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Kinase Fusion Gene:ADD1_SLK |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ADD1_SLK | KinaseFusionDB ID: KFG188 | FusionGDB2.0 ID: KFG188 | Hgene | Tgene | Gene symbol | ADD1 | SLK | Gene ID | 118 | 9748 | |
| Gene name | adducin 1 | STE20 like kinase | ||||||||||
| Synonyms | ADDA | LOSK|STK2|bA16H23.1|se20-9 | ||||||||||
| Cytomap | 4p16.3 | 10q24.33-q25.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | alpha-adducinadducin 1 (alpha)alpha-adducin 1erythrocyte adducin alpha subunit | STE20-like serine/threonine-protein kinaseCTCL tumor antigen se20-9Long Ste20-like KinaseSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinaseSNF1 sucrose nonfermenting like kinaseSTE20-related kinaseSTE20- | ||||||||||
| Modification date | 20240407 | 20240305 | ||||||||||
| UniProtAcc | P35611 | Q9H2G2 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000264758, ENST00000355842, ENST00000398123, ENST00000398125, ENST00000398129, ENST00000446856, ENST00000503455, ENST00000513328, ENST00000538860, | ENST00000335753, ENST00000369755, ENST00000474260, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ADD1 [Title/Abstract] AND SLK [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ADD1(2881080)-SLK(105788834), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADD1 | GO:0032092 | positive regulation of protein binding | 3693401|7642559 |
| Hgene | ADD1 | GO:0051016 | barbed-end actin filament capping | 8626479 |
| Hgene | ADD1 | GO:0051017 | actin filament bundle assembly | 3693401 |
| Hgene | ADD1 | GO:0071277 | cellular response to calcium ion | 25978380 |
| Hgene | ADD1 | GO:1903142 | positive regulation of establishment of endothelial barrier | 25978380 |
| Hgene | ADD1 | GO:1903393 | positive regulation of adherens junction organization | 25978380 |
| Tgene | SLK | GO:0042981 | regulation of apoptotic process | 22203681 |
| Tgene | SLK | GO:0046777 | protein autophosphorylation | 18239682 |
| Tgene | SLK | GO:0051893 | regulation of focal adhesion assembly | 23128389 |
| Kinase Fusion gene breakpoints across ADD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across SLK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | FN121743 | ADD1 | chr4 | 2881080 | SLK | chr10 | 105788834 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:2881080/:105788834) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADD1 | SLK |
| FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. | FUNCTION: Mediates apoptosis and actin stress fiber dissolution. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ADD1_SLK |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| SLK | Q9H2G2 | human | RDX | P35241 | T564 | AGRDKyKtLRQIRQG | ERM_C |
| SLK | Q9H2G2 | human | EZR | P15311 | T567 | QGRDkyKtLRQIRQG | ERM_C |
| SLK | Q9H2G2 | human | SLK | Q9H2G2 | T183 | VsAkNtRtIQRRDsF | Pkinase |
| SLK | Q9H2G2 | human | MSN | P26038 | T558 | LGRDKyKtLRQIRQG | ERM_C |
| SLK | Q9H2G2 | human | SLK | Q9H2G2 | S189 | RtIQRRDsFIGtPyW | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| SLK | ID | Description | 0.00e+00 |
| SLK | GO:1902946 | protein localization to early endosome | 7.80e-08 |
| SLK | GO:1905668 | positive regulation of protein localization to endosome | 7.80e-08 |
| SLK | GO:1905666 | regulation of protein localization to endosome | 7.80e-08 |
| SLK | GO:1903651 | positive regulation of cytoplasmic transport | 9.30e-08 |
| SLK | GO:2000641 | regulation of early endosome to late endosome transport | 1.58e-07 |
| SLK | GO:0036010 | protein localization to endosome | 3.98e-07 |
| SLK | GO:1903649 | regulation of cytoplasmic transport | 5.79e-07 |
| SLK | GO:0045022 | early endosome to late endosome transport | 1.35e-06 |
| SLK | GO:0061028 | establishment of endothelial barrier | 1.50e-06 |
| SLK | GO:0098927 | vesicle-mediated transport between endosomal compartments | 1.50e-06 |
| SLK | GO:0001885 | endothelial cell development | 3.09e-06 |
| SLK | GO:0045446 | endothelial cell differentiation | 2.10e-05 |
| SLK | GO:0008360 | regulation of cell shape | 2.77e-05 |
| SLK | GO:0003158 | endothelium development | 2.77e-05 |
| SLK | GO:0016482 | cytosolic transport | 5.35e-05 |
| SLK | GO:0032388 | positive regulation of intracellular transport | 6.76e-05 |
| SLK | GO:0045732 | positive regulation of protein catabolic process | 7.26e-05 |
| SLK | GO:0002064 | epithelial cell development | 7.26e-05 |
| SLK | GO:1902115 | regulation of organelle assembly | 7.27e-05 |
| SLK | GO:0022604 | regulation of cell morphogenesis | 1.01e-04 |
| SLK | GO:0032386 | regulation of intracellular transport | 2.41e-04 |
| SLK | GO:0010737 | protein kinase A signaling | 2.46e-04 |
| SLK | GO:0042176 | regulation of protein catabolic process | 2.79e-04 |
| SLK | GO:0032535 | regulation of cellular component size | 2.81e-04 |
| SLK | GO:0031122 | cytoplasmic microtubule organization | 5.26e-04 |
| SLK | GO:1903829 | positive regulation of protein localization | 5.51e-04 |
| SLK | GO:0022406 | membrane docking | 1.19e-03 |
| SLK | GO:0051017 | actin filament bundle assembly | 3.51e-03 |
| SLK | GO:0061572 | actin filament bundle organization | 3.56e-03 |
| SLK | GO:0008361 | regulation of cell size | 4.42e-03 |
| SLK | GO:0072659 | protein localization to plasma membrane | 1.02e-02 |
| SLK | GO:1990778 | protein localization to cell periphery | 1.39e-02 |
| SLK | GO:0030953 | astral microtubule organization | 1.39e-02 |
| SLK | GO:0051660 | establishment of centrosome localization | 1.39e-02 |
| SLK | GO:0071803 | positive regulation of podosome assembly | 1.39e-02 |
| SLK | GO:0072697 | protein localization to cell cortex | 1.46e-02 |
| SLK | GO:0034111 | negative regulation of homotypic cell-cell adhesion | 1.46e-02 |
| SLK | GO:0071394 | cellular response to testosterone stimulus | 1.46e-02 |
| SLK | GO:0140694 | non-membrane-bounded organelle assembly | 1.46e-02 |
| SLK | GO:0032530 | regulation of microvillus organization | 1.46e-02 |
| SLK | GO:0032536 | regulation of cell projection size | 1.46e-02 |
| SLK | GO:0070486 | leukocyte aggregation | 1.46e-02 |
| SLK | GO:0071801 | regulation of podosome assembly | 1.46e-02 |
| SLK | GO:0007159 | leukocyte cell-cell adhesion | 1.46e-02 |
| SLK | GO:0043254 | regulation of protein-containing complex assembly | 1.46e-02 |
| SLK | GO:0032486 | Rap protein signal transduction | 1.48e-02 |
| SLK | GO:0001771 | immunological synapse formation | 1.48e-02 |
| SLK | GO:0003376 | sphingosine-1-phosphate receptor signaling pathway | 1.48e-02 |
| SLK | GO:0045176 | apical protein localization | 1.48e-02 |
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Related Drugs to ADD1_SLK |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ADD1-SLK and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ADD1_SLK |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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