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Kinase Fusion Gene:ERG_MAPK11 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: ERG_MAPK11 | KinaseFusionDB ID: KFG2146 | FusionGDB2.0 ID: KFG2146 | Hgene | Tgene | Gene symbol | ERG | MAPK11 | Gene ID | 2078 | 5600 | |
| Gene name | ETS transcription factor ERG | mitogen-activated protein kinase 11 | ||||||||||
| Synonyms | LMPHM14|erg-3|p55 | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta | ||||||||||
| Cytomap | 21q22.2 | 22q13.33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 oncogene homologv-ets avian erythroblastosis | mitogen-activated protein kinase 11MAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b | ||||||||||
| Modification date | 20240323 | 20240305 | ||||||||||
| UniProtAcc | Q9Y282 | Q15759 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000398910, ENST00000398911, ENST00000398919, ENST00000417133, ENST00000442448, ENST00000398897, ENST00000485493, ENST00000288319, ENST00000398905, ENST00000398907, ENST00000429727, ENST00000453032, | ENST00000449719, ENST00000495277, ENST00000330651, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: ERG [Title/Abstract] AND MAPK11 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ERG(39947586)-MAPK11(50706378), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ERG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18195090|23913826 |
| Tgene | MAPK11 | GO:0031098 | stress-activated protein kinase signaling cascade | 35857590 |
| Tgene | MAPK11 | GO:0038066 | p38MAPK cascade | 10330143 |
| Tgene | MAPK11 | GO:0051403 | stress-activated MAPK cascade | 8663524|35857590 |
| Tgene | MAPK11 | GO:0071347 | cellular response to interleukin-1 | 8663524 |
| Tgene | MAPK11 | GO:0071493 | cellular response to UV-B | 35857590 |
| Kinase Fusion gene breakpoints across ERG (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MAPK11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-63-7022-01A | ERG | chr21 | 39947586 | MAPK11 | chr22 | 50706378 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39947586/:50706378) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERG | MAPK11 |
| FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. Positively regulates trafficking of the secretory proteins SERPINA1/alpha1-antitrypsin and HP/haptoglobin (PubMed:31142615). {ECO:0000269|PubMed:31142615}. | FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:9430721, PubMed:10330143, PubMed:15356147). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:9430721, PubMed:10330143, PubMed:15356147). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:15356147, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000303|PubMed:12452429, ECO:0000303|PubMed:20626350}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of ERG_MAPK11 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAPK11 | Q15759 | human | EP300 | Q09472 | S12 | VVEPGPPsAkRPKLs | |
| MAPK11 | Q15759 | human | ATF2 | P15336 | T69 | sVIVADQtPtPtRFL | |
| MAPK11 | Q15759 | human | ATF2 | P15336 | T71 | IVADQtPtPtRFLkN | |
| MAPK11 | Q15759 | human | SOD2 | P04179 | T79 | ALAKGDVtAQIALQP | Sod_Fe_N |
| MAPK11 | Q15759 | human | MAPK11 | Q15759 | T241 | RIMEVVGtPsPEVLA | Pkinase |
| MAPK11 | Q15759 | human | SNX27 | Q96L92 | S51 | VRIVksEsGYGFNVR | PDZ |
| MAPK11 | Q15759 | human | EEF2K | O00418 | S396 | TFDsLPssPssAtPH | |
| MAPK11 | Q15759 | human | HSF1 | Q00613 | S307 | EPPsPPQsPRVEEAs | Vert_HS_TF |
| MAPK11 | Q15759 | human | RPTOR | Q8N122 | S771 | SASSTLGsPENEEHI | |
| MAPK11 | Q15759 | human | E2F1 | Q01094 | T433 | DCDFGDLtPLDF___ | |
| MAPK11 | Q15759 | human | EGFR | P00533 | S1039 | tPLLSsLsAtsNNst | |
| MAPK11 | Q15759 | human | RPTOR | Q8N122 | S863 | LtQsAPAsPtNkGVH | |
| MAPK11 | Q15759 | human | MAPKAPK5 | Q8IW41 | T182 | IDQGDLMtPQFtPyY | Pkinase |
| MAPK11 | Q15759 | human | MAPK11 | Q15759 | S261 | HARTYIQsLPPMPQK | Pkinase |
| MAPK11 | Q15759 | human | NLRP1 | Q9C000 | S107 | PSEPHLGsPSQPTST | |
| MAPK11 | Q15759 | human | CDC25B | P30305 | S249 | kMEVEELsPLALGRF | M-inducer_phosp |
| MAPK11 | Q15759 | human | HSF1 | Q00613 | S303 | RVkEEPPsPPQsPRV | Vert_HS_TF |
| MAPK11 | Q15759 | human | KAT5 | Q92993-2 | T106 | VEVVsPAtPVPSETA | |
| MAPK11 | Q15759 | human | HNF4A | P41235 | S167 | VLSRQItsPVsGING | |
| MAPK11 | Q15759 | human | SOD2 | P04179 | S106 | SIFWTNLsPNGGGEP | Sod_Fe_N |
| MAPK11 | Q15759 | human | EGFR | P00533 | T1041 | LLSsLsAtsNNstVA | |
| MAPK11 | Q15759 | human | ATF7 | P17544 | T51 | sVIIADQtPtPtRFL | |
| MAPK11 | Q15759 | human | GYS1 | P13807 | S727 | StPsEPLsPtssLGE | |
| MAPK11 | Q15759 | human | HSF1 | Q00613 | S326 | ssVDtLLsPTALIDs | Vert_HS_TF |
| MAPK11 | Q15759 | human | GYS1 | P13807 | T721 | AtsssLStPsEPLsP | |
| MAPK11 | Q15759 | human | PRKCE | Q02156 | S350 | RsKsAPtsPCDQEIK | |
| MAPK11 | Q15759 | human | GYS1 | P13807 | S653 | PsLsRHssPHQsEDE | Glycogen_syn |
| MAPK11 | Q15759 | human | GYS1 | P13807 | S645 | RPAsVPPsPsLsRHs | Glycogen_syn |
| MAPK11 | Q15759 | human | SREBF1 | P36956 | S63 | AGGtDPAsPDTSSPG | |
| MAPK11 | Q15759 | human | E2F1 | Q01094 | S403 | PEEFISLsPPHEALD | |
| MAPK11 | Q15759 | human | EWSR1 | Q01844 | T79 | QPPTGYTtPTAPQAY | |
| MAPK11 | Q15759 | human | SREBF1 | P36956 | T426 | TEVEDTLtPPPsDAG | |
| MAPK11 | Q15759 | human | CCND3 | P30281 | T283 | QGPsQtstPtDVtAI | |
| MAPK11 | Q15759 | human | KAT5 | Q92993 | T158 | VEVVsPAtPVPSETA | |
| MAPK11 | Q15759 | human | NR3C1 | P04150 | S226 | IDENCLLsPLAGEDD | GCR |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAPK11 | ID | Description | 0.00e+00 |
| MAPK11 | GO:0036293 | response to decreased oxygen levels | 3.56e-05 |
| MAPK11 | GO:0045787 | positive regulation of cell cycle | 3.56e-05 |
| MAPK11 | GO:0070482 | response to oxygen levels | 3.56e-05 |
| MAPK11 | GO:0009314 | response to radiation | 1.20e-04 |
| MAPK11 | GO:0001666 | response to hypoxia | 2.13e-04 |
| MAPK11 | GO:0031667 | response to nutrient levels | 2.13e-04 |
| MAPK11 | GO:0019216 | regulation of lipid metabolic process | 3.64e-04 |
| MAPK11 | GO:0071230 | cellular response to amino acid stimulus | 4.23e-04 |
| MAPK11 | GO:0034284 | response to monosaccharide | 4.77e-04 |
| MAPK11 | GO:0071229 | cellular response to acid chemical | 5.07e-04 |
| MAPK11 | GO:0009743 | response to carbohydrate | 6.69e-04 |
| MAPK11 | GO:0009410 | response to xenobiotic stimulus | 8.04e-04 |
| MAPK11 | GO:0045444 | fat cell differentiation | 8.04e-04 |
| MAPK11 | GO:0031669 | cellular response to nutrient levels | 8.04e-04 |
| MAPK11 | GO:0090068 | positive regulation of cell cycle process | 9.08e-04 |
| MAPK11 | GO:0071392 | cellular response to estradiol stimulus | 9.08e-04 |
| MAPK11 | GO:0043200 | response to amino acid | 9.55e-04 |
| MAPK11 | GO:0045931 | positive regulation of mitotic cell cycle | 9.59e-04 |
| MAPK11 | GO:0031668 | cellular response to extracellular stimulus | 1.02e-03 |
| MAPK11 | GO:0001101 | response to acid chemical | 1.26e-03 |
| MAPK11 | GO:0045834 | positive regulation of lipid metabolic process | 1.34e-03 |
| MAPK11 | GO:0009411 | response to UV | 1.51e-03 |
| MAPK11 | GO:0062197 | cellular response to chemical stress | 1.51e-03 |
| MAPK11 | GO:1902895 | positive regulation of miRNA transcription | 1.57e-03 |
| MAPK11 | GO:0036294 | cellular response to decreased oxygen levels | 1.58e-03 |
| MAPK11 | GO:0071214 | cellular response to abiotic stimulus | 1.65e-03 |
| MAPK11 | GO:0104004 | cellular response to environmental stimulus | 1.65e-03 |
| MAPK11 | GO:0062012 | regulation of small molecule metabolic process | 1.66e-03 |
| MAPK11 | GO:0071496 | cellular response to external stimulus | 1.79e-03 |
| MAPK11 | GO:0046686 | response to cadmium ion | 1.79e-03 |
| MAPK11 | GO:0071453 | cellular response to oxygen levels | 1.79e-03 |
| MAPK11 | GO:0030522 | intracellular receptor signaling pathway | 1.79e-03 |
| MAPK11 | GO:0072331 | signal transduction by p53 class mediator | 1.79e-03 |
| MAPK11 | GO:0009267 | cellular response to starvation | 1.89e-03 |
| MAPK11 | GO:0071478 | cellular response to radiation | 1.92e-03 |
| MAPK11 | GO:2000630 | positive regulation of miRNA metabolic process | 1.95e-03 |
| MAPK11 | GO:0006109 | regulation of carbohydrate metabolic process | 2.09e-03 |
| MAPK11 | GO:0046890 | regulation of lipid biosynthetic process | 2.09e-03 |
| MAPK11 | GO:0009749 | response to glucose | 2.21e-03 |
| MAPK11 | GO:1902893 | regulation of miRNA transcription | 2.28e-03 |
| MAPK11 | GO:0009746 | response to hexose | 2.28e-03 |
| MAPK11 | GO:0061614 | miRNA transcription | 2.28e-03 |
| MAPK11 | GO:0007623 | circadian rhythm | 2.43e-03 |
| MAPK11 | GO:0071233 | cellular response to leucine | 2.43e-03 |
| MAPK11 | GO:0071493 | cellular response to UV-B | 2.43e-03 |
| MAPK11 | GO:1901654 | response to ketone | 2.51e-03 |
| MAPK11 | GO:0071361 | cellular response to ethanol | 2.75e-03 |
| MAPK11 | GO:0042594 | response to starvation | 2.88e-03 |
| MAPK11 | GO:0010867 | positive regulation of triglyceride biosynthetic process | 3.07e-03 |
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Related Drugs to ERG_MAPK11 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning ERG-MAPK11 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to ERG_MAPK11 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ERG | C0033578 | Prostatic Neoplasms | 7 | CTD_human |
| Hgene | ERG | C0376358 | Malignant neoplasm of prostate | 7 | CTD_human |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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