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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ETV6_SYK

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ETV6_SYK
KinaseFusionDB ID: KFG2184
FusionGDB2.0 ID: KFG2184
HgeneTgene
Gene symbol

ETV6

SYK

Gene ID

2120

6850

Gene nameETS variant transcription factor 6spleen associated tyrosine kinase
SynonymsTEL|TEL/ABL|THC5IMD82|p72-Syk
Cytomap

12p13.2

9q22.2

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS-related protein Tel1ETV6-RUNX1 fusion proteinTEL1 oncogeneets variant gene 6 (TEL oncogene)tyrosine-protein kinase SYKspleen tyrosine kinase
Modification date2024030520240411
UniProtAcc

P41212

P43405

Ensembl transtripts involved in fusion geneENST idsENST00000396373, ENST00000544715, 
ENST00000375746, ENST00000476708, 
ENST00000375747, ENST00000375751, 
ENST00000375754, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ETV6 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502

TgeneSYK

GO:0006468

protein phosphorylation

17681949

TgeneSYK

GO:0007159

leukocyte cell-cell adhesion

12885943

TgeneSYK

GO:0018108

peptidyl-tyrosine phosphorylation

11606584

TgeneSYK

GO:0030593

neutrophil chemotaxis

12885943

TgeneSYK

GO:0035556

intracellular signal transduction

11606584|15509800

TgeneSYK

GO:1904263

positive regulation of TORC1 signaling

34634301


check buttonKinase Fusion gene breakpoints across ETV6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across SYK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerKB3.ETV6chr12

12022903

SYKchr9

93627329



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000396373ENST00000375751ETV6chr1212022903SYKchr9936273295275683

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000396373_ENST00000375751_ETV6_chr12_12022903_SYK_chr9_93627329_length(amino acids)=683
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGNVNFGGRPQLPGSHPASSPAQGN
RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK
ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH
RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

SYK

P43405

FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269|PubMed:25581430}.FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development (PubMed:12387735, PubMed:33782605). Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include DEPTOR, VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK (PubMed:12456653, PubMed:15388330, PubMed:8657103, PubMed:34634301). Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition (PubMed:12456653). Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR also plays a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion (PubMed:12387735). Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Also plays a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:33782605, ECO:0000269|PubMed:34634301, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneETV612022903SYK93627329ENST00000396373413371_631265613DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneETV612022903SYK93627329ENST00000396373414371_631265636DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>180_ETV6_SYKENST00000396373ENST00000375751ETV6chr1212022903SYKchr993627329
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGNVNFGGRPQLPGSHPASSPAQGN
RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK
ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH
RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT
683
3D view using mol* of 180_ETV6_SYK
PDB file >>>TKFP_326_ETV6_SYKENST00000396373ENST00000375751ETV6chr1212022903SYKchr993627329
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGNVNFGGRPQLPGSHPASSPAQGN
RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK
ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH
RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT
683_ETV6_SYK


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ETV6_SYK does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/180_ETV6_SYK.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
180_ETV6_SYK.png
all structure sitemap plddt3 180_ETV6_SYK.png
180_ETV6_SYK.png
all structure sitemap plddt4 180_ETV6_SYK.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

180_ETV6_SYK_ramachandran.png
all structure ETV6-SYK

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case
all structure ETV6-SYK

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
180_ETV6_SYK-DOCK_HTVS_1-001Midostaurin-5.70504-5.70504-45.5701
180_ETV6_SYK-DOCK_HTVS_1-001Neratinib-5.464180000000001-5.64648-51.2854
180_ETV6_SYK-DOCK_HTVS_1-001Neratinib-5.464180000000001-5.64648-51.2854
180_ETV6_SYK-DOCK_HTVS_1-001Larotrectinib-5.25777-5.25777-38.5575
180_ETV6_SYK-DOCK_HTVS_1-001Neratinib-5.25553-5.44143-48.4944
180_ETV6_SYK-DOCK_HTVS_1-001Dacomitinib-5.12721-5.23621-47.0168
180_ETV6_SYK-DOCK_HTVS_1-001Lapatinib-4.999569999999999-5.088369999999999-49.0274
180_ETV6_SYK-DOCK_HTVS_1-001Pralsetinib-4.9505099999999995-5.042009999999999-48.3499
180_ETV6_SYK-DOCK_HTVS_1-001Midostaurin-4.94883-4.94883-46.1499
180_ETV6_SYK-DOCK_HTVS_1-001Larotrectinib-4.9313-4.9313-42.7152
180_ETV6_SYK-DOCK_HTVS_1-001Dacomitinib-4.85365-4.96195-46.653
180_ETV6_SYK-DOCK_HTVS_1-001Dacomitinib-4.85365-4.96195-46.653
180_ETV6_SYK-DOCK_HTVS_1-001Ponatinib-4.81951-5.02611-48.0996
180_ETV6_SYK-DOCK_HTVS_1-001Ponatinib-4.81951-5.02611-48.0996
180_ETV6_SYK-DOCK_HTVS_1-001Ponatinib-4.81951-5.02611-48.0996
180_ETV6_SYK-DOCK_HTVS_1-001Cabozantinib-4.793019999999999-4.838019999999999-44.3595
180_ETV6_SYK-DOCK_HTVS_1-001Cabozantinib-4.793019999999999-4.838019999999999-44.3595
180_ETV6_SYK-DOCK_HTVS_1-001Pralsetinib-4.7424800000000005-4.83398-44.7838
180_ETV6_SYK-DOCK_HTVS_1-001Neratinib-4.69371-4.87961-45.4631
180_ETV6_SYK-DOCK_HTVS_1-001Tofacitinib-4.65564-4.66714-27.756999999999998

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Kinase-Substrate Information of ETV6_SYK


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
SYKP43405humanSLC4A1P02730Y904EEEGRDEyDEVAMPV
SYKP43405humanGCSAMQ8N6F7Y106sGNsAEEyyENVPCkHGAL
SYKP43405humanSHC1P29353-2Y317ELFDDPSyVNVQNLD
SYKP43405humanFCGR2CP31995Y310tDDDKNIyLTLPPND
SYKP43405humanPRDX2P32119Y193NVDDskEyFskHN__1-cysPrx_C
SYKP43405humanSLC4A1P02730Y21ENLEQEEyEDPDIPE
SYKP43405humanLAX1Q8IWV1Y268SSQISNDyVNMTGLDLAX
SYKP43405humanSLC4A1P02730Y8MEELQDDyEDMMEEN
SYKP43405humanPLCG1P19174Y771IGtAEPdyGALyEGR
SYKP43405humanBLNKQ8WV28Y96EENADDSyEPPPVEQ
SYKP43405humanPLCG2P16885Y759LyDVsRMyVDPsEIN
SYKP43405humanHCLS1P14317Y378EPEPENDyEDVEEMD
SYKP43405humanSHC1P29353-2Y239EEPPDHQyyNDFPGK
SYKP43405humanFCGR2AP12318Y304tDDDKNIyLTLPPND
SYKP43405humanIKZF1Q13422S361LAEGtPRsNHsAQDs
SYKP43405humanCFTRP13569Y512NIIFGVsyDEyRYRSABC_tran
SYKP43405humanLAT2Q9GZY6Y233EEDGEPDyVNGEVAALAT2
SYKP43405humanIKZF1Q13422S364GtPRsNHsAQDsAVE
SYKP43405humanDEPTORQ8TB45Y289ssCGssGyFsssPtL
SYKP43405humanCTTNQ14247Y421rLPssPVyEDAAsFK
SYKP43405humanARHGDIBP52566Y24ELdskLNykPPPQksRho_GDI
SYKP43405humanBLNKQ8WV28Y84EHSDSEMyVMPAEEN
SYKP43405humanPLCG1P19174Y783EGRNPGFyVEANPMP
SYKP43405humanSTAT5AP42229Y694LAkAVDGyVkPQIkQ
SYKP43405humanLAT2Q9GZY6Y193EDEEsEDyQNsAsIHLAT2
SYKP43405humanCBLP22681Y700EGEEDtEyMtPssRP
SYKP43405humanFCGR2CP31995Y287PEETNNDyETADGGy
SYKP43405humanGCSAMQ8N6F7Y86tysEELCytLINHRVHGAL
SYKP43405humanSLC4A1P02730Y359AKPDssFyKGLDLNG
SYKP43405humanSNCAP37840Y133EMPsEEGyQDyEPEA
SYKP43405humanSHC1P29353-2Y240EPPDHQyyNDFPGKE
SYKP43405humanLAT2Q9GZY6Y136EDDDANsyENVLICKLAT2
SYKP43405humanSNCAP37840Y136sEEGyQDyEPEA___
SYKP43405humanDUSP3P51452Y138SPTLVIAyLMMRQKMDSPc
SYKP43405humanSYKP43405Y352tEVyEsPyADPEEIR
SYKP43405humanSNCAP37840Y125VDPDNEAyEMPsEEGSynuclein
SYKP43405humanDOCK2Q92608Y224SsPTHsLyVFVRNFVDOCK_N
SYKP43405humanBLNKQ8WV28Y178LLEDEADyVVPVEDN
SYKP43405humanFCGR2AP12318Y281LEEtNNDyEtADGGy
SYKP43405humanDOCK2Q92608Y122LQVQSMMyDLMEWRSDOCK_N
SYKP43405humanDOCK2Q92608Y985DLIGKNVyPGDWMAM
SYKP43405humanBTKQ06187Y551RYVLDDEytsSVGSkPK_Tyr_Ser-Thr
SYKP43405humanLAX1Q8IWV1Y294AFQCCRDyENVPAADLAX
SYKP43405humanGCSAMQ8N6F7Y128LGGTEtEySLLHMPSHGAL
SYKP43405humanSYKP43405Y348LPMDtEVyEsPyADP
SYKP43405humanCBLP22681Y774sENEDDGyDVPKPPV
SYKP43405humanDUSP3P51452Y38NEVTPRIyVGNASVADSPc
SYKP43405humanGCSAMQ8N6F7Y107GNsAEEyyENVPCkAHGAL
SYKP43405humanCBLP22681Y731QQIDSCTyEAMyNIQ
SYKP43405humanBLNKQ8WV28Y72SDDFDSDyENPDEHS
SYKP43405humanLAX1Q8IWV1Y373SNEDSSDyENVLTAKLAX
SYKP43405humanMAPTP10636Y18MEDHAGTyGLGDRKD
SYKP43405humanGCSAMQ8N6F7Y80QDNVDQtysEELCytHGAL
SYKP43405humanSYKP43405Y525ALRADENyykAQtHGPK_Tyr_Ser-Thr
SYKP43405humanPTPN11Q06124Y542sKRkGHEytNIKysL
SYKP43405humanRHBGQ9H310Y429SPPDSQHyEDQVHWQ
SYKP43405humanLCP2Q13094Y113ssFEEDDyESPNDDQ
SYKP43405humanSYKP43405Y526LRADENyykAQtHGKPK_Tyr_Ser-Thr
SYKP43405humanBLNKQ8WV28Y189VEDNDENyIHPtESS
SYKP43405humanHCLS1P14317Y397EDEPEGDyEEVLEPE
SYKP43405humanDOCK2Q92608Y1405VkNAPGQyIQCFTVQDHR-2_Lobe_B
SYKP43405humanSTAT1P42224Y701DGPkGtGyIktELIs
SYKP43405humanPIP5K1BO14986Y105FGIKPDDyLYSICSE
SYKP43405humanLCP2Q13094Y128DGEDDGDyEsPNEEE
SYKP43405humanSTING1Q86WV6Y240AGIKDRVysNSIyELTMEM173
SYKP43405humanLAX1Q8IWV1Y193SSEDSHDyVNVPTAELAX


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
SYKIDDescription0.00e+00
SYKGO:0050851antigen receptor-mediated signaling pathway9.96e-10
SYKGO:0002429immune response-activating cell surface receptor signaling pathway3.67e-08
SYKGO:0002757immune response-activating signaling pathway3.67e-08
SYKGO:0002768immune response-regulating cell surface receptor signaling pathway3.67e-08
SYKGO:0002274myeloid leukocyte activation3.67e-08
SYKGO:0002764immune response-regulating signaling pathway5.28e-08
SYKGO:0050853B cell receptor signaling pathway5.47e-07
SYKGO:0002275myeloid cell activation involved in immune response2.08e-06
SYKGO:0038095Fc-epsilon receptor signaling pathway1.22e-05
SYKGO:0045576mast cell activation1.33e-05
SYKGO:0032481positive regulation of type I interferon production1.50e-05
SYKGO:0045807positive regulation of endocytosis2.15e-05
SYKGO:0043254regulation of protein-containing complex assembly3.20e-05
SYKGO:0033673negative regulation of kinase activity6.40e-05
SYKGO:0048872homeostasis of number of cells6.40e-05
SYKGO:0031334positive regulation of protein-containing complex assembly6.82e-05
SYKGO:0007173epidermal growth factor receptor signaling pathway7.07e-05
SYKGO:0019722calcium-mediated signaling8.55e-05
SYKGO:0051348negative regulation of transferase activity1.13e-04
SYKGO:0032479regulation of type I interferon production1.13e-04
SYKGO:0032606type I interferon production1.13e-04
SYKGO:0038127ERBB signaling pathway1.13e-04
SYKGO:0043303mast cell degranulation1.15e-04
SYKGO:0002279mast cell activation involved in immune response1.23e-04
SYKGO:0038093Fc receptor signaling pathway1.23e-04
SYKGO:0002448mast cell mediated immunity1.27e-04
SYKGO:0050852T cell receptor signaling pathway1.93e-04
SYKGO:2000377regulation of reactive oxygen species metabolic process2.06e-04
SYKGO:2000379positive regulation of reactive oxygen species metabolic process2.32e-04
SYKGO:0030098lymphocyte differentiation2.36e-04
SYKGO:0018108peptidyl-tyrosine phosphorylation2.36e-04
SYKGO:0018212peptidyl-tyrosine modification2.36e-04
SYKGO:0042113B cell activation2.36e-04
SYKGO:0030100regulation of endocytosis2.98e-04
SYKGO:0002366leukocyte activation involved in immune response3.51e-04
SYKGO:0002262myeloid cell homeostasis3.55e-04
SYKGO:0002263cell activation involved in immune response3.56e-04
SYKGO:0043299leukocyte degranulation3.56e-04
SYKGO:0140029exocytic process3.64e-04
SYKGO:0019932second-messenger-mediated signaling3.64e-04
SYKGO:0006469negative regulation of protein kinase activity3.67e-04
SYKGO:1903131mononuclear cell differentiation3.68e-04
SYKGO:0032418lysosome localization3.90e-04
SYKGO:1990849vacuolar localization3.90e-04
SYKGO:0042326negative regulation of phosphorylation4.38e-04
SYKGO:0006887exocytosis6.19e-04
SYKGO:0050764regulation of phagocytosis6.64e-04
SYKGO:0032755positive regulation of interleukin-6 production6.76e-04
SYKGO:0050878regulation of body fluid levels7.48e-04

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Related Drugs to ETV6_SYK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning ETV6-SYK and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to ETV6_SYK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
ETV6SYKBreast Invasive Ductal CarcinomaMyCancerGenome
ETV6SYKInvasive Breast CarcinomaMyCancerGenome
ETV6SYKLung AdenocarcinomaMyCancerGenome
ETV6SYKAppendix AdenocarcinomaMyCancerGenome
ETV6SYKColon AdenocarcinomaMyCancerGenome

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C4015537THROMBOCYTOPENIA 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia3CTD_human;GENOMICS_ENGLAND
HgeneETV6C0023480Leukemia, Myelomonocytic, Chronic2ORPHANET
HgeneETV6C1332965Congenital Mesoblastic Nephroma2ORPHANET


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate