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Kinase Fusion Gene:DYRK1B_CNOT3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: DYRK1B_CNOT3 | KinaseFusionDB ID: KFG1804 | FusionGDB2.0 ID: KFG1804 | Hgene | Tgene | Gene symbol | DYRK1B | CNOT3 | Gene ID | 9149 | 4849 | |
| Gene name | dual specificity tyrosine phosphorylation regulated kinase 1B | CCR4-NOT transcription complex subunit 3 | ||||||||||
| Synonyms | AOMS3|MIRK | IDDSADF|LENG2|NOT3|NOT3H | ||||||||||
| Cytomap | 19q13.2 | 19q13.42 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | dual specificity tyrosine-phosphorylation-regulated kinase 1Bdual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Bminibrain-related kinasemirk protein kinase | CCR4-NOT transcription complex subunit 3CCR4-associated factor 3NOT3 (negative regulator of transcription 3, yeast) homologleukocyte receptor cluster member 2 | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q9Y463 | O75175 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000323039, ENST00000348817, ENST00000430012, ENST00000601972, ENST00000593685, ENST00000597639, | ENST00000221232, ENST00000358389, ENST00000406403, ENST00000496327, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: DYRK1B [Title/Abstract] AND CNOT3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | DYRK1B(40324662)-CNOT3(54655962), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DYRK1B | GO:0006468 | protein phosphorylation | 11980910 |
| Hgene | DYRK1B | GO:0045893 | positive regulation of DNA-templated transcription | 11980910 |
| Kinase Fusion gene breakpoints across DYRK1B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CNOT3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | 235N | DYRK1B | chr19 | 40324662 | CNOT3 | chr19 | 54655962 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40324662/:54655962) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DYRK1B | CNOT3 |
| FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035, ECO:0000269|PubMed:33469661}. | FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of DYRK1B_CNOT3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| DYRK1B | Q9Y463 | human | ID2 | Q02363 | T27 | LGISRSKtPVDDPMS | |
| DYRK1B | Q9Y463 | human | DYRK1B | Q9Y463 | Y271 | CQLGQRIyQyIQsRF | Pkinase |
| DYRK1B | Q9Y463 | human | NKX3-1 | Q99801 | S186 | TKRkQLssELGDLEK | |
| DYRK1B | Q9Y463 | human | CDKN1A | P38936 | S153 | sMTDFyHskRrLIFS | |
| DYRK1B | Q9Y463 | human | HNF1A | P20823 | S249 | IQRGVsPsQAQGLGS | |
| DYRK1B | Q9Y463 | human | NKX3-1 | Q99801 | S185 | KTKRkQLssELGDLE | |
| DYRK1B | Q9Y463 | human | DYRK1B | Q9Y463 | Y273 | LGQRIyQyIQsRFYR | Pkinase |
| DYRK1B | Q9Y463 | human | H3-3A | P84243 | T45 | PHryrPGtVALrEIR | Histone |
| DYRK1B | Q9Y463 | human | EHMT2 | Q96KQ7 | T555 | IPRGDGVtPPAGtAA | |
| DYRK1B | Q9Y463 | human | CCND1 | P24385 | T288 | VDLACtPtDVRDVDI | |
| DYRK1B | Q9Y463 | human | DYRK1B | Q9Y463 | S421 | YEPAARIsPLGALQH | Pkinase |
| DYRK1B | Q9Y463 | human | LIN52 | Q52LA3 | S28 | FEKLDRAsPDLWPEQ | LIN52 |
| DYRK1B | Q9Y463 | human | SF3B1 | O75533 | T434 | PARkLtAtPtPLGGM | SF3b1 |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| DYRK1B | ID | Description | 0.00e+00 |
| DYRK1B | GO:0060749 | mammary gland alveolus development | 6.45e-03 |
| DYRK1B | GO:0061377 | mammary gland lobule development | 6.45e-03 |
| DYRK1B | GO:0009410 | response to xenobiotic stimulus | 6.45e-03 |
| DYRK1B | GO:0048732 | gland development | 6.45e-03 |
| DYRK1B | GO:0050673 | epithelial cell proliferation | 6.45e-03 |
| DYRK1B | GO:0033598 | mammary gland epithelial cell proliferation | 6.45e-03 |
| DYRK1B | GO:0031571 | mitotic G1 DNA damage checkpoint signaling | 6.45e-03 |
| DYRK1B | GO:0044819 | mitotic G1/S transition checkpoint signaling | 6.45e-03 |
| DYRK1B | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 6.45e-03 |
| DYRK1B | GO:1902806 | regulation of cell cycle G1/S phase transition | 8.60e-03 |
| DYRK1B | GO:0031056 | regulation of histone modification | 1.01e-02 |
| DYRK1B | GO:0000082 | G1/S transition of mitotic cell cycle | 1.24e-02 |
| DYRK1B | GO:0044843 | cell cycle G1/S phase transition | 1.55e-02 |
| DYRK1B | GO:0048599 | oocyte development | 1.68e-02 |
| DYRK1B | GO:0031100 | animal organ regeneration | 1.68e-02 |
| DYRK1B | GO:0009994 | oocyte differentiation | 1.68e-02 |
| DYRK1B | GO:0009416 | response to light stimulus | 1.68e-02 |
| DYRK1B | GO:0061180 | mammary gland epithelium development | 1.68e-02 |
| DYRK1B | GO:0048663 | neuron fate commitment | 1.94e-02 |
| DYRK1B | GO:1901990 | regulation of mitotic cell cycle phase transition | 2.04e-02 |
| DYRK1B | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 2.09e-02 |
| DYRK1B | GO:0044773 | mitotic DNA damage checkpoint signaling | 2.09e-02 |
| DYRK1B | GO:1904029 | regulation of cyclin-dependent protein kinase activity | 2.09e-02 |
| DYRK1B | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | 2.09e-02 |
| DYRK1B | GO:0044774 | mitotic DNA integrity checkpoint signaling | 2.09e-02 |
| DYRK1B | GO:1902807 | negative regulation of cell cycle G1/S phase transition | 2.40e-02 |
| DYRK1B | GO:0042692 | muscle cell differentiation | 2.44e-02 |
| DYRK1B | GO:0009314 | response to radiation | 2.50e-02 |
| DYRK1B | GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 2.57e-02 |
| DYRK1B | GO:0048477 | oogenesis | 2.63e-02 |
| DYRK1B | GO:0090398 | cellular senescence | 2.63e-02 |
| DYRK1B | GO:1901987 | regulation of cell cycle phase transition | 2.63e-02 |
| DYRK1B | GO:0044772 | mitotic cell cycle phase transition | 2.72e-02 |
| DYRK1B | GO:1902749 | regulation of cell cycle G2/M phase transition | 2.72e-02 |
| DYRK1B | GO:0016570 | histone modification | 2.83e-02 |
| DYRK1B | GO:0000077 | DNA damage checkpoint signaling | 3.03e-02 |
| DYRK1B | GO:0045931 | positive regulation of mitotic cell cycle | 3.04e-02 |
| DYRK1B | GO:0050864 | regulation of B cell activation | 3.05e-02 |
| DYRK1B | GO:0030879 | mammary gland development | 3.05e-02 |
| DYRK1B | GO:0048565 | digestive tract development | 3.05e-02 |
| DYRK1B | GO:0031570 | DNA integrity checkpoint signaling | 3.05e-02 |
| DYRK1B | GO:0000086 | G2/M transition of mitotic cell cycle | 3.13e-02 |
| DYRK1B | GO:0001889 | liver development | 3.13e-02 |
| DYRK1B | GO:0007093 | mitotic cell cycle checkpoint signaling | 3.13e-02 |
| DYRK1B | GO:0061008 | hepaticobiliary system development | 3.17e-02 |
| DYRK1B | GO:0055123 | digestive system development | 3.17e-02 |
| DYRK1B | GO:0008584 | male gonad development | 3.22e-02 |
| DYRK1B | GO:0046546 | development of primary male sexual characteristics | 3.22e-02 |
| DYRK1B | GO:0009411 | response to UV | 3.22e-02 |
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Related Drugs to DYRK1B_CNOT3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning DYRK1B-CNOT3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to DYRK1B_CNOT3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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