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Kinase Fusion Gene:FER_RPS14 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: FER_RPS14 | KinaseFusionDB ID: KFG2290 | FusionGDB2.0 ID: KFG2290 | Hgene | Tgene | Gene symbol | FER | RPS14 | Gene ID | 2241 | 6208 | |
| Gene name | FER tyrosine kinase | ribosomal protein S14 | ||||||||||
| Synonyms | PPP1R74|TYK3|p94-Fer | EMTB|S14|uS11 | ||||||||||
| Cytomap | 5q21.3 | 5q33.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | tyrosine-protein kinase Ferfeline encephalitis virus-related kinase FERfer (fps/fes related) tyrosine kinasefujinami poultry sarcoma/Feline sarcoma-related protein Ferphosphoprotein NCP94protein phosphatase 1, regulatory subunit 74proto-oncogene c-F | small ribosomal subunit protein uS1140S ribosomal protein S14emetine resistance | ||||||||||
| Modification date | 20240411 | 20240407 | ||||||||||
| UniProtAcc | Q96AC1 | P62263 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000281092, ENST00000438717, ENST00000502752, ENST00000536402, | ENST00000312037, ENST00000401695, ENST00000407193, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: FER [Title/Abstract] AND RPS14 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FER(108121980)-RPS14(149823825), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FER | GO:0007260 | tyrosine phosphorylation of STAT protein | 19147545 |
| Hgene | FER | GO:0010591 | regulation of lamellipodium assembly | 19738202 |
| Hgene | FER | GO:0018108 | peptidyl-tyrosine phosphorylation | 12972546|19738202 |
| Hgene | FER | GO:0046777 | protein autophosphorylation | 7623846 |
| Tgene | RPS14 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 7867928 |
| Tgene | RPS14 | GO:0042274 | ribosomal small subunit biogenesis | 34516797 |
| Kinase Fusion gene breakpoints across FER (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across RPS14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | EC560630 | FER | chr5 | 108121980 | RPS14 | chr5 | 149823825 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:108121980/:149823825) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FER | RPS14 |
| FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}. | FUNCTION: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of FER_RPS14 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| FER | P16591 | human | PRKCD | Q05655 | Y374 | ELkGRGEyFAIKALK | Pkinase |
| FER | P16591 | human | DPYSL2 | Q16555 | Y499 | rGVPRGLyDGPVCEV | |
| FER | P16591 | human | MET | P08581 | Y1349 | stFIGEHyVHVNAty | |
| FER | P16591 | human | FER | P16591 | Y402 | EPPPVVNyEEDARsV | |
| FER | P16591 | human | IRS4 | O14654 | Y921 | EADSSsDyVNMDFTk | |
| FER | P16591 | human | IRS4 | O14654 | Y828 | GQNDNsEyVPMLPGk | |
| FER | P16591 | human | STAT3 | P40763 | Y705 | DPGsAAPyLktKFIC | |
| FER | P16591 | human | FER | P16591 | Y615 | EAkILkQyDHPNIVK | PK_Tyr_Ser-Thr |
| FER | P16591 | human | IRS4 | O14654 | Y847 | GLDkEVSyNWDPKDA | |
| FER | P16591 | human | EZR | P15311 | Y478 | PPPPPPVyEPVsyHV | |
| FER | P16591 | human | AR | P10275 | Y225 | PtsSKDNyLGGTSTI | Androgen_recep |
| FER | P16591 | human | IRS4 | O14654 | Y656 | SGGRFRLyFCVDrGA | |
| FER | P16591 | human | IRS4 | O14654 | Y779 | DNDsEsDyMFMAPGA | |
| FER | P16591 | human | DPYSL2 | Q16555 | Y479 | kPFPDFVyKRIKARS | |
| FER | P16591 | human | EZR | P15311 | Y354 | LMLRLQDyEEktKKA | ERM_helical |
| FER | P16591 | human | MAPK1 | P28482 | Y187 | HtGFLtEyVAtRWyr | Pkinase |
| FER | P16591 | human | NSF | P46459 | Y83 | QEIEVSLyTFDKAKQ | CDC48_N |
| FER | P16591 | human | FER | P16591 | Y714 | RQEDGGVyssSGLkQ | PK_Tyr_Ser-Thr |
| FER | P16591 | human | EZR | P15311 | Y146 | kEVHksGyLSsERLI | FERM_M |
| FER | P16591 | human | JUP | P14923 | Y550 | AAGtQQPytDGVRME | |
| FER | P16591 | human | GAB1 | Q13480 | Y627 | KGDKQVEyLDLDLDs |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| FER | ID | Description | 0.00e+00 |
| FER | GO:0008286 | insulin receptor signaling pathway | 7.57e-06 |
| FER | GO:0071375 | cellular response to peptide hormone stimulus | 7.57e-06 |
| FER | GO:1901653 | cellular response to peptide | 1.54e-05 |
| FER | GO:0032869 | cellular response to insulin stimulus | 2.11e-05 |
| FER | GO:0043434 | response to peptide hormone | 2.11e-05 |
| FER | GO:0032868 | response to insulin | 6.55e-05 |
| FER | GO:0034614 | cellular response to reactive oxygen species | 2.72e-04 |
| FER | GO:0000302 | response to reactive oxygen species | 6.11e-04 |
| FER | GO:0006935 | chemotaxis | 6.11e-04 |
| FER | GO:0042330 | taxis | 6.11e-04 |
| FER | GO:0002064 | epithelial cell development | 6.40e-04 |
| FER | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 9.85e-04 |
| FER | GO:0034599 | cellular response to oxidative stress | 1.08e-03 |
| FER | GO:0072659 | protein localization to plasma membrane | 1.67e-03 |
| FER | GO:0062197 | cellular response to chemical stress | 2.20e-03 |
| FER | GO:0060326 | cell chemotaxis | 2.28e-03 |
| FER | GO:0032386 | regulation of intracellular transport | 2.34e-03 |
| FER | GO:0072520 | seminiferous tubule development | 2.34e-03 |
| FER | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 2.45e-03 |
| FER | GO:1990778 | protein localization to cell periphery | 2.51e-03 |
| FER | GO:0038127 | ERBB signaling pathway | 2.64e-03 |
| FER | GO:2000641 | regulation of early endosome to late endosome transport | 2.72e-03 |
| FER | GO:0032970 | regulation of actin filament-based process | 2.88e-03 |
| FER | GO:0006979 | response to oxidative stress | 3.41e-03 |
| FER | GO:0051090 | regulation of DNA-binding transcription factor activity | 3.46e-03 |
| FER | GO:0035264 | multicellular organism growth | 3.54e-03 |
| FER | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 3.62e-03 |
| FER | GO:0070102 | interleukin-6-mediated signaling pathway | 4.05e-03 |
| FER | GO:0006606 | protein import into nucleus | 4.15e-03 |
| FER | GO:0051170 | import into nucleus | 4.39e-03 |
| FER | GO:0007009 | plasma membrane organization | 4.53e-03 |
| FER | GO:0007015 | actin filament organization | 4.53e-03 |
| FER | GO:1903649 | regulation of cytoplasmic transport | 5.11e-03 |
| FER | GO:0045766 | positive regulation of angiogenesis | 5.11e-03 |
| FER | GO:1904018 | positive regulation of vasculature development | 5.11e-03 |
| FER | GO:0003382 | epithelial cell morphogenesis | 5.11e-03 |
| FER | GO:0002764 | immune response-regulating signaling pathway | 5.23e-03 |
| FER | GO:0032388 | positive regulation of intracellular transport | 6.10e-03 |
| FER | GO:0032271 | regulation of protein polymerization | 6.21e-03 |
| FER | GO:0042307 | positive regulation of protein import into nucleus | 6.61e-03 |
| FER | GO:0071354 | cellular response to interleukin-6 | 6.61e-03 |
| FER | GO:0045022 | early endosome to late endosome transport | 7.63e-03 |
| FER | GO:0070741 | response to interleukin-6 | 7.63e-03 |
| FER | GO:0098927 | vesicle-mediated transport between endosomal compartments | 9.26e-03 |
| FER | GO:0030521 | androgen receptor signaling pathway | 9.43e-03 |
| FER | GO:0048009 | insulin-like growth factor receptor signaling pathway | 9.76e-03 |
| FER | GO:1902895 | positive regulation of miRNA transcription | 9.76e-03 |
| FER | GO:0038093 | Fc receptor signaling pathway | 1.11e-02 |
| FER | GO:0110053 | regulation of actin filament organization | 1.14e-02 |
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Related Drugs to FER_RPS14 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning FER-RPS14 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to FER_RPS14 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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