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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ETV6_PDGFRB

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ETV6_PDGFRB
KinaseFusionDB ID: KFG2182
FusionGDB2.0 ID: KFG2182
HgeneTgene
Gene symbol

ETV6

PDGFRB

Gene ID

2120

5159

Gene nameETS variant transcription factor 6platelet derived growth factor receptor beta
SynonymsTEL|TEL/ABL|THC5CD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT
Cytomap

12p13.2

5q32

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS-related protein Tel1ETV6-RUNX1 fusion proteinTEL1 oncogeneets variant gene 6 (TEL oncogene)platelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv
Modification date2024030520240413
UniProtAcc

P41212

P09619

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000523456, ENST00000261799, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ETV6 [Title/Abstract] AND PDGFRB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgenePDGFRB

GO:0007165

signal transduction

10821867

TgenePDGFRB

GO:0010863

positive regulation of phospholipase C activity

1653029

TgenePDGFRB

GO:0018108

peptidyl-tyrosine phosphorylation

1653029|2536956|2850496

TgenePDGFRB

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRB

GO:0032516

positive regulation of phosphoprotein phosphatase activity

7691811

TgenePDGFRB

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRB

GO:0046777

protein autophosphorylation

2536956|2850496

TgenePDGFRB

GO:0048008

platelet-derived growth factor receptor signaling pathway

1314164|2536956

TgenePDGFRB

GO:0051897

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

1314164

TgenePDGFRB

GO:0060326

cell chemotaxis

2554309|17991872


check buttonKinase Fusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across PDGFRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerKB3.ETV6chr12

12006495

PDGFRBchr5

149506177

ChimerKB4.ETV6chr12

12006495

PDGFRBchr5

149506177

COSMIC2759418ETV6chr12

12038960

PDGFRBchr5

149509531



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000396373ENST00000261799ETV6chr1212038960PDGFRBchr514950953154071068
ENST00000396373ENST00000261799ETV6chr1212006495PDGFRBchr51495061774405734

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000396373_ENST00000261799_ETV6_chr12_12038960_PDGFRB_chr5_149509531_length(amino acids)=1068
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRW
EDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRCPRELPPTLLGNSSEEESQLETNVTYWEEEQE
FEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHE
YIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLL
GACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMK
GDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLA
RDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQ
KCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDP

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>ENST00000396373_ENST00000261799_ETV6_chr12_12006495_PDGFRB_chr5_149506177_length(amino acids)=734
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEALPFKVVVISAILALVVLTIISLIIL
IMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARS
SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSL
TGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNC
VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ
FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPL
DTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDS

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr5:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

PDGFRB

P09619

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:1314164, ECO:0000269|PubMed:1396585, ECO:0000269|PubMed:1653029, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:1846866, ECO:0000269|PubMed:20494825, ECO:0000269|PubMed:20529858, ECO:0000269|PubMed:21098708, ECO:0000269|PubMed:21679854, ECO:0000269|PubMed:21733313, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:26599395, ECO:0000269|PubMed:2835772, ECO:0000269|PubMed:2850496, ECO:0000269|PubMed:7685273, ECO:0000269|PubMed:7691811, ECO:0000269|PubMed:7692233, ECO:0000269|PubMed:8195171}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneETV612006495PDGFRB149506177ENST00000396373923600_9625261107DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612038960PDGFRB149509531ENST00000396373823600_9624551107DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>179_ETV6_PDGFRBENST00000396373ENST00000261799ETV6chr1212006495PDGFRBchr5149506177
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEALPFKVVVISAILALVVLTIISLIIL
IMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARS
SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSL
TGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNC
VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ
FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPL
DTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDS
734
3D view using mol* of 179_ETV6_PDGFRB
PDB file >>>TKFP_324_ETV6_PDGFRBENST00000396373ENST00000261799ETV6chr1212038960PDGFRBchr5149509531
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRW
EDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRCPRELPPTLLGNSSEEESQLETNVTYWEEEQE
FEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHE
YIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLL
GACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMK
GDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLA
RDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQ
KCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDP
1068_ETV6_PDGFRB
PDB file >>>TKFP_325_ETV6_PDGFRBENST00000396373ENST00000261799ETV6chr1212006495PDGFRBchr5149506177
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEALPFKVVVISAILALVVLTIISLIIL
IMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARS
SEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSL
TGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNC
VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQ
FYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPL
DTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDS
734_ETV6_PDGFRB
3D view using mol* of TKFP_325_ETV6_PDGFRB


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.
3D view using mol* of viewer/superimpose_isoforms/TKFP_324_ETV6_PDGFRB_vs_TKFP_325_ETV6_PDGFRB_superimposed.pdb.html

check button Comparison of the Secondary Structures of Fusion Protein Isoforms
./secondary_str/TKFP_324_ETV6_PDGFRB_vs_TKFP_325_ETV6_PDGFRB.png
secondary structure of ./secondary_str/TKFP_324_ETV6_PDGFRB_vs_TKFP_325_ETV6_PDGFRB.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ETV6_PDGFRB does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/179_ETV6_PDGFRB.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_325_ETV6_PDGFRB_updated_violin_plot.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
179_ETV6_PDGFRB.png
all structure sitemap plddt3 179_ETV6_PDGFRB.png
179_ETV6_PDGFRB.png
all structure sitemap plddt4 179_ETV6_PDGFRB.png
TKFP_325_ETV6_PDGFRB.png
all structure sitemap plddt3 TKFP_325_ETV6_PDGFRB.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
TKFP_325_ETV6_PDGFRB1.108971.161454.4750.6450.7850.8170.8860.7241.2250.786Chain A: 251,253,254,257,258,290,296,310,311,312,3
13,417,418,419,463,464,467,469,601,604,605,608,609
,610,611

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

179_ETV6_PDGFRB_ramachandran.png
all structure ETV6-PDGFRB
TKFP_325_ETV6_PDGFRB_ramachandran.png
all structure ETV6-PDGFRB

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case
all structure ETV6-PDGFRB

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
179_ETV6_PDGFRB-DOCK_HTVS_1-001Belumosudil-7.02177-7.02947-48.6487
179_ETV6_PDGFRB-DOCK_HTVS_1-001Lapatinib-7.00144-7.09024-60.1682
179_ETV6_PDGFRB-DOCK_HTVS_1-001Belumosudil-6.9670000000000005-6.9747-49.0734
179_ETV6_PDGFRB-DOCK_HTVS_1-001Pexidartinib-6.93805-7.15485-47.0966
179_ETV6_PDGFRB-DOCK_HTVS_1-001Pexidartinib-6.93805-7.15485-47.0966
179_ETV6_PDGFRB-DOCK_HTVS_1-001Ripretinib-6.51485-6.52185-44.6239
179_ETV6_PDGFRB-DOCK_HTVS_1-001Ripretinib-6.51485-6.52185-44.6239
179_ETV6_PDGFRB-DOCK_HTVS_1-001Lapatinib-6.1298900000000005-6.2186900000000005-57.7308
179_ETV6_PDGFRB-DOCK_HTVS_1-001Avapritinib-6.00746-6.33876-54.2569
179_ETV6_PDGFRB-DOCK_HTVS_1-001Avapritinib-6.00746-6.33876-54.2569
179_ETV6_PDGFRB-DOCK_HTVS_1-001Avapritinib-6.00746-6.33876-54.2569
179_ETV6_PDGFRB-DOCK_HTVS_1-001Avapritinib-6.00746-6.33876-54.2569
179_ETV6_PDGFRB-DOCK_HTVS_1-001Larotrectinib-5.97991-5.97991-43.3449
179_ETV6_PDGFRB-DOCK_HTVS_1-001Trametinib-5.71603-5.71603-48.7491
179_ETV6_PDGFRB-DOCK_HTVS_1-001Regorafenib-5.70169-5.70169-50.8211
179_ETV6_PDGFRB-DOCK_HTVS_1-001Afatinib-5.66109-5.84339-46.7631
179_ETV6_PDGFRB-DOCK_HTVS_1-001Afatinib-5.66109-5.84339-46.7631
179_ETV6_PDGFRB-DOCK_HTVS_1-001Afatinib-5.65969-5.84339-46.7631
179_ETV6_PDGFRB-DOCK_HTVS_1-001Larotrectinib-5.59483-5.59483-41.8299
179_ETV6_PDGFRB-DOCK_HTVS_1-001Ruxolitinib-5.5041199999999995-5.5041199999999995-34.455

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Kinase-Substrate Information of ETV6_PDGFRB


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
PDGFRBP09619humanPDGFRBP09619Y1021PNEGDNDyIIPLPDP
PDGFRBP09619humanPDGFRAP16234Y754ERKEVsKysDIQRsLPK_Tyr_Ser-Thr
PDGFRBP09619humanPDGFRBP09619Y1009LDTSSVLyTAVQPNE
PDGFRBP09619humanPTK2Q05397Y5___MAAAyLDPNLNH
PDGFRBP09619humanABL2P42684Y272KCNKPTVyGVsPIHD
PDGFRBP09619humanPDGFRBP09619Y579VSSDGHEyIyVDPMQ
PDGFRBP09619humanPDGFRBP09619Y562LWQKKPRyEIRWKVI
PDGFRBP09619humanTHOC5Q13769Y225EIEVKKEyLSSLQPRFmiP_Thoc5
PDGFRBP09619humanABL2P42684Y139EKLRVLGyNQNGEWSSH3_1
PDGFRBP09619humanPLCG1P19174Y783EGRNPGFyVEANPMP
PDGFRBP09619humanPDGFRBP09619Y740TGESDGGyMDMSKDEPK_Tyr_Ser-Thr
PDGFRBP09619humanABL2P42684Y439RLMtGDtytAHAGAkPK_Tyr_Ser-Thr
PDGFRBP09619humanFYNP06241Y28sLNQssGyRyGTDPT
PDGFRBP09619humanETV6P41212Y17IkQERIsytPPEsPV
PDGFRBP09619humanPTK2Q05397Y194ALEKKSNyEVLEkDVFERM_M
PDGFRBP09619humanPDGFRBP09619Y763DMKGDVKyADIESSNPK_Tyr_Ser-Thr
PDGFRBP09619humanTNK2Q07912Y635PLPPPPAyDDVAQDE
PDGFRBP09619humanPDGFRBP09619Y581SDGHEyIyVDPMQLP
PDGFRBP09619humanABL2P42684Y116PNLFVALyDFVAsGDSH3_1
PDGFRBP09619humanABL2P42684Y303GGQyGEVyVGVWKKyPK_Tyr_Ser-Thr
PDGFRBP09619humanMUC1P15941Y1218tyHtHGRyVPPsstD
PDGFRBP09619humanABL2P42684Y310yVGVWKKysLtVAVKPK_Tyr_Ser-Thr
PDGFRBP09619humanPDGFRBP09619Y857DIMRDSNyISKGSTFPK_Tyr_Ser-Thr
PDGFRBP09619humanPDGFRBP09619Y775SSNyMAPyDNyVPSAPK_Tyr_Ser-Thr
PDGFRBP09619humanMUC1P15941Y1203IFPARDtyHPMsEyP
PDGFRBP09619humanPDGFRBP09619Y771ADIESSNyMAPyDNyPK_Tyr_Ser-Thr
PDGFRBP09619humanABL2P42684Y161QGWVPsNyItPVNSL
PDGFRBP09619humanETV6P41212Y27PEsPVPsyAsstPLH
PDGFRBP09619humanSRCP12931Y419RLIEDNEytARQGAkPK_Tyr_Ser-Thr
PDGFRBP09619humanPDGFRBP09619Y751SKDESVDyVPMLDMKPK_Tyr_Ser-Thr
PDGFRBP09619humanABL2P42684Y299HKLGGGQyGEVyVGVPK_Tyr_Ser-Thr
PDGFRBP09619humanPDGFRBP09619Y778yMAPyDNyVPSAPERPK_Tyr_Ser-Thr


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
PDGFRBIDDescription0.00e+00
PDGFRBGO:0018108peptidyl-tyrosine phosphorylation1.87e-08
PDGFRBGO:0018212peptidyl-tyrosine modification1.87e-08
PDGFRBGO:0038093Fc receptor signaling pathway6.42e-06
PDGFRBGO:0036120cellular response to platelet-derived growth factor stimulus4.63e-05
PDGFRBGO:0036119response to platelet-derived growth factor4.63e-05
PDGFRBGO:0002433immune response-regulating cell surface receptor signaling pathway involved in phagocytosis4.63e-05
PDGFRBGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.63e-05
PDGFRBGO:0002431Fc receptor mediated stimulatory signaling pathway6.79e-05
PDGFRBGO:0002862negative regulation of inflammatory response to antigenic stimulus6.79e-05
PDGFRBGO:0038094Fc-gamma receptor signaling pathway6.79e-05
PDGFRBGO:0010863positive regulation of phospholipase C activity8.77e-05
PDGFRBGO:1900274regulation of phospholipase C activity9.45e-05
PDGFRBGO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction1.34e-04
PDGFRBGO:0002861regulation of inflammatory response to antigenic stimulus1.52e-04
PDGFRBGO:0010518positive regulation of phospholipase activity1.52e-04
PDGFRBGO:0048013ephrin receptor signaling pathway1.61e-04
PDGFRBGO:0046777protein autophosphorylation1.87e-04
PDGFRBGO:0048008platelet-derived growth factor receptor signaling pathway2.11e-04
PDGFRBGO:0010517regulation of phospholipase activity2.11e-04
PDGFRBGO:0060193positive regulation of lipase activity2.11e-04
PDGFRBGO:0048010vascular endothelial growth factor receptor signaling pathway2.11e-04
PDGFRBGO:0051896regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction3.46e-04
PDGFRBGO:0060191regulation of lipase activity4.05e-04
PDGFRBGO:0002437inflammatory response to antigenic stimulus4.19e-04
PDGFRBGO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transduction5.64e-04
PDGFRBGO:0002429immune response-activating cell surface receptor signaling pathway7.80e-04
PDGFRBGO:0035791platelet-derived growth factor receptor-beta signaling pathway8.61e-04
PDGFRBGO:0007173epidermal growth factor receptor signaling pathway8.61e-04
PDGFRBGO:0033674positive regulation of kinase activity8.77e-04
PDGFRBGO:0002768immune response-regulating cell surface receptor signaling pathway9.40e-04
PDGFRBGO:2001243negative regulation of intrinsic apoptotic signaling pathway9.40e-04
PDGFRBGO:0072224metanephric glomerulus development1.11e-03
PDGFRBGO:0038127ERBB signaling pathway1.14e-03
PDGFRBGO:2000811negative regulation of anoikis1.18e-03
PDGFRBGO:0055003cardiac myofibril assembly1.24e-03
PDGFRBGO:0061298retina vasculature development in camera-type eye1.24e-03
PDGFRBGO:0050900leukocyte migration1.29e-03
PDGFRBGO:0043552positive regulation of phosphatidylinositol 3-kinase activity1.45e-03
PDGFRBGO:0051347positive regulation of transferase activity1.46e-03
PDGFRBGO:0050921positive regulation of chemotaxis1.49e-03
PDGFRBGO:0002223stimulatory C-type lectin receptor signaling pathway1.54e-03
PDGFRBGO:1990840response to lectin1.54e-03
PDGFRBGO:1990858cellular response to lectin1.54e-03
PDGFRBGO:0034614cellular response to reactive oxygen species1.60e-03
PDGFRBGO:2000209regulation of anoikis1.60e-03
PDGFRBGO:0090218positive regulation of lipid kinase activity1.85e-03
PDGFRBGO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.97e-03
PDGFRBGO:0002757immune response-activating signaling pathway1.99e-03
PDGFRBGO:0032102negative regulation of response to external stimulus2.07e-03

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Related Drugs to ETV6_PDGFRB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
ETV6PDGFRBImatinibPubMed17508004

check button Distribution of the number of studies mentioning ETV6-PDGFRB and kinase inhibitors the PubMed Abstract (04-01-2024)
all structure sitemap plddt ETV6-PDGFRB

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title
ETV6-PDGFRB AND ImatinibFIP1L1-PDGFRA AND Nilotinib208068172003-02-0110.2174/1389450033346885"ABL1, SRC and other non-receptor protein tyrosine kinases as new targets for specific anticancer therapy"
ETV6-PDGFRB AND ImatinibFIP1L1-PDGFRA AND Nilotinib208068172003-02-0110.2174/1389450033346885"ABL1, SRC and other non-receptor protein tyrosine kinases as new targets for specific anticancer therapy"
ETV6-PDGFRB AND Imatinib 277468191905-07-0810.1155/2016/8324791"Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature."
ETV6-PDGFRB AND ImatinibFIP1L1-PDGFRA AND Imatinib224320871993-310.1097/00008390-199303000-00064Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis.
ETV6-PDGFRB AND Imatinib 146716121905-06-2510.1038/sj.thj.6200294Effective treatment of hypereosinophilic syndrome with imatinib mesylate.
ETV6-PDGFRB AND Imatinib 121814022002-08-1510.1056/nejmoa020150Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta.

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Related Diseases to ETV6_PDGFRB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6PDGFRBChronic Myeloproliferative DiseasePubMed17508004
ETV6PDGFRBBreast Invasive Ductal CarcinomaMyCancerGenome
ETV6PDGFRBInvasive Breast CarcinomaMyCancerGenome
ETV6PDGFRBColon AdenocarcinomaMyCancerGenome
ETV6PDGFRBLung AdenocarcinomaMyCancerGenome
ETV6PDGFRBAnaplastic OligoastrocytomaMyCancerGenome

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH IDMeSH term
D015464Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Precursor Cell Lymphoblastic Leukemia-Lymphoma
D054198Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Precursor Cell Lymphoblastic Leukemia-Lymphoma
D015464Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Precursor Cell Lymphoblastic Leukemia-Lymphoma
D054198Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Precursor Cell Lymphoblastic Leukemia-Lymphoma

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET
TgenePDGFRBC3554321BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 46CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0393590Fahr's syndrome (disorder)3GENOMICS_ENGLAND;ORPHANET
TgenePDGFRBC4225270Kosaki overgrowth syndrome3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDGFRBC4551572MYOFIBROMATOSIS, INFANTILE, 13GENOMICS_ENGLAND;UNIPROT
TgenePDGFRBC0013421Dystonia2GENOMICS_ENGLAND
TgenePDGFRBC0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
TgenePDGFRBC0023893Liver Cirrhosis, Experimental2CTD_human
TgenePDGFRBC0036341Schizophrenia2PSYGENET
TgenePDGFRBC0432284Infantile myofibromatosis2CTD_human;GENOMICS_ENGLAND;ORPHANET


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate