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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ETV6_ABL1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ETV6_ABL1
KinaseFusionDB ID: KFG2172
FusionGDB2.0 ID: KFG2172
HgeneTgene
Gene symbol

ETV6

ABL1

Gene ID

2120

25

Gene nameETS variant transcription factor 6ABL proto-oncogene 1, non-receptor tyrosine kinase
SynonymsTEL|TEL/ABL|THC5ABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-abl
Cytomap

12p13.2

9q34.12

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS-related protein Tel1ETV6-RUNX1 fusion proteinTEL1 oncogeneets variant gene 6 (TEL oncogene)tyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1BCR-ABL1 p190BCR/ABL e8a2 fusionBCR/ABL1 e1a2 fusion proteinbcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncog
Modification date2024030520240416
UniProtAcc

P41212

P00519

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000318560, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ETV6 [Title/Abstract] AND ABL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ETV6(12006495)-ABL1(133729449), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgeneABL1

GO:0006974

DNA damage response

15657060

TgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

TgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060|18280240

TgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

TgeneABL1

GO:0046777

protein autophosphorylation

10713049

TgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

TgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

TgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

TgeneABL1

GO:0071103

DNA conformation change

9558345

TgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

TgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

TgeneABL1

GO:2000042

negative regulation of double-strand break repair via homologous recombination

9461559


check buttonKinase Fusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across ABL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4Z35761ETV6chr12

12006495

ABL1chr9

133729449

ChimerKB3.ETV6chr12

12022903

ABL1chr9

133729450

ChiTaRS5.0Z35761ETV6chr12

12006495

ABL1chr9

133729449

COSMIC2652545ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652546ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652547ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652548ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652549ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652550ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652551ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2652552ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657306ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657308ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657337ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657338ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657360ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657361ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657607ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657608ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2657609ETV6chr12

12006495

ABL1chr9

133729451

COSMIC2657610ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659040ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659041ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659042ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659118ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659119ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659453ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659510ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659511ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659549ETV6chr12

12022903

ABL1chr9

133729451

COSMIC2659564ETV6chr12

12006495

ABL1chr9

133729451

COSMIC2659625ETV6chr12

12022903

ABL1chr9

133729451



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000396373ENST00000318560ETV6chr1212022903ABL1chr913372945165891440
ENST00000396373ENST00000318560ETV6chr1212006495ABL1chr913372945160431258
ENST00000396373ENST00000318560ETV6chr1212006495ABL1chr913372944960431258
ENST00000396373ENST00000318560ETV6chr1212022903ABL1chr913372945065891440

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000396373_ENST00000318560_ETV6_chr12_12022903_ABL1_chr9_133729451_length(amino acids)=1440
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

>ENST00000396373_ENST00000318560_ETV6_chr12_12006495_ABL1_chr9_133729451_length(amino acids)=1258
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEEALQRPVASDFEPQGLSEAARWNSKE
NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLS
SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA
YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI
SDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLP
KDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAP
GGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPG
EGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLA

--------------------------------------------------------------

>ENST00000396373_ENST00000318560_ETV6_chr12_12006495_ABL1_chr9_133729449_length(amino acids)=1258
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEEALQRPVASDFEPQGLSEAARWNSKE
NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLS
SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA
YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI
SDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLP
KDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAP
GGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPG
EGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLA

--------------------------------------------------------------

>ENST00000396373_ENST00000318560_ETV6_chr12_12022903_ABL1_chr9_133729450_length(amino acids)=1440
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12006495/chr9:133729449)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

ABL1

P00519

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 (PubMed:22810897). Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:22810897, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneETV612006495ABL1133729449ENST00000396373011242_493261131DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612006495ABL1133729451ENST00000396373011242_493261131DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612022903ABL1133729450ENST00000396373011242_493261131DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612022903ABL1133729451ENST00000396373011242_493261131DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612006495ABL1133729449ENST00000396373011127_217261131DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TgeneETV612006495ABL1133729451ENST00000396373011127_217261131DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TgeneETV612022903ABL1133729450ENST00000396373011127_217261131DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TgeneETV612022903ABL1133729451ENST00000396373011127_217261131DomainNote=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191
TgeneETV612006495ABL1133729449ENST0000039637301161_121261131DomainNote=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TgeneETV612006495ABL1133729451ENST0000039637301161_121261131DomainNote=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TgeneETV612022903ABL1133729450ENST0000039637301161_121261131DomainNote=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192
TgeneETV612022903ABL1133729451ENST0000039637301161_121261131DomainNote=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>175_ETV6_ABL1ENST00000396373ENST00000318560ETV6chr1212022903ABL1chr9133729450
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
1440
3D view using mol* of 175_ETV6_ABL1
PDB file >>>TKFP_309_ETV6_ABL1ENST00000396373ENST00000318560ETV6chr1212022903ABL1chr9133729451
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
1440_ETV6_ABL1
PDB file >>>TKFP_310_ETV6_ABL1ENST00000396373ENST00000318560ETV6chr1212006495ABL1chr9133729451
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEEALQRPVASDFEPQGLSEAARWNSKE
NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLS
SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA
YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI
SDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLP
KDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAP
GGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPG
EGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLA
1258_ETV6_ABL1
3D view using mol* of TKFP_310_ETV6_ABL1
PDB file >>>TKFP_311_ETV6_ABL1ENST00000396373ENST00000318560ETV6chr1212006495ABL1chr9133729449
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEEALQRPVASDFEPQGLSEAARWNSKE
NLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLS
SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGN
LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA
YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI
SDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLP
KDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFR
SPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS
DQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAP
GGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPG
EGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLA
1258_ETV6_ABL1
PDB file >>>TKFP_312_ETV6_ABL1ENST00000396373ENST00000318560ETV6chr1212022903ABL1chr9133729450
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAEALQRPVASDFEPQGLSEAARWNS
KENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYL
LSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP
NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTY
GNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES
LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES
SISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERL
LPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSG
FRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGEN
RSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSG
APGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQ
PGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALC
LAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
1440_ETV6_ABL1


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.
3D view using mol* of viewer/superimpose_isoforms/TKFP_309_ETV6_ABL1_vs_TKFP_310_ETV6_ABL1_superimposed.pdb.html

check button Comparison of the Secondary Structures of Fusion Protein Isoforms
./secondary_str/TKFP_310_ETV6_ABL1_vs_TKFP_309_ETV6_ABL1.png
secondary structure of ./secondary_str/TKFP_310_ETV6_ABL1_vs_TKFP_309_ETV6_ABL1.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ETV6_ABL1 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/175_ETV6_ABL1.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_310_ETV6_ABL1_updated_violin_plot.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
175_ETV6_ABL1.png
all structure sitemap plddt3 175_ETV6_ABL1.png
175_ETV6_ABL1.png
all structure sitemap plddt4 175_ETV6_ABL1.png
TKFP_310_ETV6_ABL1.png
all structure sitemap plddt3 TKFP_310_ETV6_ABL1.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
TKFP_310_ETV6_ABL11.0751961.043592.3610.430.811.0581.0211.1760.8690.774Chain A: 376,377,379,380,381,384,397,398,399,410,4
14,418,427,441,443,444,445,446,449,450,489,490,491
,495,496,498,508,509,510,511,512,513,514,521,523,5
24,527,528,529,530,745

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

175_ETV6_ABL1_ramachandran.png
all structure ETV6-ABL1
TKFP_310_ETV6_ABL1_ramachandran.png
all structure ETV6-ABL1

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case
all structure ETV6-ABL1

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
175_ETV6_ABL1-DOCK_HTVS_1-001Erdafitinib-10.0021-10.0023-58.8599
175_ETV6_ABL1-DOCK_HTVS_1-001Lapatinib-9.10914-9.19794-67.8949
175_ETV6_ABL1-DOCK_HTVS_1-001Lapatinib-8.53309-8.621889999999999-65.428
175_ETV6_ABL1-DOCK_HTVS_1-001Pazopanib-8.13827-8.14517-44.4913
175_ETV6_ABL1-DOCK_HTVS_1-001Pazopanib-8.13827-8.14517-44.4913
175_ETV6_ABL1-DOCK_HTVS_1-001Ibrutinib-7.90215-7.90215-51.1095
175_ETV6_ABL1-DOCK_HTVS_1-001Entrectinib-7.840039999999999-7.904739999999999-49.9274
175_ETV6_ABL1-DOCK_HTVS_1-001Entrectinib-7.840039999999999-7.904739999999999-49.9274
175_ETV6_ABL1-DOCK_HTVS_1-001Entrectinib-7.7583-7.8229999999999995-53.8379
175_ETV6_ABL1-DOCK_HTVS_1-001Larotrectinib-7.710789999999999-7.710789999999999-36.2744
175_ETV6_ABL1-DOCK_HTVS_1-001Alectinib-7.611269999999999-7.76337-32.0762
175_ETV6_ABL1-DOCK_HTVS_1-001Alectinib-7.611269999999999-7.76337-32.0762
175_ETV6_ABL1-DOCK_HTVS_1-001Vandetanib-7.5659600000000005-7.5659600000000005-50.6983
175_ETV6_ABL1-DOCK_HTVS_1-001Imatinib-7.524439999999999-7.731039999999999-57.9601
175_ETV6_ABL1-DOCK_HTVS_1-001Imatinib-7.524439999999999-7.731039999999999-57.9601
175_ETV6_ABL1-DOCK_HTVS_1-001Imatinib-7.524439999999999-7.731039999999999-57.9601
175_ETV6_ABL1-DOCK_HTVS_1-001Crizotinib-7.45955-7.79575-39.7624
175_ETV6_ABL1-DOCK_HTVS_1-001Crizotinib-7.45955-7.79575-39.7624
175_ETV6_ABL1-DOCK_HTVS_1-001Netarsudil-7.37507-7.38617-53.2692
175_ETV6_ABL1-DOCK_HTVS_1-001Netarsudil-7.37507-7.38617-53.2692

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Kinase-Substrate Information of ETV6_ABL1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
ABL1P00519humanYAP1P46937Y407sGLsMsSySVPRtPD
ABL1P00519humanDCBLD2Q96PD2Y750PAPDELVyQVPQStQ
ABL1P00519humanSMAD4Q13485Y301MPPHPGHyWPVHNEL
ABL1P00519humanDCBLD1Q8N8Z6S657GDyQRPHsAQPADRG
ABL1P00519humanTBX21Q9UL17Y305QFIAVTAyQNAEITQT-box
ABL1P00519humanCATP04040Y231NANGEAVyCkFHYkTCatalase
ABL1P00519humanMYLKQ15746Y1449EKEPEVDyRTVTINT
ABL1P00519humanABL1P00519Y393RLMtGDtytAHAGAkPK_Tyr_Ser-Thr
ABL1P00519humanTP73O15350Y99SVPTHSPyAQPSSTF
ABL1P00519humanDCBLD2Q96PD2Y715PPPLVGtyNtLLsRt
ABL1P00519humanSORBS2O94875-2Y59RPFSPSAySLPASLN
ABL1P00519humanDCBLD2Q96PD2Y565KKkTEGtyDLPyWDR
ABL1P00519humanCDC73Q6P1J9Y315KIDTMGTyHGMTLkS
ABL1P00519humanDCBLD1Q8N8Z6S695THPGTsDsysAPRDC
ABL1P00519humanMETP08581Y1349stFIGEHyVHVNAty
ABL1P00519humanHRASP01112Y137AQDLARSyGIPYIEtRas
ABL1P00519humanMYCP01106Y89sGLCsPSyVAVtPFsMyc_N
ABL1P00519humanMDM4O15151Y55TVKEVMHyLGQYIMVSWIB
ABL1P00519humanPIK3AP1Q6ZUJ8Y513LGQEEDVyHTVDDDE
ABL1P00519humanPDGFRBP09619Y970GEGYKKKyQQVDEEF
ABL1P00519humanKAT5Q92993Y294HPPGNEIyRkGTISFMOZ_SAS
ABL1P00519humanMYCP01106Y47CDEEENFyQQQQQSEMyc_N
ABL1P00519humanCRKP46108Y221GGPEPGPyAQPsVNt
ABL1P00519humanCASP9P55211Y153RGNADLAyILSMEPC
ABL1P00519humanPLSCR1O15162Y69PVPNQPVyNQPVyNQ
ABL1P00519humanANXA1P04083Y21IENEEQEyVQtVkss
ABL1P00519humanPXNP49023Y118VGEEEHVysFPNkQkPaxillin
ABL1P00519humanSMAD4Q13485Y195NRASTETyStPALLA
ABL1P00519humanROBO1Q9Y6N7Y1038MLPESTVyGDVDLSN
ABL1P00519humanCRKLP46109Y207IPEPAHAyAQPQttt
ABL1P00519humanVAV1P15498Y174EAEGDEIyEDLMRsE
ABL1P00519humanTP63Q9H3D4Y290RQSVLVPyEPPQVGTP53
ABL1P00519humanDCBLD2Q96PD2T756VyQVPQStQEVsGAG
ABL1P00519humanRB1P06400Y805rIPGGNIyIsPLksPRb_C
ABL1P00519humanNOX5Q96PH1Y476FHYRPGDyLyLNIPTFAD_binding_8
ABL1P00519humanFHL2Q14192Y176ITTGGVtyREQPWHKLIM
ABL1P00519humanMDM2Q00987Y394QsQESEDysQPSTSS
ABL1P00519humanESR1P03372Y219sIQGHNDyMCPATNQzf-C4
ABL1P00519humanRAPGEF1Q13905Y504APIPSVPyAPFAAIL
ABL1P00519humanPLK1P53350Y445DSTRLILyNDGDsLQPOLO_box
ABL1P00519humanCRKP46108Y239NLQNGPIyARVIQKRSH3_2
ABL1P00519humanZAP70P43403Y319tsVyEsPysDPEELk
ABL1P00519humanJUNBP17275Y182GPEPPPVyTNLSSySJun
ABL1P00519humanEGFRP00533Y1092tFLPVPEyINQsVPk
ABL1P00519humanDCBLD2Q96PD2S600tPVRysssEVNHLsP
ABL1P00519humanABI1Q8IZP0Y213PPtVPNDyMtsPARL
ABL1P00519humanMAVSQ7Z434Y30DVVEILPyLPCLTARCARD_2
ABL1P00519humanPHF5AQ7RTV0Y36kCVICDSyVRPCTLVPHF5
ABL1P00519humanTP63Q9H3D4Y149SVTAPSPyAQPSSTF
ABL1P00519humanABL1P00519-2Y412RLMTGDtyTAHAGAKPK_Tyr_Ser-Thr
ABL1P00519humanDCBLD1Q8N8Z6S697PGTsDsysAPRDCLT
ABL1P00519humanPXNP49023Y31FLSEEtPysyPtGNH
ABL1P00519humanWASF3Q9UPY6Y151KKDGLKFyTDPSyFF
ABL1P00519humanDCBLD1Q8N8Z6Y665AQPADRGyDRPKAVs
ABL1P00519humanPDGFRBP09619Y686IITEyCRyGDLVDyLPK_Tyr_Ser-Thr
ABL1P00519humanDCBLD2Q96PD2S598EEtPVRysssEVNHL
ABL1P00519humanCDC73Q6P1J9Y293IPAAyNRyDQERFkGCDC73_N
ABL1P00519humanCASP9P55211Y397AVSVkGIyKQMPGCFPeptidase_C14
ABL1P00519humanPYCARDQ9ULZ3Y146kVLTDEQyQAVRAEPCARD
ABL1P00519humanCD19P15391Y508EDMRGILyAAPQLRs
ABL1P00519humanCDKN1BP46527Y88kGsLPEFyyRPPRPP
ABL1P00519humanCTNNB1P35222Y86VADIDGQyAMTRAQR
ABL1P00519humanFOXA1P55317Y429QALQYsPyGSTLPASHNF_C
ABL1P00519humanMYLKQ15746Y792QPWHAGQyEILLKNRI-set
ABL1P00519humanMYLKQ15746Y464QEGsIEVyEDAGsHyI-set
ABL1P00519humanDCBLD2Q96PD2Y655GyADLDPyNsPGQEV
ABL1P00519humanJUNBP17275Y173PAGPGGVyAGPEPPPJun
ABL1P00519humanSNCAP37840Y125VDPDNEAyEMPsEEGSynuclein
ABL1P00519humanNOX5Q96PH1Y478YRPGDyLyLNIPTIAFAD_binding_8
ABL1P00519humanMYLKQ15746Y231NQDDVGVyTCLVVNGI-set
ABL1P00519humanMYLKQ15746Y846DGGGSDRyGsLRPGW
ABL1P00519humanPIK3AP1Q6ZUJ8Y594DRPQssIyDPFAGMk
ABL1P00519humanGPX1P07203Y98EILNSLkyVRPGGGFGSHPx
ABL1P00519humanSRCIN1Q9C0H9Y396LVKGEGLyADPyGLL
ABL1P00519humanNOS3P29474Y81WEVGSITyDTLSAQA
ABL1P00519humanDCBLD2Q96PD2S760PQStQEVsGAGRDGE
ABL1P00519humanMDM4O15151Y99VkDPsPLyDMLRKNL
ABL1P00519humanHIPK2Q9H2X6Y367tyLQsRYyRAPEIILPkinase
ABL1P00519humanTRIM33Q9UPN9Y1048MMKVVQVyADtQEINBromodomain
ABL1P00519humanTBX21Q9UL17Y220SMPGNRLyVHPDSPNT-box
ABL1P00519humanPSMA7O14818Y106EDPVTVEyItRyIASProteasome
ABL1P00519humanPPARGP37231Y78SSISTPHyEDIPFTRPPARgamma_N
ABL1P00519humanATRQ13535Y291DTDQLKLyEEPLSkL
ABL1P00519humanDCBLD2Q96PD2Y649EEGKEAGyADLDPyN
ABL1P00519humanAHSA1O95433Y223LtsPEELyRVFTTQEAHSA1
ABL1P00519humanDCBLD1Q8N8Z6Y589QRAGRHEyALPLAPP
ABL1P00519humanDNM1LO00429Y266TDSIRDEyAFLQkkYDynamin_M
ABL1P00519humanLGALS3P17931Y107AYPATGPyGAPAGPL
ABL1P00519humanLGALS3P17931Y79GAPAPGVyPGPPSGP
ABL1P00519humanDCBLD1Q8N8Z6Y600LAPPEPEyAtPIVER
ABL1P00519humanWASF3Q9UPY6Y486SRRIAVEySDSDDDS
ABL1P00519humanDCBLD1Q8N8Z6S556GTVTRKGsTFRPMDT
ABL1P00519humanESR2Q92731Y36SIYIPSSyVDSHHEYERbeta_N
ABL1P00519humanRAD51Q06609Y54HTVEAVAyAPkkELIHHH_5
ABL1P00519humanEGFRP00533Y1197stAENAEyLRVAPQS
ABL1P00519humanGLO1Q04760Y136GIAVPDVysACkRFEGlyoxalase
ABL1P00519humanSTX17P56962Y157SQSLTQIyALPEIPQ
ABL1P00519humanPPARGP37231Y102yDLKLQEyQSAIkVEPPARgamma_N
ABL1P00519humanGMNNO75496Y150EVAEHVQyMAELIERGeminin
ABL1P00519humanSNCAP37840Y39kTkEGVLyVGsKTkESynuclein
ABL1P00519humanNFKBIAP25963Y305FtEDELPyDDCVFGG
ABL1P00519humanMUC1P15941Y1243NGGSsLsytNPAVAA
ABL1P00519humanDCBLD1Q8N8Z6S693PPTHPGTsDsysAPR
ABL1P00519humanSORBS2O94875-2Y573NTKGAEDyPDPPIPH
ABL1P00519humanERRFI1Q9UJM3Y394KKVsstHyyLLPERP
ABL1P00519humanCAV1Q03135Y14VDsEGHLytVPIREQ
ABL1P00519humanRAD51Q06609Y315EtRICKIyDSPCLPERad51
ABL1P00519humanFOXA1P55317Y464PAYYQGVySRPVLNT
ABL1P00519humanRTCBQ9Y3I0Y316GMAAAGNyAWVNRSSRtcB
ABL1P00519humanESR1P03372Y52DssKPAVyNYPEGAAOest_recep
ABL1P00519humanATRQ13535Y310FPFEAEAyRNIEPVY
ABL1P00519humanBCRP11274Y177ADAEKPFyVNVEFHH
ABL1P00519humanPLCG1P19174Y1003KGKKFLQyNRLQLSRPI-PLC-Y
ABL1P00519humanMETP08581Y1356yVHVNAtyVNVKCVA
ABL1P00519humanBTKQ06187Y223LKKVVALyDyMPMNASH3_1
ABL1P00519humanEGFRP00533Y1016DVVDADEyLIPQQGF
ABL1P00519humanRACK1P63244Y52LtrDEtNyGIPQRAL
ABL1P00519humanSORBS2O94875-2Y175YTYNAGLyNPPYSAQ
ABL1P00519humanABL2P42684Y261GLVTTLHyPAPKCNK
ABL1P00519humanSTK3Q13188Y81MQQCDSPyVVKYYGSPkinase
ABL1P00519humanPLCG1P19174Y771IGtAEPdyGALyEGR
ABL1P00519humanPLK1P53350Y217tLCGtPNyIAPEVLsPkinase
ABL1P00519humanSNW1Q13573Y292AKLAEALyIADRKARSKIP_SNW
ABL1P00519humanPIK3AP1Q6ZUJ8Y570QERPGNFyVSSEsIR
ABL1P00519humanCEBPBP17676Y78RAIDFsPyLEPLGAP
ABL1P00519humanDCBLD1Q8N8Z6Y540ITsDMADyQQPLMIG
ABL1P00519humanOTULINQ96BN8Y56AEHEEDMyRAADEIE
ABL1P00519humanJUNP05412Y170LHSEPPVyANLSNFNJun
ABL1P00519humanIRF3Q14653Y292rLGHCHTyWAVSEELIRF-3
ABL1P00519humanDCBLD2Q96PD2Y597HEEtPVRysssEVNH
ABL1P00519humanDCBLD2Q96PD2Y621LQADsAEyAQPLVGG
ABL1P00519humanCTTNQ14247Y486yPAEDStyDEYENDL
ABL1P00519humanTP63Q9H3D4Y171AIPSNTDyPGPHSFDP53
ABL1P00519humanNCOA3Q9Y6Q9Y1357HPQAASIyQSSEMKG
ABL1P00519humanRBM39Q14498Y95DRRFRGRyrsPysGP
ABL1P00519humanSNW1Q13573Y433EDEIyNVyDQAWrGG
ABL1P00519humanEMDP50402Y167AyQsItHyRPVsAsR
ABL1P00519humanDCBLD2Q96PD2T679ITGPEyAtPIIMDMS
ABL1P00519humanNCK1P16333Y105VDPGERLyDLNMPAy
ABL1P00519humanPIK3AP1Q6ZUJ8Y694AKVEFGVyEsGPRKs
ABL1P00519humanDCBLD2Q96PD2Y677LPITGPEyAtPIIMD
ABL1P00519humanCATP04040Y386yRARVANyQRDGPMCCatalase
ABL1P00519humanRAD52P43351Y104DLNNGKFyVGVCAFVRad52_Rad22
ABL1P00519humanROBO1Q9Y6N7Y1114QEVAPVQyNIVEQNk
ABL1P00519humanYAP1P46937-3Y357SGLSMSSySVPRtPD
ABL1P00519humanWASF3Q9UPY6Y337LPAQIIEyYNPSGPP
ABL1P00519humanDDX5P17844Y593NGMNQQAyAyPATAA
ABL1P00519humanDCBLD1Q8N8Z6S513yPFARHQsAEFtISY
ABL1P00519humanPLK1P53350Y425SDkYGLGyQLCDNSVPOLO_box
ABL1P00519humanDCBLD2Q96PD2S618TTVLQADsAEyAQPL
ABL1P00519humanCDC73Q6P1J9Y290kQPIPAAyNRyDQERCDC73_N
ABL1P00519humanARHGDIBP52566Y24ELdskLNykPPPQksRho_GDI
ABL1P00519humanTBX21Q9UL17Y266VLQsLHKyQPRLHIVT-box
ABL1P00519humanMYLKQ15746Y1635VAPEVINyEPIGYATPkinase
ABL1P00519humanJUNBP17275Y188VyTNLSSySPASASSJun
ABL1P00519humanDCBLD2Q96PD2Y666GQEVyHAyAEPLPIT
ABL1P00519humanPIK3AP1Q6ZUJ8Y553QLPDNEPyIFKVFAE
ABL1P00519humanGMFGO60234Y104kPEQQMMyAGSkNRLCofilin_ADF
ABL1P00519humanSRCIN1Q9C0H9Y264IYRKEPLyAAFPGSHAIP3
ABL1P00519humanPSMA7O14818Y153QTDPsGtyHAWkANAProteasome
ABL1P00519humanTRIM33Q9UPN9Y524QHMQQQVyAQKHQQL
ABL1P00519humanCDKN1BP46527Y89GsLPEFyyRPPRPPK
ABL1P00519humanNUMA1Q14980Y1774VEsLEsLyFtPIPAR
ABL1P00519humanDCBLD1Q8N8Z6Y578STDAGGHyDCPQRAG
ABL1P00519humanCRKP46108Y251QKRVPNAyDktALALSH3_2
ABL1P00519humanDNM1LO00429Y368CGGARICyIFHETFGDynamin_M
ABL1P00519humanZNF746Q6NUN9Y137ETLVSLDyAISKPEV
ABL1P00519humanDCBLD2Q96PD2T593kAVDHEEtPVRysss
ABL1P00519humanTUBG1P23258Y443HAATRPDyISWGTQE
ABL1P00519humanPLEKHG2Q9H7P9Y489sEPVKDPyVMFPQNA
ABL1P00519humanDDB1Q16531Y182APTICFVyQDPQGRHMMS1_N
ABL1P00519humanSORBS2O94875-2Y50AVSPMSYyQRPFSPS
ABL1P00519humanLGALS3P17931Y118AGPLIVPyNLPLPGGGal-bind_lectin
ABL1P00519humanPRAG1Q86YV5Y413ATQPEPIyAEsTKRK
ABL1P00519humanMYLKQ15746Y611KSSRkSEyLLPVAPS
ABL1P00519humanCTNNB1P35222Y489QNAVRLHyGLPVVVk
ABL1P00519humanCTNNB1P35222Y654RNEGVAtyAAAVLFR
ABL1P00519humanSORBS2O94875-2Y164PDDDTDMyNTPYTYN
ABL1P00519humanDNM1LO00429Y449IIQHCSNySTQELLRDynamin_M
ABL1P00519humanPLSCR1O15162Y74PVyNQPVyNQPVGAA
ABL1P00519humanERCC6Q03468Y932GANRVVIyDPDWNPSHelicase_C
ABL1P00519humanDCBLD2Q96PD2T714QPPPLVGtyNtLLsR
ABL1P00519humanPRKNO60260Y143sPAGRSIyNSFYVYC
ABL1P00519humanMYLKQ15746Y556LNGQPIQyARSTCEAI-set
ABL1P00519humanSNW1Q13573Y430AGGEDEIyNVyDQAW
ABL1P00519humanFHL2Q14192Y97TDCySNEySSkCQECLIM
ABL1P00519humanRAD9AQ99638Y28SRIGDELyLEPLEDGRad9
ABL1P00519humanSPTLC1O15269Y164KTEEAIIySYGFATIAminotran_1_2
ABL1P00519humanMAVSQ7Z434Y71RRPGWVEyFIAALRGCARD_2
ABL1P00519humanCHCHD2Q9Y6H1Y99PARPDITyQEPQGTQ
ABL1P00519humanSTK4Q13043Y433kIPQDGDyEFLksWtMst1_SARAH
ABL1P00519humanPDGFRBP09619Y934AHAsDEIyEIMQKCWPK_Tyr_Ser-Thr
ABL1P00519humanRBM39Q14498Y99RGRyrsPysGPkFNs
ABL1P00519humanNFAT5O94916Y143PkRHtVLyIsPPPED
ABL1P00519humanDCBLD2Q96PD2Y663NsPGQEVyHAyAEPL
ABL1P00519humanERRFI1Q9UJM3Y395KVsstHyyLLPERPP
ABL1P00519humanTRIM33Q9UPN9Y610PrHSGPQySMMQPHL
ABL1P00519humanWASF3Q9UPY6Y248HASDVtDySYPATPN
ABL1P00519humanHDAC2Q92769Y222IGAGkGkyYAVNFPMHist_deacetyl
ABL1P00519humanFHL2Q14192Y236SGLGGTkyIsFEERQLIM
ABL1P00519humanROBO1Q9Y6N7Y1073PSGQPTPyAtTQLIQ
ABL1P00519humanMYLKQ15746Y1575QISEGVEyIHKQGIVPkinase
ABL1P00519humanPDHA1P08559Y301MsDPGVsyRtREEIQE1_dh
ABL1P00519humanMDM2Q00987Y276sDEDDEVyQVtVyQA
ABL1P00519humanRTCBQ9Y3I0Y306AsPEGQDyLkGMAAARtcB
ABL1P00519humanPDK1Q15118Y243ARRLCDLyyINSPEL
ABL1P00519humanFUSP35637Y526QDrrErPy_______
ABL1P00519humanFHL2Q14192Y217LNCFCDLyAKkCAGCLIM
ABL1P00519humanDCBLD2Q96PD2S599EtPVRysssEVNHLs
ABL1P00519humanMDM2Q00987Y405STSSSIIyssQEDVK
ABL1P00519humanDCBLD1Q8N8Z6Y621tFsAQsGyRVPGPQP
ABL1P00519humanDCBLD1Q8N8Z6Y696HPGTsDsysAPRDCL
ABL1P00519humanLASP1Q14847Y171IPtsAPVyQQPQQQP
ABL1P00519humanPRKD1Q15139Y463NDTGsRYyKEIPLSEPH
ABL1P00519humanYY1P25490Y254sPPDySEyMTGkKLP
ABL1P00519humanARHGDIBP52566Y130LkYVQHtyRTGVkVDRho_GDI
ABL1P00519humanDDB1Q16531Y718HIRtVPLyEsPRkIC
ABL1P00519humanWASP42768Y291AEtsKLIyDFIEDQGPBD
ABL1P00519humanCKMT1BP12532Y153AsKIRsGyFDErYVL
ABL1P00519humanDCBLD1Q8N8Z6S535QkLDLITsDMADyQQ
ABL1P00519humanKAT5Q92993Y44ISGRKLFyVHYIDFNTudor-knot
ABL1P00519humanMAVSQ7Z434Y9PFAEDkTykyICRNFCARD_2
ABL1P00519humanRTCBQ9Y3I0Y475MEEAPESykNVTDVVRtcB
ABL1P00519humanDCBLD1Q8N8Z6Y652VGAQDGDyQRPHsAQ
ABL1P00519humanTOP1P11387Y268AkMLDHEyTTkEIFRTopoisom_I_N
ABL1P00519humanSMAD4Q13485Y322SNHPAPEyWCSIAYF
ABL1P00519humanVAV1P15498Y267TPGAANLyQVFIKYKRhoGEF


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
ABL1IDDescription0.00e+00
ABL1GO:0097193intrinsic apoptotic signaling pathway2.05e-15
ABL1GO:0062197cellular response to chemical stress1.46e-14
ABL1GO:0034599cellular response to oxidative stress9.05e-12
ABL1GO:2001233regulation of apoptotic signaling pathway1.04e-10
ABL1GO:0006979response to oxidative stress1.04e-10
ABL1GO:0030522intracellular receptor signaling pathway1.04e-10
ABL1GO:0050673epithelial cell proliferation2.35e-10
ABL1GO:0000302response to reactive oxygen species4.09e-10
ABL1GO:0072331signal transduction by p53 class mediator6.46e-10
ABL1GO:0032355response to estradiol8.39e-10
ABL1GO:0042770signal transduction in response to DNA damage1.51e-09
ABL1GO:0032970regulation of actin filament-based process1.94e-09
ABL1GO:1902903regulation of supramolecular fiber organization2.61e-09
ABL1GO:0032956regulation of actin cytoskeleton organization2.61e-09
ABL1GO:0050678regulation of epithelial cell proliferation5.06e-09
ABL1GO:0002757immune response-activating signaling pathway6.54e-09
ABL1GO:0051098regulation of binding6.54e-09
ABL1GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator1.06e-08
ABL1GO:0002764immune response-regulating signaling pathway1.42e-08
ABL1GO:0034614cellular response to reactive oxygen species1.67e-08
ABL1GO:0031334positive regulation of protein-containing complex assembly2.17e-08
ABL1GO:0061614miRNA transcription4.65e-08
ABL1GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage5.89e-08
ABL1GO:1902905positive regulation of supramolecular fiber organization6.15e-08
ABL1GO:0010212response to ionizing radiation6.56e-08
ABL1GO:0010586miRNA metabolic process6.96e-08
ABL1GO:0031400negative regulation of protein modification process7.69e-08
ABL1GO:0048144fibroblast proliferation7.79e-08
ABL1GO:2001242regulation of intrinsic apoptotic signaling pathway1.31e-07
ABL1GO:0051090regulation of DNA-binding transcription factor activity1.86e-07
ABL1GO:2000628regulation of miRNA metabolic process1.86e-07
ABL1GO:0010517regulation of phospholipase activity1.86e-07
ABL1GO:0048145regulation of fibroblast proliferation2.43e-07
ABL1GO:0001933negative regulation of protein phosphorylation2.59e-07
ABL1GO:0043254regulation of protein-containing complex assembly2.59e-07
ABL1GO:0051099positive regulation of binding3.27e-07
ABL1GO:0009314response to radiation3.32e-07
ABL1GO:0045936negative regulation of phosphate metabolic process4.34e-07
ABL1GO:0010563negative regulation of phosphorus metabolic process4.38e-07
ABL1GO:0048732gland development5.01e-07
ABL1GO:0042326negative regulation of phosphorylation5.46e-07
ABL1GO:0098781ncRNA transcription5.46e-07
ABL1GO:1902893regulation of miRNA transcription5.58e-07
ABL1GO:0030330DNA damage respons1.01e-08
ABL1GO:2001235positive regulation of apoptotic signaling pathway9.26e-07
ABL1GO:0033673negative regulation of kinase activity1.19e-06
ABL1GO:0060191regulation of lipase activity1.19e-06
ABL1GO:0010332response to gamma radiation1.20e-06
ABL1GO:0051091positive regulation of DNA-binding transcription factor activity1.28e-06

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Related Drugs to ETV6_ABL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
ETV6ABL1Nilotinib Or DasatinibPubMed32279331

check button Distribution of the number of studies mentioning ETV6-ABL1 and kinase inhibitors the PubMed Abstract (04-01-2024)
all structure sitemap plddt ETV6-ABL1

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title
ETV6-ABL1 AND Imatinib 278125001905-07-0810.1016/j.lrr.2016.09.002An ETV6-ABL1 fusion in a patient with chronic myeloproliferative neoplasm: Initial response to Imatinib followed by rapid transformation into ALL.

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Related Diseases to ETV6_ABL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6ABL1Myeloid NeoplasmsPubMed32279331
ETV6ABL1Breast Invasive Ductal CarcinomaMyCancerGenome
ETV6ABL1Invasive Breast CarcinomaMyCancerGenome
ETV6ABL1Lung AdenocarcinomaMyCancerGenome
ETV6ABL1Appendix AdenocarcinomaMyCancerGenome
ETV6ABL1AstrocytomaMyCancerGenome

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
TgeneABL1C0023473Myeloid Leukemia, Chronic3CGI;CTD_human;ORPHANET
TgeneABL1C0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C0023453L2 Acute Lymphoblastic Leukemia2CTD_human
TgeneABL1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate