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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:FGFR2_ATE1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: FGFR2_ATE1
KinaseFusionDB ID: KFG2326
FusionGDB2.0 ID: KFG2326
HgeneTgene
Gene symbol

FGFR2

ATE1

Gene ID

2263

11101

Gene namefibroblast growth factor receptor 2arginyltransferase 1
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25-
Cytomap

10q26.13

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14arginyl-tRNA--protein transferase 1R-transferase 1arginine-tRNA--protein transferase 1arginyl-tRNA-protein transferase
Modification date2024041620240407
UniProtAcc

P21802

O95260

Ensembl transtripts involved in fusion geneENST idsENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000359354, 
ENST00000360144, ENST00000369056, 
ENST00000369059, ENST00000369060, 
ENST00000369061, ENST00000457416, 
ENST00000478859, ENST00000490349, 
ENST00000224652, ENST00000481784, 
ENST00000535655, ENST00000543447, 
ENST00000369040, ENST00000540606, 
ENST00000369043, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: FGFR2 [Title/Abstract] AND ATE1 [Title/Abstract] AND fusion [Title/Abstract]

Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26 (pmid: 28123544)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FGFR2(123298106)-ATE1(123503373), # samples:2
FGFR2(123353223)-ATE1(123503373), # samples:2
ATE1(123549684)-FGFR2(123263455), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell population proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check buttonKinase Fusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across ATE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-AX-A3G3-01AFGFR2chr10

123298106

ATE1chr10

123683844

ChimerDB4TCGA-44-2657-01AFGFR2chr10

123353223

ATE1chr10

123600778

ChimerDB4TCGA-AN-A0AK-01AFGFR2chr10

123243212

ATE1chr10

123549804

ChimerDB4TCGA-D8-A142-01AFGFR2chr10

123353223

ATE1chr10

123503373

ChimerDB4TCGA-DK-A3X2-01AFGFR2chr10

123298106

ATE1chr10

123503373

ChimerDB4TCGA-D8-A142-01AFGFR2chr10

123357476

ATE1chr10

123683844

ChimerDB4TCGA-D8-A142FGFR2chr10

123357475

ATE1chr10

123683844



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000357555ENST00000224652FGFR2chr10123298106ATE1chr101235033731548253
ENST00000369061ENST00000369043FGFR2chr10123243212ATE1chr101235498045671788
ENST00000369061ENST00000369043FGFR2chr10123298106ATE1chr101236838445605766

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000357555_ENST00000224652_FGFR2_chr10_123298106_ATE1_chr10_123503373_length(amino acids)=253
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVS
ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN

--------------------------------------------------------------

>ENST00000369061_ENST00000369043_FGFR2_chr10_123243212_ATE1_chr10_123549804_length(amino acids)=788
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEGQYRPSDLLCPETYVWVPIEQCLPSLENSKY

--------------------------------------------------------------

>ENST00000369061_ENST00000369043_FGFR2_chr10_123298106_ATE1_chr10_123683844_length(amino acids)=766
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCE
DEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSK
PPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSF
SLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVY
SALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQ

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123298106/chr10:123503373)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

ATE1

O95260

FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues. {ECO:0000250|UniProtKB:Q9Z2A5}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
655650651678679765768765767768134249160160249249249249249249249134249160160249249249249249249249655650651678679765768765767768249249249249249249249249249249249249249249249249655650651678679765768765767768768767768
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneFGFR2123243212ATE1123549804ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755541625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755551525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755551725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755551725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755551725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755551725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755561625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755561825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755561825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST0000035755561825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123503373ENST000003575556725_1251255DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906141625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906151525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906151725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906151725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906151725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906151725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906161625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906161825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906161825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST0000036906161825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123298106ATE1123683844ENST000003690616725_1251255DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212ATE1123549804ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555515154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555517154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555517154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555616154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555618154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555618154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST00000357555618154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123503373ENST0000035755567154_2471255DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061515154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061517154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061517154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061616154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061618154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061618154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST00000369061618154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123298106ATE1123683844ENST0000036906167154_2471255DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212ATE1123549804ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212ATE1123549804ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212ATE1123549804ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212ATE1123549804ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>103_FGFR2_ATE1ENST00000369061ENST00000369043FGFR2chr10123298106ATE1chr10123683844
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCE
DEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSK
PPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSF
SLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVY
SALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQ
766
3D view using mol* of 103_FGFR2_ATE1
PDB file >>>HKFP_143_FGFR2_ATE1ENST00000357555ENST00000224652FGFR2chr10123298106ATE1chr10123503373
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVS
ENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN
253_FGFR2_ATE1
PDB file >>>HKFP_144_FGFR2_ATE1ENST00000369061ENST00000369043FGFR2chr10123243212ATE1chr10123549804
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEGQYRPSDLLCPETYVWVPIEQCLPSLENSKY
788_FGFR2_ATE1
3D view using mol* of HKFP_144_FGFR2_ATE1
PDB file >>>HKFP_145_FGFR2_ATE1ENST00000369061ENST00000369043FGFR2chr10123298106ATE1chr10123683844
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCE
DEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSK
PPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSF
SLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVY
SALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQ
766_FGFR2_ATE1
3D view using mol* of HKFP_145_FGFR2_ATE1


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.
3D view using mol* of viewer/superimpose_isoforms/HKFP_143_FGFR2_ATE1_vs_HKFP_144_FGFR2_ATE1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_143_FGFR2_ATE1_vs_HKFP_145_FGFR2_ATE1_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/HKFP_144_FGFR2_ATE1_vs_HKFP_145_FGFR2_ATE1_superimposed.pdb.html

check button Comparison of the Secondary Structures of Fusion Protein Isoforms
./secondary_str/HKFP_143_FGFR2_ATE1_vs_HKFP_144_FGFR2_ATE1.png
secondary structure of ./secondary_str/HKFP_143_FGFR2_ATE1_vs_HKFP_144_FGFR2_ATE1.png
./secondary_str/HKFP_145_FGFR2_ATE1_vs_HKFP_143_FGFR2_ATE1.png
secondary structure of ./secondary_str/HKFP_145_FGFR2_ATE1_vs_HKFP_143_FGFR2_ATE1.png
./secondary_str/HKFP_145_FGFR2_ATE1_vs_HKFP_144_FGFR2_ATE1.png
secondary structure of ./secondary_str/HKFP_145_FGFR2_ATE1_vs_HKFP_144_FGFR2_ATE1.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

FGFR2_ATE1 does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
103_FGFR2_ATE1.png
all structure sitemap plddt 103_FGFR2_ATE1.png
103_FGFR2_ATE1.png
all structure sitemap plddt2 103_FGFR2_ATE1.png
HKFP_144_FGFR2_ATE1.png
all structure sitemap plddt HKFP_144_FGFR2_ATE1.png
HKFP_145_FGFR2_ATE1.png
all structure sitemap plddt HKFP_145_FGFR2_ATE1.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
HKFP_144_FGFR2_ATE11.0621201.113348.1450.4740.720.9791.0290.7961.2921.371Chain A: 363,364,365,366,367,369,451,454,455,458,4
59,461,462,463,542,543,544,570,571,572,574,575
HKFP_145_FGFR2_ATE11.0851491.029540.2250.4660.8251.0620.4431.2440.3560.671Chain A: 295,304,305,306,307,311,362,363,364,546,5
49,550,551,552,566,613,614,615,616,618,626,627,628
,631,632,635,652,654,655,656,663,664,666,667

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

103_FGFR2_ATE1_ramachandran.png
all structure FGFR2-ATE1
HKFP_144_FGFR2_ATE1_ramachandran.png
all structure FGFR2-ATE1
HKFP_145_FGFR2_ATE1_ramachandran.png
all structure FGFR2-ATE1

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure FGFR2-ATE1
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Larotrectinib-6.1466400000000005-6.1466400000000005-39.5474
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Lenvatinib-6.01704-6.01704-45.1213
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Brigatinib-6.01296-6.02646-46.408
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Brigatinib-6.01296-6.02646-46.408
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Upadacitinib-5.92026-5.92126-35.2665
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Axitinib-5.59601-5.59921-35.1209
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Sorafenib-5.58975-5.60185-47.7184
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Sorafenib-5.58975-5.60185-47.7184
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Belumosudil-5.56918-5.57688-44.0177
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Gilteritinib-5.5088599999999985-5.53526-27.485
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Gilteritinib-5.5088599999999985-5.53526-27.485
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Gilteritinib-5.5088599999999985-5.53526-27.485
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Gilteritinib-5.5088599999999985-5.53526-27.485
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Fedratinib-5.4956-5.5470000000000015-46.5512
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Fedratinib-5.4956-5.5470000000000015-46.5512
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Tofacitinib-5.42631-5.43781-34.6242
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Tofacitinib-5.42631-5.43781-34.6242
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Regorafenib-5.421880000000002-5.421880000000002-43.6629
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Nilotinib-5.32272-5.46232-48.3884
HKFP_144_FGFR2_ATE1_vsw_2-DOCK_HTVS_1-001Nilotinib-5.32272-5.46232-48.3884
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Tofacitinib-7.65228-7.66378-43.0277
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Tofacitinib-7.65228-7.66378-43.0277
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Ruxolitinib-7.32712-7.32712-41.5664
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Temsirolimus-7.0350100000000015-7.036410000000001-68.5189
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Sorafenib-6.8143-6.8264-53.8259
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Sorafenib-6.8143-6.8264-53.8259
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Lapatinib-6.74718-6.83598-65.5592
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Upadacitinib-6.6821100000000015-6.683110000000001-43.4964
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Netarsudil-6.6582-6.6693-55.5628
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Netarsudil-6.6582-6.6693-55.5628
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Upadacitinib-6.53284-6.5338400000000005-35.8774
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Neratinib-6.52265-6.70855-60.464
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Regorafenib-6.47255-6.47255-50.7723
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Ripretinib-6.47025-6.47725-50.7849
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Ripretinib-6.47025-6.47725-50.7849
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Temsirolimus-6.44753-6.448930000000002-53.1382
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Midostaurin-6.41259-6.41259-43.6909
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Neratinib-6.36407-6.54637-65.4315
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Neratinib-6.36407-6.54637-65.4315
HKFP_145_FGFR2_ATE1_vsw_3-DOCK_HTVS_1-001Neratinib-6.31625-6.49855-56.5619
103_FGFR2_ATE1-DOCK_HTVS_1-001Netarsudil-7.001530000000001-7.012630000000001-48.9338
103_FGFR2_ATE1-DOCK_HTVS_1-001Netarsudil-7.001530000000001-7.012630000000001-48.9338
103_FGFR2_ATE1-DOCK_HTVS_1-001Mobocertinib-6.55307-6.56077-58.1605
103_FGFR2_ATE1-DOCK_HTVS_1-001Netarsudil-6.2782599999999995-6.28936-48.922
103_FGFR2_ATE1-DOCK_HTVS_1-001Netarsudil-6.2782599999999995-6.28936-48.922
103_FGFR2_ATE1-DOCK_HTVS_1-001Ibrutinib-6.18847-6.18847-50.0036
103_FGFR2_ATE1-DOCK_HTVS_1-001Midostaurin-6.01203-6.01203-49.7234
103_FGFR2_ATE1-DOCK_HTVS_1-001Lapatinib-6.0063-6.0951-60.2062
103_FGFR2_ATE1-DOCK_HTVS_1-001Midostaurin-5.976030000000001-5.976030000000001-42.2799
103_FGFR2_ATE1-DOCK_HTVS_1-001Capmatinib-5.973-5.9786-50.3197
103_FGFR2_ATE1-DOCK_HTVS_1-001Entrectinib-5.96882-6.033519999999999-56.1224
103_FGFR2_ATE1-DOCK_HTVS_1-001Entrectinib-5.96882-6.033519999999999-56.1224
103_FGFR2_ATE1-DOCK_HTVS_1-001Belumosudil-5.8943900000000005-5.90209-54.2282
103_FGFR2_ATE1-DOCK_HTVS_1-001Erdafitinib-5.8675-5.8677-50.8756
103_FGFR2_ATE1-DOCK_HTVS_1-001Larotrectinib-5.84211-5.84211-49.7963
103_FGFR2_ATE1-DOCK_HTVS_1-001Pralsetinib-5.81948-5.91098-53.8691
103_FGFR2_ATE1-DOCK_HTVS_1-001Vemurafenib-5.81652-6.26052-44.5465
103_FGFR2_ATE1-DOCK_HTVS_1-001Vemurafenib-5.81652-6.26052-44.5465
103_FGFR2_ATE1-DOCK_HTVS_1-001Baricitinib-5.79649-5.79649-44.8356
103_FGFR2_ATE1-DOCK_HTVS_1-001Midostaurin-5.78664-5.78664-48.2955

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Kinase-Substrate Information of FGFR2_ATE1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
FGFR2P21802humanFGFR2P21802Y769TLTTNEEyLDLSQPL
FGFR2P21802humanCTNNB1P35222Y142AVVNLINyQDDAELA
FGFR2P21802humanPTENP60484Y240RREDKFMyFEFPQPLPTEN_C2
FGFR2P21802humanGLO1Q04760Y136GIAVPDVysACkRFEGlyoxalase
FGFR2P21802humanTFRCP02786Y20FGGEPLsytRFsLAR
FGFR2P21802humanGRB2P62993Y160QVPQQPtyVQALFDF


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
FGFR2IDDescription0.00e+00
FGFR2GO:0008543fibroblast growth factor receptor signaling pathway7.81e-04
FGFR2GO:0030316osteoclast differentiation7.81e-04
FGFR2GO:0044344cellular response to fibroblast growth factor stimulus7.81e-04
FGFR2GO:0060742epithelial cell differentiation involved in prostate gland development7.81e-04
FGFR2GO:0021761limbic system development7.81e-04
FGFR2GO:0071774response to fibroblast growth factor7.81e-04
FGFR2GO:0001704formation of primary germ layer7.81e-04
FGFR2GO:0060670branching involved in labyrinthine layer morphogenesis7.81e-04
FGFR2GO:0060572morphogenesis of an epithelial bud9.34e-04
FGFR2GO:0097091synaptic vesicle clustering9.61e-04
FGFR2GO:0048660regulation of smooth muscle cell proliferation1.18e-03
FGFR2GO:0048659smooth muscle cell proliferation1.18e-03
FGFR2GO:0001837epithelial to mesenchymal transition1.18e-03
FGFR2GO:0061138morphogenesis of a branching epithelium1.23e-03
FGFR2GO:0060713labyrinthine layer morphogenesis1.23e-03
FGFR2GO:0007369gastrulation1.26e-03
FGFR2GO:0060571morphogenesis of an epithelial fold1.26e-03
FGFR2GO:0001763morphogenesis of a branching structure1.26e-03
FGFR2GO:0002053positive regulation of mesenchymal cell proliferation1.26e-03
FGFR2GO:0060669embryonic placenta morphogenesis1.40e-03
FGFR2GO:0060441epithelial tube branching involved in lung morphogenesis1.61e-03
FGFR2GO:0002573myeloid leukocyte differentiation1.61e-03
FGFR2GO:0051091positive regulation of DNA-binding transcription factor activity1.62e-03
FGFR2GO:0010464regulation of mesenchymal cell proliferation1.62e-03
FGFR2GO:0033002muscle cell proliferation1.62e-03
FGFR2GO:0031069hair follicle morphogenesis1.62e-03
FGFR2GO:0048762mesenchymal cell differentiation1.80e-03
FGFR2GO:0010092specification of animal organ identity1.80e-03
FGFR2GO:0048730epidermis morphogenesis1.83e-03
FGFR2GO:0010463mesenchymal cell proliferation2.43e-03
FGFR2GO:0060428lung epithelium development2.43e-03
FGFR2GO:0060711labyrinthine layer development2.58e-03
FGFR2GO:0060070canonical Wnt signaling pathway2.59e-03
FGFR2GO:0035987endodermal cell differentiation2.62e-03
FGFR2GO:0048546digestive tract morphogenesis2.62e-03
FGFR2GO:0060485mesenchyme development2.62e-03
FGFR2GO:0030850prostate gland development2.64e-03
FGFR2GO:0060688regulation of morphogenesis of a branching structure2.78e-03
FGFR2GO:0060425lung morphogenesis2.85e-03
FGFR2GO:0097479synaptic vesicle localization2.85e-03
FGFR2GO:0001706endoderm formation3.21e-03
FGFR2GO:0001701in utero embryonic development3.84e-03
FGFR2GO:0045453bone resorption3.84e-03
FGFR2GO:0001655urogenital system development3.84e-03
FGFR2GO:0048645animal organ formation3.84e-03
FGFR2GO:0051090regulation of DNA-binding transcription factor activity3.84e-03
FGFR2GO:0030900forebrain development3.84e-03
FGFR2GO:0051347positive regulation of transferase activity3.96e-03
FGFR2GO:1904888cranial skeletal system development4.12e-03

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Related Drugs to FGFR2_ATE1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning FGFR2-ATE1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to FGFR2_ATE1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 123CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome21CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0001193Apert syndrome19CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0795998JACKSON-WEISS SYNDROME10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0175699Saethre-Chotzen Syndrome8CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C2936791Antley-Bixler Syndrome, Autosomal Dominant7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia6CTD_human;ORPHANET
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0010278Craniosynostosis4CTD_human;GENOMICS_ENGLAND
HgeneFGFR2C1863389Apert-Crouzon Disease4CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0006142Malignant neoplasm of breast3CTD_human;UNIPROT
HgeneFGFR2C0030044Acrocephaly3CTD_human
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0221356Brachycephaly3CTD_human
HgeneFGFR2C0265534Scaphycephaly3CTD_human
HgeneFGFR2C0265535Trigonocephaly3CTD_human
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C0678222Breast Carcinoma3CTD_human
HgeneFGFR2C1257931Mammary Neoplasms, Human3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C1833340Synostotic Posterior Plagiocephaly3CTD_human
HgeneFGFR2C1860819Metopic synostosis3CTD_human
HgeneFGFR2C2931150Synostotic Anterior Plagiocephaly3CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C4551902Craniosynostosis, Type 13CTD_human
HgeneFGFR2C4704874Mammary Carcinoma, Human3CTD_human
HgeneFGFR2C0008925Cleft Palate2CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0024623Malignant neoplasm of stomach2CGI;CTD_human
HgeneFGFR2C0038356Stomach Neoplasms2CGI;CTD_human
HgeneFGFR2C1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneFGFR2C1837218Cleft palate, isolated2CTD_human


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate