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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:EFCAB7_ATM

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: EFCAB7_ATM
KinaseFusionDB ID: KFG1839
FusionGDB2.0 ID: KFG1839
HgeneTgene
Gene symbol

EFCAB7

ATM

Gene ID

84455

472

Gene nameEF-hand calcium binding domain 7ATM serine/threonine kinase
Synonyms-AT1|ATA|ATC|ATD|ATDC|ATE|TEL1|TELO1
Cytomap

1p31.3

11q22.3

Type of geneprotein-codingprotein-coding
DescriptionEF-hand calcium-binding domain-containing protein 7serine-protein kinase ATMA-T mutatedAT mutatedTEL1, telomere maintenance 1, homologataxia telangiectasia mutatedserine/threonine kinase ATM
Modification date2024030520240413
UniProtAcc

A8K855

Q13315

Ensembl transtripts involved in fusion geneENST idsENST00000371088, ENST00000461039, 
ENST00000278616, ENST00000452508, 
ENST00000525178, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: EFCAB7 [Title/Abstract] AND ATM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EFCAB7(64001623)-ATM(108175794), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATM

GO:0000077

DNA damage checkpoint signaling

30886146

TgeneATM

GO:0000425

pexophagy

26344566

TgeneATM

GO:0006302

double-strand break repair

26240375

TgeneATM

GO:0006468

protein phosphorylation

15448695|15916964

TgeneATM

GO:0006974

DNA damage response

9733515|16213212

TgeneATM

GO:0010212

response to ionizing radiation

9733515|11375976

TgeneATM

GO:0018105

peptidyl-serine phosphorylation

9733515|26323318

TgeneATM

GO:0034614

cellular response to reactive oxygen species

26344566

TgeneATM

GO:0042770

signal transduction in response to DNA damage

26774286

TgeneATM

GO:0046777

protein autophosphorylation

9733515|15790808

TgeneATM

GO:0071044

histone mRNA catabolic process

16086026

TgeneATM

GO:0071480

cellular response to gamma radiation

9925639|16213212

TgeneATM

GO:0071481

cellular response to X-ray

26323318

TgeneATM

GO:0071500

cellular response to nitrosative stress

23878245


check buttonKinase Fusion gene breakpoints across EFCAB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ATM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0DX571517EFCAB7chr1

64001623

ATMchr11

108175794



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:64001623/:108175794)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFCAB7

A8K855

ATM

Q13315

FUNCTION: Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. {ECO:0000250|UniProtKB:Q8VDY4}.FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Recognizes the substrate consensus sequence [ST]-Q (PubMed:9733514, PubMed:10550055, PubMed:10839545, PubMed:10910365, PubMed:12556884, PubMed:14871926, PubMed:15456891, PubMed:15448695, PubMed:15916964, PubMed:17923702). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738, PubMed:30886146, PubMed:26774286). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed:19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed:15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed:15448695). Also involved in pexophagy by mediating phosphorylation of PEX5: translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed:26344566). {ECO:0000250|UniProtKB:Q62388, ECO:0000269|PubMed:10550055, ECO:0000269|PubMed:10766245, ECO:0000269|PubMed:10802669, ECO:0000269|PubMed:10839545, ECO:0000269|PubMed:10910365, ECO:0000269|PubMed:10973490, ECO:0000269|PubMed:11375976, ECO:0000269|PubMed:12086603, ECO:0000269|PubMed:12556884, ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:16086026, ECO:0000269|PubMed:16858402, ECO:0000269|PubMed:17923702, ECO:0000269|PubMed:19431188, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:26344566, ECO:0000269|PubMed:26774286, ECO:0000269|PubMed:29203878, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:30886146, ECO:0000269|PubMed:9733514, ECO:0000269|PubMed:9733515, ECO:0000269|PubMed:9843217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of EFCAB7_ATM


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
ATMQ13315humanFANCIQ9NVI1S972SLLNLLSsQEEDFNSFANCI_S3
ATMQ13315humanKHDC3LQ587J8T145IEVREAGtQRSVEVR
ATMQ13315humanNKX3-1Q99801T166kNLkLTEtQVKIWFQHomeodomain
ATMQ13315humanTP53BP1Q12888S29IEDsQPEsQVLEDDS
ATMQ13315humanKHSRPQ92945S670GPGAPPGsQPDySAADUF1897
ATMQ13315humanDCLRE1CQ96SD1S503NDEITDEsLENFPSS
ATMQ13315humanRRM2BQ7LG56S72TAEEVDLsKDLPHWNRibonuc_red_sm
ATMQ13315humanDBN1Q16643-3S647SEGYFSQsQEEEFAQ
ATMQ13315humanKHDC3LQ587J8T156VEVREAGtQRSVEVQ
ATMQ13315humanCROCCQ5TZA2-2S922TESELRAsQEKISKM
ATMQ13315humanFANCD2Q9BXW9S222LPEILGDsQHADVGKFancD2
ATMQ13315humanFBXW7Q969H0S26LRGNPSssQVDEEQM
ATMQ13315humanUIMC1Q96RL1S205sGsWDQSsQPVFENV
ATMQ13315humanWAPLQ7Z5K2S498PPESNDNsQDSQSGT
ATMQ13315humanE2F1Q01094S31ALRLLDSsQIVIISA
ATMQ13315humanMDM2Q00987S407SSSIIyssQEDVKEF
ATMQ13315humanTP53P04637S37NVLsPLPsQAMDDLMTAD2
ATMQ13315humanCHEK2O96017S33tQsQGSSsQsQGIss
ATMQ13315humanSLX4Q8IY92S1631PHCQTLAsQTYKPSR
ATMQ13315humanNFAT5O94916S1247AMQSNSPsQEQQQQQ
ATMQ13315humanTRIM24O15164S217PEAVGVTsQRPVFCP
ATMQ13315humanPOLLQ9UGP5T204EASDGEEtQVSAADL
ATMQ13315humanPTENP60484T398PFDEDQHtQItkV__
ATMQ13315humanXPAP23025S196RSLEVWGsQEALEEA
ATMQ13315humanFUSP35637S42QQSYSGYsQSTDTSG
ATMQ13315humanMDM2Q00987S386DDKITQAsQsQESED
ATMQ13315humanUSP2O75604S2______MsQLSSTLK
ATMQ13315humanHUWE1Q7Z6Z7S3797QAAtsESsQSEAsVR
ATMQ13315humanSP1P08047S101DLTATQLsQGANGWQ
ATMQ13315humanNRF1Q16656T259QKQRVSWtQALRTIVNrf1_DNA-bind
ATMQ13315humanMED1Q15648S872FNPDLLNsQsQSGFG
ATMQ13315humanHSP90AA1P07900T7_MPEEtQtQDQPMEE
ATMQ13315humanSMC3Q9UQE7S1067GDVEGsQsQDEGEGsSMC_N
ATMQ13315humanNABP2Q9BQ15T117EPNPEYstQQAPNKA
ATMQ13315humanYAP1P46937Y391PFLNsGtyHSRDEst
ATMQ13315humanMCPH1Q8NEM0S322QKQAAGMsQETFEEkMicrocephalin
ATMQ13315humanDTYMKP23919S88PLIkEKLsQGVtLVVThymidylate_kin
ATMQ13315humanRNF40O75150S853EkELTLRsQALELNK
ATMQ13315humanTOP2BQ02880-2S1134SSDsGTPsGPDFNYIDNA_topoisoIV
ATMQ13315humanPPM1GO15355S183GTGEEPGsQGLNGEA
ATMQ13315humanAVENQ9NQS1S308NILPDQTsQDLKSKE
ATMQ13315humanMEN1O00255-1S399EERPGEQsQGTQSQGMenin
ATMQ13315humanTP53BP1Q12888S1778FNkQYTEsQLRAGAG
ATMQ13315humanHUWE1Q7Z6Z7S3377kACsPCSsQSSSSGI
ATMQ13315humanRPA2P15927S29QsPGGFGsPAPsQAE
ATMQ13315humanDBF4Q9UBU7S502FSTDNSGsQPKQKsD
ATMQ13315humanPPP1R2P41236S44DEELSKKsQKWDEMN
ATMQ13315humanDCLRE1CQ96SD1S649NADsQsssDFEVPst
ATMQ13315humanCBLP22681S866SEIENLMsQGYSYQDUBA
ATMQ13315humanCHEK2O96017S28PHGsVtQsQGSSsQs
ATMQ13315humanPRPF19Q9UMS4S149VPQAVPSsQPSVVGA
ATMQ13315humanMAD1L1Q9Y6D9S214kIQELQAsQEARADHMAD
ATMQ13315humanUCHL3P15374S75EEEEKIKsQGQDVTSPeptidase_C12
ATMQ13315humanRANBP9Q96S59S550NSINMSRsQQVNNFTCTLH
ATMQ13315humanSMC3Q9UQE7S1083EsErGsGsQssVPSVSMC_N
ATMQ13315humanATMQ13315S367DTRSLEIsQSyTttQ
ATMQ13315humanPNKPQ96T60S114EEtRtPEsQPDtPPG
ATMQ13315humanTAOK1Q7L7X3T643EELNKRQtQKDLEHA
ATMQ13315humanRBBP8Q99708S664IDPGADLsQYKMDVT
ATMQ13315humanTP53P04637S46AMDDLMLsPDDIEQWTAD2
ATMQ13315humanTOPBP1Q92547S853LEtPGRPsQQkRKPs
ATMQ13315humanNIPBLQ6KC79S563sItQDSDsIKKPEEI
ATMQ13315humanTAOK1Q7L7X3S990SrSTsVTsQIsNGSH
ATMQ13315humanFANCIQ9NVI1S1121TLSEEAssQATLPNQFANCI_S4
ATMQ13315humanFANCD2Q9BXW9S717KDGGPVTsQESGQkLFancD2
ATMQ13315humanAVENQ9NQS1S135VNNESGEsQRGTDFS
ATMQ13315humanHUWE1Q7Z6Z7S927ISVNQWGsQLGLSVL
ATMQ13315humanMRE11P49959S678sskIMsQsQVsKGVD
ATMQ13315humanZEB1P37275S585GDGNLsPsQPPLKNL
ATMQ13315humanFANCIQ9NVI1S730LDksADFsQsTSIGIFANCI_HD2
ATMQ13315humanHUWE1Q7Z6Z7S2339GQPEVLSsQEMQVEN
ATMQ13315humanATMQ13315T1885sQTSRsTtPANLDsE
ATMQ13315humanMED1Q15648S1141sQGSSGSsQSKNSsQ
ATMQ13315humanFANCD2Q9BXW9T691yGLEEYDtQDGIAINFancD2
ATMQ13315humanL3MBTL2Q969R5S335RLEVVDKsQVsRTRMMBT
ATMQ13315humanAPLFQ8IW19S116MQCTLRNsQVLDEDN
ATMQ13315humanKDM2AQ9Y2K7T632EVDQNEEtQDFEKKLPHD_4
ATMQ13315humanID3Q02535S65VPRGTQLsQVEILQRHLH
ATMQ13315humanATMQ13315S2996QECkRNLsDIDQSFN
ATMQ13315humanBAG6P46379S26VLVktLDsQTRTFIVubiquitin
ATMQ13315humanSMC1AQ14683S957IsQEEGssQGEDsVsSMC_N
ATMQ13315humanDCLRE1CQ96SD1T656sDFEVPstPEAELPK
ATMQ13315humanBRCA1P38398S1524LQNRNYPsQEELIKV
ATMQ13315humanTERF1P54274S367SRIPVSKsQPVtPEK
ATMQ13315humanGIT2Q14161S384NNQHsVEsQDNDQPd
ATMQ13315humanPDS5AQ29RF7S1278GRRPKsEsQGNATKN
ATMQ13315humanBRCA1P38398S1387EDCSGLSsQSDILTt
ATMQ13315humanATMQ13315S1893PANLDsEsEHFFRCC
ATMQ13315humanCOPS5Q92905S320EAIHGLMsQVIkDkLCSN5_C
ATMQ13315humanRNF138Q8WVD3S124IIPNFQIsQDsVGNS
ATMQ13315humanSLX4Q8IY92S1271sRSRDCSsQtQISSL
ATMQ13315humanATF2P15336S490QSTEPALsQIVMAPS
ATMQ13315humanMDC1Q14676T4____MEDtQAIDWDV
ATMQ13315humanHIF1AQ16665S696NVLsVALsQRTtVPE
ATMQ13315humanBLMP54132T99NAPAGQEtQRGGSkSBLM_N
ATMQ13315humanUSP28Q96RU2S720SsQDYSTsQEPSVAS
ATMQ13315humanUSP10Q14694T42SGTVLCGtQAVDKLP
ATMQ13315humanDCLRE1CQ96SD1S645NLSTNADsQsssDFE
ATMQ13315humanCREB1P16220S107sVDsVtDsQKRREILpKID
ATMQ13315humanEZH2Q15910-2S734LFFDYRYsQADALKY
ATMQ13315humanUBR5O95071S1532SDQSSSSsQSQSSYI
ATMQ13315humanUSP34Q70CQ2S718ATHIAQGsQESCITR
ATMQ13315humanMDM2Q00987S425EtQDKEEsVESsLPL
ATMQ13315humanSMC1AQ14683S360RMEEEsQsQGRDLtLSMC_N
ATMQ13315humanKHDRBS1Q07666T61GARAsPAtQPPPLLP
ATMQ13315humanHUWE1Q7Z6Z7S2636HDQsTAtsQAGTLSS
ATMQ13315humanATF2P15336S498QIVMAPSsQSQPSGS
ATMQ13315humanWAPLQ7Z5K2S305RANKTkssQGASNFD
ATMQ13315humanDDX1Q92499S671EHLNCTIsQVEPDIK
ATMQ13315humanTP53P04637S33LPENNVLsPLPsQAM
ATMQ13315humanTERF1P54274S219SKLLMIIsQKDTFHSTRF
ATMQ13315humanHNF1AP20823S249IQRGVsPsQAQGLGS
ATMQ13315humanATMQ13315S440SPLLMILsQLLPQQR
ATMQ13315humanMDC1Q14676T98DCGsLNGtQILRPPKFHA
ATMQ13315humanPPP2R5CQ13362S520CRADELAsQDGR___
ATMQ13315humanRIF1Q5UIP0S1851sEAMsLEsQEsPNEN
ATMQ13315humanBECN1Q14457T57AQAkPGEtQEEETNs
ATMQ13315humanDYRK2Q92630T106NKRTVLTtQPNGLTT
ATMQ13315humanMDM2Q00987S395sQESEDysQPSTSSS
ATMQ13315humanSMC1AQ14683S358EERMEEEsQsQGRDLSMC_N
ATMQ13315humanBRCA1P38398S1423AVLEQHGsQPSNSYP
ATMQ13315humanAATFQ9NY61S189EGDDAEDsQGEsEED
ATMQ13315humanMLLT1Q03111S398FEPsQNHsQGPLRsM
ATMQ13315humanSMURF2Q9HAU4S384kILRQELsQQQPQAG
ATMQ13315humanSMC1AQ14683S966GEDsVsGsQRIssIySMC_N
ATMQ13315humanPELP1Q8IZL8S1033LAPEALPsQGEVERE
ATMQ13315humanRAD17O75943S646ETWSLPLsQNSASEL
ATMQ13315humanPIDD1Q9HB75T788DAETGFLtQSNLLSV
ATMQ13315humanCHEK1O14757S345LVQGIsFsQPtCPDH
ATMQ13315humanTP53BP1Q12888S1219DDtEsLHsQGEEEFD
ATMQ13315humanNIPBLQ6KC79S553HQAGRVDsQAsItQD
ATMQ13315humanTOPBP1Q92547S554ITEEGLFsQKSFLVL
ATMQ13315humanMED1Q15648S887EEYFDESsQSGDNDD
ATMQ13315humanTP53BP1Q12888S25PCLIIEDsQPEsQVL
ATMQ13315humanSLX4Q8IY92S1138PDHsSSRsQKSSSKL
ATMQ13315humanCCDC6Q16204T434tPPPSPNtQTPVQPP
ATMQ13315humanAGERQ15109S391ERAELNQsEEPEAGE
ATMQ13315humanBAG6P46379S218PEPVALSsQTSEPVE
ATMQ13315humanMED1Q15648S1134LsSSMyssQGSSGSs
ATMQ13315humanTDP1Q9NUW8S563KQKFFAGsQEPMATFTyr-DNA_phospho
ATMQ13315humanBRCA1P38398S1497EPGVERssPsKCPsL
ATMQ13315humanBUB1O43683S314sHEDLPAsQERSEVN
ATMQ13315humanBRCA1P38398S1189QKGELsRsPsPFtHT
ATMQ13315humanSARS1P49591S241MQEVAQLsQFDEELy
ATMQ13315humanAPBB1O00213S228DSSWATLsQGSPSYG
ATMQ13315humanHIC1Q14526S713DKAAEVLsQGAHLAA
ATMQ13315humanSMC3Q9UQE7S383YAkQGRGsQFTsKEE
ATMQ13315humanDGCR8Q8WYQ5S677RVGKQLAsQKILQLLdsrm
ATMQ13315humanSMARCC2Q8TAQ2S969PPALPPGsQPIPPTG
ATMQ13315humanUSP10Q14694S337ASGTLPVsQPKsWAS
ATMQ13315humanPRKDCP78527T2638VAGQIRAtQQQHDFtDNAPKcs_CC5
ATMQ13315humanUFL1O94874S462DDDsDDEsQssHtGK
ATMQ13315humanDCLRE1CQ96SD1S648TNADsQsssDFEVPs
ATMQ13315humanSMAD1Q15797S239DPMTQDGsQPMDTNM
ATMQ13315humanVCPP55072S326EVERRIVsQLLtLMDAAA
ATMQ13315humanMCM3P25205S535ATDDPNFsQEDQQDT
ATMQ13315humanCBLP22681T640DVPRLGstFsLDtsM
ATMQ13315humanNBNO60934S343TtPGPsLsQGVsVDE
ATMQ13315humanPRKDCP78527T2609LtPMFVEtQAsQGtLDNAPKcs_CC5
ATMQ13315humanSP1P08047S56tGGGGQEsQPsPLAL
ATMQ13315humanUBR5O95071S191VIPEELIsQAQVVLQE3_UbLigase_EDD
ATMQ13315humanRANBP9Q96S59S603tEMEVDSsQLRRQLCCTLH
ATMQ13315humanTOPBP1Q92547T1062NDSkGVLtQtLEMRE
ATMQ13315humanSARS1P49591S101ALANLkVsQIKKVRLSeryl_tRNA_N
ATMQ13315humanNFAT5O94916S1197HIQTPMLsQEQAQPP
ATMQ13315humanXRCC6P12956S27QEENLEAsGDykYsG
ATMQ13315humanTAOK3Q9H2K8S359SMSVSTGsQSSSVNS
ATMQ13315humanUSP28Q96RU2S495STSTEsSsQDVESTFUCH
ATMQ13315humanBTRCQ9Y297S158EFVEHLIsQMCHYQHBeta-TrCP_D
ATMQ13315humanITCHQ96J02-2S161TTCSESAsQNDDGSR
ATMQ13315humanMETTL3Q86U44S43rNPEAALsPTFRsDs
ATMQ13315humanRFWD3Q6PCD5S63APAEVISsQATPPLL
ATMQ13315humanZNF148Q9UQR1S202GEkPFQCsQCDMRFIzf-C2H2
ATMQ13315humanPNKPQ96T60S126PPGtPLVsQDEKRDA
ATMQ13315humanRAD17O75943T633EESLGEPtQATVPET
ATMQ13315humanRASSF1Q9NS23S135EWETPDLsQAEIEQk
ATMQ13315humanNKX3-1Q99801T134SRAAFSHtQVIELERHomeodomain
ATMQ13315humanABRAXAS1Q6UWZ7S406GFGEYsRsPtF____
ATMQ13315humanDCLRE1CQ96SD1S516SSTVAGGsQsPKLFS
ATMQ13315humanCREB1P16220S119EILsRRPsyRkILNDpKID
ATMQ13315humanKHDRBS1Q07666S388EGYEGYysQsQGDSESam68-YY
ATMQ13315humanSMC3Q9UQE7S1065KkGDVEGsQsQDEGESMC_N
ATMQ13315humanTAOK3Q9H2K8S551DLTTFLEsQKKQYKI
ATMQ13315humanUBR5O95071S174rGsGLLGsQPQPVIP
ATMQ13315humanSRPK1Q96SB4S408QNGDSSTsQETDSCT
ATMQ13315humanCREB1P16220-1T100LKRLFsGtQISTIAE
ATMQ13315humanCDKN1BP46527S140PkTDPSDsQTGLAEQ
ATMQ13315humanMED1Q15648S816DSSSSGHsQSTLFDS
ATMQ13315humanCREB1P16220S97TIAEsEDsQEsVDsV
ATMQ13315humanBRCA1P38398S1457SEKAVLTsQKsSEYP
ATMQ13315humanEHMT2Q96KQ7S569APAPPPLsQDVPGRA
ATMQ13315humanCOP1Q8NHY2S387SDDSRTAsQLDEFQE
ATMQ13315humanRBBP8Q99708S745SCLADSFsQAADEEE
ATMQ13315humanXPAP23025S173VKkNPHHsQWGDMKLXPA_C
ATMQ13315humanRNF20Q5VTR2S545PDsEDLSsQSsAsKA
ATMQ13315humanKIFC1Q9BW19S26RPLIkAPsQLPLsGs
ATMQ13315humanPKMP14618T328GkPVICAtQMLESMIPK
ATMQ13315humanCHD4Q14839S1349QVNYNDGsQEDRDWQDUF1087
ATMQ13315humanMRE11P49959S676tSsskIMsQsQVsKG
ATMQ13315humanSLX4Q8IY92S1716GSDSSLSsQSSSSCE
ATMQ13315humanZNF420Q8TAQ5S68NTYETELsQWEMSDR
ATMQ13315humanPRKDCP78527T2647QQHDFtLtQTADGRsDNAPKcs_CC5
ATMQ13315humanHUWE1Q7Z6Z7S3695ENVVIVAsQkRPLGG
ATMQ13315humanNUSAP1Q9BXS6S124QNHEKQEsQDLRATA
ATMQ13315humanRAD18Q9NS91S403TSVTNHFsQSKLDsP
ATMQ13315humanPRKDCP78527S2612MFVEtQAsQGtLQtRDNAPKcs_CC5
ATMQ13315humanCTTNQ14247S113skLskHCsQVDsVrGHS1_rep
ATMQ13315humanNSD2O96028S102DAkLRFEsQEMKGIG
ATMQ13315humanZNF207O43670S104LEQktQEsQKKKQQD
ATMQ13315humanUSP34Q70CQ2S1751NIHIkDAsQTTLLDL
ATMQ13315humanTHOC5Q13769S312EDsQDDEsDsDAEEEFmiP_Thoc5
ATMQ13315humanMED1Q15648S874PDLLNsQsQSGFGEE
ATMQ13315humanHSP90AA1P07900T5___MPEEtQtQDQPM
ATMQ13315humanZBTB2Q8N680S115IQEASLAsQGAFSHPBTB
ATMQ13315humanRNF40O75150S819EQVLGLksQVDAQLL
ATMQ13315humanKHDRBS1Q07666S390YEGYysQsQGDSEyySam68-YY
ATMQ13315humanMDM2Q00987T419KEFEREEtQDKEEsV
ATMQ13315humanABRAXAS1Q6UWZ7S404MkGFGEYsRsPtF__
ATMQ13315humanTP63Q9H3D4S479MNKLPsVsQLINPQQ
ATMQ13315humanDCKP27707S74EFEELtMsQkNGGNVdNK
ATMQ13315humanKHSRPQ92945S274MILIQDGsQNtNVDkKH_1
ATMQ13315humanBMAL1O00327S183VFKILNYsQNDLIGQ
ATMQ13315humanCHUKO15111S473KNTLISAsQQLKAKLIKBKB_SDD
ATMQ13315humanDBF4Q9UBU7T449DDIRQNFtQLPLHkN
ATMQ13315humanWRAP53Q9BUR4S64PVAGSAVsQELREGD
ATMQ13315humanWWC1Q8IX03T1006RTWHSQLtQEISVLK
ATMQ13315humanRNF40O75150S114ALLRCHEsQGELSSA
ATMQ13315humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
ATMQ13315humanESCO2Q56NI9S196SNAPRVLsQKIKPQV
ATMQ13315humanMRE11P49959S264EQQLFYIsQPGSSVV
ATMQ13315humanSLC2A1P11166S490FHPLGADsQV_____
ATMQ13315humanUSP15Q9Y4E8S678LPSENENsQSEDSVGUCH
ATMQ13315humanLARP7Q4G0J3T440ANREECRtQEKVNAt
ATMQ13315humanRPA2P15927S23GAGGYtQsPGGFGsP
ATMQ13315humanBRCA1P38398S1542EEQQLEEsGPHDLtE
ATMQ13315humanCHEK2O96017S35sQGSSsQsQGIssss
ATMQ13315humanTDP1Q9NUW8S365TPGrFQGsQkDNWGHTyr-DNA_phospho
ATMQ13315humanBLMP54132T122PKEVVCTtQNtPtVkBLM_N
ATMQ13315humanSIM2Q14190S115ASVHLGLsQVELTGNPAS
ATMQ13315humanRASSF1Q9NS23-2S131EWETPDLsQAEIEQK
ATMQ13315humanRANBP9Q96S59S181kFSYIGLsQNNLRVH
ATMQ13315humanSMC3Q9UQE7S787ELGtDLLsQLsLEDQSMC_N
ATMQ13315humanUBR5O95071S1679SDSDSSSsQSDDIEQ
ATMQ13315humanFBXO31Q5XUX0S278LMKFIytsQYDNCLt
ATMQ13315humanGIT2Q14161T195VYGADPGtQDSSGKTAnk_2
ATMQ13315humanATMQ13315S1981sLAFEEGsQSTtIss
ATMQ13315humanKAT8Q9H7Z6T392LSQMTSItQNDIISTMOZ_SAS
ATMQ13315humanUSP2O75604T137YDQGVTLtQKLDsQs
ATMQ13315humanUSP28Q96RU2S714ESSTNSSsQDYSTsQ
ATMQ13315humanRFWD3Q6PCD5S46VPADVVSsQGVPSIL
ATMQ13315humanSMC1AQ14683S951kGtMDDIsQEEGssQSMC_N
ATMQ13315humanEP300Q09472S106GPGQVMAsQAQQSSP
ATMQ13315humanRAD50Q92878S635KLFDVCGsQDFEsDL
ATMQ13315humanPRKDCP78527S3205tPLPEDNsMNVDQDGFAT
ATMQ13315humanNBNO60934S278VDTGITNsQTLIPDCNIBRIN_BRCT_II
ATMQ13315humanTRIM28Q13263S824LPGAGLssQELsGGP
ATMQ13315humanCHEK2O96017T68SsLEtVstQELYsIP
ATMQ13315humanXRCC6P12956S33AsGDykYsGRDsLIF
ATMQ13315humanSRPK1Q96SB4T326ENPPNKMtQEKLEEs
ATMQ13315humanFANCIQ9NVI1S559SLSSsQCsQSLSVsQFANCI_HD2
ATMQ13315humanRPA2P15927T21yGGAGGYtQsPGGFG
ATMQ13315humanH2AXP16104S139GkkAtQAsQEy____
ATMQ13315humanTAOK1Q7L7X3T785SINEMLStQALRLDE
ATMQ13315humanESCO2Q56NI9T233NEPSLGRtQKSKSEV
ATMQ13315humanRNF20Q5VTR2S522sGsALLQsQsstEDP
ATMQ13315humanNOP53Q9NZM5T289PATEQAAtQESTFQENop53
ATMQ13315humanNOP53Q9NZM5S233ARLHTKPsQAPAVEVNop53
ATMQ13315humanMDM4O15151S403DLAHSSEsQETISSM
ATMQ13315humanRAD17O75943S656SASELPAsQPQPFSA
ATMQ13315humanNHEJ1Q9H9Q4S251AsLQGIDsQCVNQPE
ATMQ13315humanWRNQ14191S1141PEKAYSSsQPVISAQ
ATMQ13315humanPRKAA2P54646T172sDGEFLRtsCGsPNyPkinase
ATMQ13315humanPRKDCP78527T4102EsGLSEEtQVkCLMD
ATMQ13315humanMED1Q15648S1147SsQSKNSsQsGGKPG
ATMQ13315humanTOPBP1Q92547S492QADEDLLsQyENGss
ATMQ13315humanESPL1Q14674S1660ADQLQGLsLQEMPGD
ATMQ13315humanDAXXQ9UER7S564LEEESPVsQLFELEI
ATMQ13315humanEIF4EBP1Q13541S94DEPPMEAsQSHLRNseIF_4EBP
ATMQ13315humanTRIM24O15164S768TsLLLNSsQSstSEE
ATMQ13315humanLAMTOR5O43504S26VGVLCTDsQGLNLGCLAMTOR5
ATMQ13315humanTHOC5Q13769S314sQDDEsDsDAEEEQtFmiP_Thoc5
ATMQ13315humanDBF4Q9UBU7S539GLItINSsQEHLTVQ
ATMQ13315humanCHEK2O96017T26sQPHGsVtQsQGSSs
ATMQ13315humanNBNO60934S615VPEssKIsQENEIGK
ATMQ13315humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
ATMQ13315humanNFAT5O94916S1367LVQGSPSsQEQQVTL
ATMQ13315humanTOPBP1Q92547S1138PDVNTEPsQNEQIIW
ATMQ13315humanSMARCA4P51532S721VDDEyGVsQALARGL
ATMQ13315humanTDP1Q9NUW8S81PKRQKsGsQEDLGWC
ATMQ13315humanPTENP60484S113EDLDQWLsEDDNHVA
ATMQ13315humanNBNO60934S397EQKFRMLsQDAPtVK
ATMQ13315humanRNF20Q5VTR2S172SSSEEMEsQLQERVE
ATMQ13315humanUBR5O95071S2586LRQLILAsQSSDADAHECT
ATMQ13315humanBUB3O43684S135PCNAGtFsQPEkVyT
ATMQ13315humanDCLRE1CQ96SD1S647STNADsQsssDFEVP
ATMQ13315humanDYRK2Q92630S442IELLGMPsQKLLDAsPkinase
ATMQ13315humanSIAH1Q8IUQ4S19GtSkCPPsQRVPALT
ATMQ13315humanEWSR1Q01844T79QPPTGYTtPTAPQAY
ATMQ13315humanGPS1Q13098S474ksPPREGsQGELtPA
ATMQ13315humanPAN2Q504Q3S1003TKSTIkPsQMSVARIRNase_T
ATMQ13315humanRAD9AQ99638S272LSDtDSHsQDLGsPE
ATMQ13315humanMLH1P40692S406PLSkPLSsQPQAIVT
ATMQ13315humanTHOC5Q13769S307LFKPPEDsQDDEsDsFmiP_Thoc5
ATMQ13315humanTRIM24O15164S808kSEWLDPsQKsPLHV
ATMQ13315humanFANCIQ9NVI1S556VLGSLSSsQCsQSLSFANCI_HD2
ATMQ13315humanMLLT1Q03111S394SDSDFEPsQNHsQGP
ATMQ13315humanPBRM1Q86U86S948SGLHRTYsQDCSFKN
ATMQ13315humanEYA3Q99504S266PSTsPsLsQttPsKD
ATMQ13315humanUSP28Q96RU2S67DERVkEPsQDtVATE
ATMQ13315humanUBQLN4Q9NRR5S318GNSDsSSsQPLRTEN
ATMQ13315humanMED1Q15648S953LMEHHsGsQGPLLTT
ATMQ13315humanMDM2Q00987S429KEEsVESsLPLNAIE
ATMQ13315humanDDX1Q92499S377DEADGLLsQGysDFIDEAD
ATMQ13315humanSPOPO43791S119EETKAMEsQRAYRFVMATH
ATMQ13315humanMATR3P43243S208DyDHGsRsQEsGyyD
ATMQ13315humanPEX5P50542S141DYNETDWsQEFISEV


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
ATMIDDescription0.00e+00
ATMGO:0006302double-strand break repair6.77e-44
ATMGO:0010948negative regulation of cell cycle process1.96e-40
ATMGO:0000075cell cycle checkpoint signaling2.12e-40
ATMGO:1901988negative regulation of cell cycle phase transition1.98e-39
ATMGO:1901987regulation of cell cycle phase transition1.54e-38
ATMGO:0045786negative regulation of cell cycle3.36e-37
ATMGO:0000077DNA damage checkpoint signaling9.21e-37
ATMGO:0031570DNA integrity checkpoint signaling1.03e-35
ATMGO:0042770signal transduction in response to DNA damage5.23e-35
ATMGO:0007093mitotic cell cycle checkpoint signaling5.23e-35
ATMGO:0044773mitotic DNA damage checkpoint signaling5.26e-31
ATMGO:0045930negative regulation of mitotic cell cycle1.15e-30
ATMGO:0044774mitotic DNA integrity checkpoint signaling1.84e-30
ATMGO:1901991negative regulation of mitotic cell cycle phase transition9.15e-29
ATMGO:1901990regulation of mitotic cell cycle phase transition1.56e-27
ATMGO:0044772mitotic cell cycle phase transition2.22e-26
ATMGO:0010212response to ionizing radiation2.64e-26
ATMGO:0006310DNA recombination1.14e-24
ATMGO:0051054positive regulation of DNA metabolic process1.30e-20
ATMGO:0000725recombinational repair1.72e-20
ATMGO:0009314response to radiation2.84e-20
ATMGO:0000724double-strand break repair via homologous recombination1.82e-19
ATMGO:0006303double-strand break repair via nonhomologous end joining1.51e-18
ATMGO:0044818mitotic G2/M transition checkpoint1.52e-18
ATMGO:0010972negative regulation of G2/M transition of mitotic cell cycle2.47e-18
ATMGO:0006260DNA replication4.07e-18
ATMGO:1902750negative regulation of cell cycle G2/M phase transition5.23e-18
ATMGO:0072331signal transduction by p53 class mediator5.26e-17
ATMGO:0044839cell cycle G2/M phase transition6.89e-17
ATMGO:1902749regulation of cell cycle G2/M phase transition8.29e-17
ATMGO:0000086G2/M transition of mitotic cell cycle1.56e-16
ATMGO:0007059chromosome segregation1.89e-16
ATMGO:0010389regulation of G2/M transition of mitotic cell cycle2.30e-16
ATMGO:0098813nuclear chromosome segregation7.51e-16
ATMGO:0097193intrinsic apoptotic signaling pathway1.40e-14
ATMGO:0007095mitotic G2 DNA damage checkpoint signaling2.77e-14
ATMGO:0006282regulation of DNA repair4.94e-14
ATMGO:0000280nuclear division3.42e-13
ATMGO:0044843cell cycle G1/S phase transition8.23e-13
ATMGO:0051053negative regulation of DNA metabolic process1.64e-12
ATMGO:0010332response to gamma radiation1.87e-12
ATMGO:0048285organelle fission3.51e-12
ATMGO:0031571mitotic G1 DNA damage checkpoint signaling3.51e-12
ATMGO:0044819mitotic G1/S transition checkpoint signaling3.51e-12
ATMGO:0045739positive regulation of DNA repair3.62e-12
ATMGO:0071479cellular response to ionizing radiation3.67e-12
ATMGO:0000723telomere maintenance4.25e-12
ATMGO:0032200telomere organization6.53e-12
ATMGO:0033044regulation of chromosome organization6.94e-12

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Related Drugs to EFCAB7_ATM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning EFCAB7-ATM and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to EFCAB7_ATM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate