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Kinase Fusion Gene:EEF2K_N4BP2L2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: EEF2K_N4BP2L2 | KinaseFusionDB ID: KFG1827 | FusionGDB2.0 ID: KFG1827 | Hgene | Tgene | Gene symbol | EEF2K | N4BP2L2 | Gene ID | 29904 | 10443 | |
| Gene name | eukaryotic elongation factor 2 kinase | NEDD4 binding protein 2 like 2 | ||||||||||
| Synonyms | CaMKIII|HSU93850|eEF-2K | 92M18.3|CG005|CG016|PFAAP5 | ||||||||||
| Cytomap | 16p12.2 | 13q13.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | eukaryotic elongation factor 2 kinasealternative protein EEF2Kcalcium/calmodulin-dependent eukaryotic elongation factor-2 kinasecalmodulin-dependent protein kinase IIIeEF-2 kinaseelongation factor-2 kinaseeukaroytic elongation factor 2 kinase | NEDD4-binding protein 2-like 2phosphonoformate immuno-associated protein 5protein from BRCA2 region | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | O00418 | Q92802 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263026, ENST00000561791, | ENST00000267068, ENST00000357505, ENST00000380121, ENST00000399396, ENST00000446957, ENST00000504114, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: EEF2K [Title/Abstract] AND N4BP2L2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | EEF2K(22237296)-N4BP2L2(33095586), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EEF2K | GO:0046777 | protein autophosphorylation | 9144159|23184662 |
| Kinase Fusion gene breakpoints across EEF2K (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across N4BP2L2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-CJ-4888-01A | EEF2K | chr16 | 22237296 | N4BP2L2 | chr13 | 33095586 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22237296/:33095586) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EEF2K | N4BP2L2 |
| FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of EEF2K_N4BP2L2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| EEF2K | O00418 | human | EEF2 | P13639 | T57 | rAGEtRFtDtRkDEQ | GTP_EFTU |
| EEF2K | O00418 | human | EEF2K | O00418 | S396 | TFDsLPssPssAtPH | |
| EEF2K | O00418 | human | EEF2K | O00418 | S366 | sPQVRtLsGSRPPLL | |
| EEF2K | O00418 | human | EEF2K | O00418 | S78 | ssGsPANsFHFkEAW | |
| EEF2K | O00418 | human | STAT3 | P40763 | Y705 | DPGsAAPyLktKFIC | |
| EEF2K | O00418 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
| EEF2K | O00418 | human | EEF2K | O00418 | S441 | EsENsGDsGyPsEkR | |
| EEF2K | O00418 | human | EEF2K | O00418 | S500 | RLHLPRAsAVALEVQ | |
| EEF2K | O00418 | human | EEF2K | O00418 | T348 | kLLQsAktILRGtEE | |
| EEF2K | O00418 | human | EEF2K | O00418 | T353 | AktILRGtEEKCGsP | |
| EEF2K | O00418 | human | EEF2K | O00418 | S445 | sGDsGyPsEkRGELD | |
| EEF2K | O00418 | human | EEF2K | O00418 | S474 | kYEsDEDsLGssGRV | |
| EEF2K | O00418 | human | PKM | P14618 | T129 | GLIkGsGtAEVELkk | PK |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| EEF2K | ID | Description | 0.00e+00 |
| EEF2K | GO:0071375 | cellular response to peptide hormone stimulus | 1.88e-04 |
| EEF2K | GO:1901653 | cellular response to peptide | 1.99e-04 |
| EEF2K | GO:0043434 | response to peptide hormone | 2.32e-04 |
| EEF2K | GO:0032869 | cellular response to insulin stimulus | 1.68e-03 |
| EEF2K | GO:2000737 | negative regulation of stem cell differentiation | 1.94e-03 |
| EEF2K | GO:0032868 | response to insulin | 2.49e-03 |
| EEF2K | GO:0045912 | negative regulation of carbohydrate metabolic process | 6.54e-03 |
| EEF2K | GO:0048814 | regulation of dendrite morphogenesis | 7.48e-03 |
| EEF2K | GO:0006414 | translational elongation | 7.96e-03 |
| EEF2K | GO:2000736 | regulation of stem cell differentiation | 8.90e-03 |
| EEF2K | GO:0006096 | glycolytic process | 1.01e-02 |
| EEF2K | GO:0106027 | neuron projection organization | 1.01e-02 |
| EEF2K | GO:0050773 | regulation of dendrite development | 1.10e-02 |
| EEF2K | GO:0006090 | pyruvate metabolic process | 1.46e-02 |
| EEF2K | GO:0043467 | regulation of generation of precursor metabolites and energy | 1.71e-02 |
| EEF2K | GO:0048813 | dendrite morphogenesis | 1.71e-02 |
| EEF2K | GO:0045727 | positive regulation of translation | 1.71e-02 |
| EEF2K | GO:0016052 | carbohydrate catabolic process | 2.15e-02 |
| EEF2K | GO:0034250 | positive regulation of amide metabolic process | 2.19e-02 |
| EEF2K | GO:0045766 | positive regulation of angiogenesis | 2.34e-02 |
| EEF2K | GO:1904018 | positive regulation of vasculature development | 2.34e-02 |
| EEF2K | GO:0006109 | regulation of carbohydrate metabolic process | 2.34e-02 |
| EEF2K | GO:0046777 | protein autophosphorylation | 2.51e-02 |
| EEF2K | GO:0016358 | dendrite development | 3.16e-02 |
| EEF2K | GO:0032984 | protein-containing complex disassembly | 3.16e-02 |
| EEF2K | GO:0048863 | stem cell differentiation | 3.16e-02 |
| EEF2K | GO:0034504 | protein localization to nucleus | 3.16e-02 |
| EEF2K | GO:0033210 | leptin-mediated signaling pathway | 3.16e-02 |
| EEF2K | GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | 3.16e-02 |
| EEF2K | GO:0070874 | negative regulation of glycogen metabolic process | 3.16e-02 |
| EEF2K | GO:1903799 | negative regulation of miRNA processing | 3.16e-02 |
| EEF2K | GO:1905050 | positive regulation of metallopeptidase activity | 3.16e-02 |
| EEF2K | GO:0048638 | regulation of developmental growth | 3.16e-02 |
| EEF2K | GO:0006983 | ER overload response | 3.16e-02 |
| EEF2K | GO:0035723 | interleukin-15-mediated signaling pathway | 3.16e-02 |
| EEF2K | GO:0070669 | response to interleukin-2 | 3.16e-02 |
| EEF2K | GO:0071350 | cellular response to interleukin-15 | 3.16e-02 |
| EEF2K | GO:1901984 | negative regulation of protein acetylation | 3.16e-02 |
| EEF2K | GO:1903564 | regulation of protein localization to cilium | 3.16e-02 |
| EEF2K | GO:2001223 | negative regulation of neuron migration | 3.16e-02 |
| EEF2K | GO:0006913 | nucleocytoplasmic transport | 3.16e-02 |
| EEF2K | GO:0051169 | nuclear transport | 3.16e-02 |
| EEF2K | GO:0034454 | microtubule anchoring at centrosome | 3.16e-02 |
| EEF2K | GO:0060965 | negative regulation of miRNA-mediated gene silencing | 3.16e-02 |
| EEF2K | GO:0070672 | response to interleukin-15 | 3.16e-02 |
| EEF2K | GO:0072497 | mesenchymal stem cell differentiation | 3.16e-02 |
| EEF2K | GO:0106014 | regulation of inflammatory response to wounding | 3.16e-02 |
| EEF2K | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 3.16e-02 |
| EEF2K | GO:1904338 | regulation of dopaminergic neuron differentiation | 3.16e-02 |
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Related Drugs to EEF2K_N4BP2L2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning EEF2K-N4BP2L2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to EEF2K_N4BP2L2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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