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Kinase Fusion Gene:ELK3_GRK6 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ELK3_GRK6 | KinaseFusionDB ID: KFG1954 | FusionGDB2.0 ID: KFG1954 | Hgene | Tgene | Gene symbol | ELK3 | GRK6 | Gene ID | 2004 | 2870 | |
| Gene name | ETS transcription factor ELK3 | G protein-coupled receptor kinase 6 | ||||||||||
| Synonyms | ERP|NET|SAP-2|SAP2 | GPRK6 | ||||||||||
| Cytomap | 12q23.1 | 5q35.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | ETS domain-containing protein Elk-3ELK3, ETS transcription factorELK3, ETS-domain protein (SRF accessory protein 2)ETS-related protein ERPETS-related protein NETSRF accessory protein 2serum response factor accessory protein 2 | G protein-coupled receptor kinase 6 | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | P41970 | P43250 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000228741, ENST00000549529, ENST00000552142, | ENST00000355472, ENST00000355958, ENST00000393576, ENST00000507633, ENST00000528793, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ELK3 [Title/Abstract] AND GRK6 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ELK3(96663325)-GRK6(176859727), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ELK3 | GO:0045892 | negative regulation of DNA-templated transcription | 12933792 |
| Hgene | ELK3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12788937 |
| Kinase Fusion gene breakpoints across ELK3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across GRK6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | DD229597 | ELK3 | chr12 | 96663325 | GRK6 | chr5 | 176859727 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:96663325/:176859727) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ELK3 | GRK6 |
| FUNCTION: May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. | FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ELK3_GRK6 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| GRK6 | P43250 | human | CXCR4 | P61073 | S324 | LtsVsRGssLkILsk | |
| GRK6 | P43250 | human | GRK6 | P43250 | S484 | VLDIEQFstVkGVEL | |
| GRK6 | P43250 | human | GRK6 | P43250 | T485 | LDIEQFstVkGVELE | |
| GRK6 | P43250 | human | IGF1R | P08069 | S1321 | LPLPDRHsGHKAENG | |
| GRK6 | P43250 | human | ADRB2 | P07550 | S355 | KAyGNGyssNGNtGE | |
| GRK6 | P43250 | human | CXCR4 | P61073 | S325 | tsVsRGssLkILskG | |
| GRK6 | P43250 | human | LTB4R | Q15722 | T308 | VAKLLEGtGsEAsst | |
| GRK6 | P43250 | human | ADRB2 | P07550 | S356 | AyGNGyssNGNtGEQ | |
| GRK6 | P43250 | human | NHERF1 | O14745 | S290 | PALVRsAssDtsEEL | EBP50_C |
| GRK6 | P43250 | human | OCLN | Q16625 | S471 | LDDyREEsEEyMAAA | Occludin_ELL |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| GRK6 | ID | Description | 0.00e+00 |
| GRK6 | GO:1903036 | positive regulation of response to wounding | 1.24e-03 |
| GRK6 | GO:0120162 | positive regulation of cold-induced thermogenesis | 1.40e-03 |
| GRK6 | GO:0120161 | regulation of cold-induced thermogenesis | 2.35e-03 |
| GRK6 | GO:0106106 | cold-induced thermogenesis | 2.35e-03 |
| GRK6 | GO:1990845 | adaptive thermogenesis | 2.35e-03 |
| GRK6 | GO:1903034 | regulation of response to wounding | 2.35e-03 |
| GRK6 | GO:0001659 | temperature homeostasis | 2.38e-03 |
| GRK6 | GO:0034764 | positive regulation of transmembrane transport | 3.47e-03 |
| GRK6 | GO:0043243 | positive regulation of protein-containing complex disassembly | 4.75e-03 |
| GRK6 | GO:0003018 | vascular process in circulatory system | 5.26e-03 |
| GRK6 | GO:1904646 | cellular response to amyloid-beta | 5.26e-03 |
| GRK6 | GO:1904645 | response to amyloid-beta | 7.34e-03 |
| GRK6 | GO:0006936 | muscle contraction | 8.62e-03 |
| GRK6 | GO:0090303 | positive regulation of wound healing | 8.62e-03 |
| GRK6 | GO:0010959 | regulation of metal ion transport | 1.12e-02 |
| GRK6 | GO:0002028 | regulation of sodium ion transport | 1.42e-02 |
| GRK6 | GO:0003012 | muscle system process | 1.43e-02 |
| GRK6 | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 2.22e-02 |
| GRK6 | GO:0043244 | regulation of protein-containing complex disassembly | 2.49e-02 |
| GRK6 | GO:0061041 | regulation of wound healing | 2.77e-02 |
| GRK6 | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 2.88e-02 |
| GRK6 | GO:0030010 | establishment of cell polarity | 3.24e-02 |
| GRK6 | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 3.24e-02 |
| GRK6 | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 3.24e-02 |
| GRK6 | GO:0007009 | plasma membrane organization | 3.50e-02 |
| GRK6 | GO:0009266 | response to temperature stimulus | 3.50e-02 |
| GRK6 | GO:0043409 | negative regulation of MAPK cascade | 3.57e-02 |
| GRK6 | GO:0050954 | sensory perception of mechanical stimulus | 3.64e-02 |
| GRK6 | GO:0009612 | response to mechanical stimulus | 4.28e-02 |
| GRK6 | GO:0043270 | positive regulation of monoatomic ion transport | 4.28e-02 |
| GRK6 | GO:0007163 | establishment or maintenance of cell polarity | 4.28e-02 |
| GRK6 | GO:0032984 | protein-containing complex disassembly | 4.28e-02 |
| GRK6 | GO:0022604 | regulation of cell morphogenesis | 4.28e-02 |
| GRK6 | GO:0006814 | sodium ion transport | 4.28e-02 |
| GRK6 | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 4.28e-02 |
| GRK6 | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.28e-02 |
| GRK6 | GO:0030643 | intracellular phosphate ion homeostasis | 4.28e-02 |
| GRK6 | GO:1903943 | regulation of hepatocyte apoptotic process | 4.28e-02 |
| GRK6 | GO:0010764 | negative regulation of fibroblast migration | 4.28e-02 |
| GRK6 | GO:0035090 | maintenance of apical/basal cell polarity | 4.28e-02 |
| GRK6 | GO:0044062 | regulation of excretion | 4.28e-02 |
| GRK6 | GO:0045199 | maintenance of epithelial cell apical/basal polarity | 4.28e-02 |
| GRK6 | GO:0021537 | telencephalon development | 4.28e-02 |
| GRK6 | GO:0001894 | tissue homeostasis | 4.28e-02 |
| GRK6 | GO:0060249 | anatomical structure homeostasis | 4.28e-02 |
| GRK6 | GO:0010739 | positive regulation of protein kinase A signaling | 4.28e-02 |
| GRK6 | GO:0032782 | bile acid secretion | 4.28e-02 |
| GRK6 | GO:0040015 | negative regulation of multicellular organism growth | 4.28e-02 |
| GRK6 | GO:0071389 | cellular response to mineralocorticoid stimulus | 4.28e-02 |
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Related Drugs to ELK3_GRK6 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ELK3-GRK6 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ELK3_GRK6 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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