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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ERBB2_SLC29A3

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ERBB2_SLC29A3
KinaseFusionDB ID: KFG2091
FusionGDB2.0 ID: KFG2091
HgeneTgene
Gene symbol

ERBB2

SLC29A3

Gene ID

2064

55315

Gene nameerb-b2 receptor tyrosine kinase 2solute carrier family 29 member 3
SynonymsCD340|HER-2|HER-2/neu|HER2|MLN 19|MLN-19|NEU|NGL|TKR1|VSCN2|c-ERB-2|c-ERB2|p185(erbB2)ENT3|HCLAP|HJCD|PHID
Cytomap

17q12

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologproto-oncequilibrative nucleoside transporter 3solute carrier family 29 (equilibrative nucleoside transporter), member 3solute carrier family 29 (nucleoside transporters), member 3
Modification date2024041620240411
UniProtAcc

Q96RT1

Q9BZD2

Ensembl transtripts involved in fusion geneENST idsENST00000269571, ENST00000406381, 
ENST00000445658, ENST00000540147, 
ENST00000541774, ENST00000584450, 
ENST00000584601, ENST00000540042, 
ENST00000578199, ENST00000584888, 
ENST00000469204, ENST00000373189, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ERBB2 [Title/Abstract] AND SLC29A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ERBB2(37883256)-SLC29A3(73121711), # samples:3
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERBB2

GO:0007165

signal transduction

10572067

HgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

HgeneERBB2

GO:0007169

cell surface receptor protein tyrosine kinase signaling pathway

7514177|7556068

HgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

HgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

HgeneERBB2

GO:0035556

intracellular signal transduction

19372587

HgeneERBB2

GO:0038134

ERBB2-EGFR signaling pathway

8702723

HgeneERBB2

GO:0042060

wound healing

12646923

HgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneERBB2

GO:0043491

phosphatidylinositol 3-kinase/protein kinase B signal transduction

7556068

HgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

HgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

HgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870

TgeneSLC29A3

GO:0006837

serotonin transport

19164483

TgeneSLC29A3

GO:0015851

nucleobase transport

19164483

TgeneSLC29A3

GO:0015858

nucleoside transport

15701636|20595384|28729424

TgeneSLC29A3

GO:0015861

cytidine transport

19164483

TgeneSLC29A3

GO:0015862

uridine transmembrane transport

19164483|28729424

TgeneSLC29A3

GO:0015872

dopamine transport

19164483

TgeneSLC29A3

GO:0015874

norepinephrine transport

19164483

TgeneSLC29A3

GO:0032238

adenosine transport

15701636|20595384|28729424

TgeneSLC29A3

GO:0035340

inosine transport

19164483|28729424

TgeneSLC29A3

GO:1901642

nucleoside transmembrane transport

15701636|20595384|28729424

TgeneSLC29A3

GO:1903716

guanine transmembrane transport

19164483

TgeneSLC29A3

GO:1903791

uracil transmembrane transport

19164483

TgeneSLC29A3

GO:1904082

pyrimidine nucleobase transmembrane transport

19164483

TgeneSLC29A3

GO:1904823

purine nucleobase transmembrane transport

19164483


check buttonKinase Fusion gene breakpoints across ERBB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across SLC29A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-AR-A254-01AERBB2chr17

37883255

SLC29A3chr10

73121710

ChimerDB4TCGA-AR-A254-01AERBB2chr17

37883256

SLC29A3chr10

73121711

ChimerDB4TCGA-AR-A254ERBB2chr17

37883256

SLC29A3chr10

73121710



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000584601ENST00000373189ERBB2chr1737883256SLC29A3chr107312171152981052
ENST00000584601ENST00000373189ERBB2chr1737883256SLC29A3chr107312171052981052
ENST00000584601ENST00000373189ERBB2chr1737883255SLC29A3chr107312171052981052

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000584601_ENST00000373189_ERBB2_chr17_37883256_SLC29A3_chr10_73121711_length(amino acids)=1052
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>ENST00000584601_ENST00000373189_ERBB2_chr17_37883256_SLC29A3_chr10_73121710_length(amino acids)=1052
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

>ENST00000584601_ENST00000373189_ERBB2_chr17_37883255_SLC29A3_chr10_73121710_length(amino acids)=1052
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37883256/chr10:73121711)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERBB2

Q96RT1

SLC29A3

Q9BZD2

FUNCTION: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.FUNCTION: Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Functions as a non-electrogenic Na(+)-independent transporter (PubMed:15701636, PubMed:19164483, PubMed:28729424). Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments (PubMed:15701636, PubMed:19164483, PubMed:28729424). Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation (PubMed:28729424). May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids (PubMed:28729424). Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine) (PubMed:15701636, PubMed:19164483, PubMed:20595384, PubMed:28729424). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil) (PubMed:15701636, PubMed:19164483). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine (PubMed:19164483). Capable of transporting ATP (PubMed:19164483). Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers (By similarity). {ECO:0000250|UniProtKB:Q99P65, ECO:0000269|PubMed:15701636, ECO:0000269|PubMed:19164483, ECO:0000269|PubMed:20595384, ECO:0000269|PubMed:28729424}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
103810531038105310381053
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneERBB237883255SLC29A373121710ENST000005846012527720_98711241DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneERBB237883255SLC29A373121710ENST000005846012527720_98711256DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneERBB237883256SLC29A373121710ENST000005846012527720_98711241DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneERBB237883256SLC29A373121710ENST000005846012527720_98711256DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneERBB237883256SLC29A373121711ENST000005846012527720_98711241DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneERBB237883256SLC29A373121711ENST000005846012527720_98711256DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>95_ERBB2_SLC29A3ENST00000584601ENST00000373189ERBB2chr1737883255SLC29A3chr1073121710
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY
1052
3D view using mol* of 95_ERBB2_SLC29A3
PDB file >>>HKFP_132_ERBB2_SLC29A3ENST00000584601ENST00000373189ERBB2chr1737883256SLC29A3chr1073121711
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY
1052_ERBB2_SLC29A3
PDB file >>>HKFP_133_ERBB2_SLC29A3ENST00000584601ENST00000373189ERBB2chr1737883256SLC29A3chr1073121710
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY
1052_ERBB2_SLC29A3
PDB file >>>HKFP_134_ERBB2_SLC29A3ENST00000584601ENST00000373189ERBB2chr1737883255SLC29A3chr1073121710
MPRGSWKPQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGT
QLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPC
SPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNP
EGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGL
ALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYV
NARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAE
QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWEL
MTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFY
1052_ERBB2_SLC29A3


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ERBB2_SLC29A3 does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
95_ERBB2_SLC29A3.png
all structure sitemap plddt 95_ERBB2_SLC29A3.png
95_ERBB2_SLC29A3.png
all structure sitemap plddt2 95_ERBB2_SLC29A3.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

95_ERBB2_SLC29A3_ramachandran.png
all structure ERBB2-SLC29A3

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure ERBB2-SLC29A3
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Lapatinib-7.9692-8.058-51.725
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Lapatinib-7.789630000000001-7.878430000000001-51.1294
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Netarsudil-6.34845-6.35955-44.5947
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Netarsudil-6.34845-6.35955-44.5947
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Nilotinib-5.88976-6.02936-59.0885
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Nilotinib-5.88976-6.02936-59.0885
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Dacomitinib-5.839930000000001-5.948230000000001-50.9525
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Dacomitinib-5.839930000000001-5.948230000000001-50.9525
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Dacomitinib-5.81459-5.92359-50.5229
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Sorafenib-5.561640000000001-5.57374-52.8055
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Sorafenib-5.561640000000001-5.57374-52.8055
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Mobocertinib-5.39637-5.40407-60.9858
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Crizotinib-5.39417-5.89007-34.1348
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Crizotinib-5.39417-5.89007-34.1348
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Neratinib-5.38245-5.56475-55.2971
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Neratinib-5.38245-5.56475-55.2971
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Tivozanib-5.3509199999999995-5.3509199999999995-48.4973
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Netarsudil-5.31354-5.3246400000000005-42.5322
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Netarsudil-5.31354-5.3246400000000005-42.5322
95_ERBB2_SLC29A3-DOCK_HTVS_1-001Sunitinib-5.27617-5.28037-32.0715

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Kinase-Substrate Information of ERBB2_SLC29A3


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
ERBB2P04626humanBBC3Q9BXH1Y172PsPWRVLyNLIMGLLPUMA
ERBB2P04626humanERBB2P04626Y1222PAFDNLyyWDQDPPE
ERBB2P04626humanDOCK7Q96N67Y1257METVPQLyDFTETHN
ERBB2P04626humanBBC3Q9BXH1Y58PTLLPAAyLCAPTAPPUMA
ERBB2P04626humanERBB2P04626Y1023DLVDAEEyLVPQQGF
ERBB2P04626humanPLXNB1O43157Y1708DSVGEPLyMLFRGIKPlexin_cytopl
ERBB2P04626humanBBC3Q9BXH1Y152ADDLNAQyERRRQEEPUMA
ERBB2P04626humanPLXNB1O43157Y1732SVtGKAKyTLNDNRLPlexin_cytopl
ERBB2P04626humanERBB2P04626Y877LDIDEtEyHADGGkVPK_Tyr_Ser-Thr
ERBB2P04626humanCTNNB1P35222Y654RNEGVAtyAAAVLFR
ERBB2P04626humanERBB2P04626Y1112DPsPLQRySEDPTVP
ERBB2P04626humanERBB2P04626Y1221sPAFDNLyyWDQDPP
ERBB2P04626humanERBB2P04626Y1248PtAENPEyLGLDVPV
ERBB2P04626humanERBB2P04626Y1139tCsPQPEyVNQPDVR
ERBB2P04626humanCDK1P06493Y15EkIGEGtyGVVykGRPkinase
ERBB2P04626humanLDHAP00338Y10tLkDQLIyNLLkEEQ
ERBB2P04626humanERBB2P04626Y1196GAVENPEyLtPQGGA


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
ERBB2IDDescription0.00e+00
ERBB2GO:0090316positive regulation of intracellular protein transport1.24e-02
ERBB2GO:0032388positive regulation of intracellular transport1.24e-02
ERBB2GO:0033157regulation of intracellular protein transport1.24e-02
ERBB2GO:0043547positive regulation of GTPase activity1.24e-02
ERBB2GO:0010001glial cell differentiation1.24e-02
ERBB2GO:0043087regulation of GTPase activity1.48e-02
ERBB2GO:0051222positive regulation of protein transport1.48e-02
ERBB2GO:1904951positive regulation of establishment of protein localization1.48e-02
ERBB2GO:0032386regulation of intracellular transport1.48e-02
ERBB2GO:0042063gliogenesis1.48e-02
ERBB2GO:0050767regulation of neurogenesis2.05e-02
ERBB2GO:0045685regulation of glial cell differentiation2.10e-02
ERBB2GO:0007405neuroblast proliferation2.10e-02
ERBB2GO:0007422peripheral nervous system development2.10e-02
ERBB2GO:0007409axonogenesis2.11e-02
ERBB2GO:0033077T cell differentiation in thymus2.11e-02
ERBB2GO:0051960regulation of nervous system development2.11e-02
ERBB2GO:0045995regulation of embryonic development2.11e-02
ERBB2GO:1903829positive regulation of protein localization2.11e-02
ERBB2GO:0050808synapse organization2.11e-02
ERBB2GO:1905477positive regulation of protein localization to membrane2.21e-02
ERBB2GO:0048709oligodendrocyte differentiation2.21e-02
ERBB2GO:0048144fibroblast proliferation2.21e-02
ERBB2GO:2001252positive regulation of chromosome organization2.21e-02
ERBB2GO:1902106negative regulation of leukocyte differentiation2.21e-02
ERBB2GO:1903707negative regulation of hemopoiesis2.40e-02
ERBB2GO:0007098centrosome cycle3.15e-02
ERBB2GO:0042552myelination3.21e-02
ERBB2GO:0007272ensheathment of neurons3.21e-02
ERBB2GO:0008366axon ensheathment3.21e-02
ERBB2GO:0031023microtubule organizing center organization3.41e-02
ERBB2GO:0061351neural precursor cell proliferation3.67e-02
ERBB2GO:1905475regulation of protein localization to membrane3.67e-02
ERBB2GO:0042129regulation of T cell proliferation3.67e-02
ERBB2GO:2001242regulation of intrinsic apoptotic signaling pathway3.67e-02
ERBB2GO:0007416synapse assembly3.67e-02
ERBB2GO:0042098T cell proliferation3.67e-02
ERBB2GO:0050679positive regulation of epithelial cell proliferation3.67e-02
ERBB2GO:0007411axon guidance3.67e-02
ERBB2GO:0097485neuron projection guidance3.67e-02
ERBB2GO:0050670regulation of lymphocyte proliferation3.67e-02
ERBB2GO:0032944regulation of mononuclear cell proliferation3.67e-02
ERBB2GO:0050769positive regulation of neurogenesis3.67e-02
ERBB2GO:0033002muscle cell proliferation3.67e-02
ERBB2GO:0033044regulation of chromosome organization3.67e-02
ERBB2GO:0045930negative regulation of mitotic cell cycle3.67e-02
ERBB2GO:0097305response to alcohol3.67e-02
ERBB2GO:0045927positive regulation of growth3.67e-02
ERBB2GO:0007440foregut morphogenesis3.67e-02

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Related Drugs to ERBB2_SLC29A3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning ERBB2-SLC29A3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to ERBB2_SLC29A3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate