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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:EIF2AK2_STRN

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: EIF2AK2_STRN
KinaseFusionDB ID: KFG1912
FusionGDB2.0 ID: KFG1912
HgeneTgene
Gene symbol

EIF2AK2

STRN

Gene ID

5610

6801

Gene nameeukaryotic translation initiation factor 2 alpha kinase 2striatin
SynonymsDYT33|EIF2AK1|LEUDEN|PKR|PPP1R83|PRKRPPP2R6A|SG2NA|STRN1
Cytomap

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptioninterferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase RNA-regulatedpstriatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding protein
Modification date2024041120240403
UniProtAcc

P19525

Q9NRL3

Ensembl transtripts involved in fusion geneENST idsENST00000233057, ENST00000395127, 
ENST00000405334, 		ENST00000263918, 
ENST00000379213, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: EIF2AK2 [Title/Abstract] AND STRN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EIF2AK2(37341874)-STRN(37152351), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF2AK2

GO:0006468

protein phosphorylation

19189853

HgeneEIF2AK2

GO:0017148

negative regulation of translation

12882984

HgeneEIF2AK2

GO:0035455

response to interferon-alpha

19840259

HgeneEIF2AK2

GO:0046777

protein autophosphorylation

22801494

HgeneEIF2AK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15121867

HgeneEIF2AK2

GO:0140374

antiviral innate immune response

22948139


check buttonKinase Fusion gene breakpoints across EIF2AK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across STRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-OL-A5D8-01AEIF2AK2chr2

37341874

STRNchr2

37152351



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000405334ENST00000263918EIF2AK2chr237341874STRNchr23715235191791120

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000405334_ENST00000263918_EIF2AK2_chr2_37341874_STRN_chr2_37152351_length(amino acids)=1120
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLEYALK
QERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRP
SSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALA
FHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSV
LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI
LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:37341874/chr2:37152351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF2AK2

P19525

STRN

Q9NRL3

FUNCTION: IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18835251, PubMed:19507191, PubMed:19189853, PubMed:21123651, PubMed:21072047, PubMed:22948139, PubMed:23229543, PubMed:22381929). Inhibits viral replication via the integrated stress response (ISR): EIF2S1/eIF-2-alpha phosphorylation in response to viral infection converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, resulting to a shutdown of cellular and viral protein synthesis, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4 (PubMed:19189853, PubMed:21123651, PubMed:22948139, PubMed:23229543). Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1) (PubMed:11836380, PubMed:19189853, PubMed:20171114, PubMed:19840259, PubMed:21710204, PubMed:23115276, PubMed:23399035). Also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation: phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11 (PubMed:11836380, PubMed:22214662, PubMed:19229320). In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteasomal degradation (PubMed:20395957). Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding pro-inflammatory cytokines and IFNs (PubMed:22948139, PubMed:23084476, PubMed:23372823). Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6 (PubMed:10848580, PubMed:15121867, PubMed:15229216). Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). Can regulate NLRP3 inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 and NLRC4 inflammasomes (PubMed:22801494). Plays a role in the regulation of the cytoskeleton by binding to gelsolin (GSN), sequestering the protein in an inactive conformation away from actin (By similarity). {ECO:0000250|UniProtKB:Q03963, ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853, ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191, ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114, ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959, ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494, ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476, ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543, ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035, ECO:0000269|PubMed:32197074}.FUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
418459418459
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneEIF2AK237341874STRN37152351ENST0000040533411149_771511DomainNote=DRBM 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:9736623;Dbxref=PMID:9736623
HgeneEIF2AK237341874STRN37152351ENST0000040533414179_771552DomainNote=DRBM 1;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:9736623;Dbxref=PMID:9736623
HgeneEIF2AK237341874STRN37152351ENST000004053341114100_1671511DomainNote=DRBM 2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:9736623;Dbxref=PMID:9736623
HgeneEIF2AK237341874STRN37152351ENST000004053341417100_1671552DomainNote=DRBM 2;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:9736623;Dbxref=PMID:9736623


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>80_EIF2AK2_STRNENST00000405334ENST00000263918EIF2AK2chr237341874STRNchr237152351
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLEYALK
QERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRP
SSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALA
FHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSV
LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI
LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC
1120
3D view using mol* of 80_EIF2AK2_STRN
PDB file >>>HKFP_110_EIF2AK2_STRNENST00000405334ENST00000263918EIF2AK2chr237341874STRNchr237152351
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSKKEAKNAAAKLAVEILNKEKKAVSPLLLTTT
NSSEGLSMGNYIGLINRIAQKKRLTVNYEQCASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKA
LAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQAQIAFLQGERKGQENLKKDLVRRIKMLEYALK
QERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDK
NQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDF
LVTSEEGDNESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRP
SSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALA
FHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSV
LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI
LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC
1120_EIF2AK2_STRN


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

EIF2AK2_STRN does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
80_EIF2AK2_STRN.png
all structure sitemap plddt 80_EIF2AK2_STRN.png
80_EIF2AK2_STRN.png
all structure sitemap plddt2 80_EIF2AK2_STRN.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

80_EIF2AK2_STRN_ramachandran.png
all structure EIF2AK2-STRN

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure EIF2AK2-STRN
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
80_EIF2AK2_STRN-DOCK_HTVS_1-001Larotrectinib-6.08092-6.08092-43.6561
80_EIF2AK2_STRN-DOCK_HTVS_1-001Imatinib-5.85191-6.05851-39.8321
80_EIF2AK2_STRN-DOCK_HTVS_1-001Imatinib-5.85191-6.05851-39.8321
80_EIF2AK2_STRN-DOCK_HTVS_1-001Imatinib-5.85191-6.05851-39.8321
80_EIF2AK2_STRN-DOCK_HTVS_1-001Pazopanib-5.4778400000000005-5.48474-36.9539
80_EIF2AK2_STRN-DOCK_HTVS_1-001Pazopanib-5.4778400000000005-5.48474-36.9539
80_EIF2AK2_STRN-DOCK_HTVS_1-001Regorafenib-5.36195-5.36195-38.0845
80_EIF2AK2_STRN-DOCK_HTVS_1-001Larotrectinib-5.33321-5.33321-37.4226
80_EIF2AK2_STRN-DOCK_HTVS_1-001Midostaurin-5.3312-5.3312-32.3233
80_EIF2AK2_STRN-DOCK_HTVS_1-001Lapatinib-5.30077-5.38957-51.6405
80_EIF2AK2_STRN-DOCK_HTVS_1-001Fostamatinib-5.25287-5.31647-46.3418
80_EIF2AK2_STRN-DOCK_HTVS_1-001Fostamatinib-5.25287-5.31647-46.3418
80_EIF2AK2_STRN-DOCK_HTVS_1-001Encorafenib-5.21336-5.60186-45.0655
80_EIF2AK2_STRN-DOCK_HTVS_1-001Netarsudil-5.20869-5.21979-39.2264
80_EIF2AK2_STRN-DOCK_HTVS_1-001Netarsudil-5.20869-5.21979-39.2264
80_EIF2AK2_STRN-DOCK_HTVS_1-001Pralsetinib-5.16143-5.25293-49.1604
80_EIF2AK2_STRN-DOCK_HTVS_1-001Capmatinib-5.133430000000001-5.13903-42.0611
80_EIF2AK2_STRN-DOCK_HTVS_1-001Midostaurin-5.06594-5.06594-30.3082
80_EIF2AK2_STRN-DOCK_HTVS_1-001Lapatinib-5.04397-5.13277-42.3314
80_EIF2AK2_STRN-DOCK_HTVS_1-001Vandetanib-5.02654-5.02654-39.1454

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Kinase-Substrate Information of EIF2AK2_STRN


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
EIF2AK2P19525humanEIF2AK2P19525S242NQRKAKRsLAPRFDL
EIF2AK2P19525humanEIF2AK2P19525S83NkEKkAVsPLLLttt
EIF2AK2P19525humanEIF2AK2P19525T451kRtRSKGtLRyMsPEPkinase
EIF2AK2P19525humanCDK1P06493Y4____MEDytkIEkIGPkinase
EIF2AK2P19525humanEIF2AK2P19525Y293HRIDGKTyVIKRVkYPkinase
EIF2AK2P19525humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
EIF2AK2P19525humanKDM4CQ9H3R0S918MFDDGsFsRDTFPED
EIF2AK2P19525humanTP53P04637S392FktEGPDsD______
EIF2AK2P19525humanEIF2AK2P19525T446LkNDGkRtRSKGtLRPkinase
EIF2AK2P19525humanEIF2AK2P19525S6__MAGDLsAGFFMEE
EIF2AK2P19525humanEIF2AK2P19525Y162QLAAkLAyLQILSEEdsrm
EIF2AK2P19525humanEIF2S1P05198S49IEGMILLsELsRRRIS1
EIF2AK2P19525humanEIF2AK2P19525T255DLPDMkEtKytVDKR
EIF2AK2P19525humanMAPTP10636-8S356rVQskIGsLDNItHVTubulin-binding
EIF2AK2P19525humanEIF2AK2P19525T89VsPLLLtttNssEGL
EIF2AK2P19525humanEIF2AK2P19525T88AVsPLLLtttNssEG
EIF2AK2P19525humanPPP2R5AQ15172S28VDGFTRKsVRKAQRQ
EIF2AK2P19525humanTRIM28Q13263S473sGVkRsRsGEGEVsG
EIF2AK2P19525humanEIF2AK2P19525T90sPLLLtttNssEGLs
EIF2AK2P19525humanEIF2S1P05198S52MILLsELsRRRIRsIS1
EIF2AK2P19525humanEIF2AK2P19525Y101EGLsMGNyIGLINRIdsrm
EIF2AK2P19525humanEIF2AK2P19525T258DMkEtKytVDKRFGM


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
EIF2AK2IDDescription0.00e+00
EIF2AK2GO:0034599cellular response to oxidative stress1.67e-03
EIF2AK2GO:0062197cellular response to chemical stress1.98e-03
EIF2AK2GO:0006979response to oxidative stress3.31e-03
EIF2AK2GO:0016032viral process3.36e-03
EIF2AK2GO:0072594establishment of protein localization to organelle3.42e-03
EIF2AK2GO:0006606protein import into nucleus3.95e-03
EIF2AK2GO:0051170import into nucleus3.95e-03
EIF2AK2GO:0009267cellular response to starvation4.33e-03
EIF2AK2GO:0034063stress granule assembly5.56e-03
EIF2AK2GO:0042594response to starvation5.56e-03
EIF2AK2GO:0051348negative regulation of transferase activity5.56e-03
EIF2AK2GO:0060218hematopoietic stem cell differentiation5.56e-03
EIF2AK2GO:0043550regulation of lipid kinase activity5.56e-03
EIF2AK2GO:0048863stem cell differentiation5.56e-03
EIF2AK2GO:0033044regulation of chromosome organization5.56e-03
EIF2AK2GO:0042307positive regulation of protein import into nucleus5.56e-03
EIF2AK2GO:0031669cellular response to nutrient levels5.56e-03
EIF2AK2GO:0034976response to endoplasmic reticulum stress6.24e-03
EIF2AK2GO:0006984ER-nucleus signaling pathway6.48e-03
EIF2AK2GO:0031668cellular response to extracellular stimulus6.60e-03
EIF2AK2GO:0034198cellular response to amino acid starvation7.06e-03
EIF2AK2GO:0010823negative regulation of mitochondrion organization7.06e-03
EIF2AK2GO:1990928response to amino acid starvation7.06e-03
EIF2AK2GO:0045071negative regulation of viral genome replication7.06e-03
EIF2AK2GO:0034504protein localization to nucleus7.06e-03
EIF2AK2GO:0019058viral life cycle7.26e-03
EIF2AK2GO:0042306regulation of protein import into nucleus7.26e-03
EIF2AK2GO:0006913nucleocytoplasmic transport7.32e-03
EIF2AK2GO:0051169nuclear transport7.32e-03
EIF2AK2GO:0046824positive regulation of nucleocytoplasmic transport7.34e-03
EIF2AK2GO:0042063gliogenesis7.34e-03
EIF2AK2GO:0071496cellular response to external stimulus7.62e-03
EIF2AK2GO:0034605cellular response to heat7.70e-03
EIF2AK2GO:2000379positive regulation of reactive oxygen species metabolic process7.77e-03
EIF2AK2GO:0010038response to metal ion7.77e-03
EIF2AK2GO:0045936negative regulation of phosphate metabolic process8.48e-03
EIF2AK2GO:0010563negative regulation of phosphorus metabolic process8.48e-03
EIF2AK2GO:0030968endoplasmic reticulum unfolded protein response8.63e-03
EIF2AK2GO:0001701in utero embryonic development8.87e-03
EIF2AK2GO:2000736regulation of stem cell differentiation8.87e-03
EIF2AK2GO:0044773mitotic DNA damage checkpoint signaling9.79e-03
EIF2AK2GO:0045069regulation of viral genome replication9.94e-03
EIF2AK2GO:0043254regulation of protein-containing complex assembly9.94e-03
EIF2AK2GO:0044774mitotic DNA integrity checkpoint signaling1.00e-02
EIF2AK2GO:0034620cellular response to unfolded protein1.03e-02
EIF2AK2GO:0034644cellular response to UV1.03e-02
EIF2AK2GO:0048525negative regulation of viral process1.05e-02
EIF2AK2GO:1900182positive regulation of protein localization to nucleus1.05e-02
EIF2AK2GO:0072091regulation of stem cell proliferation1.07e-02

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Related Drugs to EIF2AK2_STRN


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning EIF2AK2-STRN and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to EIF2AK2_STRN


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate