 | regulation of polysaccharide metabolic process | 1.79e-02 |
| MAP3K10 | GO:0097720 | calcineurin-mediated signaling | 1.79e-02 |
| MAP3K10 | GO:0016447 | somatic recombination of immunoglobulin gene segments | 1.98e-02 |
| MAP3K10 | GO:0000271 | polysaccharide biosynthetic process | 1.98e-02 |
| MAP3K10 | GO:0016445 | somatic diversification of immunoglobulins | 1.98e-02 |
| MAP3K10 | GO:0002562 | somatic diversification of immune receptors via germline recombination within a single locus | 1.98e-02 |
| MAP3K10 | GO:0016444 | somatic cell DNA recombination | 1.98e-02 |
| MAP3K10 | GO:0005977 | glycogen metabolic process | 1.98e-02 |
| MAP3K10 | GO:0002200 | somatic diversification of immune receptors | 1.98e-02 |
| MAP3K10 | GO:0044042 | glucan metabolic process | 1.98e-02 |
| MAP3K10 | GO:0045913 | positive regulation of carbohydrate metabolic process | 1.98e-02 |
| MAP3K10 | GO:0050848 | regulation of calcium-mediated signaling | 1.98e-02 |
| MAP3K10 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 1.98e-02 |
| MAP3K10 | GO:0006112 | energy reserve metabolic process | 1.99e-02 |
| MAP3K10 | GO:0045666 | positive regulation of neuron differentiation | 1.99e-02 |
| MAP3K10 | GO:0018107 | peptidyl-threonine phosphorylation | 1.99e-02 |
| MAP3K10 | GO:0005976 | polysaccharide metabolic process | 1.99e-02 |
| MAP3K10 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 1.99e-02 |
| MAP3K10 | GO:0010906 | regulation of glucose metabolic process | 1.99e-02 |
| MAP3K10 | GO:0043255 | regulation of carbohydrate biosynthetic process | 1.99e-02 |
| MAP3K10 | GO:1901796 | regulation of signal transduction by p53 class mediator | 1.99e-02 |
| MAP3K10 | GO:0018210 | peptidyl-threonine modification | 2.00e-02 |
| MAP3K10 | GO:0043467 | regulation of generation of precursor metabolites and energy | 2.46e-02 |
| MAP3K10 | GO:0062013 | positive regulation of small molecule metabolic process | 2.49e-02 |
| MAP3K10 | GO:0007224 | smoothened signaling pathway | 2.49e-02 |
| MAP3K10 | GO:0030183 | B cell differentiation | 2.52e-02 |
| MAP3K10 | GO:0072331 | signal transduction by p53 class mediator | 2.81e-02 |
| MAP3K10 | GO:0006109 | regulation of carbohydrate metabolic process | 2.87e-02 |
| MAP3K10 | GO:0006006 | glucose metabolic process | 2.87e-02 |
| MAP3K10 | GO:0002377 | immunoglobulin production | 2.87e-02 |
| MAP3K10 | GO:0045664 | regulation of neuron differentiation | 2.87e-02 |
| MAP3K10 | GO:0002520 | immune system development | 2.87e-02 |
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Related Drugs to DVL2_MAP3K10 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning DVL2-MAP3K10 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DVL2_MAP3K10 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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