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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:EGFR_PPM1H

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: EGFR_PPM1H
	KinaseFusionDB ID: KFG1876
	FusionGDB2.0 ID: KFG1876
		Hgene	Tgene
	Gene symbol	EGFR	PPM1H
	Gene ID	1956	57460
	Gene name	epidermal growth factor receptor	protein phosphatase, Mg2+/Mn2+ dependent 1H
	Synonyms	ERBB\|ERBB1\|ERRP\|HER1\|NISBD2\|PIG61\|mENA	ARHCL1\|NERPP-2C\|URCC2
	Cytomap	7p11.2	12q14.1-q14.2
	Type of gene	protein-coding	protein-coding
	Description	epidermal growth factor receptorEGFR vIIIavian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyro	protein phosphatase 1Hneurite extension-related protein phosphatase related to PP2Cprotein phosphatase 1H (PP2C domain containing)ras homolog gene family, member C like 1
	Modification date	20240416	20240305
	UniProtAcc	P00533	Q9ULR3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000463948, ENST00000275493, ENST00000342916, ENST00000344576, ENST00000420316, ENST00000442591, ENST00000455089, ENST00000454757,	ENST00000228705, ENST00000551214,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: EGFR [Title/Abstract] AND PPM1H [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EGFR(55087058)-PPM1H(63195940), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EGFR	GO:0001934	positive regulation of protein phosphorylation	20551055
Hgene	EGFR	GO:0007165	signal transduction	10572067
Hgene	EGFR	GO:0007166	cell surface receptor signaling pathway	7736574
Hgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	7736574
Hgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	9890893\|12435727\|12828935
Hgene	EGFR	GO:0008284	positive regulation of cell population proliferation	7736574
Hgene	EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	22732145
Hgene	EGFR	GO:0030307	positive regulation of cell growth	15467833
Hgene	EGFR	GO:0038134	ERBB2-EGFR signaling pathway	11336639
Hgene	EGFR	GO:0042177	negative regulation of protein catabolic process	17115032
Hgene	EGFR	GO:0042327	positive regulation of phosphorylation	15082764
Hgene	EGFR	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	EGFR	GO:0045739	positive regulation of DNA repair	17115032
Hgene	EGFR	GO:0045740	positive regulation of DNA replication	17115032
Hgene	EGFR	GO:0045944	positive regulation of transcription by RNA polymerase II	20551055
Hgene	EGFR	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	EGFR	GO:0070141	response to UV-A	18483258
Hgene	EGFR	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20551055
Hgene	EGFR	GO:0071392	cellular response to estradiol stimulus	20551055
Hgene	EGFR	GO:1900020	positive regulation of protein kinase C activity	22732145
Hgene	EGFR	GO:1903078	positive regulation of protein localization to plasma membrane	22732145

Kinase Fusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across PPM1H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-19-2624	EGFR	chr7	55087058	PPM1H	chr12	63195940

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:55087058/:63195940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EGFR P00533	PPM1H Q9ULR3
FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). {ECO:0000250\|UniProtKB:Q01279, ECO:0000269\|PubMed:10805725, ECO:0000269\|PubMed:11116146, ECO:0000269\|PubMed:11483589, ECO:0000269\|PubMed:11602604, ECO:0000269\|PubMed:12297049, ECO:0000269\|PubMed:12297050, ECO:0000269\|PubMed:12620237, ECO:0000269\|PubMed:12873986, ECO:0000269\|PubMed:15374980, ECO:0000269\|PubMed:15590694, ECO:0000269\|PubMed:15611079, ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:17909029, ECO:0000269\|PubMed:19560417, ECO:0000269\|PubMed:20462955, ECO:0000269\|PubMed:20837704, ECO:0000269\|PubMed:21258366, ECO:0000269\|PubMed:27153536, ECO:0000269\|PubMed:2790960, ECO:0000269\|PubMed:7679104, ECO:0000269\|PubMed:8144591, ECO:0000269\|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269\|PubMed:21516087}.	FUNCTION: Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. {ECO:0000269\|PubMed:22586611}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase-Substrate Information of EGFR_PPM1H

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
EGFR	P00533	human	GNAI1	P63096	Y320	RKDTkEIyTHFTCAT	G-alpha
EGFR	P00533	human	GSTP1	P09211	Y8	MPPyTVVyFPVRGRC	GST_N
EGFR	P00533	human	SHC1	P29353-3	Y194	EEPPDHQyyNDFPGK
EGFR	P00533	human	GSTP1	P09211	Y4	____MPPyTVVyFPV	GST_N
EGFR	P00533	human	SHC1	P29353-3	Y272	ELFDDPSyVNVQNLD
EGFR	P00533	human	VAV2	P52735	Y172	EDGGDDIyEDIIKVE
EGFR	P00533	human	CTNNB1	P35222	Y142	AVVNLINyQDDAELA
EGFR	P00533	human	SHC1	P29353-2	Y239	EEPPDHQyyNDFPGK
EGFR	P00533	human	GAB1	Q13480	Y406	DAssQDCyDIPRAFP
EGFR	P00533	human	PELI1	Q96FA3	T264	EGLSHTPtVkHLEAL
EGFR	P00533	human	BECN1	Q14457	Y233	EAQyQREysEFkRQQ	APG6_N
EGFR	P00533	human	GPRC5A	Q8NFJ5	Y350	WPsPykDyEVkKEGs
EGFR	P00533	human	SQSTM1	Q13501	Y433	AALDtIQyskHPPPL	UBA_5
EGFR	P00533	human	SCD	O00767	Y14	QDDISSSyTTTTTIT
EGFR	P00533	human	ANXA1	P04083	Y21	IENEEQEyVQtVkss
EGFR	P00533	human	SCD	O00767	Y55	PDIkDDIyDPTykDk
EGFR	P00533	human	HIP1	O00291	Y152	LLRTKMEyHTkNPRF	ANTH
EGFR	P00533	human	BECN1	Q14457	Y229	LDQEEAQyQREysEF	APG6_N
EGFR	P00533	human	PTPN1	P18031	Y66	LHQEDNDyINAsLIk	Y_phosphatase
EGFR	P00533	human	EGFR	P00533	Y1092	tFLPVPEyINQsVPk
EGFR	P00533	human	GAB1	Q13480	Y659	VADERVDyVVVDQQK
EGFR	P00533	human	SHC1	P29353-2	Y240	EPPDHQyyNDFPGKE
EGFR	P00533	human	GAB1	Q13480	Y373	AsDtDssyCIPTAGM
EGFR	P00533	human	SHC3	Q92529-2	Y218	GDGSDHPyyNSIPSK
EGFR	P00533	human	KCNJ4	P48050	Y234	YMTQEGEyLPLDQRD	IRK_C
EGFR	P00533	human	GAB1	Q13480	Y589	SHDSEENyVPMNPNL
EGFR	P00533	human	SHC3	Q92529-2	Y256	FAGKEQTyyQGRHLG
EGFR	P00533	human	PPP2CA	P67775	Y307	VTRRtPDyFl_____
EGFR	P00533	human	PKM	P14618	Y148	kItLDNAyMEkCDEN	PK
EGFR	P00533	human	USP8	P40818	Y810	DYFNRNCyQDDINRS	UCH
EGFR	P00533	human	ASAP3	Q8TDY4	Y34	FAAKMPRyRGAALAR	BAR_3
EGFR	P00533	human	GNAI1	P63096	Y155	LNDSAAyyLNDLDRI	G-alpha
EGFR	P00533	human	PELI1	Q96FA3	Y154	PPFTARIyAAGFDSS	Pellino
EGFR	P00533	human	EGFR	P00533	Y1110	GsVQNPVyHNQPLNP
EGFR	P00533	human	KCNN1	Q92952	Y109	KRKRLsDyALIFGMF	SK_channel
EGFR	P00533	human	CCDC88A	Q3V6T2	Y1799	QSkDsNPyAtLPRAS
EGFR	P00533	human	EGFR	P00533	Y1197	stAENAEyLRVAPQS
EGFR	P00533	human	AGO2	Q9UKV8	Y393	AsFNtDPyVREFGIM	ArgoL2
EGFR	P00533	human	PRKDC	P78527	T2609	LtPMFVEtQAsQGtL	DNAPKcs_CC5
EGFR	P00533	human	VAV2	P52735	Y142	TENDDDVyRSLEELA
EGFR	P00533	human	GPRC5A	Q8NFJ5	Y320	GDtLyAPystHFQLQ
EGFR	P00533	human	PFKP	Q01813	Y64	VYFIYEGyQGMVDGG	PFK
EGFR	P00533	human	SHC1	P29353-2	Y317	ELFDDPSyVNVQNLD
EGFR	P00533	human	STING1	Q86WV6	Y245	RVysNSIyELLENGQ	TMEM173
EGFR	P00533	human	CCDC50	Q8IVM0	Y304	SSHkGFHyKH_____
EGFR	P00533	human	EGFR	P00533	Y1016	DVVDADEyLIPQQGF
EGFR	P00533	human	ESR1	P03372	S118	LHPPPQLsPFLQPHG	Oest_recep
EGFR	P00533	human	PLCG1	P19174	Y771	IGtAEPdyGALyEGR
EGFR	P00533	human	PTK2	Q05397	Y5	___MAAAyLDPNLNH
EGFR	P00533	human	PCNA	P12004	Y211	QLTFALryLNFFtkA	PCNA_C
EGFR	P00533	human	SPRED1	Q7Z699	S105	KFGLTFQsPADARAF	WH1
EGFR	P00533	human	PLD2	O14939	Y296	LILkCSSyRQARWWA
EGFR	P00533	human	USP8	P40818	Y717	PsKLKRsyssPDItQ
EGFR	P00533	human	SCD	O00767	Y41	kLETMPLyLEDDIRP
EGFR	P00533	human	EGFR	P00533	Y869	LGAEEkEyHAEGGkV	PK_Tyr_Ser-Thr
EGFR	P00533	human	VAV2	P52735	Y159	HDLGEDIyDCVPCED
EGFR	P00533	human	BECN1	Q14457	Y352	KSKELPLyCSGGLRF	APG6
EGFR	P00533	human	EPB41	P11171-4	Y418	RLDGENIyIRHSNLM
EGFR	P00533	human	GAB1	Q13480	Y447	SEELDENyVPMNPNs
EGFR	P00533	human	GAB1	Q13480	Y472	EPIQEANyVPMtPGT
EGFR	P00533	human	SHC1	P29353-3	Y195	EPPDHQyyNDFPGKE
EGFR	P00533	human	NIBAN2	Q96TA1	Y593	PIDWGEEysNSGGGG
EGFR	P00533	human	HDAC6	Q9UBN7	Y570	SSNFDSIyICPSTFA	Hist_deacetyl
EGFR	P00533	human	LRRK1	Q38SD2	Y971	TQQTEEQyFQFLAKF	COR
EGFR	P00533	human	ATM	Q13315	Y370	SLEIsQSyTttQRES
EGFR	P00533	human	PDP1	Q9P0J1	Y381	DQLNDNEyTkFIPPN	PP2C
EGFR	P00533	human	PLCG1	P19174	Y783	EGRNPGFyVEANPMP
EGFR	P00533	human	HDAC1	Q13547	Y72	TkYHSDDyIkFLRSI	Hist_deacetyl
EGFR	P00533	human	TLR3	O15455	Y858	FLEEIPDyKLNHALC	TIR
EGFR	P00533	human	ABCA1	O95477	S2054	GGNkRKLsTAMALIG	ABC_tran
EGFR	P00533	human	RGS16	O15492	Y168	TLMEKDSyPRFLkSP	RGS
EGFR	P00533	human	GNAI1	P63096	Y154	QLNDSAAyyLNDLDR	G-alpha
EGFR	P00533	human	PTK2	Q05397	Y194	ALEKKSNyEVLEkDV	FERM_M
EGFR	P00533	human	CTNNB1	P35222	Y654	RNEGVAtyAAAVLFR
EGFR	P00533	human	CCDC88C	Q9P219	Y2025	PQTVWyEyGCV____
EGFR	P00533	human	EZR	P15311	Y354	LMLRLQDyEEktKKA	ERM_helical
EGFR	P00533	human	TRIP13	Q15645	Y206	RLSSRYRyGQLIEIN	AAA
EGFR	P00533	human	LYN	P07948	Y32	RNTERtIyVRDPTSN
EGFR	P00533	human	GAB1	Q13480	Y285	TEADGELyVFNTPSG
EGFR	P00533	human	GSTP1	P09211	Y199	AFLAsPEyVNLPING
EGFR	P00533	human	CCDC50	Q8IVM0	Y279	tDGEDADytHFtNQQ
EGFR	P00533	human	SOX2	P48431	Y277	LRDMISMyLPGAEVP
EGFR	P00533	human	IKBKE	Q14164	Y179	sVYGTEEyLHPDMYE	Pkinase
EGFR	P00533	human	KCND3	Q9UK17	Y136	GDCCYEEyKDRKREN
EGFR	P00533	human	GPRC5A	Q8NFJ5	Y317	EEtGDtLyAPystHF
EGFR	P00533	human	CCDC88A	Q3V6T2	Y1765	PRktEDtyFISSAGk
EGFR	P00533	human	CCDC50	Q8IVM0	Y217	MAEEkKAykkAkERE
EGFR	P00533	human	GPRC5A	Q8NFJ5	Y347	AHAWPsPykDyEVkK
EGFR	P00533	human	SHC3	Q92529-2	Y301	PTGEAPTyVNTQQIP
EGFR	P00533	human	EZR	P15311	Y146	kEVHksGyLSsERLI	FERM_M
EGFR	P00533	human	MYL12A	P19105	Y155	DkkGNFNyIEFTRIL	EF-hand_11
EGFR	P00533	human	SHC3	Q92529-2	Y257	AGKEQTyyQGRHLGD
EGFR	P00533	human	PPARD	Q03181	Y108	TIRMKLEyEKCERSC	zf-C4
EGFR	P00533	human	SHC3	Q92529-2	Y283	RQGSSDIySTPEGKL
EGFR	P00533	human	PPARG	P37231-2	Y74	YDLKLQEyQSAIkVE	PPARgamma_N
EGFR	P00533	human	SHC3	Q92529-2	Y219	DGSDHPyyNSIPSKM
EGFR	P00533	human	EGFR	P00533	Y1172	IsLDNPDyQQDFFPk
EGFR	P00533	human	GAB1	Q13480	Y627	KGDKQVEyLDLDLDs
EGFR	P00533	human	TRIP13	Q15645	Y56	HNIVFGDyTWTEFDE
EGFR	P00533	human	IKBKE	Q14164	Y153	GEEGQSIykLTDFGA	Pkinase

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
EGFR	ID	Description	0.00e+00
EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	4.35e-08
EGFR	GO:0038127	ERBB signaling pathway	8.30e-08
EGFR	GO:0031400	negative regulation of protein modification process	2.28e-06
EGFR	GO:0002757	immune response-activating signaling pathway	4.65e-05
EGFR	GO:0000302	response to reactive oxygen species	5.39e-05
EGFR	GO:0002764	immune response-regulating signaling pathway	5.43e-05
EGFR	GO:0001933	negative regulation of protein phosphorylation	6.14e-05
EGFR	GO:0034614	cellular response to reactive oxygen species	6.63e-05
EGFR	GO:0045088	regulation of innate immune response	6.63e-05
EGFR	GO:0050727	regulation of inflammatory response	6.63e-05
EGFR	GO:0043434	response to peptide hormone	6.63e-05
EGFR	GO:0042326	negative regulation of phosphorylation	6.63e-05
EGFR	GO:0038093	Fc receptor signaling pathway	9.66e-05
EGFR	GO:0045765	regulation of angiogenesis	9.66e-05
EGFR	GO:0030522	intracellular receptor signaling pathway	9.66e-05
EGFR	GO:1901342	regulation of vasculature development	9.66e-05
EGFR	GO:0043122	regulation of canonical NF-kappaB signal transduction	1.06e-04
EGFR	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	1.06e-04
EGFR	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	1.06e-04
EGFR	GO:0045936	negative regulation of phosphate metabolic process	1.24e-04
EGFR	GO:0010563	negative regulation of phosphorus metabolic process	1.24e-04
EGFR	GO:0002431	Fc receptor mediated stimulatory signaling pathway	2.02e-04
EGFR	GO:0007249	canonical NF-kappaB signal transduction	2.02e-04
EGFR	GO:1904377	positive regulation of protein localization to cell periphery	2.02e-04
EGFR	GO:0038094	Fc-gamma receptor signaling pathway	2.17e-04
EGFR	GO:0071375	cellular response to peptide hormone stimulus	2.34e-04
EGFR	GO:0070373	negative regulation of ERK1 and ERK2 cascade	2.34e-04
EGFR	GO:0010887	negative regulation of cholesterol storage	2.92e-04
EGFR	GO:0072697	protein localization to cell cortex	2.92e-04
EGFR	GO:0006909	phagocytosis	3.76e-04
EGFR	GO:0030111	regulation of Wnt signaling pathway	3.76e-04
EGFR	GO:0045089	positive regulation of innate immune response	4.05e-04
EGFR	GO:0034599	cellular response to oxidative stress	5.35e-04
EGFR	GO:0050673	epithelial cell proliferation	5.35e-04
EGFR	GO:0061912	selective autophagy	5.35e-04
EGFR	GO:0060828	regulation of canonical Wnt signaling pathway	5.98e-04
EGFR	GO:0002833	positive regulation of response to biotic stimulus	5.98e-04
EGFR	GO:1901653	cellular response to peptide	6.33e-04
EGFR	GO:0070663	regulation of leukocyte proliferation	6.33e-04
EGFR	GO:0043409	negative regulation of MAPK cascade	6.33e-04
EGFR	GO:0032868	response to insulin	6.34e-04
EGFR	GO:0006469	negative regulation of protein kinase activity	6.64e-04
EGFR	GO:0010586	miRNA metabolic process	6.75e-04
EGFR	GO:0002218	activation of innate immune response	6.82e-04
EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	6.82e-04
EGFR	GO:0043407	negative regulation of MAP kinase activity	6.85e-04
EGFR	GO:0018212	peptidyl-tyrosine modification	6.85e-04
EGFR	GO:0006979	response to oxidative stress	8.17e-04
EGFR	GO:0010883	regulation of lipid storage	8.17e-04

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Related Drugs to EGFR_PPM1H

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning EGFR-PPM1H and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to EGFR_PPM1H

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date