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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ETV6_NTRK3

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: ETV6_NTRK3
	KinaseFusionDB ID: KFG2180
	FusionGDB2.0 ID: KFG2180
		Hgene	Tgene
	Gene symbol	ETV6	NTRK3
	Gene ID	2120	4916
	Gene name	ETS variant transcription factor 6	neurotrophic receptor tyrosine kinase 3
	Synonyms	TEL\|TEL/ABL\|THC5	GP145-TrkC\|TRKC\|gp145(trkC)
	Cytomap	12p13.2	15q25.3
	Type of gene	protein-coding	protein-coding
	Description	transcription factor ETV6ETS-related protein Tel1ETV6-RUNX1 fusion proteinTEL1 oncogeneets variant gene 6 (TEL oncogene)	NT-3 growth factor receptorETS related protein-neurotrophic receptor tyrosine kinase fusion proteinETV6-NTRK3 fusionneurotrophic tyrosine kinase, receptor, type 3tyrosine kinase receptor C
	Modification date	20240305	20240411
	UniProtAcc	P41212	Q16288
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000396373, ENST00000544715,	ENST00000355254, ENST00000357724, ENST00000360948, ENST00000394480, ENST00000557856, ENST00000540489, ENST00000558306, ENST00000317501, ENST00000542733, ENST00000558676,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: ETV6 [Title/Abstract] AND NTRK3 [Title/Abstract] AND fusion [Title/Abstract] A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma (pmid: 9462753)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ETV6(12006495)-NTRK3(88576276), # samples:23 NTRK3(88669502)-ETV6(12022358), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ETV6	GO:0000122	negative regulation of transcription by RNA polymerase II	10514502
Tgene	NTRK3	GO:0001933	negative regulation of protein phosphorylation	23027130
Tgene	NTRK3	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	23027130
Tgene	NTRK3	GO:0008284	positive regulation of cell population proliferation	23027130
Tgene	NTRK3	GO:0010628	positive regulation of gene expression	23027130
Tgene	NTRK3	GO:0030335	positive regulation of cell migration	23027130
Tgene	NTRK3	GO:0032148	activation of protein kinase B activity	23027130
Tgene	NTRK3	GO:0033138	positive regulation of peptidyl-serine phosphorylation	23027130
Tgene	NTRK3	GO:0043406	positive regulation of MAP kinase activity	23027130
Tgene	NTRK3	GO:0050927	positive regulation of positive chemotaxis	23027130
Tgene	NTRK3	GO:0090630	activation of GTPase activity	23027130

Kinase Fusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across NTRK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerKB3	.	ETV6	chr12	12022903	NTRK3	chr15	88420143
ChimerDB4	AF041811	ETV6	chr12	12022903	NTRK3	chr15	88419991
ChimerDB4	TCGA-CE-A27D-01A	ETV6	chr12	12006495	NTRK3	chr15	88576276
ChimerKB3	.	ETV6	chr12	12006495	NTRK3	chr15	88576276
ChimerDB4	TCGA-AO-A03U-01B	ETV6	chr12	12022902	NTRK3	chr15	88483983
ChimerDB4	TCGA-AO-A03U-01B	ETV6	chr12	12022903	NTRK3	chr15	88483984
ChimerKB3	.	ETV6	chr12	12006495	NTRK3	chr15	88483984
ChimerKB3	.	ETV6	chr12	12022903	NTRK3	chr15	88483984
ChiTaRS5.0	AF041811	ETV6	chr12	12022903	NTRK3	chr15	88483987
ChimerKB4	.	ETV6	chr12	12006360	NTRK3	chr15	12006360
ChimerKB4	.	ETV6	chr12	12022357	NTRK3	chr15	12022357
COSMIC	2068813	ETV6	chr12	12022903	NTRK3	chr15	88576276

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88576276	4301	696
ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88483984	4112	633
ENST00000396373	ENST00000394480	ETV6	chr12	12006495	NTRK3	chr15	88576276	3755	514
ENST00000396373	ENST00000394480	ETV6	chr12	12022902	NTRK3	chr15	88483983	4112	633
ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88483987	4112	633
ENST00000396373	ENST00000394480	ETV6	chr12	12006495	NTRK3	chr15	88483984	3566	451

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000396373_ENST00000394480_ETV6_chr12_12022903_NTRK3_chr15_88576276_length(amino acids)=696
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGPVAVISGEEDSASPLHHINHGIT
TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL
AARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY
LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ

--------------------------------------------------------------

>ENST00000396373_ENST00000394480_ETV6_chr12_12022903_NTRK3_chr15_88483984_length(amino acids)=633
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>ENST00000396373_ENST00000394480_ETV6_chr12_12006495_NTRK3_chr15_88576276_length(amino acids)=514
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP
SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA
RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA
SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS

--------------------------------------------------------------

>ENST00000396373_ENST00000394480_ETV6_chr12_12022902_NTRK3_chr15_88483983_length(amino acids)=633
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>ENST00000396373_ENST00000394480_ETV6_chr12_12022903_NTRK3_chr15_88483987_length(amino acids)=633
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV
FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG
QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD

--------------------------------------------------------------

>ENST00000396373_ENST00000394480_ETV6_chr12_12006495_NTRK3_chr15_88483984_length(amino acids)=451
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL
AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP
RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT
TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12006495/chr15:88576276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ETV6 P41212	NTRK3 Q16288
FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269\|PubMed:25581430}.	FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269\|PubMed:25196463}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	14	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	15	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	14	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	15	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	14	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	15	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	14	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	15	210_300	0	613	Domain	Note=Ig-like C2-type 1
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	14	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	15	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	14	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	15	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	14	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	15	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	14	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	15	309_382	0	613	Domain	Note=Ig-like C2-type 2
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	14	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	15	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	14	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	15	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	14	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	15	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	14	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	15	160_209	0	613	Domain	Note=LRRCT
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	14	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	0	15	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	12	18	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	12	19	538_839	528	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88483984	ENST00000396373	13	19	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88576276	ENST00000396373	10	14	538_839	465	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88576276	ENST00000396373	11	15	538_839	465	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88576276	ENST00000396373	11	18	538_839	465	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88576276	ENST00000396373	11	19	538_839	465	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12006495	NTRK3	88576276	ENST00000396373	12	19	538_839	465	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	14	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	0	15	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	12	18	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	12	19	538_839	528	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022902	NTRK3	88483983	ENST00000396373	13	19	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	14	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	0	15	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	12	18	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	12	19	538_839	528	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483984	ENST00000396373	13	19	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	14	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	0	15	538_839	0	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	12	18	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	12	19	538_839	528	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88483987	ENST00000396373	13	19	538_839	528	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88576276	ENST00000396373	10	14	538_839	465	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88576276	ENST00000396373	11	15	538_839	465	613	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88576276	ENST00000396373	11	18	538_839	465	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88576276	ENST00000396373	11	19	538_839	465	840	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	ETV6	12022903	NTRK3	88576276	ENST00000396373	12	19	538_839	465	826	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>178_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12006495	NTRK3	chr15	88483984	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL	451
3D view using mol* of 178_ETV6_NTRK3

PDB file >>>TKFP_318_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88576276	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGPVAVISGEEDSASPLHHINHGIT TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL AARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ	696_ETV6_NTRK3
PDB file >>>TKFP_319_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88483984	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD	633_ETV6_NTRK3
3D view using mol* of TKFP_319_ETV6_NTRK3

PDB file >>>TKFP_320_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12006495	NTRK3	chr15	88576276	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEGPVAVISGEEDSASPLHHINHGITTP SSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLA SQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS	514_ETV6_NTRK3
3D view using mol* of TKFP_320_ETV6_NTRK3

PDB file >>>TKFP_321_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12022902	NTRK3	chr15	88483983	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD	633_ETV6_NTRK3
PDB file >>>TKFP_322_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12022903	NTRK3	chr15	88483987	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADVQHIKRRDIVLKRELGEGAFGKV FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDG QPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK FTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLD	633_ETV6_NTRK3
PDB file >>>TKFP_323_ETV6_NTRK3	ENST00000396373	ENST00000394480	ETV6	chr12	12006495	NTRK3	chr15	88483984	MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDVQHIKRRDIVLKRELGEGAFGKVFL AECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQP RQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFT TESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDIL	451_ETV6_NTRK3
3D view using mol* of TKFP_323_ETV6_NTRK3

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_264_NTRK3_ETV6_vs_HKFP_265_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_264_NTRK3_ETV6_vs_HKFP_266_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_264_NTRK3_ETV6_vs_HKFP_267_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_265_NTRK3_ETV6_vs_HKFP_266_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_265_NTRK3_ETV6_vs_HKFP_267_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_266_NTRK3_ETV6_vs_HKFP_267_NTRK3_ETV6_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_318_ETV6_NTRK3_vs_TKFP_319_ETV6_NTRK3_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_318_ETV6_NTRK3_vs_TKFP_320_ETV6_NTRK3_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_318_ETV6_NTRK3_vs_TKFP_323_ETV6_NTRK3_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_319_ETV6_NTRK3_vs_TKFP_320_ETV6_NTRK3_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_319_ETV6_NTRK3_vs_TKFP_323_ETV6_NTRK3_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_320_ETV6_NTRK3_vs_TKFP_323_ETV6_NTRK3_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_318_ETV6_NTRK3_vs_TKFP_319_ETV6_NTRK3.png

./secondary_str/TKFP_318_ETV6_NTRK3_vs_TKFP_320_ETV6_NTRK3.png

./secondary_str/TKFP_318_ETV6_NTRK3_vs_TKFP_323_ETV6_NTRK3.png

./secondary_str/TKFP_319_ETV6_NTRK3_vs_TKFP_320_ETV6_NTRK3.png

./secondary_str/TKFP_323_ETV6_NTRK3_vs_TKFP_319_ETV6_NTRK3.png

./secondary_str/TKFP_323_ETV6_NTRK3_vs_TKFP_320_ETV6_NTRK3.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ETV6_NTRK3 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/178_ETV6_NTRK3.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_319_ETV6_NTRK3_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_320_ETV6_NTRK3_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_323_ETV6_NTRK3_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

178_ETV6_NTRK3.png

TKFP_319_ETV6_NTRK3.png

TKFP_320_ETV6_NTRK3.png

TKFP_323_ETV6_NTRK3.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_319_ETV6_NTRK3	1.146	76	1.161	146.118	0.35	0.97	1.382	2.28	0.738	3.088	1.437	Chain A: 268,269,270,271,274,380,396,400,403,408,4 09,425,478,483,485,487,492,503,504,505,507,517
TKFP_320_ETV6_NTRK3	1.093	174	1.137	621.859	0.528	0.772	0.971	1.132	0.815	1.389	0.827	Chain A: 199,200,201,202,205,206,236,237,238,261,2 63,264,265,270,273,274,276,277,280,281,365,366,367 ,368,373,386,387,388,389,390,391,392,394,395,398,4 05,406,407,408,420,422
TKFP_323_ETV6_NTRK3	1.022	235	1.054	757.687	0.574	0.702	0.9	0.714	0.941	0.758	1.375	Chain A: 43,44,57,58,59,90,92,93,95,96,98,99,114,1 15,117,118,119,121,122,124,125,126,147,148,149,150 ,151,152,153,155,206,208,209,210,211,212,213,216,2 17,220,221,234,239,299,301,302

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

178_ETV6_NTRK3_ramachandran.png

TKFP_319_ETV6_NTRK3_ramachandran.png

TKFP_320_ETV6_NTRK3_ramachandran.png

TKFP_323_ETV6_NTRK3_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
178_ETV6_NTRK3-DOCK_HTVS_1-001	Osimertinib	-6.015680000000001	-6.02338	-23.9223
178_ETV6_NTRK3-DOCK_HTVS_1-001	Asciminib	-5.471509999999999	-5.93651	-46.9756
178_ETV6_NTRK3-DOCK_HTVS_1-001	Avapritinib	-5.30881	-5.64011	-37.2235
178_ETV6_NTRK3-DOCK_HTVS_1-001	Avapritinib	-5.30881	-5.64011	-37.2235
178_ETV6_NTRK3-DOCK_HTVS_1-001	Avapritinib	-5.30881	-5.64011	-37.2235
178_ETV6_NTRK3-DOCK_HTVS_1-001	Avapritinib	-5.30881	-5.64011	-37.2235
178_ETV6_NTRK3-DOCK_HTVS_1-001	Regorafenib	-5.29419	-5.29419	-39.662
178_ETV6_NTRK3-DOCK_HTVS_1-001	Asciminib	-5.28576	-5.75076	-46.8909
178_ETV6_NTRK3-DOCK_HTVS_1-001	Afatinib	-5.2281699999999995	-5.41047	-33.2832
178_ETV6_NTRK3-DOCK_HTVS_1-001	Afatinib	-5.2281699999999995	-5.41047	-33.2832
178_ETV6_NTRK3-DOCK_HTVS_1-001	Afatinib	-5.22677	-5.41047	-33.2832
178_ETV6_NTRK3-DOCK_HTVS_1-001	Netarsudil	-5.19721	-5.20831	-38.8586
178_ETV6_NTRK3-DOCK_HTVS_1-001	Netarsudil	-5.19721	-5.20831	-38.8586
178_ETV6_NTRK3-DOCK_HTVS_1-001	Belumosudil	-5.1886	-5.1963	-48.2916
178_ETV6_NTRK3-DOCK_HTVS_1-001	Bosutinib	-5.07457	-6.22927	-40.7379
178_ETV6_NTRK3-DOCK_HTVS_1-001	Bosutinib	-5.07457	-6.22927	-40.7379
178_ETV6_NTRK3-DOCK_HTVS_1-001	Bosutinib	-5.07457	-6.22927	-40.7379
178_ETV6_NTRK3-DOCK_HTVS_1-001	Ribociclib	-5.0595	-5.1285	-35.8003
178_ETV6_NTRK3-DOCK_HTVS_1-001	Ribociclib	-5.0595	-5.1285	-35.8003
178_ETV6_NTRK3-DOCK_HTVS_1-001	Lapatinib	-4.94413	-5.03293	-43.2842

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Kinase-Substrate Information of ETV6_NTRK3

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase

Kinase UniProt Acc

Kinase species

Substrate

Substrate UniProt Acc

Substrate phosphorylated residues

Substrate phosphorylated sites (+/-7AA)

Domain

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase

GOID

GO term

P.adjust

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Related Drugs to ETV6_NTRK3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
ETV6	NTRK3	Resistance To Entrectinib And Selitrectinib	PubMed	34429303

Distribution of the number of studies mentioning ETV6-NTRK3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1	Fusion gene - drug pair 2	PMID	Publication date	DOI	Study title
ETV6-NTRK3 AND Crizotinib		28497708	2017-05-12	10.1177/1066896917709350	"Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib."
ETV6-NTRK3 AND Crizotinib		23811600	2013-06-30	10.1038/nbt.2620	Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.
ETV6-NTRK3 AND Cabozantinib	ETV6-NTRK3 AND Entrectinib	34250401	2021-11	10.1200/po.20.00278	Response to Cabozantinib Following Acquired Entrectinib Resistance in a Patient With ETV6-NTRK3 Fusion-Positive Carcinoma Harboring the NTRK3 (G623R) Solvent-Front Mutation.
ETV6-NTRK3 AND Cabozantinib		33028644	2020-10	10.1101/mcs.a005645	Infantile fibrosarcoma-like tumor driven by novel RBPMS-MET fusion consolidated with cabozantinib.
ETV6-NTRK3 AND Larotrectinib		37576877	2023-07-27	10.3389/fonc.2023.1206833	Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review.
ETV6-NTRK3 AND Larotrectinib		37338765	1905-07-15	10.47056/1814-3490-2023-1-20-26	Development of a Cell Line Containing the Chimeric ETV6-NTRK3 Gene. The Search for Mutations of the Tyrosine Kinase Chimeric Domain That Cause Resistance to Larotrectinib.
ETV6-NTRK3 AND Larotrectinib		35761904	2022-1	10.1055/s-0042-1748866	Larotrectinib as an Effective Therapy in Congenital Infantile Fibrosarcoma: Report of Two Cases.
ETV6-NTRK3 AND Larotrectinib		35536733	2022-05-10	10.1093/oncolo/oyac080	Larotrectinib Treatment for Patients With TRK Fusion-Positive Salivary Gland Cancers.
ETV6-NTRK3 AND Larotrectinib	ETV6-NTRK3 AND Entrectinib	34372873	2021-08-09	10.1186/s13000-021-01133-z	"Characterization of an ETV6-NTRK3 rearrangement with unusual, but highly significant FISH signal pattern in a secretory carcinoma of the salivary gland: a case report."
ETV6-NTRK3 AND Larotrectinib		34231337	2021-07-07	10.1002/cnr2.1491	Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands.
ETV6-NTRK3 AND Larotrectinib		33936613	2021-02-20	10.1002/ccr3.3900	Complete response to larotrectinib treatment in a patient with papillary thyroid cancer harboring an ETV6-NTRK3 gene fusion.
ETV6-NTRK3 AND Larotrectinib	NACC2-NTRK2 AND Larotrectinib	33093355	2020-10-21	10.1097/mph.0000000000001983	Adjuvant Maintenance Larotrectinib Therapy in 2 Children With NTRK Fusion-positive High-grade Cancers.
ETV6-NTRK3 AND Larotrectinib		32923892	2020-11	10.1200/po.20.00017	Regression of ETV6-NTRK3 Infantile Glioblastoma After First-Line Treatment With Larotrectinib.
ETV6-NTRK3 AND Larotrectinib		31725893	2019-11-14	10.1182/bloodadvances.2019000700	Larotrectinib in TRK fusion-positive pediatric B-cell acute lymphoblastic leukemia.
ETV6-NTRK3 AND Larotrectinib		29233640	2018-6	10.1016/j.clbc.2017.11.017	Rapid Response to Larotrectinib (LOXO-101) in an Adult Chemotherapy-Naive Patients With Advanced Triple-Negative Secretory Breast Cancer Expressing ETV6-NTRK3 Fusion.
ETV6-NTRK3 AND Entrectinib		37601665	2023-08-04	10.3389/fonc.2023.1247435	Case Report: A case of complete response to entrectinib in NTRK fusion gene-positive parotid gland cancer.
ETV6-NTRK3 AND Entrectinib		36378538	2023-02-01	10.1530/etj-22-0179	Entrectinib in the neoadjuvant setting of anaplastic thyroid cancer: a case report.
ETV6-NTRK3 AND Entrectinib		35735423	2022-05-31	10.3390/curroncol29060314	TRK Inhibition with Entrectinib in Metastatic Salivary Secretory Carcinoma (SC): A Case Report.
ETV6-NTRK3 AND Entrectinib		34030125	2021-5	10.6004/jnccn.2021.7022	Clinical Activity of Selitrectinib in a Patient With Mammary Analogue Secretory Carcinoma of the Parotid Gland With Secondary Resistance to Entrectinib.
ETV6-NTRK3 AND Entrectinib		31965543	2020-01-22	10.1007/s40272-020-00380-9	The Evolving Diagnostic and Treatment Landscape of NTRK-Fusion-Driven Pediatric Cancers.
ETV6-NTRK3 AND Entrectinib		29237803	2018-02-01	10.1158/1535-7163.mct-17-0419	"Antitumor Activity of Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor, in ETV6-NTRK3-Positive Acute Myeloid Leukemia."

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Related Diseases to ETV6_NTRK3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
ETV6	NTRK3	Pediatric Glioma	PubMed	34429303
ETV6	NTRK3	Mammary Analog Secretory Carcinoma Of Salivary Gland	MyCancerGenome
ETV6	NTRK3	Fibrosarcoma	MyCancerGenome
ETV6	NTRK3	Colon Adenocarcinoma	MyCancerGenome
ETV6	NTRK3	Pancreatic Adenocarcinoma	MyCancerGenome
ETV6	NTRK3	Thyroid Gland Papillary Carcinoma	MyCancerGenome

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID	MeSH term
D018450	Disease Progression
D015470	Leukemia, Myeloid, Acute

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ETV6	C4015537	THROMBOCYTOPENIA 5	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	ETV6	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3	CTD_human
Hgene	ETV6	C0040034	Thrombocytopenia	3	CTD_human;GENOMICS_ENGLAND
Hgene	ETV6	C0023480	Leukemia, Myelomonocytic, Chronic	2	ORPHANET
Hgene	ETV6	C1332965	Congenital Mesoblastic Nephroma	2	ORPHANET
Tgene	NTRK3	C0036341	Schizophrenia	3	PSYGENET
Tgene	NTRK3	C0041696	Unipolar Depression	2	PSYGENET
Tgene	NTRK3	C1269683	Major Depressive Disorder	2	PSYGENET
Tgene	NTRK3	C1332965	Congenital Mesoblastic Nephroma	2	ORPHANET

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date