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Kinase Fusion Gene:F2RL1_SBK2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: F2RL1_SBK2 | KinaseFusionDB ID: KFG2209 | FusionGDB2.0 ID: KFG2209 | Hgene | Tgene | Gene symbol | F2RL1 | SBK2 | Gene ID | 2150 | 646643 | |
| Gene name | F2R like trypsin receptor 1 | SH3 domain binding kinase family member 2 | ||||||||||
| Synonyms | GPR11|PAR2 | SGK069 | ||||||||||
| Cytomap | 5q13.3 | 19q13.42 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | proteinase-activated receptor 2G-protein coupled receptor 11coagulation factor II (thrombin) receptor-like 1protease-activated receptor 2thrombin receptor-like 1 | serine/threonine-protein kinase SBK2SH3-binding domain kinase family, member 2Sugen kinase 69 | ||||||||||
| Modification date | 20240416 | 20240305 | ||||||||||
| UniProtAcc | P55085 | P0C263 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000296677, | ENST00000344158, ENST00000413299, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: F2RL1 [Title/Abstract] AND SBK2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | F2RL1(76131133)-SBK2(56044206), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | F2RL1 | GO:0002690 | positive regulation of leukocyte chemotaxis | 17991872 |
| Hgene | F2RL1 | GO:0002720 | positive regulation of cytokine production involved in immune response | 11441110 |
| Hgene | F2RL1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 10725339 |
| Hgene | F2RL1 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 19781631 |
| Hgene | F2RL1 | GO:0030193 | regulation of blood coagulation | 17848177 |
| Hgene | F2RL1 | GO:0030836 | positive regulation of actin filament depolymerization | 17500066 |
| Hgene | F2RL1 | GO:0032682 | negative regulation of chemokine production | 19865078 |
| Hgene | F2RL1 | GO:0032722 | positive regulation of chemokine production | 19494303|21501162 |
| Hgene | F2RL1 | GO:0032731 | positive regulation of interleukin-1 beta production | 15155775 |
| Hgene | F2RL1 | GO:0032733 | positive regulation of interleukin-10 production | 18453611 |
| Hgene | F2RL1 | GO:0032755 | positive regulation of interleukin-6 production | 11447194|15155775 |
| Hgene | F2RL1 | GO:0032757 | positive regulation of interleukin-8 production | 15155775|17404307|18622013|19865078 |
| Hgene | F2RL1 | GO:0032930 | positive regulation of superoxide anion generation | 11714832 |
| Hgene | F2RL1 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway | 18622013 |
| Hgene | F2RL1 | GO:0042119 | neutrophil activation | 15155775 |
| Hgene | F2RL1 | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 18453611 |
| Hgene | F2RL1 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 11413129 |
| Hgene | F2RL1 | GO:0043311 | positive regulation of eosinophil degranulation | 11714832 |
| Hgene | F2RL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16410250 |
| Hgene | F2RL1 | GO:0046328 | regulation of JNK cascade | 16410250 |
| Hgene | F2RL1 | GO:0046329 | negative regulation of JNK cascade | 19781631 |
| Hgene | F2RL1 | GO:0046330 | positive regulation of JNK cascade | 11413129 |
| Hgene | F2RL1 | GO:0050900 | leukocyte migration | 15155775 |
| Hgene | F2RL1 | GO:0050927 | positive regulation of positive chemotaxis | 17991872 |
| Hgene | F2RL1 | GO:0051607 | defense response to virus | 18453611|19494303 |
| Hgene | F2RL1 | GO:0060100 | positive regulation of phagocytosis, engulfment | 21501162 |
| Hgene | F2RL1 | GO:0061028 | establishment of endothelial barrier | 20826780 |
| Hgene | F2RL1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10725339 |
| Hgene | F2RL1 | GO:0070963 | positive regulation of neutrophil mediated killing of gram-negative bacterium | 21501162 |
| Hgene | F2RL1 | GO:0097029 | mature conventional dendritic cell differentiation | 16478888 |
| Hgene | F2RL1 | GO:2000341 | regulation of chemokine (C-X-C motif) ligand 2 production | 21501162 |
| Kinase Fusion gene breakpoints across F2RL1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across SBK2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AX381390 | F2RL1 | chr5 | 76131133 | SBK2 | chr19 | 56044206 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:76131133/:56044206) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| F2RL1 | SBK2 |
| FUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. {ECO:0000269|PubMed:10086357, ECO:0000269|PubMed:10725339, ECO:0000269|PubMed:11413129, ECO:0000269|PubMed:11441110, ECO:0000269|PubMed:11447194, ECO:0000269|PubMed:11714832, ECO:0000269|PubMed:12832443, ECO:0000269|PubMed:15155775, ECO:0000269|PubMed:16359518, ECO:0000269|PubMed:16410250, ECO:0000269|PubMed:16478888, ECO:0000269|PubMed:16714334, ECO:0000269|PubMed:17404307, ECO:0000269|PubMed:17500066, ECO:0000269|PubMed:18424071, ECO:0000269|PubMed:18453611, ECO:0000269|PubMed:18474671, ECO:0000269|PubMed:18622013, ECO:0000269|PubMed:19494303, ECO:0000269|PubMed:19781631, ECO:0000269|PubMed:19864598, ECO:0000269|PubMed:19865078, ECO:0000269|PubMed:20826780, ECO:0000269|PubMed:21501162, ECO:0000269|PubMed:23202369, ECO:0000269|PubMed:28445455}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of F2RL1_SBK2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
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Related Drugs to F2RL1_SBK2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning F2RL1-SBK2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to F2RL1_SBK2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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